-
1
-
-
0036849331
-
-
Brazil DP, Park J, Hemmings BA (2002) PKB Binding Proteins: Getting in on the Akt. Cell 111: 293-303.
-
Brazil DP, Park J, Hemmings BA (2002) PKB Binding Proteins: Getting in on the Akt. Cell 111: 293-303.
-
-
-
-
2
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277.
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
3
-
-
0001582482
-
Molecular cloning of the Akt oncogene and its human homologues Akt1 and Akt2: Amplification of Akt1 in a primary human gastric adenocarcinoma
-
Staal SP (1987) Molecular cloning of the Akt oncogene and its human homologues Akt1 and Akt2: amplification of Akt1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci U S A 84: 5034-5037.
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
4
-
-
0027470177
-
Structure, expression and chromosomal mapping of c-akt: Relationship to v-akt and its implications
-
Bellacosa A, Franke TF, Gonzalez-Portal ME, Datta K, Taguichi T, et al. (1993) Structure, expression and chromosomal mapping of c-akt: Relationship to v-akt and its implications. Oncogene 8: 745-754.
-
(1993)
Oncogene
, vol.8
, pp. 745-754
-
-
Bellacosa, A.1
Franke, T.F.2
Gonzalez-Portal, M.E.3
Datta, K.4
Taguichi, T.5
-
5
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, et al. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 2: 727-736.
-
(1995)
Cell
, vol.2
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
-
6
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 18: 1098-1101.
-
(2005)
Science
, vol.18
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
7
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, et al. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
-
8
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 23: 1919-1931.
-
(2008)
EMBO J
, vol.23
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
9
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dedependent phosphorylation
-
Chan TO, Rittenhouse SE, Tsichlis PN (1999) AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dedependent phosphorylation. Annu Rev Biochem 68: 965-1014.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
10
-
-
0037107414
-
A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation
-
Frödin M, Antal TL, Dümmler BA, Jensen CJ, Deak M, et al. (2002) A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. EMBO J 21: 5396-5407.
-
(2002)
EMBO J
, vol.21
, pp. 5396-5407
-
-
Frödin, M.1
Antal, T.L.2
Dümmler, B.A.3
Jensen, C.J.4
Deak, M.5
-
11
-
-
0346434149
-
Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation
-
Bijur GN, Jope RS (2003) Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation. J Neurochem 87: 1427-1435.
-
(2003)
J Neurochem
, vol.87
, pp. 1427-1435
-
-
Bijur, G.N.1
Jope, R.S.2
-
12
-
-
46149115394
-
-
PLoS
-
Finocchietto P, Barreyro F, Holod S, Peralta J, Franco MC, et al. (2008) Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome. PLoS ONE 3: e1749.
-
(2008)
Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: Implications for the metabolic syndrome
, vol.ONE 3
-
-
Finocchietto, P.1
Barreyro, F.2
Holod, S.3
Peralta, J.4
Franco, M.C.5
-
13
-
-
1642422748
-
Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease
-
Carreras MC, Franco MC, Peralta JG, Poderoso JJ (2004) Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease. Mol Aspects Med 25: 125-139.
-
(2004)
Mol Aspects Med
, vol.25
, pp. 125-139
-
-
Carreras, M.C.1
Franco, M.C.2
Peralta, J.G.3
Poderoso, J.J.4
-
14
-
-
34250635065
-
Mitochondrial nitric oxide in the signaling of cell integrated responses
-
Carreras MC, Poderoso JJ (2007) Mitochondrial nitric oxide in the signaling of cell integrated responses. Am J Physiol Cell Physiol 292: C1569-1580.
-
(2007)
Am J Physiol Cell Physiol
, vol.292
-
-
Carreras, M.C.1
Poderoso, J.J.2
-
15
-
-
0032575752
-
Mitochondria and apoptosis
-
Green DR, Reed JC (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
-
(1998)
Science
, vol.281
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
16
-
-
60549111398
-
Is Akt the "Warburg kinase"?_Akt-energy metabolism interactions and oncogenesis
-
Robey RB, Hay N (2005) Is Akt the "Warburg kinase"?_Akt-energy metabolism interactions and oncogenesis. Seminars in Cancer Biology 19: 25-31.
