Roles of Nox1 and other Nox isoforms in cancer development

Cancer Science

Volumn 100, Issue 8, 2009, Pages 1382-1388

  Kamata, Tohru ^a  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RAS PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1;

BACTERICIDAL ACTIVITY; CANCER CELL; CANCER RISK; CARCINOGENESIS; CELL ADHESION; CELL GROWTH; CELL STRUCTURE; CELL SURVIVAL; CELL TRANSFORMATION; COLORECTAL CANCER; ENZYME ACTIVITY; ESOPHAGEAL ADENOCARCINOMA; EXTRACELLULAR MATRIX; HUMAN; KIDNEY CARCINOMA; LUNG CANCER; MELANOMA; MOLECULAR MECHANICS; NONHUMAN; OXIDATIVE STRESS; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RISK FACTOR; SIGNAL TRANSDUCTION; STOMACH CANCER; TRANSCRIPTION REGULATION;

CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOENZYMES; NADPH OXIDASE; NEOPLASMS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 67650657198     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2009.01207.x     Document Type: Review

References (71)

1. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol. 2004; 4: 181-9.
2. Lambeth JD. Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy. Free Radic Biol Med. 2007; 43: 332-47.
3. Bedard K, Krause KH. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev. 2007; 87: 245-313.
4. Lambeth JD, Kawahara T, Diebold B.. Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med. 2007; 43: 319-31.
5. 2+-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem. 2001; 276: 37 594-601.
6. Edens WA, Sharling L, Cheng G. et al. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/ peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol. 2001; 154: 879-91.
7. De Deken X, Wang D, Many MC. et al. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem. 2000; 275: 23 227-33.
8. Sumimoto H, Miyano K, Takeya R.. Molecular composition and regulation of the Nox family NAD(P)H oxidases. Biochem Biophys Res Commun. 2005; 338: 677-86.
9. Banfi B, Clark RA, Steger K, Krause KH. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003; 278: 3510-13.
10. Geiszt M, Lekstrom K, Witta J, Leto TL. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem. 2003; 278: 20 006-12.
11. Ueno N, Takeya R, Miyano K, Kikuchi H, Sumimoto H.. The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem. 2005; 280: 23 328-39.
12. Ambasta RK, Kumar P, Griendling KK, Schmidt HH, Busse R, Brandes RP. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem. 2004; 279: 45 935-41.
13. Kawahara T, Ritsick D, Cheng G, Lambeth JD. Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem. 2005; 280: 31 859-69.
14. 2 generation in thyroid cells does not involve Rac1 activation. Eur J Endocrinol. 2005; 152: 127-33.
15. Suh YA, Arnold RS, Lassegue B. et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature. 1999; 401: 79-82.
16. Geiszt M, Lekstrom K, Brenner S. et al. NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes. J Immunol. 2003; 171: 299-306.
17. Kawahara T, Kuwano Y, Teshima-Kondo S. et al. Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. J Immunol. 2004; 172: 3051-8.
18. Mitsushita J, Lambeth JD, Kamata T.. The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res. 2004; 64: 3580-5.
19. Kikuchi H, Hikage M, Miyashita H, Fukumoto M.. NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells. Gene. 2000; 254: 237-43.
20. Roos D.. X-CGDbase. a database of X-CGD-causing mutations. Immunol Today. 1996; 17: 517-21.
21. Banfi B, Malgrange B, Knisz J, Steger K, Dubois-Dauphin M, Krause KH. NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem. 2004; 279: 46 065-72.
22. Paffenholz R, Bergstrom RA, Pasutto F. et al. Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004; 18: 486-91.
23. Geiszt M, Kopp JB, Varnai P, Leto TL. Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci USA. 2000; 97: 8010-14.
24. 2 and plays an integral role in insulin signal transduction. Mol Cell Biol. 2004; 24: 1844-54.
25. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto TL. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003; 17: 1502-4.
26. Moreno JC, Bikker H, Kempers MJ. et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med. 2002; 347: 95-102.
27. Downward J.. Control of ras activation. Cancer Surv. 1996; 27: 87-100.
28. Irani K, Xia Y, Zweier JL. et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science. 1997; 275: 1649-52.
29. Adachi Y, Shibai Y, Mitsushita J, Shang WH, Hirose K, Kamata T.. Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. Oncogene. 2008; 27: 4921-32.
30. Lorentz O, Cadoret A, Duluc I. et al. Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras. Oncogene. 1999; 18: 87-92.
31. Maurer CA, Friess H, Kretschmann B. et al. Increased expression of erbB3 in colorectal cancer is associated with concomitant increase in the level of erbB2. Hum Pathol. 1998; 29: 771-7.
32. Gao X, Sedgwick T, Shi YB, Evans T.. Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation. Mol Cell Biol. 1998; 18: 2901-11.
33. Tenhunen O, Sarman B, Kerkela R. et al. Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart. J Biol Chem. 2004; 279: 24 852-60.
