Mechanisms associated with mitochondrialgenerated reactive oxygen species in cancer

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 3, 2010, Pages 204-219

  Verschoor, Meghan L ^a   Wilson, Leigh A ^a   Singh, Gurmit ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Cancer; ETS; Hypoxia; Mitochondria; Mitochondrial signaling; Nuclear crosstalk; Reactive oxygen species; Transcription factors

Indexed keywords

DNA; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR;

BREAST CANCER; CANCER CELL; CELL NUCLEUS INCLUSION BODY; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL CANCER; DNA BINDING; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; GENE EXPRESSION; GENE MUTATION; GERM CELL TUMOR; GLYCOLYSIS; HUMAN; MELANOMA; MENINGIOMA; MITOCHONDRION; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; STOMACH CANCER; THYROID CANCER; UPREGULATION; ANIMAL; GENETICS; METABOLISM; MUTATION; NEOPLASM; PHYSIOLOGY;

ANIMALS; HUMANS; MITOCHONDRIA; MUTATION; NEOPLASMS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 77950910067     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-135     Document Type: Review

References (152)

1. Abate, C., Patel, L.,Rauscher, F.J.,3rd,and Curran,T.1990. Redoxreg-ulation of fos and jun DNA-binding activity in vitro. Science, 249(4973): 1157-1161. doi:10.1126/science.2118682. PMID: 2118682.
2. Adam, M., Schmidt, D., Wardelmann, E., Wernert, N., and Albers, P. 2003. Angiogenetic protooncogene ets-1 induced neovascular-ization is involved in the metastatic process of testicular germ cell tumors. Eur. Urol. 44(3): 329-336. doi:10.1016/S0302-2838(03)00262-8. PMID: 12932931.
3. Adler, V., Yin, Z., Tew, K.D., and Ronai, Z. 1999. Role of redox potential and reactive oxygen species in stress signaling. Onco-gene, 18(45): 6104-6111. doi:10.1038/sj.onc.1203128. PMID: 10557101.
4. Akinci, M., Kosova, F., Cetin, B., Sepici, A., Altan, N., Aslan, S., and Cetin, A. 2008. Oxidant/antioxidant balance in patients with thyroid cancer. Acta Cir. Bras. 23(6): 551-554. doi:10.1590/S0102-86502008000600013. PMID: 19030755.
5. Alipov, G., Nakayama, T., Ito, M., Kawai, K., Naito, S., Naka-shima, M., et al. 2005. Overexpression of Ets-1 proto-oncogene in latent and clinical prostatic carcinomas. Histopathology, 46(2): 202-208. doi:10.1111/j.1365-2559. 2005.02059.x. PMID: 15693893.
6. Andreyev, A.Y., Kushnareva, Y.E., and Starkov, A.A. 2005. Mito-chondrial metabolism of reactive oxygen species. Biochemistry (Mosc.), 70(2): 200-214. doi:10.1007/s10541-005-0102-7. PMID: 15807660.
7. Aringer, M., Hofmann, S.R., Frucht, D.M., Chen, M., Centola, M., Morinobu, A., et al. 2003. Characterization and analysis of the proximal Janus kinase 3 promoter. J. Immunol. 170(12): 6057-6064. PMID: 12794134.
8. Arsova-Sarafinovska, Z., Eken, A., Matevska, N., Erdem, O., Sayal, A., Savaser, A., et al. 2009. Increased oxidative/nitrosa-tive stress and decreased antioxidant enzyme activities in prostate cancer. Clin. Biochem. 42(12): 1228-1235. doi:10.1016/j. clinbiochem.2009.05.009. PMID: 19465015.
9. Barber, D.A., and Harris, S.R. 1994. Oxygen free radicals and anti-oxidants: a review. Am. Pharm. NS34(9): 26-35. PMID: 7977023.
10. Behrens, P., Rothe, M., Wellmann, A., Krischler, J., and Wernert, N. 2001. The Ets-1 transcription factor is up-regulated together with MMP 1 and MMP 9 in the stroma of pre-invasive breast cancer. J. Pathol. 194(1): 43-50. doi:10.1002/path.844. PMID: 11329140.
11. Behrens, P., Mathiak, M., Mangold, E., Kirdorf, S., Wellmann, A., Fogt, F., et al. 2003. Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and-9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers. Int. J. Cancer, 107(2): 183-188. doi:10.1002/ijc.11336. PMID: 12949792.
12. Betteridge, D.J. 2000. What is oxidative stress? Metabolism, 49(Suppl. 1): 3-8. doi:10.1016/S0026-0495(00)80077-3. PMID: 10693912.
13. Bonekamp, N.A., Völkl, A., Fahimi, H.D., and Schrader, M. 2009. Reactive oxygen species and peroxisomes: struggling for balance. Biofactors, 35(4): 346-355. doi:10.1002/biof.48. PMID: 19459143.
14. Bories, J.C., Willerford, D.M., Grévin, D., Davidson, L., Camus, A., Martin, P., et al. 1995. Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature, 377(6550): 635-638. doi:10.1038/377635a0. PMID: 7566176.
