Drug-induced senescence generates chemoresistant stemlike cells with low reactive oxygen species

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37813-37829

  Achuthan, Santhi ^a   Santhoshkumar, Thankayyan R ^a   Prabhakar, Jem ^b   Nair, S Asha ^a   Pillai, M Radhakrishna ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^b REGIONAL CANCER CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

26 S PROTEASOME; ANTIOXIDANT ENZYME; BREAST TUMOR; CANCER CELLS; CANCER STEM CELLS; CONVENTIONAL TREATMENTS; EXPERIMENTAL DATA; IN-VITRO; LOW LEVEL; MOLECULAR EVENTS; QUIESCENT STATE; REACTIVE OXYGEN SPECIES; SIGNALING EVENTS; SUPER OXIDE DISMUTASE; TUMOR CELLS;

CELL DEATH; CHEMOTHERAPY; DISEASES; OXYGEN; STEM CELLS;

TUMORS;

CASPASE 3; CD133 ANTIGEN; COLCHICINE; DOXORUBICIN; FLUOROURACIL; NOCODAZOLE; OCTAMER TRANSCRIPTION FACTOR 4; PACLITAXEL; PODOPHYLLOTOXIN; PROTEIN P21; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; VERAPAMIL; VINCRISTINE;

ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; CANCER CELL; CELL COUNT; CELL CYCLE G2 PHASE; CELL DEATH; CHEMOREACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; ENRICHMENT CULTURE; ENZYME REACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IMMUNOPRECIPITATION; IN VITRO STUDY; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SENESCENCE; SIDE POPULATION CELL; SIGNAL TRANSDUCTION;

ANTIGENS, CD; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL AGING; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; NF-E2-RELATED FACTOR 2; OCTAMER TRANSCRIPTION FACTOR-3; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; REACTIVE OXYGEN SPECIES;

EID: 80054796744     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.200675     Document Type: Article

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