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Volumn 23, Issue 5, 2009, Pages 537-548

Tumor suppressors and cell metabolism: A recipe for cancer growth

Author keywords

Apoptosis; Cancer biology; Cellular metabolism; Oncogenes; Proliferation; Tumor suppressors

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE LKB1; PROTEIN P53; TUBERIN; VON HIPPEL LINDAU PROTEIN;

EID: 61849135453     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1756509     Document Type: Review
Times cited : (858)

References (116)
  • 2
    • 50349090461 scopus 로고    scopus 로고
    • Convergent energy and stress signaling
    • Baena-Gonzalez, E. and Sheen, J. 2008. Convergent energy and stress signaling. Trends Plant Sci 13: 474-482.
    • (2008) Trends Plant Sci , vol.13 , pp. 474-482
    • Baena-Gonzalez, E.1    Sheen, J.2
  • 5
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer, D.E., Hatzivassiliou, G., Zhao, F., Andreadis, C, and Thompson, C.B. 2005. ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24: 6314-6322.
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 7
    • 1642328617 scopus 로고    scopus 로고
    • Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
    • Browne, G.J., Finn, S.G., and Proud, C.G, 2004. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. Biol. Chem. 279: 12220-12231.
    • (2004) Biol. Chem , vol.279 , pp. 12220-12231
    • Browne, G.J.1    Finn, S.G.2    Proud, C.G.3
  • 9
    • 48449101433 scopus 로고    scopus 로고
    • p53 target genes sestrinl and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov, A.V. and Karin, M. 2008. p53 target genes sestrinl and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134: 451-460.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 12
    • 0019566797 scopus 로고
    • Mutants of yeast defective in sucrose utilization
    • Carlson, M., Osmond, B.C., and Botstein, D. 1981. Mutants of yeast defective in sucrose utilization. Genetics 98: 25-40.
    • (1981) Genetics , vol.98 , pp. 25-40
    • Carlson, M.1    Osmond, B.C.2    Botstein, D.3
  • 16
    • 3042818799 scopus 로고    scopus 로고
    • Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
    • Corradetti, M.N., Inoki, K., Bardeesy, N., DePinho, R.A., and Guan, K.L. 2004. Regulation of the TSC pathway by LKB1: Evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes & Dev. 18: 1533-1538.
    • (2004) Genes & Dev , vol.18 , pp. 1533-1538
    • Corradetti, M.N.1    Inoki, K.2    Bardeesy, N.3    DePinho, R.A.4    Guan, K.L.5
  • 18
    • 0033079597 scopus 로고    scopus 로고
    • Oncogenic alterations of metabolism
    • Dang, C.V. and Semenza, G.L, 1999. Oncogenic alterations of metabolism. Trends Biochem. Sci. 24: 68-72.
    • (1999) Trends Biochem. Sci , vol.24 , pp. 68-72
    • Dang, C.V.1    Semenza, G.L.2
  • 19
  • 20
    • 0025192341 scopus 로고
    • Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase
    • Davies, S.P., Sim, A.T., and Hardie, D.G, 1990. Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase. Eur. J. Biochem. 187: 183-190.
    • (1990) Eur. J. Biochem , vol.187 , pp. 183-190
    • Davies, S.P.1    Sim, A.T.2    Hardie, D.G.3
  • 21
    • 33846005164 scopus 로고    scopus 로고
    • Phos-phatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth
    • Deberardinis, R.J., Lum, J.J., and Thompson, C.B. 2006. Phos-phatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J. Biol. Chem. 281: 37372-37380.
    • (2006) J. Biol. Chem , vol.281 , pp. 37372-37380
    • Deberardinis, R.J.1    Lum, J.J.2    Thompson, C.B.3
  • 22
    • 37449034854 scopus 로고    scopus 로고
    • DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, L, Yudkoff, M., Wehrli, S., and Thompson, C.B. 2007. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc, Natl. Acad. Sci. 104: 19345-19350.
    • DeBerardinis, R.J., Mancuso, A., Daikhin, E., Nissim, L, Yudkoff, M., Wehrli, S., and Thompson, C.B. 2007. Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc, Natl. Acad. Sci. 104: 19345-19350.
