메뉴 건너뛰기




Volumn 11, Issue 6, 2011, Pages 393-410

Targeting hypoxia in cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

2 NITROIMIDAZOLE; 5 BROMOISOQUINOLONE; ACETYLSALICYLIC ACID; AKR 1C3; ANTINEOPLASTIC AGENT; APAZIQUONE; BANOXANTRONE; BETA AMINOPROPRIONITRILE; BLEOMYCIN; CARICOTAMIDE; CHLORAMBUCIL; CISPLATIN; COMBRETASTATIN A4; DINITROBENZAMIDE; DOXORUBICIN; ETOPOSIDE; EZN 2968; FLUOROURACIL; GEMCITABINE; METHOTREXATE; MITOMYCIN C; PIMONIDAZOLE; PR 104; SN 29730; SN 29966; SN 30000; TAXANE DERIVATIVE; TIRAPAZAMINE; TRETAZICAR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VELIPARIB;

EID: 79957534572     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3064     Document Type: Review
Times cited : (2575)

References (187)
  • 1
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • DOI 10.1126/science.1104819
    • Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005). (Pubitemid 40093472)
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 2
    • 67049155678 scopus 로고    scopus 로고
    • Structural adaptation and heterogeneity of normal and tumor microvascular networks
    • Pries, A. R. et al. Structural adaptation and heterogeneity of normal and tumor microvascular networks. PLoS Comput. Biol. 5, e1000394 (2009).
    • (2009) PLoS Comput. Biol. , vol.5
    • Pries, A.R.1
  • 3
    • 44349157832 scopus 로고    scopus 로고
    • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
    • DOI 10.1038/nrc2397, PII NRC2397
    • Dewhirst, M. W., Cao, Y. & Moeller, B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nature Rev. Cancer 8, 425-437 (2008). (Pubitemid 351744964)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 425-437
    • Dewhirst, M.W.1    Cao, Y.2    Moeller, B.3
  • 6
    • 74949118681 scopus 로고    scopus 로고
    • The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG 5
    • Rouschop, K. M. et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG 5 . J. Clin. Invest. 120, 127-141 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 127-141
    • Rouschop, K.M.1
  • 8
    • 77953488431 scopus 로고    scopus 로고
    • Oxygen-mediated endocytosis in cancer
    • Wang, Y. & Ohh, M. Oxygen-mediated endocytosis in cancer. J. Cell. Mol. Med. 14, 496-503 (2010).
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 496-503
    • Wang, Y.1    Ohh, M.2
  • 9
    • 0034021690 scopus 로고    scopus 로고
    • Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
    • Semenza, G. L. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit. Rev. Biochem. Mol. Biol. 35, 71-103 (2000). (Pubitemid 30253678)
    • (2000) Critical Reviews in Biochemistry and Molecular Biology , vol.35 , Issue.2 , pp. 71-103
    • Semenza, G.L.1
  • 10
    • 77949697909 scopus 로고    scopus 로고
    • Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice
    • Kioi, M. et al. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J. Clin. Invest. 120, 694-705 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 694-705
    • Kioi, M.1
  • 12
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • DOI 10.1016/S1535-6108(03)00085-0, PII S1535610803000850
    • Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell. 3, 347-361 (2003). (Pubitemid 38340304)
    • (2003) Cancer Cell , vol.3 , Issue.4 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3    Mazzone, M.4    Giordano, S.5    Comoglio, P.M.6
  • 13
    • 79954582454 scopus 로고    scopus 로고
    • Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer
    • Chang, Q., Jurisica, I., Do, T. & Hedley, D. W. Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res. 78, 3110-3120 (2011).
    • (2011) Cancer Res. , vol.78 , pp. 3110-3120
    • Chang, Q.1    Jurisica, I.2    Do, T.3    Hedley, D.W.4
  • 14
    • 78149260621 scopus 로고    scopus 로고
    • Hypoxic tumours and their effect on immune cells and cancer therapy
    • Yotnda, P., Wu, D. & Swanson, A. M. Hypoxic tumours and their effect on immune cells and cancer therapy. Methods Mol. Biol. 651, 1-29 (2010).
    • (2010) Methods Mol. Biol. , vol.651 , pp. 1-29
    • Yotnda, P.1    Wu, D.2    Swanson, A.M.3
  • 16
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia DNA repair and genetic instability
    • Bristow, R. G. & Hill, R. P. Hypoxia, DNA repair and genetic instability. Nature Rev. Cancer 8, 180-192 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 17
    • 34447506424 scopus 로고    scopus 로고
    • 2 histography
    • DOI 10.1089/ars.2007.1628
    • Vaupel, P., Hockel, M. & Mayer, A. Detection and characterization of tumor hypoxia using pO2 histography. Antioxid. Redox Signal. 9, 1221-1235 (2007). (Pubitemid 47080831)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.8 , pp. 1221-1235
    • Vaupel, P.1    Hockel, M.2    Mayer, A.3
  • 19
    • 77952107920 scopus 로고    scopus 로고
    • Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis
    • Jubb, A. M., Buffa, F. M. & Harris, A. L. Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis. J. Cell. Mol. Med. 14, 18-29 (2010).
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 18-29
    • Jubb, A.M.1    Buffa, F.M.2    Harris, A.L.3
  • 20
    • 0014024073 scopus 로고
    • Cure of mice bearing advanced plasma cell tumours with aniline mustard: The relationship between glucuronidase activity and tumour sensitivity
    • Connors, T. A. & Whisson, M. E. Cure of mice bearing advanced plasma cell tumours with aniline mustard: the relationship between glucuronidase activity and tumour sensitivity. Nature 210, 866-867 (1966).
    • (1966) Nature , vol.210 , pp. 866-867
    • Connors, T.A.1    Whisson, M.E.2
  • 22
    • 0017256549 scopus 로고
    • Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells
    • Mohindra, J. K. & Rauth, A. M. Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells. Cancer Res. 36, 930-936 (1976).
    • (1976) Cancer Res. , vol.36 , pp. 930-936
    • Mohindra, J.K.1    Rauth, A.M.2
  • 24
    • 34347240794 scopus 로고    scopus 로고
    • Chemical radiosensitizers for use in radiotherapy
    • DOI 10.1016/j.clon.2007.03.010, PII S0936655507005808
    • Wardman, P. Chemical radiosensitizers for use in radiotherapy. Clin. Oncol. 19, 397-417 (2007). (Pubitemid 46995615)
    • (2007) Clinical Oncology , vol.19 , Issue.6 , pp. 397-417
    • Wardman, P.1
  • 25
    • 0000653106 scopus 로고
    • Mitomycin C: Chemical and biological studies on alkylation
    • Schwartz, H. S., Sodergren, J. E. & Philips, F. S. Mitomycin C: chemical and biological studies on alkylation. Science 142, 1181-1183 (1963).
    • (1963) Science , vol.142 , pp. 1181-1183
    • Schwartz, H.S.1    Sodergren, J.E.2    Philips, F.S.3
  • 26
    • 0002548343 scopus 로고
    • Mitomycins and porfiromycins: Chemical mechanism of activation and cross-linking of DNA
    • Iyer, V. N. & Szybalski, W. Mitomycins and porfiromycins: chemical mechanism of activation and cross-linking of DNA. Science 145, 55-58 (1964).
    • (1964) Science , vol.145 , pp. 55-58
    • Iyer, V.N.1    Szybalski, W.2
  • 27
    • 0015451983 scopus 로고
    • Potential bioreductive alkylating agents. I. Benzoquinone derivatives
    • Lin, A. J., Cosby, L. A., Shanky, C. W. & Sartorelli, A. C. Potential bioreductive alkylating agents. I. Benzoquinone derivatives. J. Med. Chem. 15, 1247-1252 (1972).
