Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 15, 2007, Pages 6223-6228

  Funes, Juan M ^a,b   Quintero, Marisol ^b   Henderson, Stephen ^a,b   Martinez, Dolores ^a,b,d   Qureshi, Uzma ^c   Westwood, Claire ^a,b   Clements, Mark O ^a,b   Bourboulia, Dimitra ^a,b   Pedley, R Barbara ^c   Moncada, Salvador ^b   Boshoff, Chris ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Adult stem cells; Glycolysis; Warburg effect

Indexed keywords

ADENOSINE TRIPHOSPHATE;

ADAPTATION; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BIOENERGY; CARCINOGENESIS; CELL DIFFERENTIATION; CELL ENERGY; CELL TRANSFORMATION; CONTROLLED STUDY; ENERGY YIELD; FIBROBLAST; GLYCOLYSIS; HUMAN; HUMAN CELL; MALE; MESENCHYMAL STEM CELL; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL;

EID: 34547509586     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700690104     Document Type: Article

References (42)

1. Warburg O (1956) Science 123:309-314.
2. Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang HM, Cinalli RM, Alavi A, Rudin CM, et al. (2004) Cancer Res 64:3892-3899.
3. Chance B, Castor LN (1952) Science 116:200-202.
4. Zu XL, Guppy M (2004) Biochem Biophys Res Commun 313:459-465.
5. Gatenby RA, Gillies RJ (2004) Nat Rev Cancer 4:891-899.
6. Hatzivassiliou G, Zhao FP, Bauer DE, Andreadis C, Shaw AN, Dhanak D, Hingorani SR, Tuveson DA, Thompson CB (2005) Cancer Cell 8:311-321.
7. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM (2006) Science 312:1650-1653.
8. Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH (2006) Cell 126:107-120.
9. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA (1999) Nature 400:464-468.
10. Hahn WC, Weinberg RA (2002) N Engl J Med 347:1593-1603.
11. Rangarajan A, Hong SJ, Gifford A, Weinberg RA (2004) Cancer Cell 6:171-183.
12. Reya T, Morrison SJ, Clarke MF, Weissman IL (2001) Nature 414:105-111.
13. Bjerkvig R, Tysnes BB, Aboody KS, Najbauer J, Terzis AJ (2005) Nat Rev Cancer 5:899-904.
14. Polyak K, Hahn WC (2006) Nat Med 12:296-300.
15. Beachy PA, Karhadkar SS, Berman DM (2004) Nature 432:324-331.
16. Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo AA, Gutkind JS (2004) Cancer Res 64:8804-8807.
17. Ramanathan A, Wang C, Schreiber SL (2005) Proc Natl Acad Sci USA 102:5992-5997.
18. Helman LJ, Meltzer P (2003) Nat Rev Cancer 3:685-694.
19. Lundberg AS, Randell SH, Stewart SA, Elenbaas B, Hartwell KA, Brooks MW, Fleming MD, Olsen JC, Miller SW, Weinberg RA, et al. (2002) Oncogene 21:4577-4586.
20. Hahn WC, Dessain SK, Brooks MW, King JE, Elenbaas B, Sabatini DM, DeCaprio JA, Weinberg RA (2002) Mol Cell Biol 22:2111-2123, and erratum 22:3562.
21. Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G, Hahn WC, Stukenberg PT, Shenolikar S, Uchida T, et al. (2004) Nat Cell Biol 6:308-318.
22. Hanahan D, Weinberg RA (2000) Cell 100:57-70.
23. Henderson SR, Guiliano D, Presneau N, McLean S, Frow R, Vujovic S, Anderson J, Sebire N, Whelan J, Athanasou N, et al. (2005) Genome Biol 6:R76.1-R76.11.
24. Tian WN, Braunstein LD, Pang JD, Stuhlmeier KM, Xi QC, Tian XN, Stanton RC (1998) J Biol Chem 273:10609-10617.
25. Dang CV, Semenza GL (1999) Trends Biochem Sci 24:68-72.
26. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, et al. (1998) Nature 394:485-490.
27. Semenza GL (2000) Crit Rev Biochem Mol Biol 35:71-103.
28. Rubio D, Garcia-Castro J, Martin MC, de la Fuente R, Cigudosa JC, Lloyd AC, Bernad A (2005) Cancer Res 65:3035-3039.
29. Serakinci N, Guldberg P, Burns JS, Abdallah B, Schrodder H, Jensen T, Kassem M (2004) Oncogene 23:5095-5098.
30. Carew JS, Huang P (2002) Mol Cancer 1:9.
31. Gottlieb E, Tomlinson IP (2005) Nat Rev Cancer 5:857-866.
32. Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, DallaFavera R, Dang CV (1997) Proc Natl Acad Sci USA 94:6658-6663.
33. Flier JS, Mueckler MM, Usher P, Lodish HF (1987) Science 20:1492-1495.
34. Li F, Wang YY, Zeller KI, Potter JJ, Wonsey DR, O'Donnell KA, Kim JW, Yustein JT, Lee LA, Dang CV (2005) Mol Cell Biol 25:6225-6234.
35. Warburg O (1930) in Metabolism of Tumors, trans Dickens F (Constable, London).
36. Sulis E (1972) Lancet 1:1185.
37. Kuo WY, Lin JY, Tang TK (2000) Int J Cancer 85:857-864.
38. Pelicano H, Carney D, Huang P (2004) Drug Resist Updat 7:97-110.
39. Gambhir SS (2002) Nat Rev Cancer 2:683-693.
40. Wang J, Xie LY, Allan S, Beach D, Hannon GJ (1998) Genes Dev 12:1769-1774.
41. Zhang Z, Yu J, Stanton RC (2000) Anal Biochem 285:163-167.
42. El Emir E, Boxer GM, Petrie IA, Boden RW, Dearling JL, Begent RH, Pedley RB (2005) Eur J Cancer 41:799-806.