Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation

Free Radical Biology and Medicine

Volumn 47, Issue 4, 2009, Pages 364-374

  Dixit, Deobrat ^a   Sharma, Vivek ^a   Ghosh, Sadashib ^a   Koul, Nitin ^a   Mishra, Prakash Kumar ^a   Sen, Ellora ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

Author keywords

Free radicals; Glioblastoma; Manumycin; ROS; STAT3; Telomerase

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; COPPER ZINC SUPEROXIDE DISMUTASE; MANUMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAT3 PROTEIN; TELOMERASE; THIOREDOXIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL GROWTH; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYLCYSTEINE; APOPTOSIS; CASPASE 3; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE, TUMOR; FARNESYLTRANSTRANSFERASE; GENE EXPRESSION REGULATION; GLIOBLASTOMA; GLIOMA; HUMANS; OXIDATIVE STRESS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; POLYENES; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS P21(RAS); REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; SUPEROXIDE DISMUTASE; TELOMERASE; THIOREDOXINS;

EID: 67649842379     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.04.031     Document Type: Article

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