34. Brewer AC, Sparks EC, Shah AM. Transcriptional regulation of the NADPH oxidase isoform, Nox1, in colon epithelial cells: Role of GATA-binding factor(s). Free Radic Biol Med. 2006; 40: 260-74.
35. Kwei KA, Bashyam MD, Kao J. et al. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genet. 2008; 4: E1000081.
36. van Wetering S, van Buul JD, Quik S. et al. Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci. 2002; 115: 1837-46.
37. Shinohara M, Shang WH, Kubodera M. et al. Nox1 redox signaling mediates oncogenic Ras-induced disruption of stress fibers and focal adhesions by down-regulating Rho. J Biol Chem. 2007; 282: 17 640-8.
38. Rhee SG, Chang TS, Bae YS, Lee SR, Kang SW. Cellular regulation by hydrogen peroxide. J Am Soc Nephrol. 2003; 14: S211-15.
39. 2. J Biol Chem. 1998; 273: 32 554-60.
40. Brouns MR, Matheson SF, Settleman J.. p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation. Nat Cell Biol. 2001; 3: 361-7.
41. Chiarugi P, Fiaschi T, Taddei ML. et al. Two vicinal cysteines confer a peculiar redox regulation to low molecular weight protein tyrosine phosphatase in response to platelet-derived growth factor receptor stimulation. J Biol Chem. 2001; 276: 33 478-87.
42. Hall A.. Rho GTPases and the actin cytoskeleton. Science. 1998; 279: 509-14.
43. Maekawa M, Ishizaki T, Boku S. et al. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science. 1999; 285: 895-8.
44. Nimnual AS, Taylor LJ, Bar-Sagi D.. Redox-dependent downregulation of Rho by Rac. Nat Cell Biol. 2003; 5: 236-41.
45. Folkman J.. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1995; 1: 27-31.
46. Kranenburg O, Gebbink MF, Voest EE. Stimulation of angiogenesis by Ras proteins. Biochim Biophys Acta. 2004; 1654: 23-37.
47. Forsythe JA, Jiang BH, Iyer NV. et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996; 16: 4604-13.
48. Gille J, Swerlick RA, Caughman SW. Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/VEGF) gene requires AP-2-dependent DNA binding and transactivation. EMBO J. 1997; 16: 750-9.
49. Arbiser JL, Petros J, Klafter R. et al. Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci USA. 2002; 99: 715-20.
50. Komatsu D, Kato M, Nakayama J, Miyagawa S, Kamata T. NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene. 2008; 27: 4724-32.
51. Kondoh K, Nishida E.. Regulation of MAP kinases by MAP kinase phosphatases. Biochim Biophys Acta. 2007; 1773: 1227-37.
52. Szanto I, Rubbia-Brandt L, Kiss P. et al. Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. J Pathol. 2005; 207: 164-76.
53. Laurent E, McCoy JW 3rd, Macina RA. et al. Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. Int J Cancer. 2008; 123: 100-7.
54. Fantini MC, Pallone F.. Cytokines: From gut inflammation to colorectal cancer. Curr Drug Targets. 2008; 9: 375-80.
55. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M.. IKKβ is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFα. Immunity. 2003; 19: 725-37.
56. Kawahara T, Kohjima M, Kuwano Y. et al. Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am J Physiol Cell Physiol. 2005; 288: C450-7.
57. Hatakeyama M, Higashi H.. Helicobacter pylori CagA: A new paradigm for bacterial carcinogenesis. Cancer Sci. 2005; 96: 835-43.
58. Salles N, Szanto I, Herrmann F. et al. Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach. Exp Gerontol. 2005; 40: 353-7.
59. Tominaga K, Kawahara T, Sano T. et al. Evidence for cancer-associated expression of NADPH oxidase 1 (Nox1)-based oxidase system in the human stomach. Free Radic Biol Med. 2007; 43: 1627-38.
60. Chamulitrat W, Schmidt R, Tomakidi P. et al. Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene. 2003; 22: 6045-53.
61. Farrow B, Evers BM. Inflammation and the development of pancreatic cancer. Surg Oncol. 2002; 10: 153-69.
62. Sander CS, Hamm F, Elsner P, Thiele JJ. Oxidative stress in malignant melanoma and non-melanoma skin cancer. Br J Dermatol. 2003; 148: 913-22.
63. Church SL, Grant JW, Ridnour LA. et al. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci USA. 1993; 90: 3113-17.
64. Vaquero EC, Edderkaoui M, Pandol SJ, Gukovsky I, Gukovskaya AS. Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells. J Biol Chem. 2004; 279: 34.643-54.
65. Mochizuki T, Furuta S, Mitsushita J. et al. Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene. 2006; 25: 3699-707.
66. Brar SS, Kennedy TP, Sturrock AB. et al. An NAD(P)H oxidase regulates growth and transcription in melanoma cells. Am J Physiol Cell Physiol. 2002; 282: C1212-24.
67. 2-M cell cycle progression. Cancer Res. 2009; 69: 2647-54.
68. Kozar K, Sicinski P.. Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes. Cell Cycle. 2005; 4: 388-91.
69. Maranchie JK, Zhan Y.. Nox4 is critical for hypoxia-inducible factor 2-alpha transcriptional activity in von Hippel-Lindau-deficient renal cell carcinoma. Cancer Res. 2005; 65: 9190-3.
70. Fu X, Beer DG, Behar J, Wands J, Lambeth D, Cao W.. cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells. J Biol Chem. 2006; 281: 20 368-82.
71. Luxen S, Belinsky SA, Knaus UG. Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer. Cancer Res. 2008; 68: 1037-45.