Are peroxiredoxins tumor suppressors?

Current Opinion in Pharmacology

Volumn 7, Issue 4, 2007, Pages 375-380

  Neumann, Carola Anke ^a   Fang, Quan ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYSTEIC ACID; CYSTEINE; FREE RADICAL; GLUTATHIONE TRANSFERASE P1; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PEROXIREDOXIN; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CANCER CELL; CANCER INHIBITION; CANCER MORTALITY; CARCINOGENESIS; CELL ACTIVITY; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; DRUG TARGETING; ENZYME ACTIVATION; ERYTHROCYTE; GENE OVEREXPRESSION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NATURAL KILLER CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; NEOPLASMS; PEROXIDASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 34548080939     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.04.007     Document Type: Review

References (53)

1. Kim K., Kim I.H., Lee K.Y., Rhee S.G., and Stadtman E.R. The isolation and purification of a specific 'protector' protein which inhibits enzyme inactivation by a thiol/Fe(III)/O2 mixed-function oxidation system. J Biol Chem 263 (1988) 4704-4711
2. Chae H.Z., Chung S.J., and Rhee S.G. Thioredoxin-dependent peroxide reductase from yeast. J Biol Chem 269 (1994) 27670-27678
3. Neumann C.A., Krause D.S., Carman C.V., Das S., Devendra D., Abraham J.L., Bronson R.T., Fujiwara Y., Orkin S.H., and Van Etten R.A. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defense and tumor suppression. Nature 424 (2003) 561-565
4. Shau H., Gupta R.K., and Golub S.H. Identification of a natural killer enhancing factor (NKEF) from human erythroid cells. Cell Immunol 147 (1993) 1-11
5. Lee T.H., Kim S.U., Yu S.L., Kim S.H., Park do S., Moon H.B., Dho S.H., Kwon K.S., Kwon H.J., Han Y.H., et al. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood 101 (2003) 5033-5038
6. Moon E.Y., Han Y.H., Lee D.S., Han Y.M., and Yu D.Y. Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus. Eur J Immunol 34 (2004) 2119-2128
7. Moon E.Y., Noh Y.W., Han Y.H., Kim S.U., Kim J.M., Yu D.Y., and Lim J.S. T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol Lett 102 (2006) 184-190
8. 2, a necessary evil for cell signalling. Science 312 (2006) 1882-1883
9. 2, a necessary evil for cell signaling. Science 312 (2006) 1882-1883
10. Seth D., and Rudolph J. Redox regulation of MAP kinase phosphatase 3. Biochemistry 45 (2006) 8476-8487
11. Kamata H., Honda S., Maeda S., Chang L., Hirata H., and Karin M. Reactive oxygen species promote TNF-alpha-induced death and sustained JNK activation inhibiting MAP kinase phosphatases. Cell 120 (2005) 649-661
12. Wen S., and VanEtten R. The Pag gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes Dev 11 (1997) 2456-2467
13. Kim Y.J., Lee W.S., Ip C., Chae H.Z., Park E.M., and Park Y.M. Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex. Cancer Res 66 (2006) 7136-7142
14. Veal E.A., Findlay V.J., Day A.M., Bozonet S.M., Evans J.M., Quinn J., and Morgan B.A. A 2-Cys peroxiredoxin regulates peroxide-induced oxidation and activation of a stress-activated MAP kinase. Mol Cell 15 (2004) 129-139
15. Neumann CA, Wen S-T, Van Etten RA: Role of the c-Abl tyrosine kinase in the cellular response to oxidative stress, Blood 92:10,1. Blood 1998, 92:10,11.
16. Wada T., and Penninger J.M. Mitogen-activated protein kinases in apoptosis regulation. Oncogene 23 (2004) 2838-2849