    • (1972) J. Med. Chem. , vol.15 , pp. 1247-1252
    • Lin, A.J.1    Cosby, L.A.2    Shanky, C.W.3    Sartorelli, A.C.4
  • 28
    • 36949065485 scopus 로고
    • Measurement of electrode potentials in living and dead tissues
    • Carter, D. B. & Phillips, A. F. Measurement of electrode potentials in living and dead tissues. Nature 174, 121-123 (1954).
    • (1954) Nature , vol.174 , pp. 121-123
    • Carter, D.B.1    Phillips, A.F.2
  • 29
    • 0018852436 scopus 로고
    • Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells
    • Kennedy, K. A., Rockwell, S. & Sartorelli, A. C. Preferential activation of mitomycin C to cytotoxic metabolites by hypoxic tumor cells. Cancer Res. 40, 2356-2360 (1980). (Pubitemid 10082250)
    • (1980) Cancer Research , vol.40 , Issue.7 , pp. 2356-2360
    • Kennedy, K.A.1    Rockwell, S.2    Sartorelli, A.C.3
  • 30
    • 0018194637 scopus 로고
    • A general mechanism for microsomal activation of quinone anticancer agents to free radicals
    • Bachur, N. R., Gordon, S. L. & Gee, M. V. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res. 38, 1745-1750 (1978). (Pubitemid 8349723)
    • (1978) Cancer Research , vol.38 , Issue.6 , pp. 1745-1750
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3
  • 31
    • 0027288316 scopus 로고
    • SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
    • Brown, J. M. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br. J. Cancer 67, 1163-1170 (1993). (Pubitemid 23172847)
    • (1993) British Journal of Cancer , vol.67 , Issue.6 , pp. 1163-1170
    • Brown, J.M.1
  • 33
    • 70349921764 scopus 로고    scopus 로고
    • Spin trapping of radicals other than the *oH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase
    • Shinde, S. S., Hay, M. P., Patterson, A. V., Denny, W. A. & Anderson, R. F. Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase. J. Am. Chem. Soc. 131, 14220-14221 (2009).
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 14220-14221
    • Shinde, S.S.1    Hay, M.P.2    Patterson, A.V.3    Denny, W.A.4    Anderson, R.F.5
  • 34
    • 0027220811 scopus 로고
    • Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: A new class of bioreductive agent
    • Patterson, L. H. Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent. Cancer Metastasis Rev. 12, 119-134 (1993). (Pubitemid 23220676)
    • (1993) Cancer and Metastasis Reviews , vol.12 , Issue.2 , pp. 119-134
    • Patterson, L.H.1
  • 35
    • 0026520313 scopus 로고
    • Bisbioreductive agents as hypoxia-selective cytotoxins: Nitracrine N-oxide
    • Wilson, W. R., van Zijl, P. & Denny, W. A. Bisbioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide. Int. J. Radiat. Oncol. Biol. Phys. 22, 693-696 (1992).
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 693-696
    • Wilson, W.R.1    Van Zijl, P.2    Denny, W.A.3
  • 36
    • 0027160629 scopus 로고
    • Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards
    • Ware, D. C., Palmer, B. D., Wilson, W. R. & Denny, W. A. Hypoxia-selective antitumor agents. 7. Metal complexes of aliphatic mustards as a new class of hypoxia-selective cytotoxins. Synthesis and evaluation of cobalt(III) complexes of bidentate mustards. J. Med. Chem. 36, 1839-1846 (1993). (Pubitemid 23203741)
    • (1993) Journal of Medicinal Chemistry , vol.36 , Issue.13 , pp. 1839-1846
    • Ware, D.C.1    Palmer, B.D.2    Wilson, W.R.3    Denny, W.A.4
  • 37
    • 33646497001 scopus 로고    scopus 로고
    • Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator
    • Ahn, G. O. et al. Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator. Biochem. Pharmacol. 71, 1683-1694 (2006).
    • (2006) Biochem. Pharmacol. , vol.71 , pp. 1683-1694
    • Ahn, G.O.1
  • 39
    • 79955490434 scopus 로고    scopus 로고
    • Phase 1 study of the safety, tolerability and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies
    • Weiss, G. J. et al. Phase 1 study of the safety, tolerability and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies. Clin. Cancer Res. 17, 2997-3004 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2997-3004
    • Weiss, G.J.1
  • 40
    • 0035010504 scopus 로고    scopus 로고
    • Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
    • Wardman, P. Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Curr. Med. Chem. 8, 739-761 (2001). (Pubitemid 32427904)
    • (2001) Current Medicinal Chemistry , vol.8 , Issue.7 , pp. 739-761
    • Wardman, P.1
  • 41
    • 0037267664 scopus 로고    scopus 로고
    • Combining bioreductive drugs and radiation for the treatment of solid tumors
    • DOI 10.1053/srao.2003.50008
    • Stratford, I. J., Williams, K. J., Cowen, R. L. & Jaffar, M. Combining bioreductive drugs and radiation for the treatment of solid tumors. Semin. Radiat. Oncol. 13, 42-52 (2003). (Pubitemid 36173259)
    • (2003) Seminars in Radiation Oncology , vol.13 , Issue.1 , pp. 42-52
    • Stratford, I.J.1    Williams, K.J.2    Cowen, R.L.3    Jaffar, M.4
  • 42
    • 34347212864 scopus 로고    scopus 로고
    • Targeting tumors with hypoxia-activated cytotoxins
    • Ahn, G. O. & Brown, M. Targeting tumors with hypoxia-activated cytotoxins. Front. Biosci. 12, 3483-3501 (2007).
    • (2007) Front. Biosci. , vol.12 , pp. 3483-3501
    • Ahn, G.O.1    Brown, M.2
  • 43
    • 58849153727 scopus 로고    scopus 로고
    • Design of anticancer prodrugs for reductive activation
    • Chen, Y. & Hu, L. Design of anticancer prodrugs for reductive activation. Med. Res. Rev. 29, 29-64 (2009).
    • (2009) Med. Res. Rev. , vol.29 , pp. 29-64
    • Chen, Y.1    Hu, L.2
  • 44
    • 79952253984 scopus 로고    scopus 로고
    • Selective treatment of hypoxic tumor cells in vivo: Phosphate pre-prodrugs of nitro analogues of the duocarmycins
    • Tercel, M. et al. Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins. Angew. Chem. Int. Ed. 50, 2606-2609 (2011).
    • (2011) Angew. Chem. Int. Ed. , vol.50 , pp. 2606-2609
    • Tercel, M.1
  • 46
    • 67649354921 scopus 로고    scopus 로고
    • Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A
    • Gu, Y. et al. Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A. Mol. Cancer Ther. 8, 1714-1723 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1714-1723
    • Gu, Y.1
  • 47
    • 77649165394 scopus 로고    scopus 로고
    • Maintaining genome stability at the replication fork
    • Branzei, D. & Foiani, M. Maintaining genome stability at the replication fork. Nature Rev. Mol. Cell Biol. 11, 208-219 (2010).
    • (2010) Nature Rev. Mol. Cell Biol. , vol.11 , pp. 208-219
    • Branzei, D.1    Foiani, M.2
  • 48
    • 0031742538 scopus 로고    scopus 로고
    • Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug
    • DOI 10.1016/S0360-3016(98)00308-3, PII S0360301698003083
    • Raleigh, S. M., Wanogho, E., Burke, M. D., McKeown, S. R. & Patterson, L. H. Involvement of human cytochromes P450 (CYP) in the reductive metabolism of AQ4N, a hypoxia activated anthraquinone di-N-oxide prodrug. Int. J. Radiat. Oncol. Biol. Phys. 42, 763-767 (1998). (Pubitemid 28559413)
    • (1998) International Journal of Radiation Oncology Biology Physics , vol.42 , Issue.4 , pp. 763-767
    • Raleigh, S.M.1    Wanogho, E.2    Burke, M.D.3    McKeown, S.R.4    Patterson, L.H.5
  • 49
    • 77956241061 scopus 로고    scopus 로고
    • Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1
    • Nishida, C. R., Lee, M. & Ortiz de Montellano, P. R. Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1. Mol. Pharmacol. 78, 497-502 (2010).