  • 23
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis, R.J., Lum, J.J., Hatzivassiliou, G., and Thompson, C.B. 2008. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 24
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger, A.L. and Thompson, C.B. 2002. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol. Biol. Cell 13: 2276-2288.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 27
    • 33744783432 scopus 로고    scopus 로고
    • Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
    • Fantin, V.R., St-Pierre, J., and Leder, P. 2006. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 9: 425-434.
    • (2006) Cancer Cell , vol.9 , pp. 425-434
    • Fantin, V.R.1    St-Pierre, J.2    Leder, P.3
  • 28
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng, Z., Zhang, H., Levine, A.J., and Jin, S. 2005. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. 102: 8204-8209.
    • (2005) Proc. Natl. Acad. Sci , vol.102 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 29
    • 33744969828 scopus 로고    scopus 로고
    • Energy deregulation: Licensing tumors to grow
    • Garber, K. 2006. Energy deregulation: Licensing tumors to grow. Science 312: 1158-1159.
    • (2006) Science , vol.312 , pp. 1158-1159
    • Garber, K.1
  • 30
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby, R.A. and Gillies, R.J. 2004. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4: 891-899.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 32
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • Gordan, J.D. and Simon, M.C. 2007. Hypoxia-inducible factors: Central regulators of the tumor phenotype. Cnrr. Opin. Genet. Dev. 17: 71-77.
    • (2007) Cnrr. Opin. Genet. Dev , vol.17 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 33
    • 34547580590 scopus 로고    scopus 로고
    • HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation
    • Gordan, J.D., Thompson, C.B., and Simon, M.C, 2007. HIF and c-Myc: Sibling rivals for control of cancer cell metabolism and proliferation. Cancer Cell 12: 108-113.
    • (2007) Cancer Cell , vol.12 , pp. 108-113
    • Gordan, J.D.1    Thompson, C.B.2    Simon, M.C.3
  • 34
    • 0023779730 scopus 로고
    • Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation
    • Gottesdiener, K.M., Karpinski, B.A., Lindsten, T., Strominger, J.L., Jones, N.H., Thompson, C.B., and Leiden, J.M. 1988, Isolation and structural characterization of the human 4F2 heavy-chain gene, an inducible gene involved in T-lymphocyte activation. Mol. Cell. Biol. 8: 3809-3819.
    • (1988) Mol. Cell. Biol , vol.8 , pp. 3809-3819
    • Gottesdiener, K.M.1    Karpinski, B.A.2    Lindsten, T.3    Strominger, J.L.4    Jones, N.H.5    Thompson, C.B.6    Leiden, J.M.7
  • 35
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a Gl-phase checkpoint by low-oxygen conditions is independent of p53 status
    • Graeber, T.G., Peterson, J.F., Tsai, M., Monica, K., Fornace Jr., A.J., and Giaccia, A,J. 1994. Hypoxia induces accumulation of p53 protein, but activation of a Gl-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol. Cell. Biol. 14: 6264-6277.
    • (1994) Mol. Cell. Biol , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace Jr., A.J.5    Giaccia, A.J.6
  • 36
    • 34848861463 scopus 로고    scopus 로고
    • The energy sensor AMP-activated protein kinase directly regulates the mammalian FOX03 transcription factor
    • Greer, EL., Oskoui, PR., Banko, M.R., Maniar, J.M., Gygi, M.P., Gygi, S.P., and Brunet, A. 2007. The energy sensor AMP-activated protein kinase directly regulates the mammalian FOX03 transcription factor. J. Biol. Chem. 282: 30107-30119.
    • (2007) J. Biol. Chem , vol.282 , pp. 30107-30119
    • Greer, E.L.1    Oskoui, P.R.2    Banko, M.R.3    Maniar, J.M.4    Gygi, M.P.5    Gygi, S.P.6    Brunet, A.7
  • 37
    • 0025612599 scopus 로고
    • The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens
    • Griffiths, M. and Keast, D. 1990. The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens. Immunol. Cell Biol. 68: 405-408.
    • (1990) Immunol. Cell Biol , vol.68 , pp. 405-408
    • Griffiths, M.1    Keast, D.2
  • 38
    • 0027511220 scopus 로고
    • The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes
    • Guppy, M., Greiner, E., and Brand, K. 1993. The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes. Eur. J. Biochem. 212: 95-99.