15. Brambilla, L., Cairo, G., Sestili, P., O'Donnel, V., Azzi, A., and Cantoni, O. 1997. Mitochondrial respiratory chain deficiency leads to overexpression of antioxidant enzymes. FEBS Lett. 418(3): 247-250. doi:10.1016/S0014-5793(97)01393-8. PMID: 9428722. (Pubitemid 27515934)
16. Buggy, Y., Maguire, T.M., McGreal, G., McDermott, E., Hill, A.D., O'Higgins, N., and Duffy, M.J. 2004. Overexpression of the Ets-1 transcription factor in human breast cancer. Br. J. Cancer, 91(7): 1308-1315. doi:10.1038/sj.bjc.6602128. PMID: 15365563. (Pubitemid 39424792)
17. Burdon, R.H. 1995. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 18(4): 775-794. doi:10.1016/0891-5849(94)00198-S. PMID: 7750801.
18. Butow, R.A., and Avadhani, N.G. 2004. Mitochondrial signaling: the retrograde response. Mol. Cell, 14(1): 1-15. doi:10.1016/S1097-2765(04)00179-180 PMID: 15068799.
19. Cadenas, E., and Davies, K.J. 2000. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29(3-4): 222-230. doi:10.1016/S0891-5849(00)00317-8. PMID: 11035250.
20. Carew, J.S., and Huang, P. 2002. Mitochondrial defects in cancer. Mol. Cancer, 1(1): 9. doi:10.1186/1476-4598-1-9. PMID: 12513701. (Pubitemid 38751447)
21. Chandel, N.S., Maltepe, E., Goldwasser, E., Mathieu, C.E., Simon, M.C., and Schumacker, P.T. 1998. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl. Acad. Sci. U.S.A. 95(20): 11715-11720. doi:10.1073/pnas.95. 20.11715. PMID: 9751731. (Pubitemid 28460480)
22. 2 sensing. J. Biol. Chem. 275(33): 25130-25138. doi:10.1074/jbc.M001914200. PMID: 10833514.
23. Chang, T.C., Huang, C.J., Tam, K., Chen, S.F., Tan, K.T., Tsai, M.S., et al. 2005. Stabilization of hypoxia-inducible factor-1alpha by prostacyclin under prolonged hypoxia via reducing reactive oxygen species level in endothelial cells. J. Biol. Chem. 280(44): 36567-36574. doi:10.1074/jbc.M504280200. PMID: 16115891. (Pubitemid 41587732)
24. Chen, F., Castranova, V., and Shi, X. 2001. New insights into the role of nuclear factor-kappaB in cell growth regulation. Am. J. Pathol. 159(2): 387-397. PMID: 11485895. (Pubitemid 32751067)
25. Chen, K., Albano, A., Ho, A., and Keaney, J.F., Jr. 2003. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J. Biol. Chem. 278(41): 39527-39533. doi:10.1074/jbc.M304423200. PMID: 12890678. (Pubitemid 37248510)
26. Chen, K., Thomas, S.R., Albano, A., Murphy, M.P., and Keaney, J.F., Jr. 2004. Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling. J. Biol. Chem. 279(33): 35079-35086. doi:10.1074/jbc.M404859200. PMID: 15180991. (Pubitemid 39318144)
27. Chen, Y., Cairns, R., Papandreou, I., Koong, A., and Denko, N.C. 2009. Oxygen consumption can regulate the growth of tumors, a new perspective on the warburg effect. PLoS One. 4(9): e7033. doi:10.1371/journal.pone.0007033.
28. Choi, M.H., Lee, I.K., Kim, G.W., Kim, B.U., Han, Y.H., Yu, D.Y., et al. 2005. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature, 435(7040): 347-353. doi:10.1038/nature03587. PMID: 15902258.
29. Chung-man Ho, J., Zheng, S., Comhair, S.A., Farver, C., and Er-zurum, S.C. 2001. Differential expression of manganese super-oxide dismutase and catalase in lung cancer. Cancer Res. 61(23): 8578-8585. PMID: 11731445. (Pubitemid 33131142)
30. Colman, M.S., Afshari, C.A., and Barrett, J.C. 2000. Regulation of p53 stability and activity in response to genotoxic stress. Mutat. Res. 462(2-3): 179-188. PMID: 10767629.
31. 2 regulates the angiogenic phenotype via PTEN oxidation. J. Biol. Chem. 280(17): 16916-16924. doi:10.1074/jbc.M410690200. PMID: 15701646. (Pubitemid 41389151)
32. Cosse, J.P., Ronvaux, M., Ninane, N., Raes, M.J., and Michiels, C. 2009. Hypoxia-induced decrease in p53 protein level and increase in c-jun DNA binding activity results in cancer cell resistance to etoposide. Neoplasia, 11(10): 976-986. PMID: 19794957.
33. Csordás, G., and Hajnóczky, G. 2009. SR/ER-mitochondrial local communication: calcium and ROS. Biochim. Biophys. Acta, 1787(11): 1352-1362. doi:10.1016/j.bbabio.2009.06.004.
34. Davidson, B., Reich, R., Goldberg, I., Gotlieb, W.H., Kopolovic, J., Berner, A., et al. 2001. Ets-1 messenger RNA expression is a novel marker of poor survival in ovarian carcinoma. Clin. Cancer Res. 7(3): 551-557. PMID: 11297247. (Pubitemid 32707977)
35. Day, R.M., and Suzuki, Y.J. 2005. Cell proliferation, reactive oxygen and cellular glutathione. Dose-Response, 3(3): 425-442. doi:10.2203/dose-response. 003.03.010.
36. Delsite, R., Kachhap, S., Anbazhagan, R., Gabrielson, E., and Singh, K.K. 2002. Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells. Mol. Cancer, 1(1): 6. doi:10.1186/1476-4598-1-6. PMID: 12495447.
