Mechanism of the tumor suppressive effect of MnSOD overexpression

Biomedicine and Pharmacotherapy

Volumn 59, Issue 4, 2005, Pages 143-148

  Oberley, Larry W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Catalase; Glutathione peroxidase; Manganese containing superoxide dismutase; Tumor suppressor

Indexed keywords

CARMUSTINE; CATALASE; COMPLEMENTARY DNA; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; NITRIC OXIDE; PROTEIN; PROTEIN H30N; RETROVIRUS VECTOR; SUPEROXIDE; UNCLASSIFIED DRUG;

BREAST CANCER; CANCER CELL CULTURE; CANCER INCIDENCE; CANCER SUSCEPTIBILITY; CELL GROWTH; DNA SEQUENCE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; HUMAN; MOUTH CANCER; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW;

EID: 18044364791     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2005.03.006     Document Type: Article

References (48)

1. Abe J, Kusuhara M, Ulevitch RJ, Berk BB, Lee J-D. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J Biol Chem 1196;271:16586-6590.
2. C.B. Ambrosone, J.L. Freudenheim, P.A. Thompson, E. Bowman, J.E. Vena, and J.R. Marshall Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer Cancer Res 59 1999 602 606
3. B.S. Beckman, A.K. Balin, and R.G. Allen Superoxide dismutase induces differentiation of erythroleukemia cells J Cell Physiol 139 1989 370 376
4. G.E. Borgstahl, H.E. Parge, M.J. Hickey, M.J. Johnson, M. Boissinot, and R.A. Hallewell Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface Biochemistry 35 1996 4287 4297
5. A. Bravard, L. Sabatier, F. Hoffschir, C. Luccioni, and B. Dutrillaux SOD2: a new type of tumor suppressor gene? Int J Cancer 51 1992 475 480
6. P.A. Cerutti Proxidant states and cancer Science 227 1985 375 381
7. S.L. Church, J.W. Grant, L.A. Ridnour, L.W. Oberley, P.E. Swanson, and P.S. Meltzer Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells Proc Natl Acad Sci USA 90 1993 3113 3117
8. C.A. Davis, A.S. Hearn, B. Fletcher, J. Bickford, J.E. Garcia, and V. Leveque Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition J Biol Chem 279 2004 12769 12776
9. J.A. Fernandez-Pol, P.D. Hamilton, and D.J. Klos Correlation between the loss of the transformed phenotype and an increase in superoxide dismutase activity in a revertant subclone of sarcoma virus-infected mammalian cells Cancer Res 42 1982 609 617
10. D. Hernandez-Saavedra, and J.M. McCord Paradoxical effects of thiol reagents on Jurkat cells and a new thiol-sensitive mutant form of human mitochondrial superoxide dismutase Cancer Res 63 2003 159 163
11. Y. Huang, T. He, and F.E. Domann Decreased MnSOD expression in transformed cells is associated with increased cytosine methylation of the SOD2 gene DNA Cell Biol 18 1999 643 652
12. S.M. Keyse, and E.A. Emslie Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase Nature 359 1992 644 647
13. J. LiJ, L.W. Oberley, M. Fan, and N.H. Colburn Inhibition of AP-1 and NF-κB by manganese-containing superoxide dismutase in human breast cancer cells FASEB J 12 1998 1713 1723
14. J.J. Li, L.W. Oberley, D.K. St Clair, L.A. Ridnour, and T.D. Oberley Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase Oncogene 10 1995 1989 2000
15. N. Li, T.D. Oberley, L.W. Oberley, and W. Zhong Overexpression of manganese superoxide dismutase in DU145 human prostate carcinoma cells has multiple effects on cell phenotype Prostate 35 1998 221 233
16. N. Li, T.D. Oberley, L.W. Oberley, and W. Zhong Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: mechanistic studies J Cell Physiol 75 1998 359 369
17. S. Li, T. Yan, J.-Q. Yang, T.D. Oberley, and L.W. Oberley The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase Cancer Res 60 2000 3927 3939
18. B.C. Liang, D.A. Ross, H.S. Greenburg, P.S. Meltzer, and J.M. Trent Evidence for allelic imbalance of chromosome 6 in human astrocytomas Neurology 44 1994 533 536
19. J. Liu, M.M. Hinkhouse, W. Sun, C.J. Weydert, J.M. Ritchie, and L.W. Oberley Redox regulation of pancreatic cancer cell growth: role of glutathione peroxidase in the suppression of the malignant phenotype Hum Gene Ther 15 2004 239 250
20. Liu R. Effects of overexpression of manganese superoxide dismutase and endothelial nitric oxide synthase on tumor biology of human oral carcinoma SCC-25 cells. Ph.D. thesis, University of Iowa, May 1996.
21. R. Liu, T.D. Oberley, and L.W. Oberley Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells Hum Gene Ther 8 1997 585 595