    • (2010) Mol. Pharmacol. , vol.78 , pp. 497-502
    • Nishida, C.R.1    Lee, M.2    Ortiz De Montellano, P.R.3
  • 50
    • 34249724969 scopus 로고    scopus 로고
    • A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia
    • DOI 10.1074/jbc.M609617200
    • Rivera, S. P. et al. A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia. J. Biol. Chem. 282, 10881-10893 (2007). (Pubitemid 47100738)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 10881-10893
    • Rivera, S.P.1    Wang, F.2    Saarikoski, S.T.3    Taylor, R.T.4    Chapman, B.5    Zhang, R.6    Hankinson, O.7
  • 51
    • 50249160554 scopus 로고    scopus 로고
    • Reductive heme-dependent activation of the N-oxide prodrug AQ4N by nitric oxide synthase
    • Nishida, C. R. & Ortiz de Montellano, P. R. Reductive heme-dependent activation of the N-oxide prodrug AQ4N by nitric oxide synthase. J. Med. Chem. 51, 5118-5120 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 5118-5120
    • Nishida, C.R.1    Ortiz De Montellano, P.R.2
  • 52
    • 38949179532 scopus 로고    scopus 로고
    • Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: From synthetic organic chemistry to compounds with anticancer potential
    • Colucci, M. A., Moody, C. J. & Couch, G. D. Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential. Org. Biomol. Chem. 6, 637-656 (2008).
    • (2008) Org. Biomol. Chem. , Issue.6 , pp. 637-656
    • Colucci, M.A.1    Moody, C.J.2    Couch, G.D.3
  • 53
    • 0024205344 scopus 로고
    • The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4- hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)
    • DOI 10.1016/0006-2952(88)90336-X
    • Knox, R. J. et al. The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitro-benzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxyla- mino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2). Biochem. Pharmacol. 37, 4671-4677 (1988). (Pubitemid 19006306)
    • (1988) Biochemical Pharmacology , vol.37 , Issue.24 , pp. 4671-4677
    • Knox, R.J.1    Boland, M.P.2    Friedlos, F.3    Coles, B.4    Southan, C.5    Roberts, J.J.6
  • 54
    • 33745672949 scopus 로고    scopus 로고
    • NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs
    • DOI 10.1016/j.bcp.2006.04.029, PII S0006295206002632
    • Celli, C. M., Tran, N., Knox, R. & Jaiswal, A. K. NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Biochem. Pharmacol. 72, 366-376 (2006). (Pubitemid 43975085)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.3 , pp. 366-376
    • Celli, C.M.1    Tran, N.2    Knox, R.3    Jaiswal, A.K.4
  • 55
    • 57349135857 scopus 로고    scopus 로고
    • Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2, 5-diaziridinyl-3-(hydroxymethyl)-6- methyl-1,4-benzo quinone (RH1)
    • Yan, C., Kepa, J. K., Siegel, D., Stratford, I. J. & Ross, D. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2, 5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzo quinone (RH1). Mol. Pharmacol. 74, 1657-1665 (2008).
    • (2008) Mol. Pharmacol. , vol.74 , pp. 1657-1665
    • Yan, C.1    Kepa, J.K.2    Siegel, D.3    Stratford, I.J.4    Ross, D.5
  • 56
    • 76749161362 scopus 로고    scopus 로고
    • The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3
    • Guise, C. P. et al. The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3. Cancer Res. 70, 1573-1584 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 1573-1584
    • Guise, C.P.1
  • 57
    • 34548565804 scopus 로고    scopus 로고
    • In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity
    • DOI 10.1158/0008-5472.CAN-06-4480
    • Adikesavan, A. K., Barrios, R. & Jaiswal, A. K. In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity. Cancer Res. 67, 7966-7971 (2007). (Pubitemid 47395126)
    • (2007) Cancer Research , vol.67 , Issue.17 , pp. 7966-7971
    • Adikesavan, A.K.1    Barrios, R.2    Jaiswal, A.K.3
  • 58
    • 0033801337 scopus 로고    scopus 로고
    • Immunodetection of NAD(P) H:quinone oxidoreductase 1 (NQO1) in human tissues 6
    • Siegel, D. & Ross, D. Immunodetection of NAD(P) H:quinone oxidoreductase 1 (NQO1) in human tissues 6. Free Rad. Biol. Med. 29, 246-253 (2000).
    • (2000) Free Rad. Biol. Med. , vol.29 , pp. 246-253
    • Siegel, D.1    Ross, D.2
  • 59
    • 33644911742 scopus 로고    scopus 로고
    • Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction
    • Wang, W. & Jaiswal, A. K. Nuclear factor Nrf2 and antioxidant response element regulate NRH:quinone oxidoreductase 2 (NQO2) gene expression and antioxidant induction. Free Rad. Biol. Med. 40, 1119-1130 (2006).
    • (2006) Free Rad. Biol. Med. , vol.40 , pp. 1119-1130
    • Wang, W.1    Jaiswal, A.K.2
  • 60
    • 70249138697 scopus 로고    scopus 로고
    • Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: Demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds
    • MacLeod, A. K. et al. Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds. Carcinogenesis 30, 1571-1580 (2009).
    • (2009) Carcinogenesis , vol.30 , pp. 1571-1580
    • MacLeod, A.K.1
  • 61
    • 29244462498 scopus 로고    scopus 로고
    • Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
    • DOI 10.1016/j.biocel.2005.09.018, PII S1357272505003055
    • Cullinan, S. B. & Diehl, J. A. Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. Int. J. Biochem. Cell. Biol. 38, 317-332 (2006). (Pubitemid 41821881)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.3 , pp. 317-332
    • Cullinan, S.B.1    Diehl, J.A.2
  • 62
    • 65049084348 scopus 로고    scopus 로고
    • Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): Comparative analysis of tumor recurrence rates
    • Jain, A. et al. Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates. Urology 73, 1083-1086 (2009).
    • (2009) Urology , vol.73 , pp. 1083-1086
    • Jain, A.1
  • 63
    • 79957503402 scopus 로고    scopus 로고
    • Phase i pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1
    • 4 Mar (doi:10.1093/annonc/mdq638
    • Danson, S. J. et al. Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1. Ann. Oncol. 4 Mar 2011 (doi:10.1093/annonc/ mdq638).
    • (2011) Ann. Oncol.
    • Danson, S.J.1
  • 64
    • 60449106323 scopus 로고    scopus 로고
    • The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a) anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: Implications for leukemogenesis
    • Birtwistle, J. et al. The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a) anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis. Mutat. Res. 662, 67-74 (2009).
    • (2009) Mutat. Res. , vol.662 , pp. 67-74
    • Birtwistle, J.1
  • 65
    • 77956570382 scopus 로고    scopus 로고
    • Therapeutic targeting of the hypoxic microenvironment in acute lymphocytic leukemia
    • Abstract 2040
    • Konopleva, M. et al. Therapeutic targeting of the hypoxic microenvironment in acute lymphocytic leukemia. Blood (ASH Annual Meeting Abstracts) 11 4, Abstract 2040 [online], http://ash.confex.com/ ash/2009/webprogram/Paper24327.html (2009).
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114
    • Konopleva, M.1
  • 66
    • 77956585456 scopus 로고    scopus 로고
    • Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug
    • Hu, J. et al. Targeting the multiple myeloma hypoxic niche with TH-302, a hypoxia-activated prodrug. Blood 116, 1524-1527 (2010).