    • (1993) Eur. J. Biochem , vol.212 , pp. 95-99
    • Guppy, M.1    Greiner, E.2    Brand, K.3
  • 42
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status
    • Hardie, D.G. 2003. Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status. Endocrinology 144: 5179-5183.
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 43
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNFl protein kinases: Conserved guardians of cellular energy
    • Hardie, D.G, 2007. AMP-activated/SNFl protein kinases: Conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 8: 774-785.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 44
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNFl protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie, D.G., Carling, D., and Carlson, M. 1998. The AMP-activated/SNFl protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67: 821-855.
    • (1998) Annu. Rev. Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 45
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding, H.P., Zhang, Y., and Ron, D. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 47
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRADα/β and M025α/β are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley, S.A., Boudeau, J., Reid, J.L., Mustard, K.J., Udd, L., Makela, T.P., Alessi, D.R., and Hardie, D.G. 2003. Complexes between the LKB1 tumor suppressor, STRADα/β and M025α/β are upstream kinases in the AMP-activated protein kinase cascade. J. Biol. 2: 28.
    • (2003) J. Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 48
    • 23044432463 scopus 로고    scopus 로고
    • Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase
    • Hawley, S.A., Pan, D.A., Mustard, K.J., Ross, L., Bain, J., Edelman, A.M., Frenguelli, B.G., and Hardie, D.G. 2005. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metab. 2: 9-19.
    • (2005) Cell Metab , vol.2 , pp. 9-19
    • Hawley, S.A.1    Pan, D.A.2    Mustard, K.J.3    Ross, L.4    Bain, J.5    Edelman, A.M.6    Frenguelli, B.G.7    Hardie, D.G.8
  • 50
    • 0016096198 scopus 로고
    • Control of the initiation of DNA synthesis in 3T3 cells: Low-molecular weight nutrients
    • Holley, R.W. and Kiernan, J.A. 1974. Control of the initiation of DNA synthesis in 3T3 cells: Low-molecular weight nutrients. Proc. Natl. Acad. Sci 71: 2942-2945.
    • (1974) Proc. Natl. Acad. Sci , vol.71 , pp. 2942-2945
    • Holley, R.W.1    Kiernan, J.A.2
  • 53
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K.L. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4: 648-657.
    • (2002) Nat. Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 54
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki, K., Zhu, T., and Guan, K.L. 2003. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115: 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 55
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
    • Isaacs, J.S., Jung, Y.J., Mole, D.R., Lee, S., Torres-Cabala, C, Chung, Y.L., Merino, M., Trepel, J., Zbar, B., Toro, J., et al. 2005. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability. Cancer Cell 8: 143-153.
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5    Chung, Y.L.6    Merino, M.7    Trepel, J.8    Zbar, B.9    Toro, J.10
  • 56
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-lα
    • Jager, S., Handschin, C, St-Pierre, J., and Spiegelman, B.M. 2007. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-lα. Proc. Natl Acad. Sci. 104: 12017-12022.
    • (2007) Proc. Natl Acad. Sci , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 59
    • 0034925041 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
    • Jiang, B.H., Jiang, G., Zheng, J.Z., Lu, Z., Hunter, T., and Vogt, P.K. 2001. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 12: 363-369.
    • (2001) Cell Growth Differ , vol.12 , pp. 363-369
    • Jiang, B.H.1    Jiang, G.2    Zheng, J.Z.3    Lu, Z.4    Hunter, T.5    Vogt, P.K.6
  • 61
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim, J.W., Tchernyshyov, I., Semenza, G.L., and Dang, C.V. 2006. HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 3: 177-185.
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 63
    • 33947520506 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF
    • Koivunen, P., Hirsila, M., Remes, A.M., Hassinen, I.E., Kivirikko, K.I., and Myllyharju, J. 2007. Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: Possible links between cell metabolism and stabilization of HIF. J. Biol. Chem. 282: 4524-4532.
    • (2007) J. Biol. Chem , vol.282 , pp. 4524-4532
    • Koivunen, P.1    Hirsila, M.2    Remes, A.M.3    Hassinen, I.E.4    Kivirikko, K.I.5    Myllyharju, J.6
  • 65
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α
    • Koumenis, C., Naczki, C., Koritzinsky, M., Rastani, S., Diehl, A., Sonenberg, N., Koromilas, A., and Wouters, B.G. 2002. Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α. Mol. Cell. Biol 22: 7405-7416.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 66
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: Cancer's Achilles' heel
    • Kroemer, G. and Pouyssegur, J. 2008. Tumor cell metabolism: Cancer's Achilles' heel. Cancer Cell 13: 472-482.