-
(2005)
Seminars in Cancer Biology
, vol.19
, pp. 25-31
-
-
Robey, R.B.1
Hay, N.2
-
17
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Helden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Helden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
18
-
-
56849118516
-
Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
-
Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, et al. (2008) Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14: 458-470.
-
(2008)
Cancer Cell
, vol.14
, pp. 458-470
-
-
Nogueira, V.1
Park, Y.2
Chen, C.C.3
Xu, P.Z.4
Chen, M.L.5
-
19
-
-
0141988685
-
-
Galli S, Labato MI, Bal de Kier Joffé E, Carreras MC, Poderoso JJ (2003) Decreased mitochondrial nitric oxide synthase activity and hydrogen peroxide relate persistent tumoral proliferation to embryonic behavior. Cancer Res 63: 6370-6377.
-
Galli S, Labato MI, Bal de Kier Joffé E, Carreras MC, Poderoso JJ (2003) Decreased mitochondrial nitric oxide synthase activity and hydrogen peroxide relate persistent tumoral proliferation to embryonic behavior. Cancer Res 63: 6370-6377.
-
-
-
-
20
-
-
0142117313
-
The Bcl-2 family: Roles in cell survival and oncogenesis
-
Cory S, Huang DC, Adams JM (2003) The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607.
-
(2003)
Oncogene
, vol.22
, pp. 8590-8607
-
-
Cory, S.1
Huang, D.C.2
Adams, J.M.3
-
21
-
-
2942642590
-
Automatic and quantitative measurement of protein-protein colocalization in live cells
-
Costes SV, Daelemans D, Cho E, Dobbin Z, Pavlakis G, et al. (2004) Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys J 86: 3993-4003.
-
(2004)
Biophys J
, vol.86
, pp. 3993-4003
-
-
Costes, S.V.1
Daelemans, D.2
Cho, E.3
Dobbin, Z.4
Pavlakis, G.5
-
23
-
-
9344259718
-
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
-
Kwon J, Lee SR, Yang KS, Ahn Y, Kim YJ, et al. (2004) Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc Natl Acad Sci U S A 101: 16419-16424.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 16419-16424
-
-
Kwon, J.1
Lee, S.R.2
Yang, K.S.3
Ahn, Y.4
Kim, Y.J.5
-
24
-
-
57049135307
-
Ser9-phosphorylation of mitochondrial GSK-3{beta} is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis
-
Ohori K, Miura T, Tanno M, Miki T, Sato T, et al. (2008) Ser9-phosphorylation of mitochondrial GSK-3{beta} is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis. Am J Physiol Heart Circ Physiol 295: H2079-2086.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Ohori, K.1
Miura, T.2
Tanno, M.3
Miki, T.4
Sato, T.5
-
25
-
-
42949110704
-
L prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity
-
L prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity. J Cell Physiol 215: 676-683.
-
(2008)
J Cell Physiol
, vol.215
, pp. 676-683
-
-
Wang, Y.1
Zhang, B.2
Peng, X.3
Perpetua, M.4
Harbrecht, B.G.5
-
26
-
-
6444220198
-
Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth
-
Liu X, Powlas J, Shi Y, Oleksijew AX, Shoemaker AR, et al. (2004) Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth. Anticancer Res 24: 2697-2704.
-
(2004)
Anticancer Res
, vol.24
, pp. 2697-2704
-
-
Liu, X.1
Powlas, J.2
Shi, Y.3
Oleksijew, A.X.4
Shoemaker, A.R.5
-
27
-
-
0034644523
-
Cellular signaling: Pivoting around PDK-1
-
Toker A, Newton AC (2000) Cellular signaling: pivoting around PDK-1. Cell 103: 185-188.
-
(2000)
Cell
, vol.103
, pp. 185-188
-
-
Toker, A.1
Newton, A.C.2
-
28
-
-
43249093752
-
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
-
Bayascas JR, Wullschleger S, Sakamoto K, García-Martínez JM, Clacher C, et al. (2008) Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance. Mol Cell Biol 28: 3258-3272.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3258-3272
-
-
Bayascas, J.R.1
Wullschleger, S.2
Sakamoto, K.3
García-Martínez, J.M.4
Clacher, C.5
-
29
-
-
34247391898
-
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo
-
Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, et al. (2007) Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol 4: e95.