    • (2010) Blood , vol.116 , pp. 1524-1527
    • Hu, J.1
  • 67
    • 0023689603 scopus 로고
    • Metabolism of SR 4233 by Chinese hamster ovary cells: Basis of selective hypoxic cytotoxicity
    • Baker M. A., Zeman, E. M., Hirst, V. K. & Brown, J. M. Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity. Cancer Res. 48 5947-5952 1988). (Pubitemid 18266781)
    • (1988) Cancer Research , vol.48 , Issue.21 , pp. 5947-5952
    • Baker, M.A.1    Zeman, E.M.2    Hirst, V.K.3    Brown, J.M.4
  • 68
    • 77958060317 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors
    • Hicks, K. O. et al. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors. Clin. Cancer Res. 16, 4946-4957 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4946-4957
    • Hicks, K.O.1
  • 69
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • DOI 10.1038/nrc1893, PII NRC1893
    • Minchinton, A. I. & Tannock, I. F. Drug penetration in solid tumours. Nature Rev. Cancer 6, 583-592 (2006). (Pubitemid 44140857)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.8 , pp. 583-592
    • Minchinton, A.I.1    Tannock, I.F.2
  • 70
    • 0030669672 scopus 로고    scopus 로고
    • Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice
    • DOI 10.1002/(SICI)1520-6823(1997)5:5<213::AID-ROI1>3.0.CO;2-0
    • Durand, R. E. & Olive, P. L. Physiologic and cytotoxic effects of tirapazamine in tumor-bearing mice. Radiat. Oncol. Investig. 5, 213-219 (1997). (Pubitemid 27479449)
    • (1997) Radiation Oncology Investigations , vol.5 , Issue.5 , pp. 213-219
    • Durand, R.E.1    Olive, P.L.2
  • 71
    • 0026559474 scopus 로고
    • Evaluation of bioreductive drugs in multicell spheroids
    • Durand, R. E. & Olive, P. L. Evaluation of bioreductive drugs in multicell spheroids. Int. J. Radiat. Oncol. Biol. Phys. 22, 689-692 (1992).
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 689-692
    • Durand, R.E.1    Olive, P.L.2
  • 72
    • 0031785201 scopus 로고    scopus 로고
    • Extravascular diffusion of tirapazamine: Effect of metabolic consumption assessed using the multicellular layer model
    • DOI 10.1016/S0360-3016(98)00268-5, PII S0360301698002685
    • Hicks, K. O., Fleming, Y., Siim, B. G., Koch, C. J. & Wilson, W. R. Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. Int. J. Radiat. Oncol. Biol. Phys. 42, 641-649 (1998). (Pubitemid 28501116)
    • (1998) International Journal of Radiation Oncology Biology Physics , vol.42 , Issue.3 , pp. 641-649
    • Hicks, K.O.1    Fleming, Y.2    Siim, B.G.3    Koch, C.J.4    Wilson, W.R.5
  • 73
    • 0032917763 scopus 로고    scopus 로고
    • Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model
    • DOI 10.1007/s002800050886
    • Kyle, A. H. & Minchinton, A. I. Measurement of delivery and metabolism of tirapazamine to tumour tissue using the multilayered cell culture model. Cancer Chemother. Pharmacol. 43, 213-220 (1999). (Pubitemid 29042489)
    • (1999) Cancer Chemotherapy and Pharmacology , vol.43 , Issue.3 , pp. 213-220
    • Kyle, A.H.1    Minchinton, A.I.2
  • 75
    • 51349129159 scopus 로고    scopus 로고
    • Prediction of tumour tissue diffusion coefficients of hypoxia-activated prodrugs from physicochemical parameters
    • Pruijn, F. B., Patel, K., Hay, M. P., Wilson, W. R. & Hicks, K. O. Prediction of tumour tissue diffusion coefficients of hypoxia-activated prodrugs from physicochemical parameters. Aust. J. Chem. 61, 687-693 (2008).
    • (2008) Aust. J. Chem. , vol.61 , pp. 687-693
    • Pruijn, F.B.1    Patel, K.2    Hay, M.P.3    Wilson, W.R.4    Hicks, K.O.5
  • 77
    • 0027227590 scopus 로고
    • Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin
    • Koch, C. J. Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Res. 53, 3992-3997 (1993). (Pubitemid 23267700)
    • (1993) Cancer Research , vol.53 , Issue.17 , pp. 3992-3997
    • Koch, C.J.1
  • 78
    • 3042537843 scopus 로고    scopus 로고
    • Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: Implications for extravascular transport and activity in tumors
    • DOI 10.1667/RR3178
    • Hicks, K. O., Siim, B. G., Pruijn, F. B. & Wilson, W. R. Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors. Radiat. Res. 161, 656-666 (2004). (Pubitemid 39149574)
    • (2004) Radiation Research , vol.161 , Issue.6 , pp. 656-666
    • Hicks, K.O.1    Siim, B.G.2    Pruijn, F.B.3    Wilson, W.R.4
  • 79
    • 0023741181 scopus 로고
    • Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin a mitomycin C analogue in Chinese hamster ovary cells
    • Marshall, R. S. & Rauth, A. M. Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells. Cancer Res. 48, 5655-5659 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 5655-5659
    • Marshall, R.S.1    Rauth, A.M.2
  • 80
    • 0027981814 scopus 로고
    • Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs
    • Siim, B. G., Atwell, G. J. & Wilson, W. R. Oxygen dependence of the cytotoxicity and metabolic activation of 4-alkylamino-5-nitroquinoline bioreductive drugs. Br. J. Cancer 70, 596-603 (1994). (Pubitemid 24305583)
    • (1994) British Journal of Cancer , vol.70 , Issue.4 , pp. 596-603
    • Siim, B.G.1    Atwell, G.J.2    Wilson, W.R.3
  • 81
    • 0028200679 scopus 로고
    • Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: The cobalt(III)-nitrogen mustard complex SN 24771
    • Wilson, W. R., Moselen, J. W., Cliffe, S., Denny, W. A. & Ware, D. C. Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: the cobalt(III)-nitrogen mustard complex SN 24771. Int. J. Radiat. Oncol. Biol. Phys. 29, 323-327 (1994). (Pubitemid 24166540)
    • (1994) International Journal of Radiation Oncology Biology Physics , vol.29 , Issue.2 , pp. 323-327
    • Wilson, W.R.1    Moselen, J.W.2    Cliffe, S.3    Denny, W.A.4    Ware, D.C.5
  • 82
    • 33947621321 scopus 로고    scopus 로고
    • Bystander effects of bioreductive drugs: Potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards
    • DOI 10.1667/RR0807.1
    • Wilson, W. R. et al. Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards. Radiat. Res. 167, 625-636 (2007). (Pubitemid 351292942)
    • (2007) Radiation Research , vol.167 , Issue.6 , pp. 625-636
    • Wilson, W.R.1    Hicks, K.O.2    Pullen, S.M.3    Ferry, D.M.4    Helsby, N.A.5    Patterson, A.V.6
  • 84
    • 39749166975 scopus 로고    scopus 로고
    • DNA repair pathways as targets for cancer therapy
    • DOI 10.1038/nrc2342, PII NRC2342
    • Helleday, T., Petermann, E., Lundin, C., Hodgson, B. & Sharma, R. A. DNA repair pathways as targets for cancer therapy. Nature Rev. Cancer 8, 193-204 (2008). (Pubitemid 351301852)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.3 , pp. 193-204
    • Helleday, T.1    Petermann, E.2    Lundin, C.3    Hodgson, B.4    Sharma, R.A.5
  • 85
    • 0033584157 scopus 로고    scopus 로고
    • 2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: Reductively triggered release of the parp inhibitor 5- bromoisoquinolinone
    • DOI 10.1016/S0960-894X(99)00306-6, PII S0960894X99003066
    • Parveen, I., Naughton, D. P., Whish, W. J. & Threadgill, M. D. 2-nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: reductively triggered release of the PARP inhibitor 5- bromoisoquinolinone. Bioorg. Med. Chem. Lett. 9, 2031-2036 (1999). (Pubitemid 29336395)
    • (1999) Bioorganic and Medicinal Chemistry Letters , vol.9 , Issue.14 , pp. 2031-2036
    • Parveen, I.1    Naughton, D.P.2    Whish, W.J.D.3    Threadgill, M.D.4
  • 86
    • 0033519175 scopus 로고    scopus 로고
    • Bioreductively-activated prodrugs for targeting hypoxic tissue: Elimination of aspirin from 2-nitroimidazole derivatives
    • DOI 10.1016/S0960-894X(99)00171-7, PII S0960894X99001717
    • Everett, S. A., Naylor, M. A., Patel, K. B., Stratford, M. R. L. & Wardman, P. Bioreductively-activated prodrugs for targetting hypoxic tissues: elimination of aspirin from 2-nitroimidazole derivatives. Bioorg. Med. Chem. Lett. 9, 1267-1272 (1999). (Pubitemid 29207445)
    • (1999) Bioorganic and Medicinal Chemistry Letters , vol.9 , Issue.9 , pp. 1267-1272
    • Everett, S.A.1    Naylor, M.A.2    Patel, K.B.3    Stratford, M.R.L.4    Wardman, P.5
  • 88
    • 70349780608 scopus 로고    scopus 로고
    • Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours
    • Granchi, C. et al. Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours. ChemMedChem 4, 1590-1594 (2009).