37. Dhar, S.S., Ongwijitwat, S., and Wong-Riley, M. T.T. 2007. Nuclear respiratory factor 1 regulates all ten nuclear-encoded subu-nits of cytochrome c oxidase in neurons. J. Biol. Chem. 283(6): 3120-3129. doi:10.1074/jbc. M707587200. PMID: 18077450.
38. Dittmer, J. 2003. The biology of the Ets1 proto-oncogene. Mol. Cancer, 2(1): 29. doi:10.1186/1476-4598-2-29. PMID: 12971829. (Pubitemid 38751468)
39. Duvoix, A., Schnekenburger, M., Delhalle, S., Blasius, R., Borde-Chiché, P., Morceau, F., et al. 2004. Expression of glutathione S-transferase P1-1 in leukemic cells is regulated by inducible AP-1 binding. Cancer Lett. 216(2): 207-219. doi:10.1016/j. canlet.2004.05.004. PMID: 15533597. (Pubitemid 39463325)
40. Evans, M.J., and Scarpulla, R.C. 1989. Interaction of nuclear factors with multiple sites in the somatic cytochrome c promoter. Characterization of upstream NRF-1, ATF, and intron Sp1 recognition sequences. J. Biol. Chem. 264(24): 14361-14368. PMID: 2547796.
41. Felty, Q., Xiong, W.C., Sun, D., Sarkar, S., Singh, K.P., Parkash, J., and Roy, D. 2005. Estrogen-induced mitochondrial reactive oxygen species as signal-transducing messengers. Biochemistry, 44(18): 6900-6909. doi:10.1021/bi047629p. PMID: 15865435. (Pubitemid 40632408)
42. Finley, L.W., and Haigis, M.C. 2009. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res. Rev. 8(3): 173-188. doi:10.1016/j.arr. 2009.03.003. PMID: 19491041.
43. 2 sensitivity of the major constitutive MAPK phospha-tase from rat brain. Biochem. Biophys. Res. Commun. 315(3): 568-574. doi:10.1016/j.bbrc.2004.01.096. PMID: 14975738.
44. Fuhrer, D., Eszlinger, M., Karger, S., Krause, K., Engelhardt, C., Hasenclever, D., et al. 2005. Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglo-bulin mRNA expression in benign and malignant thyroid tumours. Eur. J. Endocrinol. 152(5): 785-790. doi:10.1530/eje.1. 01912. PMID: 15879365. (Pubitemid 40744548)
45. Fujimoto, J., Aoki, I., Toyoki, H., Khatun, S., Sato, E., Sakaguchi, H., and Tamaya, T. 2004. Clinical implications of expression of ETS-1 related to angiogenesis in metastatic lesions of ovarian cancers. Oncology, 66(5): 420-428. doi:10.1159/000079491. PMID: 15331930. (Pubitemid 39194365)
46. Gokul, S., Patil, V., Jailkhani, R., Hallikeri, K., and Kattappagari, K. 2009. Oxidant-antioxidant status in blood and tumor tissue of oral squamous cell carcinoma patients. Oral Dis. doi:10. 1111/j.1601-0825.2009.01598.x. PMID: 19656315.
47. Gong, Y., and Agani, F.H. 2005. Oligomycin inhibits HIF-1a expression in hypoxic tumor cells. Am. J. Physiol. Cell Physiol. 288(5): C1023-C1029. doi:10.1152/ajpcell.00443.2004. PMID: 15840558. (Pubitemid 40559378)
48. Graves, B.J., and Petersen, J.M. 1998. Specificity within the ets family of transcription factors. Adv. Cancer Res. 75: 1-57. doi:10. 1016/S0065-230X(08)60738-60741 PMID: 9709806.
49. Gugneja, S., and Scarpulla, R.C. 1997. Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. J. Biol. Chem. 272(30): 18732-18739. doi:10.1074/jbc.272.30.18732. PMID: 9228045. (Pubitemid 27318218)
50. Gugneja, S., Virbasius, J.V., and Scarpulla, R.C. 1995. Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain. Mol. Cell. Biol. 15(1): 102-111. PMID: 7799916. (Pubitemid 24379906)
51. 2. Role in cell survival following oxidant injury. J. Biol. Chem. 271(8): 4138-4142. PMID: 8626753. (Pubitemid 26070512)
52. Guyton, K.Z., Xu, Q., and Holbrook, N.J. 1996b. Induction of the mammalian stress response gene GADD153 by oxidative stress: role of AP-1 element. Biochem. J. 314(Pt 2): 547-554. PMID: 8670069. (Pubitemid 26074769)
53. Guzy, R.D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K.D., et al. 2005. Mitochondrial complex III is required for hy-poxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1(6): 401-408. doi:10.1016/j.cmet.2005.05.001. PMID: 16054089. (Pubitemid 43960623)
54. Hahne, J.C., Okuducu, A.F., Kaminski, A., Florin, A., Soncin, F., and Wernert, N. 2005. Ets-1 expression promotes epithelial cell transformation by inducing migration, invasion and anchorage-independent growth. Oncogene, 24(34): 5384-5388. doi:10. 1038/sj.onc.1208761. PMID: 15940256. (Pubitemid 43080108)
55. Han, D., Ybanez, M.D., Ahmadi, S., Yeh, K., and Kaplowitz, N. 2009. Redox regulation of tumor necrosis factor signaling. Anti-oxid. Redox Signal. 11(9): 2245-2263. doi:10.1089/ars.2009. 2611.
