Openings between defective endothelial cells explain tumor vessel leakiness

American Journal of Pathology

Volumn 156, Issue 4, 2000, Pages 1363-1380

  Hashizume, Hiroya ^a   Baluk, Peter ^a   Morikawa, Shunichi ^a   McLean, John W ^a   Thurston, Gavin ^a   Roberge, Sylvie ^b   Jain, Rakesh K ^b   McDonald, Donald M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; LECTIN; LIPOSOME;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BREAST CANCER; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPY; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TUMOR BLOOD FLOW; TUMOR CELL;

EID: 0033839080     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65006-7     Document Type: Article

References (83)

1. Microvascular architecture in a mammary carcinoma: Branching patterns and vessel dimensions
2. Microvascular corrosion casting in the study of tumor vascularity: A review
3. Geometric resistance and microvascular network architecture of human colorectal carcinoma
4. Structural and functional characteristics of the microcirculation in neoplasms
5. The vascular architecture of human xenotransplanted tumors: Histological, morphometrical, and ultrastructural studies
6. Microvessel quantification in primary colorectal carcinoma: An immunohistochemical study
7. Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast
8. Vascular permeability factor/vascular endothelial growth factor: An important mediator of angiogenesis in malignancy and inflammation
9. Definition of two angiogenic pathways by distinct alpha v integrins
10. Mechanisms of angiogenesis
11. Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice
12. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
13. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
14. Tumour vessel permeability and transcapillary exchange of large molecules of different size
15. Microvascular permeability of normal and neoplastic tissues
16. Transport of molecules across tumor vasculature
17. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
18. The Eugene M. Landis Award Lecture 1996: Delivery of molecular and cellular medicine to solid tumors
19. Correlation of dynamic contrast-enhanced MR imaging with histologic tumor grade: Comparison of macromolecular and small-molecular contrast media
20. The significance of free blood in liquid and solid tumours
21. Cancer cell invasion and metastasis
22. Angiogenesis and metastasis
23. Pathways of macromolecular tracer transport across venules and small veins: Structural basis for the hyperpermeability of tumor blood vessels
24. Pathogenesis of ascites tumor growth: Vascular permeability factor, vascular hyperpermeability, and ascites fluid accumulation
25. Perfusion of single tumor microvessels: Application to vascular permeability measurement
26. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
27. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice
28. Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
29. Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
30. The microvasculature of the 7,12-dimethylbenz(a)anthracene (DMBA)- induced rat mammary tumour. I. Vascular patterns as visualized by scanning electron microscopy of corrosion casts
31. Contrast-enhanced MR imaging assessment of tumor capillary permeability: Effect of irradiation on delivery of chemotherapy
32. Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
33. Pituitary tumorigenesis in aging female C57BL/6J mice: A light and electron microscopic study
34. The relationship between the capillary structure and hemorrhage in gliomas
35. Estrogen-induced tumors: Changes in the vasculature in two strains of rat
36. Angiosarcoma of soft tissue: A study of 80 cases
37. Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry
38. Host microvasculature influence on tumor vascular morphology and endothelial gene expression
39. Studies on inflammation. 1. The effect of histamine and serotonin on vascular permeability: An electron microscopic study
40. Endothelial gaps as sites for plasma leakage in inflammation
41. Openings through endothelial cells associated with increased microvascular permeability
42. Transgenic mice as probes into complex systems
43. Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
44. Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes
45. Endothelial gaps: Time course of formation and closure in inflamed venules of rats
46. Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding
47. Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice
48. Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli
49. Ultrastructure of the Lewis lung carcinoma
50. Neovasculature induced by vascular endothelial growth factor is fenestrated
51. Endothelial fenestral diaphragms: A quick-freeze, deep-etch study
52. Scanning electron-microscopic study of the surface characteristics of neoplastic endothelial cells of blood vessels
53. Hemangiosarcoma of the breast: Case report with scanning electron microscopic study
54. Microcirculatory blood flow, capillary morphology and local oxygen pressure of the hamster amelanotic melanoma A-Me-3
55. Reinterpretation of endothelial cell gaps induced by vasoactive mediators in guinea-pig, mouse and rat: Many are transcellular pores
56. The fine structure of blood vessels in ethylnitrosourea-induced tumours of the rat nervous system: With special reference to the breakdown of the blood-brain barrier
57. The vesiculo-vacuolar organelle (VVO): A distinct endothelial cell structure that provides a transcellular pathway for macromolecular extravasation
58. Vascular endothelial growth factor and microvascular permeability
59. Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: Downregulation by cytokines and bacterial products
60. Ultrastructural changes in the capillary bed of human pituitary tumors
61. Intracerebral tumor-associated hemorrhage caused by overexpression of the vascular endothelial growth factor isoforms VEGF121 and VEGF165 but not VEGF189
62. Traumatic enucleation for posterior uveal melanoma
63. Tumor angiogenesis: Rapid induction of endothelial mitoses demonstrated by autoradiography
64. Tumour angiogenesis: Ultrastructure of endothelial cells in mitosis
65. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis
66. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
67. Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis
68. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
69. The vascular system of xenotransplanted tumors-scanning electron and light microscopic studies
70. The fine structure of tumor blood vessels. I. Participation of non-endothelial cells in tumor angiogenesis
71. Determinants of endothelial cell phenotype in venules
72. Expression of platelet-endothelial cell adhesion molecule-1 (PE-CAM-1) during melanoma-induced angiogenesis in vivo
73. Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium
74. Expression of PECAM-1/CD31 isoforms in human brain gliomas
75. Pathogenesis of ascites tumor growth: Angiogenesis, vascular remodeling, and stroma formation in the peritoneal lining
76. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: A novel mechanism of tumor angiogenesis
77. Lectin intravital perfusion studies in tumor-bearing mice: Micrometer-resolution, wide-area mapping of microvascular labeling, distinguishing efficiently and inefficiently perfused microregions in the tumor
78. The use of fluorescent probes to identify regions of transient perfusion in murine tumors
79. The next frontier of molecular medicine: Delivery of therapeutics
80. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1