    • (2009) ChemMedChem , vol.4 , pp. 1590-1594
    • Granchi, C.1
  • 89
    • 0030004578 scopus 로고    scopus 로고
    • Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine
    • DOI 10.1021/jm9507791
    • Tercel, M., Wilson, W. R., Anderson, R. F. & Denny, W. A. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine. J. Med. Chem. 39, 1084-1094 (1996). (Pubitemid 26082941)
    • (1996) Journal of Medicinal Chemistry , vol.39 , Issue.5 , pp. 1084-1094
    • Tercel, M.1    Wilson, W.R.2    Anderson, R.F.3    Denny, W.A.4
  • 90
    • 79957480194 scopus 로고    scopus 로고
    • Cellular metabolism, murine pharmacokinetics and preclinical antitumor activity of SN29966, a novel hypoxia-activated irreversible pan-HER inhibitor
    • Patterson, A. V. et al. Cellular metabolism, murine pharmacokinetics and preclinical antitumor activity of SN29966, a novel hypoxia-activated irreversible pan-HER inhibitor. Mol. Cancer Ther. 8 (Suppl. 1), B76 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.SUPPL. 1
    • Patterson, A.V.1
  • 91
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721-732 (2003). (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 92
    • 70350452792 scopus 로고    scopus 로고
    • Targeting the hypoxia-inducible factor (HIF) pathway in cancer
    • Poon, E., Harris, A. L. & Ashcroft, M. Targeting the hypoxia-inducible factor (HIF) pathway in cancer. Expert Rev. Mol. Med. 11, e26 (2009).
    • (2009) Expert Rev. Mol. Med. , vol.11
    • Poon, E.1    Harris, A.L.2    Ashcroft, M.3
  • 93
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters, B. G. & Koritzinsky, M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nature Rev. Cancer. 8, 851-864 (2008).
    • (2008) Nature Rev. Cancer. , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 95
    • 35048875691 scopus 로고    scopus 로고
    • Evaluation of HIF-1 inhibitors as anticancer agents
    • DOI 10.1016/j.drudis.2007.08.006, PII S1359644607003248
    • Semenza, G. L. Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today 12, 853-859 (2007). (Pubitemid 47554628)
    • (2007) Drug Discovery Today , vol.12 , Issue.19-20 , pp. 853-859
    • Semenza, G.L.1
  • 97
    • 34547098129 scopus 로고    scopus 로고
    • Targeting hypoxia cell signaling for cancer therapy
    • DOI 10.1007/s10555-007-9059-x, Special issue on Hypoxia and Cancer, Guest Editor: Gregg L. Semenza
    • Melillo, G. Targeting hypoxia cell signalling for cancer therapy. Cancer Metastasis Rev. 26, 341-352 (2007). (Pubitemid 47101663)
    • (2007) Cancer and Metastasis Reviews , vol.26 , Issue.2 , pp. 341-352
    • Melillo, G.1
  • 98
    • 0037119415 scopus 로고    scopus 로고
    • Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
    • Isaacs, J. S. et al. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J. Biol. Chem. 277, 29936-29944 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 29936-29944
    • Isaacs, J.S.1
  • 99
    • 65749102069 scopus 로고    scopus 로고
    • The HIF-1-active microenvironment: An environmental target for cancer therapy
    • Kizaka-Kondoh, S., Tanaka, S., Harada, H. & Hiraoka, M. The HIF-1-active microenvironment: an environmental target for cancer therapy. Advanced Drug Deliv. Rev. 61, 623-632 (2009).
    • (2009) Advanced Drug Deliv. Rev. , vol.61 , pp. 623-632
    • Kizaka-Kondoh, S.1    Tanaka, S.2    Harada, H.3    Hiraoka, M.4
  • 100
    • 68349135032 scopus 로고    scopus 로고
    • Regulation of autophagy through multiple independent hypoxic signaling pathways
    • Rouschop, K. M. & Wouters, B. G. Regulation of autophagy through multiple independent hypoxic signaling pathways. Curr. Mol. Med. 9, 417-424 (2009).
    • (2009) Curr. Mol. Med. , vol.9 , pp. 417-424
    • Rouschop, K.M.1    Wouters, B.G.2
  • 101
    • 0036862532 scopus 로고    scopus 로고
    • 2-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum
    • DOI 10.1016/S1097-2765(02)00696-2
    • 2-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol. Cell 10, 983-994 (2002). (Pubitemid 35453820)
    • (2002) Molecular Cell , vol.10 , Issue.5 , pp. 983-994
    • Tu, B.P.1    Weissman, J.S.2
  • 105
    • 75149165640 scopus 로고    scopus 로고
    • Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth
    • Spiotto, M. T. et al. Imaging the unfolded protein response in primary tumors reveals microenvironments with metabolic variations that predict tumor growth. Cancer Res. 70, 78-88 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 78-88
    • Spiotto, M.T.1
  • 106
    • 79251589342 scopus 로고    scopus 로고
    • Identification of an Ire1á endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
    • Papandreou, I. et al. Identification of an Ire1á endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 11 7, 1311-1314 (2011).
    • (2011) Blood 11 , vol.7 , pp. 1311-1314
    • Papandreou, I.1
  • 107
    • 79953319782 scopus 로고    scopus 로고
    • Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease
    • Volkmann, K. et al. Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J. Biol. Chem. 286, 12743-12755 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 12743-12755
    • Volkmann, K.1
  • 108
    • 37649004940 scopus 로고    scopus 로고
    • Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing
    • Lee, K. P. et al. Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell 132, 89-100 (2008).