56. Hayes, J.D., and McMahon, M. 2001. Molecular basis for the contribution of the antioxidant responsive element to cancer chemo-prevention. Cancer Lett. 174(2): 103-113. doi:10.1016/S0304-3835(01)00695-4. PMID: 11689285. (Pubitemid 33026113)
57. Higuchi, M. 2007. Regulation of mitochondrial DNA content and cancer. Mitochondrion, 7(1-2): 53-57. doi:10.1016/j.mito.2006. 12.001. PMID: 17320491. (Pubitemid 46351975)
58. Huang, L.E., Arany, Z., Livingston, D.M., and Bunn, H.F. 1996. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J. Biol. Chem. 271(50): 32253-32259. doi:10.1074/jbc.271.50. 32253. PMID: 8943284. (Pubitemid 26422262)
59. Hyoudou, K., Nishikawa, M., Ikemura, M., Kobayashi, Y., Mendelsohn, A., Miyazaki, N., et al. 2009. Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase. J. Control. Release, 137(2): 110-115. doi:10.1016/j.jconrel.2009.04.005. PMID: 19361547.
60. Iurina, N.P., and Odintsova, M.S. 2008. Mitochondrial signaling: retrograde regulation in yeast Saccharomyces cerevisiae. Genet-ika, 44(11): 1445-1452. PMID: 19137726.
61. 2 sensing. Science, 292(5516): 464-468. doi:10.1126/science.1059817. PMID: 11292862. (Pubitemid 32335941)
62. 2-regulated prolyl hydro-xylation. Science, 292(5516): 468-472. doi:10.1126/science. 1059796. PMID: 11292861. (Pubitemid 32335942)
63. Jung, S.N., Yang, W.K., Kim, J., Kim, H.S., Kim, E.J., Yun, H., et al. 2008. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells. Carcinogenesis, 29(4): 713-721. doi:10.1093/carcin/bgn032. PMID: 18258605. (Pubitemid 351494158)
64. Kamata, H., and Hirata, H. 1999. Redox regulation of cellular signalling. Cell. Signal. 11(1): 1-14. doi:10.1016/S0898-6568(98) 00037-0. PMID: 10206339. (Pubitemid 28546635)
65. Kang, H.S., Nelson, M.L., Mackereth, C.D., Schärpf, M., Graves, B.J., and McIntosh, L.P. 2008. Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha. J. Mol. Biol. 377(3): 636-646. doi:10.1016/j.jmb.2008.01.054. PMID: 18295234.
66. Katayama, S., Nakayama, T., Ito, M., Naito, S., and Sekine, I. 2005. Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern. Histol. Histopathol. 20(1): 119-126. PMID: 15578430 (Pubitemid 40028990)
67. Keehn,C.A.,Smoller,B.R.,andMorgan,M.B.2003.Expressionoftheets-1 proto-oncogene in melanocytic lesions. Mod. Pathol. 16(8): 772-777.doi:10.1097/ 01.MP.0000082395.59356.4F.PMID: 12920221.
68. 2. FEBS Lett. 388(2-3): 228-232. doi:10.1016/0014-5793(96)00557-1. PMID: 8690093. (Pubitemid 26226367)
69. Kitange, G., Tsunoda, K., Anda, T., Nakamura, S., Yasunaga, A., Naito, S., and Shibata, S. 2000. Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasmi-nogen activator is correlated with the malignant and invasive potential in meningiomas. Cancer, 89(11): 2292-2300. doi:10. 1002/1097-0142(20001201)89:113.0. CO;2-0. PMID: 11147600
70. Klaunig,J.E.,andKamendulis,L.M.2004.Theroleofoxidativestressincar- cinogenesis.Annu.Rev.Pharmacol.Toxicol.44(1):239-267.doi:10. 1146/annurev.pharmtox.44.101802.121851.PMID: 14744246.
71. Konstantinov, A.A., Peskin, A.V., Popova EYu, Khomutov, G.B., and Ruuge, E.K. 1987. Superoxide generation by the respiratory chain of tumor mitochondria. Biochim. Biophys. Acta, 894(1): 1-10. doi:10.1016/0005-2728(87)90206-4. PMID: 2822106.
72. Kulawiec, M., Safina, A., Desouki, M.M., Still, I., Matsui, S., et al. 2008. Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol. Ther. 7(11): 1732-1743 PMID: 19151587.
73. Kwak, M.K., Itoh, K., Yamamoto, M., and Kensler, T.W. 2002. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response elementlike sequences in the nrf2 promoter. Mol. Cell. Biol. 22(9): 2883-2892. doi:10.1128/MCB.22.9.2883-2892.2002. PMID: 11940647. (Pubitemid 34437448)
74. Kwon, J., Lee, S.R., Yang, K.S., Ahn, Y., Kim, Y.J., Stadtman, E.R., and Rhee, S.G. 2004. Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors. Proc. Natl. Acad. Sci. U.S.A. 101(47): 16419-16424. doi:10.1073/pnas.0407396101. PMID: 15534200. (Pubitemid 39557728)
75. Lander, H.M. 1997. An essential role for free radicals and derived species in signal transduction. FASEB J. 11(2): 118-124. PMID: 9039953. (Pubitemid 27097584)
76. Lebedeva, M.A., Eaton, J.S., and Shadel, G.S. 2009. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. Biochim. Biophys. Acta, 1787(5): 328-334. doi:10.1016/j.bbabio. 2009.01.004. PMID: 19413947.