17. Li L., Shoji W., Takano H., Nishimura N., Aoki Y., Takahashi R., Goto S., Kaifu T., Takai T., and Obinata M. Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress. Biochem Biophys Res Commun 355 (2007) 715-721
18. Kropotov A., Serikov V., Suh J., Smirnova A., Bashkirov V., Zhivotovsky B., and Tomilin N. Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA. FEBS J 273 (2006) 2607-2617
19. Banmeyer I., Marchand C., Verhaeghe C., Vucic B., Rees J.F., and Knoops B. Overexpression of human peroxiredoxin 5 in subcellular compartments of Chinese hamster ovary cells: effects on cytotoxicity and DNA damage caused by peroxides. Free Radic Biol Med 36 (2004) 65-77
20. Banmeyer I., Marchand C., Clippe A., and Knoops B. Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide. FEBS Lett 579 (2005) 2327-2333
21. Han Y.H., Kim H., Kim J., Kim S., Yu D., and Moon E.Y. Inhibitory role of peroxiredoxin II (PrxII) on cellular senescence. FEBS 579 (2005) 4897-4902
22. Han K.H., Kwon J., Yu D.Y., and Moon E.Y. Inhibitory effect of peroxiredoxin II (PrxII) on Ras-ERK-NFkappaB pathway in mouse embryonic fibrblast (MEF) senescence. Free Radic Res 40 (2006) 1182-1189
23. Egler R.A., Fernandes E., Rothermund K., Sereika S., de Souza-Pinto N., Jaruga P., Dizdaroglu M., and Prochownik E.V. Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1. Oncogene 24 (2005) 8038-8050
24. Wonsey D.R., Zeller K.I., and Dang C.V. The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. Proc Natl Acad Sci USA 99 (2002) 6649-6654
25. Chang R., and Wang E. Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress. J Cell Biochem 100 (2007) 267-278
26. Yuan J., Murrell G.A., Trickett A., Landtmeters M., Knoops B., and Wang M.X. Overexpression of antioxidant enzyme peroxiredoxin 5 protects human tendon cells against apoptosis and loss of cellular function during oxidative stress. Biochim Biophys Acta 1693 (2004) 37-45
27. Bae J.Y., Ahn S.J., Han W., and Noh D.Y. Peroxiredoxin I and II inhibit H(2)O(2)-induced cell death in MCF-7 cell lines. J Cell Biochem (2007)
28. Chang T.S., Cho C.S., Park S., Yu S., Kang S.W., and Rhee S.G. PeroxiredoxinIII, a mitochondrion-sepecific peroxidase, regulates apoptotic signaling by mitochondria. J Biol Chem 279 (2004) 41975-41984
29. Trachootham D., Zhou Y., Zhng H., Demizu Y., Chen Z., Pelicano H., Ciao P., Achanta G., Arlinghaus R., Liu J., et al. Selective killing of oncogenically transformed cells through ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10 (2006) 241-252
30. Benhar M., Dalyot I., Engelberg D., and Levitzki A. Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-Terminal kinase and p38 mitogen-activted protein kinase activation and sensitization to genotoxic stress. Mol Cell Biol 21 (2001) 6913-6926
31. Noh D.Y., Ahn S.J., Lee R.A., Kim S.W., Park I.A., and Chae H.Z. Overexpression of peroxiredoxin in human breast cancer. Anticancer Res 21 (2001) 2085-2090
32. Park J.H., Kim Y.S., Lee H.L., Shim J.Y., Lee K.S., Oh Y.J., Shin S.S., Choi Y.H., Park K.J., Park R.W., et al. Expression of peroxiredoxin and thioredoxin in human lung cancer and paired normal lung. Respirology 11 (2006) 269-275
33. Quan C., Cha E.J., Lee H.L., Han K.H., Lee K.M., and Kim W.J. Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer. J Urol 175 (2006) 1512-1516
34. Wang T., Tamae D., LeBon T., Shively J.E., Yen Y., and Li J.J. The role of peroxiredoxin II in radiation-resistant MCF-7 breast cancer cells. Cancer Res 65 (2005) 10338-10346