    • (2008) Cell , vol.132 , pp. 89-100
    • Lee, K.P.1
  • 109
    • 56449087512 scopus 로고    scopus 로고
    • Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways
    • Fels, D. R. et al. Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways. Cancer Res. 68, 9323-9330 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9323-9330
    • Fels, D.R.1
  • 110
    • 33746886623 scopus 로고    scopus 로고
    • "Translating" tumor hypoxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways
    • DOI 10.1158/1541-7786.MCR-06-0150
    • Koumenis, C. & Wouters, B. G. "Translating" tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol. Cancer Res. 4, 423-436 (2006). (Pubitemid 44197038)
    • (2006) Molecular Cancer Research , vol.4 , Issue.7 , pp. 423-436
    • Koumenis, C.1    Wouters, B.G.2
  • 112
    • 32444433450 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress regulates mRNA translation and cell growth
    • DOI 10.1016/j.molcel.2006.01.010, PII S1097276506000116
    • Liu, L. et al. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol. Cell 21, 521-531 (2006). (Pubitemid 43228007)
    • (2006) Molecular Cell , vol.21 , Issue.4 , pp. 521-531
    • Liu, L.1    Cash, T.P.2    Jones, R.G.3    Keith, B.4    Thompson, C.B.5    Simon, M.C.6
  • 114
    • 63149114714 scopus 로고    scopus 로고
    • Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/ hypoxia-inducible factor-1á axis
    • Pencreach, E. et al. Marked activity of irinotecan and rapamycin combination toward colon cancer cells in vivo and in vitro is mediated through cooperative modulation of the mammalian target of rapamycin/ hypoxia-inducible factor-1á axis. Clin. Cancer Res. 15, 1297-1307 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1297-1307
    • Pencreach, E.1
  • 115
    • 76549107351 scopus 로고    scopus 로고
    • Beyond rapalog therapy: Preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2
    • Yu, K. et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Res. 70, 621-631 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 621-631
    • Yu, K.1
  • 116
    • 77955467319 scopus 로고    scopus 로고
    • Regulation of autophagy by ATF4 in response to severe hypoxia
    • Rzymski, T. et al. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 29, 4424-4435 (2010).
    • (2010) Oncogene , vol.29 , pp. 4424-4435
    • Rzymski, T.1
  • 118
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine, A. J. & Puzio-Kuter, A. M. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330, 1340-1344 (2010).
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 119
    • 34547902505 scopus 로고    scopus 로고
    • Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells
    • DOI 10.1089/ars.2007.1714
    • Kurtoglu, M., Maher, J. C. & Lampidis, T. J. Differential toxic mechanisms of 2-deoxy-D-glucose versus 2-fluorodeoxy-D-glucose in hypoxic and normoxic tumor cells. Antiox. Redox Signal. 9, 1383-1390 (2007). (Pubitemid 47255017)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.9 , pp. 1383-1390
    • Kurtoglu, M.1    Maher, J.C.2    Lampidis, T.J.3
  • 120
    • 0017168930 scopus 로고
    • Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells
    • Song, C. W., Clement, J. J. & Levitt, S. H. Preferential cytotoxicity of 5-thio-D-glucose against hypoxic tumor cells. J. Natl Cancer Inst. 57, 603-605 (1976).
    • (1976) J. Natl Cancer Inst. , vol.57 , pp. 603-605
    • Song, C.W.1    Clement, J.J.2    Levitt, S.H.3
  • 122
    • 12944262229 scopus 로고    scopus 로고
    • Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer
    • DOI 10.1002/jcp.20166
    • Macheda, M. L., Rogers, S. & Best, J. D. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J. Cell. Physiol. 202, 654-662 (2005). (Pubitemid 40175840)
    • (2005) Journal of Cellular Physiology , vol.202 , Issue.3 , pp. 654-662
    • Macheda, M.L.1    Rogers, S.2    Best, J.D.3
  • 123
    • 56249134557 scopus 로고    scopus 로고
    • A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
    • Wood, T. E. et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol. Cancer Ther. 7, 3546-3555 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 3546-3555
    • Wood, T.E.1
  • 124
    • 79957441462 scopus 로고    scopus 로고
    • Selective cytotoxic targeting of von Hippel-Lindau-deficient renal carcinoma cells
    • Abstract 67
    • Lai, E. W., Chan, D. A., Hay, M. P. & Giaccia, A. J. Selective cytotoxic targeting of von Hippel-Lindau-deficient renal carcinoma cells. Proc. Am. Assoc. Cancer Res. 51, Abstract 67 (2010).
    • (2010) Proc. Am. Assoc. Cancer Res. , vol.51
    • Lai, E.W.1    Chan, D.A.2    Hay, M.P.3    Giaccia, A.J.4
  • 125
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux, P. et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest. 118, 3930-3942 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 3930-3942
    • Sonveaux, P.1
  • 126
    • 74349094033 scopus 로고    scopus 로고
    • AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10
    • Ovens, M. J., Davies, A. J., Wilson, M. C., Murray, C. M. & Halestrap, A. P. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem. J. 425, 523-530 (2010).
    • (2010) Biochem. J. , vol.425 , pp. 523-530
    • Ovens, M.J.1    Davies, A.J.2    Wilson, M.C.3    Murray, C.M.4    Halestrap, A.P.5
  • 127
    • 33644790739 scopus 로고    scopus 로고
    • Monocarboxylate transporter MCT1 is a target for immunosuppression
    • Murray, C. M. et al. Monocarboxylate transporter MCT1 is a target for immunosuppression. Nature Chem. Biol. 1, 371-376 (2005).
    • (2005) Nature Chem. Biol. , vol.1 , pp. 371-376
    • Murray, C.M.1
  • 128
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: A common feature in cancer
    • Chiche, J., Brahimi-Horn, M. C. & Pouyssegur, J. Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J. Cell. Mol. Med. 14, 771-794 (2010).
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 129
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
    • DOI 10.1074/jbc.M511397200
    • Ullah, M. S., Davies, A. J. & Halestrap, A. P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1á-dependent mechanism. J. Biol. Chem. 281, 9030-9037 (2006). (Pubitemid 43864615)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 130
    • 34249293335 scopus 로고    scopus 로고
    • Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231
    • DOI 10.1158/0008-5472.CAN-06-3184
    • Gallagher, S. M., Castorino, J. J., Wang, D. & Philp, N. J. Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. Cancer Res. 67, 4182-4189 (2007). (Pubitemid 46815064)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4182-4189
    • Gallagher, S.M.1    Castorino, J.J.2    Wang, D.3    Philp, N.J.4
  • 131
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche, J. et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res. 69, 358-368 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 358-368
    • Chiche, J.1
  • 132
    • 69949124669 scopus 로고    scopus 로고
    • Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response
    • Van den Beucken, T. et al. Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response. J. Biol. Chem. 284, 24204-24212 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 24204-24212
    • Van Den Beucken, T.1
  • 133
    • 79955490807 scopus 로고    scopus 로고
    • Targeting tumor hypoxia: Suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors
    • Lou, Y. et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res. 71, 3364-3376 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 3364-3376
    • Lou, Y.1
  • 134
    • 33846697957 scopus 로고    scopus 로고
    • Hypoxia-induced genetic instability - A calculated mechanism underlying tumor progression
    • DOI 10.1007/s00109-006-0133-6
    • Huang, L. E., Bindra, R. S., Glazer, P. M. & Harris, A. L. Hypoxia-induced genetic instability-a calculated mechanism underlying tumor progression. J. Mol. Med. 85, 139-148 (2007). (Pubitemid 46188219)
    • (2007) Journal of Molecular Medicine , vol.85 , Issue.2 , pp. 139-148
    • Huang, L.E.1    Bindra, R.S.2    Glazer, P.M.3    Harris, A.L.4
  • 135
    • 78650333871 scopus 로고    scopus 로고
    • Targeting hypoxic cells through the DNA damage response
    • Olcina, M., Lecane, P. S. & Hammond, E. M. Targeting hypoxic cells through the DNA damage response. Clin. Cancer Res. 16, 5620-5629 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5620-5629
    • Olcina, M.1    Lecane, P.S.2    Hammond, E.M.3
  • 136
    • 68349157265 scopus 로고    scopus 로고
    • Tumor hypoxia as a modifier of DNA strand break and cross-link repair
    • Chan, N., Koch, C. J. & Bristow, R. G. Tumor hypoxia as a modifier of DNA strand break and cross-link repair. Curr. Mol. Med. 9, 401-410 (2009).