77. 2 regulates the activation of distinct MAPK pathways. Free Radic. Biol. Med. 33(8): 1121-1132. doi:10.1016/S0891-5849(02) 01000-6. PMID: 12374624.
78. Lefter, L.P., Dima, S., Sunamura, M., Furukawa, T., Sato, Y., Abe, M., et al. 2009. Transcriptional silencing of ETS-1 efficiently suppresses angiogenesis of pancreatic cancer. Cancer Gene Ther. 16(2): 137-148. doi:10.1038/cgt.2008.65. PMID: 18772901.
79. 2-mediated activation of NFkB-in-ducing kinase. J. Biol. Chem. 281(3): 1495-1505. doi:10.1074/jbc. M511153200. PMID: 16286467. (Pubitemid 43752464)
80. Liu, Y., Fiskum, G., and Schubert, D. 2002. Generation of reactive oxygen species by the mitochondrial electron transport chain. J. Neurochem. 80(5): 780-787. doi:10.1046/j.0022-3042.2002. 00744.x. PMID: 11948241. (Pubitemid 34809230)
81. Martin, M.E., Chinenov, Y., Yu, M., Schmidt, T.K., and Yang, X.Y. 1996. Redox regulation of GA-binding protein-alpha DNA binding activity. J. Biol. Chem. 271(41): 25617-25623. doi:10. 1074/jbc.271.41.25617. PMID: 8810337. (Pubitemid 26337941)
82. Martindale, J.L., and Holbrook, N.J. 2002. Cellular response to oxi-dative stress: signaling for suicide and survival. J. Cell. Physiol. 192(1): 1-15. doi:10.1002/jcp.10119. PMID: 12115731.
83. xB. Nucleic Acids Res. 21(8): 1727-1734. doi:10.1093/nar/21.8. 1727. PMID: 8493089. (Pubitemid 23178885)
84. Mattie, M.D., McElwee, M.K., and Freedman, J.H. 2008. Mechanism of copper-activated transcription: activation of AP-1, and the JNK/SAPK and p38 signal transduction pathways. J. Mol. Biol. 383(5): 1008-1018. doi:10.1016/j.jmb.2008.08.080. PMID: 18793645.
85. Menendez, D., Inga, A., and Resnick, M.A. 2009. The expanding universe of p53 targets. Nat. Rev. Cancer, 9(10): 724-737. doi:10.1038/nrc2730. PMID: 19776742.
86. Miceli, M.V., and Jazwinski, S.M. 2005. Common and cell type-specific responses of human cells to mitochondrial dysfunction. Exp. Cell Res. 302(2): 270-280. doi:10.1016/j.yexcr.2004.09. 006. PMID: 15561107. (Pubitemid 39550468)
87. Mukherjee, T., Kumar, A., Mathur, M., Chattopadhyay, T.K., and Ral-han,R.2003. Ets-1 and VEGFexpressioncorrelateswith tumoran-giogenesis, lymph node metastasis, and patient survival in esophageal squamous cell carcinoma. J. Cancer Res. Clin. Oncol. 129(7): 430-436. doi:10.1007/s00432-003-0457-3. PMID: 12851814. (Pubitemid 36995141)
88. Murphy, M.P. 2009. How mitochondria produce reactive oxygen species. Biochem. J. 417(1): 1-13. doi:10.1042/BJ20081386. PMID: 19061483.
89. Naito, S., Shimizu, S., Maeda, S., Wang, J., Paul, R., and Fagin, J.A. 1998. Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells. Am. J. Physiol. 274(Pt 1): C472-C480. PMID: 9486138. (Pubitemid 28140792)
90. Naito, A., Cook, C.C., Mizumachi, T., Wang, M., Xie, C.H., Evans, T.T., et al. 2008. Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells. Cancer Sci. 99(8): 1584-1588. doi:10. 1111/j.1349-7006.2008.00879.x. PMID: 18754870.
91. Nakada, M., Yamashita, J., Okada, Y., and Sato, H. 1999. Ets-1 positively regulates expression of urokinase-type plasminogen activator (uPA) and invasiveness of astrocytic tumors. J. Neuropathol. Exp. Neurol. 58(4): 329-334. doi:10.1097/00005072-199904000-200000003 PMID: 10218628. (Pubitemid 29187895)
92. Nomura, M., Ma, W., Chen, N., Bode, A.M., and Dong, Z. 2000. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gal-late and theaflavins. Carcinogenesis, 21(10): 1885-1890. doi:10. 1093/carcin/21.10.1885. PMID: 11023547.
93. Oberley, T.D., and Oberley, L.W. 1997. Antioxidant enzyme levels in cancer. Histol. Histopathol. 12(2): 525-535. PMID: 9151141.
94. Oikawa, M., Abe, M., Kurosawa, H., Hida, W., Shirato, K., and Sato, Y. 2001. Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1. Biochem. Biophys. Res. Commun. 289(1): 39-43. doi:10.1006/bbrc.2001.5927. PMID: 11708773. (Pubitemid 33108788)
95. Oka, T., Rairkar, A., and Chen, J.H. 1991. Structural and functional analysis of the regulatory sequences of the ets-1 gene. Onco-gene, 6(11): 2077-2083. PMID: 1945412. (Pubitemid 21924049)
96. Okuducu, A.F., Zils, U., Michaelis, S.A., Michaelides, S., and von Deimling, A. 2006. Ets-1 is up-regulated together with its target gene products matrix metalloproteinase-2 and matrix metallo-proteinase-9 in atypical and anaplastic meningiomas. Histo-pathology, 48(7): 836-845. doi:10.1111/j.1365- 2559.2006. 02432.x. PMID: 16722933. (Pubitemid 43800944)
97. Pahl, H.L. 1999. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene, 18(49): 6853-6866. doi:10. 1038/sj.onc.1203239. PMID: 10602461.