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 67
    • 33745840203 scopus 로고    scopus 로고
    • 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    • Laderoute, K.R., Amin, K., Calaoagan, J.M., Knapp, M., Le, T, Orduna, J., Foretz, M., and Viollet, B. 2006. 5′-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Mol. Cell. Biol 26: 5336-5347.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 5336-5347
    • Laderoute, K.R.1    Amin, K.2    Calaoagan, J.M.3    Knapp, M.4    Le, T.5    Orduna, J.6    Foretz, M.7    Viollet, B.8
  • 68
    • 36549026878 scopus 로고    scopus 로고
    • Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
    • Lee, C.H., Mold, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E.P., and Guan, K.L. 2007. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 26: 4812-4823.
    • (2007) EMBO J , vol.26 , pp. 4812-4823
    • Lee, C.H.1    Mold, K.2    Karbowniczek, M.3    Petroulakis, E.4    Sonenberg, N.5    Henske, E.P.6    Guan, K.L.7
  • 70
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 71
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine, B. and Klionsky, D.J. 2004. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev. Cell 6: 463-477.
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 73
    • 33846204370 scopus 로고    scopus 로고
    • UVRAG: A new player in autophagy and tumor cell growth
    • Liang, C, Feng, P., Ku, B., Oh, B.H., and Jung, J.U. 2007. UVRAG: A new player in autophagy and tumor cell growth. Autophagy 3: 69-71.
    • (2007) Autophagy , vol.3 , pp. 69-71
    • Liang, C.1    Feng, P.2    Ku, B.3    Oh, B.H.4    Jung, J.U.5
  • 74
  • 75
    • 43949102406 scopus 로고    scopus 로고
    • SNF4A-γ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy
    • Lippai, M., Csikos, G., Maroy, P., Lukacsovich, T., Juhasz, G., and Sass, M. 2008. SNF4A-γ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy. Autophagy 4: 476-486.
    • (2008) Autophagy , vol.4 , pp. 476-486
    • Lippai, M.1    Csikos, G.2    Maroy, P.3    Lukacsovich, T.4    Juhasz, G.5    Sass, M.6
  • 76
    • 32444433450 scopus 로고    scopus 로고
    • Hypoxia-induced energy stress regulates mRNA translation and cell growth
    • Liu, L., Cash, T.P., Jones, R.G., Keith, B., Thompson, C.B., and Simon, M.C. 2006. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 21: 521-531.
    • (2006) Mol Cell , vol.21 , pp. 521-531
    • Liu, L.1    Cash, T.P.2    Jones, R.G.3    Keith, B.4    Thompson, C.B.5    Simon, M.C.6
  • 81
    • 28444496362 scopus 로고    scopus 로고
    • Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila
    • Mandal, S., Guptan, P., Owusu-Ansah, E., and Banerjee, U. 2005. Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev. Cell 9: 843-854.
    • (2005) Dev. Cell , vol.9 , pp. 843-854
    • Mandal, S.1    Guptan, P.2    Owusu-Ansah, E.3    Banerjee, U.4
  • 82
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
    • Mansfield, K.D., Guzy, R.D., Pan, Y, Young, R.M., Cash, T.P., Schumacker, P.T., and Simon, M.C. 2005. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation. Cell Metab. 1: 393-399.
    • (2005) Cell Metab , vol.1 , pp. 393-399
    • Mansfield, K.D.1    Guzy, R.D.2    Pan, Y.3    Young, R.M.4    Cash, T.P.5    Schumacker, P.T.6    Simon, M.C.7
  • 83
    • 41349089950 scopus 로고    scopus 로고
    • Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation
    • Marshall, L., Kenneth, N.S., and White, R.J. 2008. Elevated tRNA(iMet) synthesis can drive cell proliferation and oncogenic transformation. Cell 133: 78-89.