    • (2009) Curr. Mol. Med. , vol.9 , pp. 401-410
    • Chan, N.1    Koch, C.J.2    Bristow, R.G.3
  • 138
    • 76249122584 scopus 로고    scopus 로고
    • Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability
    • Pires, I. M. et al. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Res. 70, 925-935 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 925-935
    • Pires, I.M.1
  • 139
    • 33746370368 scopus 로고    scopus 로고
    • Ribonucleotide reductases
    • DOI 10.1146/annurev.biochem.75.103004.142443
    • Norlund, P. & Reichard, P. Ribonucleotide reductases. Ann. Rev. Biochem. 75, 681-706 (2006). (Pubitemid 44118048)
    • (2006) Annual Review of Biochemistry , vol.75 , pp. 681-706
    • Nordlund, P.1    Reichard, P.2
  • 140
    • 4644318239 scopus 로고    scopus 로고
    • Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation
    • DOI 10.1158/0008-5472.CAN-04-1520
    • Hammond, E. M., Dorie, M. J. & Giaccia, A. J. Inhibition of AT R leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res. 64, 6556-6562 (2004). (Pubitemid 39297914)
    • (2004) Cancer Research , vol.64 , Issue.18 , pp. 6556-6562
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 141
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • DOI 10.1074/jbc.M212360200
    • Hammond, E. M., Dorie, M. J. & Giaccia, A. J. ATR/ ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem. 278, 12207-12213 (2003). (Pubitemid 36800201)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.14 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 142
    • 33749163797 scopus 로고    scopus 로고
    • CHK2-dependent phosphorylation of BRCA1 in hypoxia
    • DOI 10.1667/RR0660.1
    • Gibson, S. L., Bindra, R. S. & Glazer, P. M. CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiat. Res. 166, 646-651 (2006). (Pubitemid 44477718)
    • (2006) Radiation Research , vol.166 , Issue.4 , pp. 646-651
    • Gibson, S.L.1    Bindra, R.S.2    Glazer, P.M.3
  • 143
    • 78651454089 scopus 로고    scopus 로고
    • EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-â-catenin signaling
    • Chang, C.-J. et al. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-â-catenin signaling. Cancer Cell 19, 86-100 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 86-100
    • Chang, C.-J.1
  • 144
    • 79551542410 scopus 로고    scopus 로고
    • In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection
    • Marotta, D. et al. In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Res. 71, 779-789 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 779-789
    • Marotta, D.1
  • 147
    • 78049252736 scopus 로고    scopus 로고
    • Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment
    • Chan, N. et al. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Res. 70, 8045-8054 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 8045-8054
    • Chan, N.1
  • 148
    • 77649256273 scopus 로고    scopus 로고
    • Restoring p53 function in cancer: Novel therapeutic approaches for applying the brakes to tumorigenesis
    • Di Cintio, A., Di Gennaro, E. & Budillon, A. Restoring p53 function in cancer: novel therapeutic approaches for applying the brakes to tumorigenesis. Recent Pat. Anti-Cancer Drug Discov. 5, 1-13 (2010).
    • (2010) Recent Pat. Anti-Cancer Drug Discov. , vol.5 , pp. 1-13
    • Di Cintio, A.1    Di Gennaro, E.2    Budillon, A.3
  • 149
    • 64649086259 scopus 로고    scopus 로고
    • Small-molecule activation of p53 blocks hypoxia-inducible factor 1á and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia
    • Yang, J. et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1á and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol. Cell. Biol. 29, 2243-2253 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 2243-2253
    • Yang, J.1
  • 150
    • 70350097618 scopus 로고    scopus 로고
    • Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia
    • Hoogsteen, I. J. et al. Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia. Eur. J. Cancer 45, 2906-2914 (2009).
    • (2009) Eur. J. Cancer , vol.45 , pp. 2906-2914
    • Hoogsteen, I.J.1
  • 153
    • 77958537523 scopus 로고    scopus 로고
    • Multimodality imaging of hypoxia in preclinical settings
    • Mason, R. P. et al. Multimodality imaging of hypoxia in preclinical settings. Quart. J. Nucl. Med. Mol. Imag. 54, 259-280 (2010).
    • (2010) Quart. J. Nucl. Med. Mol. Imag. , vol.54 , pp. 259-280
    • Mason, R.P.1
  • 154
    • 0027328452 scopus 로고
    • The experimental development of bioreductive drugs and their role in cancer therapy
    • Workman, P. & Stratford, I. J. The experimental development of bioreductive drugs and their role in cancer therapy. Cancer Metastasis Rev. 12, 73-82 (1993). (Pubitemid 23220673)
    • (1993) Cancer and Metastasis Reviews , vol.12 , Issue.2 , pp. 73-82
    • Workman, P.1    Stratford, I.J.2
  • 155
    • 69449090092 scopus 로고    scopus 로고
    • Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies
    • Willers, H. et al. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. Mol. Cancer Res. 7, 1304-1309 (2009).
    • (2009) Mol. Cancer Res. , vol.7 , pp. 1304-1309
    • Willers, H.1
  • 156
    • 77955894453 scopus 로고    scopus 로고
    • Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer
    • Konstantinopoulos, P. A. et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J. Clin. Oncol. 28, 3555-3561 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3555-3561
    • Konstantinopoulos, P.A.1
  • 157
    • 77958045536 scopus 로고    scopus 로고
    • A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer
    • Graeser, M. et al. A marker of homologous recombination predicts pathological complete response to neoadjuvant chemotherapy in primary breast cancer. Clin. Cancer Res. 16, 6159-6158 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6159-6158
    • Graeser, M.1
  • 158
    • 79957503401 scopus 로고    scopus 로고
    • EF5 as a predictive biomarker for activation of the new hypoxia targeting prodrug SN30000
    • Abstract e13597
    • Wang, J. et al. EF5 as a predictive biomarker for activation of the new hypoxia targeting prodrug SN30000. Am. Soc. Clin. Oncol. Abstract e13597, (2011).
    • (2011) Am. Soc. Clin. Oncol.
    • Wang, J.1
  • 161
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabasi, A.-L., Gulbache, N. & Loscalzo, J. Network medicine: a network-based approach to human disease. Nature Rev. Genet. 12, 56-68 (2011).
    • (2011) Nature Rev. Genet. , vol.12 , pp. 56-68
    • Barabasi, A.-L.1    Gulbache, N.2    Loscalzo, J.3
  • 162
    • 2342611976 scopus 로고    scopus 로고
    • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
    • DOI 10.1016/S1535-6108(04)00115-1, PII S1535610804001151
    • Moeller, B. J., Cao, Y., Li, C. Y. & Dewhirst, M. W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429-441 (2004). (Pubitemid 38610245)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 429-441
    • Moeller, B.J.1    Cao, Y.2    Li, C.Y.3    Dewhirst, M.W.4
  • 165
    • 0029024521 scopus 로고
    • Nitric oxide synthase activity in human breast cancer
    • Thomsen, L. L. et al. Nitric oxide synthase activity in human breast cancer. Br. J. Cancer 72, 41-44 (1995).
    • (1995) Br. J. Cancer , vol.72 , pp. 41-44
    • Thomsen, L.L.1
  • 166
    • 0033074477 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase with transitional cell carcinoma of the bladder
    • Swana, H. S. et al. Inducible nitric oxide synthase with transitional cell carcinoma of the bladder. J. Urol. 161, 630-634 (1999).
