Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Garrido Urbani, Sarah ^a   Jemelin, Stephane ^a   Deffert, Christine ^a   Carnesecchi, Stéphanie ^a   Basset, Olivier ^a   Szyndralewiez, Cédric ^b   Heitz, Freddy ^b   Page, Patrick ^b   Montet, Xavier ^a   Michalik, Liliane ^c   Arbiser, Jack ^d   Rüegg, Curzio ^e   Krause, Karl Heinz ^a   Imhof, Beat ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b GENKYOTEX SA   (Switzerland)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e University of Fribourg   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; 2 (2 CHLOROPHENYL) 4 METHYL 5 (PYRIDIN 2 YLMETHYL) 1H PYRAZOLO(4,3 C)PYRIDINE 3,6(2H,5H) DIONE; 2-(2-CHLOROPHENYL)-4-METHYL-5-(PYRIDIN-2-YLMETHYL)-1H-PYRAZOLO(4,3-C)PYRIDINE-3,6(2H,5H)-DIONE; ANGIOGENESIS INHIBITOR; OXIDOREDUCTASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PYRAZOLE DERIVATIVE; PYRIDONE DERIVATIVE; SMALL INTERFERING RNA;

ANGIOGENESIS; ARTICLE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TARGETING; TUMOR GROWTH; UPREGULATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; FEMALE; GENE SILENCING; GENE TARGETING; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MOUSE MUTANT; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PHYSIOLOGY; SIGNAL TRANSDUCTION; VASCULARIZATION;

MUS;

ANGIOGENESIS INHIBITORS; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; FEMALE; GENE KNOCKDOWN TECHNIQUES; GENE TARGETING; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NADH, NADPH OXIDOREDUCTASES; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PPAR ALPHA; PYRAZOLES; PYRIDONES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 79951539813     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014665     Document Type: Article

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