-
(2007)
PLoS Biol
, vol.4
-
-
Calleja, V.1
Alcor, D.2
Laguerre, M.3
Park, J.4
Vojnovic, B.5
-
30
-
-
0033912843
-
Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation
-
Filippa N, Sable CL, Hemmings BA, Van Obberghen E (2000) Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation. Mol Cell Biol 20: 5712-5721.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5712-5721
-
-
Filippa, N.1
Sable, C.L.2
Hemmings, B.A.3
Van Obberghen, E.4
-
31
-
-
20444372545
-
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation
-
Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, et al. (2005) Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem 280: 16916-16924.
-
(2005)
J Biol Chem
, vol.280
, pp. 16916-16924
-
-
Connor, K.M.1
Subbaram, S.2
Regan, K.J.3
Nelson, K.K.4
Mazurkiewicz, J.E.5
-
32
-
-
40749096524
-
ATP-dependent modulation and autophosphorylation of rapeseed 2-Cys peroxiredoxin
-
Aran M, Caporaletti D, Senn AM, Tellez de Iñon MT, Girotti M, et al. (2008) ATP-dependent modulation and autophosphorylation of rapeseed 2-Cys peroxiredoxin. FEBS J 275: 1450-1463.
-
(2008)
FEBS J
, vol.275
, pp. 1450-1463
-
-
Aran, M.1
Caporaletti, D.2
Senn, A.M.3
Tellez de Iñon, M.T.4
Girotti, M.5
-
33
-
-
36749047453
-
Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: Mechanistic involvement of AKT catalytic activation loop cysteines
-
Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, et al. (2007) Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines. Mol Cancer Ther 6: 3028-3038.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3028-3038
-
-
Toral-Barza, L.1
Zhang, W.G.2
Huang, X.3
McDonald, L.A.4
Salaski, E.J.5
-
34
-
-
48649095021
-
-
PLoS
-
Galli S, Antico Arciuch VG, Poderoso C, Converso DP, Zhou Q, et al. (2008) Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. PLoS ONE 3: e2379.
-
(2008)
Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria
, vol.ONE 3
-
-
Galli, S.1
Antico Arciuch, V.G.2
Poderoso, C.3
Converso, D.P.4
Zhou, Q.5
-
35
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
36
-
-
1842562333
-
Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development
-
Alonso M, Melani M, Converso DP, Jaitovich A, Paz C, et al. (2004) Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development. J Neurochem 89: 248-256.
-
(2004)
J Neurochem
, vol.89
, pp. 248-256
-
-
Alonso, M.1
Melani, M.2
Converso, D.P.3
Jaitovich, A.4
Paz, C.5
-
37
-
-
0025726216
-
Rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
Nicoletti I, Migliorati G, Oagliacci MC, Grignani F, Riccardi CA (1991) Rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Meth 139: 271-279.
-
(1991)
J Immunol Meth
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Oagliacci, M.C.3
Grignani, F.4
Riccardi, C.A.5
-
38
-
-
0034635466
-
Differential localization and operation of distinct Mg(2+) transporters in apical and basolateral sides of rat liver plasma membrane
-
Cefaratti C, Romani A, Scarpa A (2000) Differential localization and operation of distinct Mg(2+) transporters in apical and basolateral sides of rat liver plasma membrane. J Biol Chem 275: 3772-3780.
-
(2000)
J Biol Chem
, vol.275
, pp. 3772-3780
-
-
Cefaratti, C.1
Romani, A.2
Scarpa, A.3
-
39
-
-
34548178909
-
In-gel digestion for mass spectrometric characterization of proteins and proteomes
-
Shevchenko A, Tomas H, Havlis J, Olsen JV, Mann M (2006) In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protocols 1: 2856-2860.
-
(2006)
Nat Protocols
, vol.1
, pp. 2856-2860
-
-
Shevchenko, A.1
Tomas, H.2
Havlis, J.3
Olsen, J.V.4
Mann, M.5
|