22. R. Liu, T.D. Oberley, and L.W. Oberley Effects of endothelial nitric oxide synthase gene expression on the tumor biology of human oral carcinoma SCC-25 cells Cell Growth Differ 9 1998 239 246
23. 2-terminal kinases J Biol Chem 271 1996 15703 15707
24. S.K. Manna, H.J. Zhang, T. Yan, L.W. Oberley, and B.B. Aggarwal Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-κB and activated protein-1 J Biol Chem 273 1998 13245 13254
25. J.A. Melendez, R.P. Melathe, A.M. Rodriguez, J.E. Mazurkiewicz, and K.J.A. Davies Nitric oxide enhances the manganese superoxide-dependent suppression of proliferation in HT-1080 fibrosarcoma cells Cell Growth Differ 10 1999 655 664
26. D. Millikan, E. Meese, B. Vogelstein, C. Witkowski, and J. Trent Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma Cancer Res 51 1991 5449 5453
27. L.W. Oberley Superoxide dismutase and cancer L.W. Oberley Superoxide Dismutase, Vol. II: Boca Rotan 1982 CRC Press Chapter 6
28. L.W. Oberley, and G.R. Buettner Role of superoxide dismutase in cancer: a review Cancer Res 39 1979 1141 1149
29. L.W. Oberley, and T.D. Oberley Free radicals, cancer, and aging J.E. Johnson Jr. R. Walford D. Harmon J. Miquel Free Radicals, Aging, and Degenerative Diseases 1986 Alan R Liss Inc New York 325 381
30. L.W. Oberley, and T.D. Oberley Role of antioxidant enzymes in cell immortalization and transformation Mol Cell Biochem 84 1988 147 153
31. L.W. Oberley, and T.D. Oberley Reactive oxygen species in the aetiology of cancer C. Ioannides D.V. Lewis Drugs, Diet, and Disease, Vol. 1 1994 Prentice Hall 49 63
32. T.D. Oberley, and L.W. Oberley Oxygen radicals and cancer B.P. Yu Free Radicals in Aging 1993 CRC Press Boca Raton 248 267
33. C.M. Pombo, J.V. Bonventre, A. Molnar, J. Kyriakis, and T. Force Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway EMBO J 15 1996 4537 4546
34. 2 Free Radic Biol Med 29 2000 801 813
35. S.E. Safford, T.D. Oberley, M. Urano, and D.K. St Clair Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase Cancer Res 54 1994 4261 4265
36. D.K. St. Clair, X.S. Wan, M. Kuroda, S. Vichitbandha, E. Tsuchida, and M. Urano Suppression of tumor metastasis by manganese superoxide dismutase is associated with reduced tumorigenicity and elevated fibronectin Oncol Rep 4 1997 753 757
37. D.K. St Clair, X.S. Wan, T.D. Oberley, K.E. Muse, and W.H. St Clair Suppression of radiation-induced neoplastic transformation by overexpression of mitochondrial superoxide dismutase Mol Carcinog 6 1992 238 242
38. Y. Sun, and L.W. Oberley Redox regulation of transcriptional activators Free Radic Biol Med 21 1996 335 348
39. H. Van Remmen, Y. Ikeno, M. Hamilton, M. Pahlavani, N. Wolf, and S.R. Thorpe Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging Physiol Genomics 16 2003 29 37
40. C. Weydert, B. Roling, J. Liu, M.M. Hinjhouse, J. Ritchie, and L.W. Oberley Suppression of the malignant phenotype in human pancreatic cancer cells by the overexpression of manganese superoxide dismutase Mol Cancer Ther 2 2003 361 369
41. C.J.D. Weydert, B.B. Smith, L. Xu, K.C. Kregel, J.M. Ritchie, and C.S. Davis Inhibition of oral cancer cell growth by adenovirusMnSOD plus BCNU treatment Free Radic Biol Med 34 2003 316 329
42. Y. Xu, A. Krishnan, S.X. Wan, H. Majima, C.-C. Yeh, and G. Ludewig Mutations in the promoter reveal a cause for the reduced expression of the human manganese superoxide dismutase gene in cancer cells Oncogene 18 1999 93 102
43. N.Y. Yamanaka, and D. Deamer Superoxide dismutase activity in WI-38 cell cultures: effects of age, trypsinization, and SV-40 transformation Physiol Chem Phys 6 1974 95 106
44. T. Yan, L.W. Oberley, W. Zhong, and D.K. St. Clair Manganese-containing superoxide dismutase overexpression causes phenotypic reversion in SV40-transformed human lung fibroblasts Cancer Res 56 1996 2864 2871
45. H.J. Zhang, T. Yan, T.D. Oberley, and L.W. Oberley Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype Cancer Res 1999 6276 6283
46. M. Zheng, F. Aslund, and G. Storz Activation of the OxyR transcription factor by reversible disulfide bond formation Science 279 1998 1718 1721
47. W. Zhong, L.W. Oberley, T.D. Oberley, and D.K. St. Clair Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase Oncogene 14 1997 481 490
48. W. Zhong, L.W. Oberley, T.D. Oberley, T. Yan, F.E. Domann, and D.K. St. Clair Inhibition of cell growth and sensitization to oxidative damage by overexpression of manganese superoxide dismutase in rat glioma cells Cell Growth Differ 7 1996 1175 1186