    • (1999) J. Urol. , vol.161 , pp. 630-634
    • Swana, H.S.1
  • 167
    • 24044461733 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: Implications for tumor progression and anti-cancer therapies
    • Lewis, C. & Murdoch, C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol. 167, 627-635 (2005). (Pubitemid 41216349)
    • (2005) American Journal of Pathology , vol.167 , Issue.3 , pp. 627-635
    • Lewis, C.1    Murdoch, C.2
  • 168
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo, G. et al. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182, 1683-1693 (1995).
    • (1995) J. Exp. Med. , vol.182 , pp. 1683-1693
    • Melillo, G.1
  • 170
    • 0037033141 scopus 로고    scopus 로고
    • 17β-oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response
    • DOI 10.1038/sj.bjc.6600032
    • Chinje, E. C. et al. 17â-Oestradiol treatment modulates nitric oxide synthase activity in MDA231 tumour with implications on growth and radiation response. Br. J. Cancer 86, 136-142 (2002). (Pubitemid 34146354)
    • (2002) British Journal of Cancer , vol.86 , Issue.1 , pp. 136-142
    • Chinje, E.C.1    Williams, K.J.2    Telfer, B.A.3    Wood, P.J.4    Van Der Kogel, A.J.5    Stratford, I.J.6
  • 171
    • 0034543132 scopus 로고    scopus 로고
    • AQ4N: A new approach to hypoxia-activated cancer chemotherapy
    • DOI 10.1054/bjoc.2000.1564
    • Patterson, L. H. & McKeown, S. R. AQ4N: a new approach to hypoxia-activated cancer chemotherapy. Br. J. Cancer 83, 1589-1593 (2000). (Pubitemid 32001698)
    • (2000) British Journal of Cancer , vol.83 , Issue.12 , pp. 1589-1593
    • Patterson, L.H.1    McKeown, S.R.2
  • 173
    • 79957447542 scopus 로고    scopus 로고
    • Identification of human oxidoreductases involved in the hypoxia-dependent activation of bioreductive prodrugs
    • Abstract 453
    • Guise, C. P. et al. Identification of human oxidoreductases involved in the hypoxia-dependent activation of bioreductive prodrugs. Proc. Am. Assoc. Cancer Res. 51, Abstract 453 (2010).
    • (2010) Proc. Am. Assoc. Cancer Res. , vol.51
    • Guise, C.P.1
  • 174
    • 78751659718 scopus 로고    scopus 로고
    • Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer
    • Kan, O. et al. Genetically modified macrophages expressing hypoxia regulated cytochrome P450 and P450 reductase for the treatment of cancer. Int. J. Mol. Med. 27, 173-180 (2011).
    • (2011) Int. J. Mol. Med. , vol.27 , pp. 173-180
    • Kan, O.1
  • 175
    • 1242271216 scopus 로고    scopus 로고
    • Hypoxia Targeted Gene Therapy to Increase the Efficacy of Tirapazamine as an Adjuvant to Radiotherapy: Reversing Tumor Radioresistance and Effecting Cure
    • DOI 10.1158/0008-5472.CAN-03-2698
    • Cowen, R. L. et al. Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure. Cancer Res. 64, 1396-1402 (2004). (Pubitemid 38235608)
    • (2004) Cancer Research , vol.64 , Issue.4 , pp. 1396-1402
    • Cowen, R.L.1    Williams, K.J.2    Chinje, E.C.3    Jaffar, M.4    Sheppard, F.C.D.5    Telfer, B.A.6    Wind, N.S.7    Stratford, I.J.8
  • 178
    • 0021332150 scopus 로고
    • Aerobic reduction of 5-nitro-2-furaldehyde semicarbazone by rat liver xanthine dehydrogenase
    • DOI 10.1016/0006-2952(84)90465-9
    • Kutcher, W. W. & McCalla, D. R. Aerobic reduction of 5-nitro-2-furaldehyde semicarbazone by rat liver xanthine dehydrogenase. Biochem. Pharmacol. 33, 799-805 (1984). (Pubitemid 14166451)
    • (1984) Biochemical Pharmacology , vol.33 , Issue.5 , pp. 799-805
    • Kutcher, W.W.1    McCalla, D.R.2
  • 179
    • 68749119336 scopus 로고    scopus 로고
    • Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours
    • Ahlskog, J. K. et al. Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours. Br. J. Cancer 101, 645-657 (2009).
    • (2009) Br. J. Cancer , vol.101 , pp. 645-657
    • Ahlskog, J.K.1
  • 180
    • 77955001665 scopus 로고    scopus 로고
    • PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors
    • Hoeben, B. A. et al. PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors. J. Nucl. Med. 51, 1076-1083 (2010).
    • (2010) J. Nucl. Med. , vol.51 , pp. 1076-1083
    • Hoeben, B.A.1
  • 181
    • 62749124795 scopus 로고    scopus 로고
    • Transcriptional control of the tumor-and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show? Biochim
    • Kaluz, S., Kaluzova, M., Liao, S. Y., Lerman, M. & Stanbridge, E. J. Transcriptional control of the tumor-and hypoxia-marker carbonic anhydrase 9: a one transcription factor (HIF-1) show? Biochim. Biophys. Acta 1795, 162-172 (2009).
    • (2009) Biophys. Acta , vol.1795 , pp. 162-172
    • Kaluz, S.1    Kaluzova, M.2    Liao, S.Y.3    Lerman, M.4    Stanbridge, E.J.5
  • 182
    • 57149111715 scopus 로고    scopus 로고
    • 18F-EF5: A new PET tracer for imaging hypoxia in head and neck cancer
    • Komar, G. et al. 18F-EF5: a new PET tracer for imaging hypoxia in head and neck cancer. J. Nucl. Med. 49, 1944-1951 (2008).
    • (2008) J. Nucl. Med. , vol.49 , pp. 1944-1951
    • Komar, G.1
  • 183
    • 33646454133 scopus 로고    scopus 로고
    • 18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: A substudy of Trans-Tasman Radiation Oncology Group study 98.02
    • DOI 10.1200/JCO.2005.05.2878
    • Rischin, D. et al. Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02. J. Clin. Oncol. 24, 2098-2104 (2006). (Pubitemid 46622121)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.13 , pp. 2098-2104
    • Rischin, D.1    Hicks, R.J.2    Fisher, R.3    Binns, D.4    Corry, J.5    Porceddu, S.6    Peters, L.J.7
  • 184
    • 77954600498 scopus 로고    scopus 로고
    • Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): A phase III trial of the Trans-Tasman Radiation Oncology Group
    • Rischin, D. et al. Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group. J. Clin. Oncol. 28, 2989-2995 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2989-2995
    • Rischin, D.1
  • 185
    • 0030926491 scopus 로고    scopus 로고
    • Cells at intermediate oxygen levels can be more important than the 'hypoxic fraction' in determining tumor response to fractionated radiotherapy
    • Wouters, B. G. & Brown, J. M. Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy. Radiat. Res. 147, 541-550 (1997). (Pubitemid 27204090)
    • (1997) Radiation Research , vol.147 , Issue.5 , pp. 541-550
    • Wouters, B.G.1    Brown, J.M.2
  • 186
    • 37549005208 scopus 로고    scopus 로고
    • Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration
    • Tuttle, S. W. et al. Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration. J. Biol. Chem. 282, 36790-36796 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 36790-36796
    • Tuttle, S.W.1
  • 187
    • 34249098462 scopus 로고    scopus 로고
    • The unfolded protein response and integrated stress response to anoxia
    • DOI 10.1158/1078-0432.CCR-06-2126
    • Rzymski, T. & Harris, A. L. The unfolded protein response and integrated stress response to anoxia. Clin. Cancer Res. 13, 2537-2540 (2007). (Pubitemid 46788018)
    • (2007) Clinical Cancer Research , vol.13 , Issue.9 , pp. 2537-2540
    • Rzymski, T.1    Harris, A.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.