35. Mukhopadhyay S.S., Leung K.S., Hicks M.J., Hastings P.J., Youssoufian H., and Plon S.E. Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia. J Cell Biol 175 (2006) 225-235
36. Kropotov A., Gogvadze V., Shupliakov O., Tomilin N., Serikov V.B., Tomilin N.V., and Zhivotovsky B. Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells. Exp Cell Res 312 (2006) 2806-2815
37. Woo H.A., Chae H.Z., Hwang S.C., Yang K.S., Kang S.W., Kim K., and Rhee S.G. Reversing the inactivation of peroxiredoxins caused by cysteine sulfenic acid formation. Science (2003) 653-656
38. Wood Z.A., Poole L.B., and Karplus P.A. Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science 300 (2003) 650-653
39. Wagner E., Luche S., Penna L., Chevallet M., Van Dorsselaer A., Leize-Wagner E., and Rabilloud T. A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. Biochem J 366 (2002) 777-785
40. Chevallet M., Wagner E., Luche S., van Dorsselaer A., Leize-Wagner E., and Rabilloud T. Regeneration of peroxiredoxins during recovery after oxidative stress. J Biol Chem 278 (2003) 37146-37153
41. Bozonet S.M., Findlay V.J., Day A.M., Cameron J., Veal E.A., and Morgan B.A. Oxidation of a eukaryotic 2-Cys peroxiredoxin is a molecular switch controlling the transcriptional response to increasing levels of hydrogen peroxide. J Biol Chem 280 (2005) 23319-23327
42. Woo H.A., Jeong W., Chang T.S., Park K.J., Park S.J., Yang J.S., and Rhee S.G. Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins. J Biol Chem 280 (2005) 3125-3128
43. Biteau B., Labarre J., and Toledano M.B. ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature 425 (2003) 980-984
44. Findlay V.J., Townsend D.M., Morris T.E., Fraser J.P., He L., and Tew K.D. A novel role for human sulfiredoxin in the reversal of glutathionylation. Cancer Res 66 (2006) 6800-6806
45. Budanov A.V., Sablina A.A., Feinstein E., Koonin E.V., and Chumakov P.M. Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD. Science 304 (2004) 596-600
46. He C.H., Gong P., Hu B., Stewart D., Choi M.E., Choi A.M., and Alam J. Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem 276 (2001) 20858-20865
47. Kim Y.J., Ahn J.Y., Liang P., Ip C., Zhang Y., and Park Y.M. Human prx1 gene is a target of Nrf2 and is upregulated by hypoxia/reoxygenation: implication to tumor biology. Cancer Res 67 (2007) 546-554
48. Woo H.A., Kang S.W., Kim H.K., Yang K.S., Chae H.Z., and Rhee S.G. Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence. J Biol Chem 278 (2003) 47361-47364
49. Moon J.C., Hah Y.S., Kim W.Y., Jung B.G., Jang H.H., Lee J.R., Kim S.Y., Lee Y.M., Jeon M.G., Kim C.W., et al. Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances HeLa cell resistance to H2O2-induced cell death. J Biol Chem 280 (2005) 28775-28784
50. Moon E.Y., Hah Y., Kim W., Jung B., Jang H., Lee J., Kim S., Lee Y., Jeon M., Kim C., et al. Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances Hela cell resistance to H2O2-induced cell death. J Biol Chem 280 (2005) 28775-28784
51. Phalen T.J., Weirather K., Deming P.B., Anathy V., Howe A.K., van der Vliet A., Jonsson T.J., Poole L.B., and Heintz N.H. Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery. J Cell Biol 175 (2006) 779-789
52. Chang T.S., Jeong W., Choi S.Y., Siquin Y., Kang S.W., and Rhee S.G. Regulation of peroxiredoxin1 activity by cdc2-mediated phosphorylationj. J Biol Chem 277 (2002) 25370-25376
53. Manevich Y., and Fisher A.B. Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism. Free Radic Biol Med 38 (2005) 1422-1432