    • (2008) Cell , vol.133 , pp. 78-89
    • Marshall, L.1    Kenneth, N.S.2    White, R.J.3
  • 85
    • 33748747706 scopus 로고    scopus 로고
    • Mammalian TAK1 activates Snfl protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
    • Momcilovic, M., Hong, S.P., and Carlson, M. 2006. Mammalian TAK1 activates Snfl protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J. Biol. Chem. 281: 25336-25343.
    • (2006) J. Biol. Chem , vol.281 , pp. 25336-25343
    • Momcilovic, M.1    Hong, S.P.2    Carlson, M.3
  • 87
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou, I., Cairns, R.A., Fontana, L., Lim, A.L., and Denko, N.C. 2006. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 3: 187-197.
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 88
    • 0003418645 scopus 로고
    • A restriction point for control of normal animal cell proliferation
    • Pardee, A.B. 1974. A restriction point for control of normal animal cell proliferation. Proc. Natl. Acad. Sci. 71: 1286-1290.
    • (1974) Proc. Natl. Acad. Sci , vol.71 , pp. 1286-1290
    • Pardee, A.B.1
  • 89
    • 52949127312 scopus 로고    scopus 로고
    • Parsons, D.W., Jones, S., Zhang, X., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.M., Gallia, G.L., et al. 2008. An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812.
    • Parsons, D.W., Jones, S., Zhang, X., Lin, J.C., Leary, R.J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.M., Gallia, G.L., et al. 2008. An integrated genomic analysis of human glioblastoma multiforme. Science 321: 1807-1812.
  • 96
    • 35148828429 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 (HIF-1) pathway
    • doi: 10.1126/stke.4072007cm8
    • Semenza, G.L. 2007. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci. STKE 2007: cm8. doi: 10.1126/stke.4072007cm8.
    • (2007) Sci. STKE , vol.2007
    • Semenza, G.L.1
  • 97
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • Semenza, G.L., Roth, P.H., Fang, H.M., and Wang, G.L. 1994. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269: 23757-23763.
    • (1994) J. Biol. Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 98
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw, R.J. and Cantley, L.C. 2006. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 100
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw, R.J., Kosmatka, M., Bardeesy, N., Hurley, R.L., Witters, L.A., DePinho, R.A., and Cantley, L.C. 2004b. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. 101: 3329-3335.
    • (2004) Proc. Natl. Acad. Sci , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 102
    • 33845949733 scopus 로고    scopus 로고
    • Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
    • Suter, M., Riek, U., Tuerk, R., Schlattner, U., Wallimann, T, and Neumann, D. 2006. Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J. Biol. Chem. 281: 32207-32216.
    • (2006) J. Biol. Chem , vol.281 , pp. 32207-32216
    • Suter, M.1    Riek, U.2    Tuerk, R.3    Schlattner, U.4    Wallimann, T.5    Neumann, D.6
  • 106
    • 33747619857 scopus 로고    scopus 로고
    • p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase
    • Teodoro, J.G., Parker, A.E., Zhu, X., and Green, M.R. 2006. p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. Science 313: 968-971.
    • (2006) Science , vol.313 , pp. 968-971
    • Teodoro, J.G.1    Parker, A.E.2    Zhu, X.3    Green, M.R.4
  • 107
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein, B. and Kinzler, K.W. 2004. Cancer genes and the pathways they control. Nat. Med. 10: 789-799.
    • (2004) Nat. Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 108
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B., Lane, D., and Levine, A.J. 2000. Surfing the p53 network. Nature 408: 307-310.
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 109
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. 1956. On the origin of cancer cells. Science 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 113
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S., Loewith, R., and Hall, M.N. 2006. TOR signaling in growth and metabolism. Cell 124: 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 115
    • 0018963044 scopus 로고
    • Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge
    • Yeh, L.A., Lee, K.H., and Kim, K.H. 1980. Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge. J. Biol. Chem. 255: 2308-2314.
    • (1980) J. Biol. Chem , vol.255 , pp. 2308-2314
    • Yeh, L.A.1    Lee, K.H.2    Kim, K.H.3
  • 116
    • 34347402459 scopus 로고    scopus 로고
    • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    • Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R., and Lazebnik, Y. 2007, Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J. Cell Biol. 178: 93-105.
    • (2007) J. Cell Biol , vol.178 , pp. 93-105
    • Yuneva, M.1    Zamboni, N.2    Oefner, P.3    Sachidanandam, R.4    Lazebnik, Y.5


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