98. Pande, P., Mathur, M., Shukla, N.K., and Ralhan, R. 1999. Ets-1: a plausible marker of invasive potential and lymphnode metastasis in human oral squamous cell carcinomas. J. Pathol. 189(1): 40-45. doi:10.1002/(SICI)1096- 9896(199909)189:13.0.CO;2-#. PMID: 10451486. (Pubitemid 29406817)
99. Park, Y.H., Jung, H.H., Ahn, J.S., and Im, Y.H. 2008. Ets-1 upre-gulates HER2-induced MMP-1 expression in breast cancer cells. Biochem. Biophys. Res. Commun. 377(2): 389-394. doi:10. 1016/j.bbrc.2008.09.135. PMID: 18851945.
100. Pelicano, H., Lu, W., Zhou, Y., Zhang, W., Chen, Z., Hu, Y., and Huang, P. 2009. Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res. 69(6): 2375-2383. doi:10.1158/0008-5472.CAN-08-3359. PMID: 19276362.
101. Peters, C.L., Morris, C.J., Mapp, P.I., Blake, D.R., Lewis, C.E., and Winrow, V.R. 2004. The transcription factors hypoxia-inducible factor 1a and Ets-1 colocalize in the hypoxic synovium of inflamed joints in adjuvant-induced arthritis. Arthritis Rheum. 50(1): 291-296. doi:10.1002/art.11473. PMID: 14730627.
102. Petit, E., Courtin, A., Kloosterboer, H.J., Rostène, W., Forgez, P., and Gompel, A. 2009. Progestins induce catalase activities in breast cancer cells through PRB isoform: correlation with cell growth inhibition. J. Steroid Biochem. Mol. Biol. 115(3-5): 153-160. doi:10.1016/j.jsbmb.2009.04.002. PMID: 19383545.
103. Piantadosi, C.A., and Suliman, H.B. 2006. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. J. Biol. Chem. 281(1): 324-333. doi:10.1074/jbc. M508805200. PMID: 16230352. (Pubitemid 44537031)
104. Picardo, M., Grammatico, P., Roccella, F., Roccella, M., Grandi-netti, M., Del Porto, G., and Passi, S. 1996. Imbalance in the antioxidant pool in melanoma cells and normal melanocytes from patients with melanoma. J. Invest. Dermatol. 107(3): 322-326. doi:10.1111/1523-1747.ep12363163. PMID: 8751964. (Pubitemid 26284337)
105. Policastro, L., Molinari, B., Larcher, F., Blanco, P., Podhajcer, O.L., Costa, C.S., et al. 2004. Imbalance of antioxidant enzymes in tumor cells and inhibition of proliferation and malignant features by scavenging hydrogen peroxide. Mol. Carcinog. 39(2): 103-113. doi:10.1002/mc.20001. PMID: 14750215. (Pubitemid 38167114)
106. 2 by catalase inhibits the proliferation of HER-2/Neu-transformed rat-1 fibroblasts through the induction of a stress response. J. Biol. Chem. 276(12): 9558-9564. doi:10. 1074/jbc.M004617200. PMID: 11134000. (Pubitemid 37385548)
107. Radjendirane, V., and Jaiswal, A.K. 1999. Coordinated induction of the c-jun gene with genes encoding quinone oxidoreductases in response to xenobiotics and antioxidants. Biochem. Pharmacol. 58(4): 597-603. doi:10.1016/S0006-2952(99)00143-4. PMID: 10413296. (Pubitemid 29296879)
108. Ristevski, S., O'Leary, D.A., Thornell, A.P., Owen, M.J., Kola, I., and Hertzog, P.J. 2004. The ETS transcription factor GABPal-pha is essential for early embryogenesis. Mol. Cell. Biol. 24(13): 5844-5849. doi:10.1128/MCB.24.13. 5844-5849.2004. PMID: 15199140. (Pubitemid 38787969)
109. Rodŕiguez-Peña, A., Escrivá, H., Handler, A., and Vallejo, C. 2002. Thyroid hormone increases transcription of GA-binding protein/nuclear respiratory factor-2 a-subunit in rat liver. FEBS Lett. 514(2): 309-314. doi:10.1016/S0014-5793(02)02389-X. PMID: 11943172. (Pubitemid 34273960)
110. Rosmarin, A.G., Resendes, K.K., Yang, Z., McMillan, J.N., and Fleming, S.L. 2004. GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions. Blood Cells Mol. Dis. 32(1): 143-154. doi:10.1016/j.bcmd.2003.09.005. PMID: 14757430. (Pubitemid 38147712)
111. Rothhammer, T., Hahne, J.C., Florin, A., Poser, I., Soncin, F., Wer-nert, N., and Bosserhoff, A.K. 2004. The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma. Cell. Mol. Life Sci. 61(1): 118-128. doi:10.1007/s00018-003-3337-3338 PMID: 14704859. (Pubitemid 38121905)
112. Salnikow, K., Aprelikova, O., Ivanov, S., Tackett, S., Kaczmarek, M., Karaczyn, A., et al. 2008. Regulation of hypoxia-inducible genes by ETS1 transcription factor. Carcinogenesis, 29(8): 1493-1499. doi:10.1093/carcin/ bgn088. PMID: 18381358.
