Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability

Nature

Volumn 436, Issue 7047, 2005, Pages 123-127

  Radisky, Derek C ^a   Levy, Dinah D ^a   Littlepage, Laurie E ^b   Liu, Hong ^a   Nelson, Celeste M ^a   Fata, Jimmie E ^a   Leake, Devin ^c   Godden, Elizabeth L ^c   Albertson, Donna G ^b   Nieto, M Angela ^d   Werb, Zena ^b   Bissell, Mina J ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Dharmacon Inc   (United States)

^d INSTITUTO DE NEUROCIENCIAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; ENZYMES; TUMORS;

BREAST TUMORS; GENOMIC INSTABILITY; MATRIX-METALLOPROTEINASE-3 (MMP-3); REACTIVE OXYGEN SPECIES (ROS);

GENES;

CARCINOGEN; DNA; RAC1 PROTEIN; RAC1B PROTEIN; REACTIVE OXYGEN METABOLITE; STROMELYSIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; MESSENGER RNA; RHO GUANINE NUCLEOTIDE BINDING PROTEIN;

MEDICINE;

ANIMAL CELL; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER CELL CULTURE; CARCINOGENESIS; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; EPITHELIAL MESENCHYMAL TRANSITION; GENOMIC INSTABILITY; IN VIVO STUDY; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ALTERNATIVE RNA SPLICING; ANIMAL; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; ENZYMOLOGY; EPITHELIUM CELL; GENETICS; HUMAN; MESODERM; METABOLISM; MITOCHONDRION; TRANSGENIC MOUSE;

ANIMALIA; GASTROPODA; MUS MUSCULUS;

ALTERNATIVE SPLICING; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; EPITHELIAL CELLS; GENOMIC INSTABILITY; HUMANS; MATRIX METALLOPROTEINASE 3; MESODERM; MICE; MICE, TRANSGENIC; MITOCHONDRIA; RAC1 GTP-BINDING PROTEIN; REACTIVE OXYGEN SPECIES; RHO GTP-BINDING PROTEINS; RNA, MESSENGER;

EID: 21844432918     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03688     Document Type: Article

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