Reduced reactive oxygen species-generating capacity contributes to the enhanced cell growth of arsenic-transformed epithelial cells

Cancer Research

Volumn 70, Issue 12, 2010, Pages 5127-5135

  Chang, Qingshan ^a   Pan, Jingju ^a   Wang, Xing ^a   Zhang, Zhuo ^a   Chen, Fei ^a,b   Shi, Xianglin ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; ARSENIC TRICHLORIDE; CATALASE; DNA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P100; PROTEIN P105; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCOSA; CELL GROWTH; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ARSENIC; BLOTTING, WESTERN; BRONCHI; CATALASE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLONY-FORMING UNITS ASSAY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; NF-KAPPA B; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 77953800122     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-0007     Document Type: Article

References (33)

1. Platanias LC. Biological responses to arsenic compounds. J Biol Chem 2009;284:18583-7.
2. Hughes MF. Arsenic toxicity and potential mechanisms of action. Toxicol Lett 2002;133:1-16. (Pubitemid 34655541)
3. Wickre JB, Folt CL, Sturup S, Karagas MR. Environmental exposure and fingernail analysis of arsenic and mercury in children and adults in a Nicaraguan gold mining community. Arch Environ Health 2004;59:400-9.
4. Basu A, Mahata J, Gupta S, Giri AK. Genetic toxicology of a paradoxical human carcinogen, arsenic: a review. Mutat Res 2001;488:171-94.
5. Chen F, Shi X. Intracellular signal transduction of cells in response to carcinogenic metals. Crit Rev Oncol Hematol 2002;42:105-21.
6. Dong Z. The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ Health Perspect 2002;110 Suppl 5:757-9.
7. Sandoval M, Morales M, Tapia R, et al. p53 response to arsenic exposure in epithelial cells: protein kinase B/Akt involvement. Toxicol Sci 2007;99:126-40.
8. Reznikova TV, Phillips MA, Rice RH. Arsenite suppresses Notch1 signaling in human keratinocytes. J Invest Dermatol 2009;129:155-61.
9. Chang Q, Bhatia D, Zhang Y, et al. Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45α expression. Cancer Res 2007;67:6146-54.
10. Zhang QY, Mao JH, Liu P, et al. A systems biology understanding of the synergistic effects of arsenic sulfide and imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A 2009;106:3378-83.
11. Soucy NV, Klei LR, Mayka DD, Barchowsky A. Signaling pathways for arsenic-stimulated vascular endothelial growth factor-A expression in primary vascular smooth muscle cells. Chem Res Toxicol 2004;17:555-63.
12. Mann KK, Miller WH, Jr. Death by arsenic: implications of PML sumoylation. Cancer Cell 2004;5:307-9.
13. Shi H, Shi X, Liu KJ. Oxidative mechanism of arsenic toxicity and carcinogenesis. Mol Cell Biochem 2004;255:67-78. (Pubitemid 38159766)
14. Partridge MA, Huang SX, Hernandez-Rosa E, Davidson MM, Hei TK. Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: implications for genotoxic mechanisms in mammalian cells. Cancer Res 2007;67:5239-47.
15. Chou WC, Jie C, Kenedy AA, et al. Role of NADPH oxidase in arsenicinduced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A 2004;101:4578-83.
16. Straub AC, Clark KA, Ross MA, et al. Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide. J Clin Invest 2008;118:3980-9.
17. Lemarie A, Bourdonnay E, Morzadec C, Fardel O, Vernhet L. Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway. J Immunol 2008;180:6010-7.
18. 2-terminal kinase activation induced by arsenic. Cancer Res 2003;63:7689-93.
19. DiPaolo JA, Casto BC. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res 1979;39:1008-13.
20. Biedermann KA, Landolph JR. Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts. Cancer Res 1987;47:3815-23.
21. Das KC, White CW. Redox systems of the cell: possible links and implications. Proc Natl Acad Sci U S A 2002;99:9617-8.
22. Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 2009;8:579-91.
23. Lawenda BD, Kelly KM, Ladas EJ, et al. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 2008;100:773-83.
24. Pervaiz S, Clement MV. Tumor intracellular redox status and drug resistance-serendipity or a causal relationship? Curr Pharm Des 2004;10:1969-77.
25. Ivshina AV, George J, Senko O, et al. Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res 2006;66:10292-301.
26. Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
27. Choi J, Liu RM, Forman HJ. Adaptation to oxidative stress: quinonemediated protection of signaling in rat lung epithelial L2 cells. Biochem Pharmacol 1997;53:987-93.
28. Shimizu T, Numata T, Okada Y. A role of reactive oxygen species in apoptotic activation of volume-sensitive Cl(-) channel. Proc Natl Acad Sci U S A 2004;101:6770-3.
29. Zhang Y, Chen F. Reactive oxygen species (ROS), troublemakers between nuclear factor-κB (NF-κB) and c-Jun NH(2)-terminal kinase (JNK). Cancer Res 2004;64:1902-5.
30. Diehn M, Cho RW, Lobo NA, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009;458:780-3.
31. Ito K, Hirao A, Arai F, et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004;431:997-1002. (Pubitemid 39434422)
32. Jang YY, Sharkis SJ. A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood 2007;110:3056-63.
33. Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007;128:325-39.