113. 2-induced apoptosis: implications for Down's syndrome. Biochem. Biophys. Res. Commun. 287(4): 1003-1008. doi:10.1006/bbrc.2001.5680. PMID: 11573964. (Pubitemid 32953575)
114. Scarpulla, R.C. 2002. Nuclear activators and coactivators in mammalian mitochondrial biogenesis. Biochim. Biophys. Acta, 1576(1-2): 1-14. PMID: 12031478.
115. Scarpulla, R.C. 2008. Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactiva-tor. Ann. N.Y. Acad. Sci. 1147: 321-334. doi:10.1196/annals. 1427.006. PMID: 19076454.
116. Sementchenko, V.I., and Watson, D.K. 2000. Ets target genes: past, present and future. Oncogene, 19(55): 6533-6548. doi:10.1038/sj.onc.1204034. PMID: 11175369. (Pubitemid 32108443)
117. Semenza, G.L. 2003. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer, 3(10): 721-732. doi:10.1038/nrc1187. PMID: 13130303.
118. Semenza, G.L. 2009. Regulation of oxygen homeostasis by hy-poxia-inducible factor 1. Physiology (Bethesda), 24: 97-106. doi:10.1152/physiol.00045.2008. PMID: 19364912.
119. Seth, A., and Papas, T.S. 1990. The c-ets-1 proto-oncogene has on-cogenic activity and is positively autoregulated. Oncogene, 5(12): 1761-1767. PMID: 2284095. (Pubitemid 120034701)
120. Shaulian, E., and Karin, M. 2001. AP-1 in cell proliferation and survival. Oncogene, 20(19): 2390-2400. doi:10.1038/sj.onc. 1204383. PMID: 11402335. (Pubitemid 32531297)
121. Shen, H.M., and Tergaonkar, V. 2009. NFkappaB signaling in car-cinogenesis and as a potential molecular target for cancer therapy. Apoptosis, 14(4): 348-363. doi:10.1007/s10495-009-0315-0. PMID: 19212815.
122. Shimizu, S., Kageyama, M., Yasuda, M., Sasaki, D., Naito, S., Ya-mamoto, T., and Kiuchi, Y. 2004. Stimulation of in vitro angio-genesis by nitric oxide through the induction of transcription factor ETS-1. Int. J. Biochem. Cell Biol. 36(1): 114-122. doi:10.1016/S1357-2725(03)00170-5. PMID: 14592537. (Pubitemid 37338477)
123. Simon, M.C. 2006. Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization. Adv. Exp. Med. Biol. 588: 165-170. doi:10.1007/978-0-387-34817-9-15. PMID: 17089888.
124. Sinha, R.J., Singh, R., Mehrotra, S., and Singh, R.K. 2009. Implications of free radicals and antioxidant levels in carcinoma of the breast: a never-ending battle for survival. Indian J. Cancer, 46(2): 146-150. doi:10.4103/0019-509X.49153. PMID: 19346649.
125. Sipos, I., Tretter, L., and Adam-Vizi, V. 2003. Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals. J. Neurochem. 84(1): 112-118. doi:10.1046/j.1471-4159.2003. 01513.x. PMID: 12485407. (Pubitemid 36182071)
126. 2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells. Biochem. Biophys. Res. Com-mun. 378(3): 610-614. doi:10.1016/j.bbrc.2008.11.106. PMID: 19059215.
127. Span, P.N., Manders, P., Heuvel, J.J., Thomas, C.M., Bosch, R.R., Beex, L.V., and Sweep, C.G. 2002. Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer. Oncogene, 21(55): 8506-8509. doi:10.1038/sj.onc.1206040. PMID: 12466970. (Pubitemid 36054891)
128. Srinivas, V., Leshchinsky, I., Sang, N., King, M.P., Minchenko, A., and Caro, J. 2001. Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J. Biol. Chem. 276(25): 21995-21998. doi:10. 1074/jbc.C100177200. PMID: 11342528. (Pubitemid 37410859)
129. Suliman, H.B., Carraway, M.S., Welty-Wolf, K.E., Whorton, A.R., and Piantadosi, C.A. 2003. Lipopolysaccharide stimulates mito-chondrial biogenesis via activation of nuclear respiratory factor-1. J. Biol. Chem. 278(42): 41510-41518. doi:10.1074/jbc. M304719200. PMID: 12902348.
130. Sun, X.Z., Vinci, C., Makmura, L., Han, S., Tran, D., Nguyen, J., et al. 2003. Formation of disulfide bond in p53 correlates with inhibition of DNA binding and tetramerization. Antioxid. Redox Signal. 5(5): 655-665. doi:10.1089/152308603770310338. PMID: 14580323. (Pubitemid 37315155)
131. 2 for platelet-derived growth factor signal transduction. Science, 270(5234): 296-299. doi:10.1126/science.270.5234.296. PMID: 7569979.
132. Suzuki, H., Kumagai, T., Goto, A., and Sugiura, T. 1998. Increase in intracellular hydrogen peroxide and upregulation of a nuclear respiratory gene evoked by impairment of mitochondrial electron transfer in human cells. Biochem.
133. Szatrowski, T.P., and Nathan, C.F. 1991. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51(3): 794-798. PMID: 1846317.
134. Takada, Y., Mukhopadhyay, A., Kundu, G.C., Mahabeleshwar, G.H., Singh, S., and Aggarwal, B.B. 2003. Hydrogen peroxide activates NF-kB through tyrosine phosphorylation of IkBa and serine phosphorylation of p65: evidence for the involvement of IkBa kinase and Syk protein-tyrosine kinase. J. Biol. Chem. 278(26): 24233-24241. doi:10.1074/jbc.M212389200. PMID: 12711606. (Pubitemid 36830260)
135. Tokuhara, K., Ogata, Y., Nakagawa, M., and Shirouzu, K. 2003. Ets-1 expression in vascular endothelial cells as an angiogenic and prognostic factor in colorectal carcinoma. Int. Surg. 88(1): 25-33. PMID: 12731728. (Pubitemid 39619795)
136. Tsutsumi, S., Kuwano, H., Nagashima, N., Shimura, T., Mochiki, E., and Asao, T. 2005. Ets-1 expression in gastric cancer. Hepa-togastroenterology, 52(62): 654-656. PMID: 15816498. (Pubitemid 40469488)
137. Vanden Hoek, T.L., Shao, Z., Li, C., Schumacker, P.T., and Becker, L.B. 1997. Mitochondrial electron transport can become a significant source of oxidative injury in cardiomyocytes. J. Mol. Cell. Cardiol. 29(9): 2441-2450. doi:10.1006/jmcc.1997. 0481. PMID: 9299367. (Pubitemid 27404436)
138. Vercauteren, K., Gleyzer, N., and Scarpulla, R.C. 2008. PGC-1-re-lated coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)- dependent respiratory gene expression. J. Biol. Chem. 283(18): 12102-12111. doi:10.1074/jbc. M710150200. PMID: 18343819.
139. Vercauteren, K., Gleyzer, N., and Scarpulla, R.C. 2009. Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactiva-tor) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. J. Biol. Chem. 284(4): 2307-2319. doi:10.1074/jbc.M806434200. PMID: 19036724.
140. Virbasius, J.V., and Scarpulla, R.C. 1991. Transcriptional activation through ETS domain binding sites in the cytochrome c oxi-dase subunit IV gene. Mol. Cell. Biol. 11(11): 5631-5638. PMID: 1656236.
141. Virbasius, C.A., Virbasius, J.V., and Scarpulla, R.C. 1993. NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators. Genes Dev. 7(12a): 2431-2445. doi:10. 1101/gad.7.12a.2431. PMID: 8253388.
142. Wagner, E.F., and Nebreda, A.R. 2009. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat. Rev. Cancer, 9(8): 537-549. doi:10.1038/nrc2694. PMID: 19629069.
143. Wallace, D.C. 2008. Mitochondria as chi. Genetics, 179(2): 727-735. doi:10.1534/genetics.104.91769. PMID: 18558648.
144. Wang, H., and Morais, R. 1997. Up-regulation of nuclear genes in response to inhibition of mitochondrial DNA expression in chicken cells. Biochim. Biophys. Acta, 1352(3): 325-334. PMID: 9224956. (Pubitemid 27293821)
145. Warburg, O. 1956. On the origin of cancer cells. Science, 123(3191): 309-314. doi:10.1126/science.123.3191.309. PMID: 13298683.
146. Watabe, T., Yoshida, K., Shindoh, M., Kaya, M., Fujikawa, K., Sato, H., et al. 1998. The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and col-lagenase genes in response to epidermal growth factor. Int. J. Cancer, 77(1): 128-137. doi:10.1002/(SICI)1097- 0215(19980703) 77:13.0.CO;2-9. PMID: 9639404. (Pubitemid 28308562)
147. Wilson, L.A., Yamamoto, H., and Singh, G. 2004. Role of the transcription factor Ets-1 in cisplatin resistance. Mol. Cancer Ther. 3(7): 823-832 PMID: 15252143. (Pubitemid 39193764)
148. 2 via an antioxidant response element. FASEB J. 19(14): 2085-2087. doi:doi:10.1096/fj.05-4401fje. PMID: 16234432. (Pubitemid 41759774)
149. Yasuda, M., Ohzeki, Y., Shimizu, S., Naito, S., Ohtsuru, A., Yama-moto, T., and Kuroiwa, Y. 1998. Stimulation of in vitro angio-genesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells. Life Sci. 64(4): 249-258. doi:10.1016/S0024-3205(98)00560-8. PMID: 10027759. (Pubitemid 29049308)
150. Zhang, C., and Wong-Riley, M.T. 2000. Depolarizing stimulation upregulates GA-binding protein in neurons: a transcription factor involved in the bigenomic expression of cytochrome oxidase subunits. Eur. J. Neurosci. 12(3): 1013-1023. doi:10.1046/j. 1460-9568.2000.00997.x. PMID: 10762332. (Pubitemid 30168780)
151. Zhang, Y., and Xiong, Y. 2001. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science, 292(5523): 1910-1915. doi:10.1126/science.1058637. PMID: 11397945. (Pubitemid 32538366)
152. Zhou, L.Z., Johnson, A.P., and Rando, T.A. 2001. NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radic. Biol. Med. 31(11): 1405-1416. doi:10.1016/S0891-5849(01)00719-5. PMID: 11728812.