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Volumn 2, Issue 4, 2011, Pages 385-391

The role of p53 in metabolic regulation

Author keywords

aerobic glycolysis; oxidative phosphorylation; oxidative stress; p53

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; FATTY ACID; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; GLUTAMINASE; GUANIDINOACETATE METHYLTRANSFERASE; LACTATE DEHYDROGENASE; METFORMIN; MUTANT PROTEIN; OCTAMER TRANSCRIPTION FACTOR 1; OXYGEN; PHOSPHOGLYCERATE MUTASE; PROTEIN P53; PUMA PROTEIN; PYRUVATE KINASE; REACTIVE OXYGEN METABOLITE;

EID: 80053036165     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601911409738     Document Type: Review
Times cited : (201)

References (59)
  • 1
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O.On respiratory impairment in cancer cells.Science. 1956;124 (3215): 269-70.
    • (1956) Science , vol.124 , Issue.3215 , pp. 269-270
    • Warburg, O.1
  • 2
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis: the seventh hallmark of cancer
    • Yeung SJ,Pan J,Lee MH.Roles of p53, MYC and HIF-1 in regulating glycolysis: the seventh hallmark of cancer.Cell Mol Life Sci. 2008;65 (24): 3981-99.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.24 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.H.3
  • 4
    • 0035917865 scopus 로고    scopus 로고
    • Cooperation and competition in the evolution of ATP-producing pathways
    • Pfeiffer T,Schuster S,Bonhoeffer S.Cooperation and competition in the evolution of ATP-producing pathways.Science. 2001;292 (5516): 504-7.
    • (2001) Science , vol.292 , Issue.5516 , pp. 504-507
    • Pfeiffer, T.1    Schuster, S.2    Bonhoeffer, S.3
  • 5
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk HR,Vander Heiden MG,Harris MH, et al.The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.Nature. 2008;452 (7184): 230-3.
    • (2008) Nature , vol.452 , Issue.7184 , pp. 230-233
    • Christofk, H.R.1    Vander Heiden, M.G.2    Harris, M.H.3
  • 6
    • 34249681337 scopus 로고    scopus 로고
    • p53: new roles in metabolism
    • Bensaad K,Vousden KH.p53: new roles in metabolism.Trends Cell Biol. 2007;17 (6): 286-91.
    • (2007) Trends Cell Biol , vol.17 , Issue.6 , pp. 286-291
    • Bensaad, K.1    Vousden, K.H.2
  • 7
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • Schwartzenberg-Bar-Yoseph F,Armoni M,Karnieli E.The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression.Cancer Res. 2004;64 (7): 2627-33.
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 8
    • 33745918951 scopus 로고    scopus 로고
    • TIGAR, a p53-inducible regulator of glycolysis and apoptosis
    • Bensaad K,Tsuruta A,Selak MA, et al.TIGAR, a p53-inducible regulator of glycolysis and apoptosis.Cell. 2006;126 (1): 107-20.
    • (2006) Cell , vol.126 , Issue.1 , pp. 107-120
    • Bensaad, K.1    Tsuruta, A.2    Selak, M.A.3
  • 9
    • 24644436766 scopus 로고    scopus 로고
    • PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    • Chipuk JE,Bouchier-Hayes L,Kuwana T,Newmeyer DD,Green DR.PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.Science. 2005;309 (5741): 1732-5.
    • (2005) Science , vol.309 , Issue.5741 , pp. 1732-1735
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Kuwana, T.3    Newmeyer, D.D.4    Green, D.R.5
  • 10
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • Hu W,Zhang C,Wu R,Sun Y,Levine A,Feng Z.Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.Proc Natl Acad Sci U S A. 2010;107 (16): 7455-60.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.16 , pp. 7455-7460
    • Hu, W.1    Zhang, C.2    Wu, R.3    Sun, Y.4    Levine, A.5    Feng, Z.6
  • 11
    • 70449093664 scopus 로고    scopus 로고
    • GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress
    • Ide T,Brown-Endres L,Chu K, et al.GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress.Mol Cell. 2009;36 (3): 379-92.
    • (2009) Mol Cell , vol.36 , Issue.3 , pp. 379-392
    • Ide, T.1    Brown-Endres, L.2    Chu, K.3
  • 12
    • 11244347171 scopus 로고    scopus 로고
    • Glycolytic enzymes can modulate cellular life span
    • Kondoh H,Lleonart ME,Gil J, et al.Glycolytic enzymes can modulate cellular life span.Cancer Res. 2005;65 (1): 177-85.
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 177-185
    • Kondoh, H.1    Lleonart, M.E.2    Gil, J.3
  • 13
    • 33745149291 scopus 로고    scopus 로고
    • p53 regulates mitochondrial respiration
    • Matoba S,Kang JG,Patino WD, et al.p53 regulates mitochondrial respiration.Science. 2006;312 (5780): 1650-3.
    • (2006) Science , vol.312 , Issue.5780 , pp. 1650-1653
    • Matoba, S.1    Kang, J.G.2    Patino, W.D.3
  • 14
    • 0037349289 scopus 로고    scopus 로고
    • p53 has a direct apoptogenic role at the mitochondria
    • Mihara M,Erster S,Zaika A, et al.p53 has a direct apoptogenic role at the mitochondria.Mol Cell. 2003;11 (3): 577-90.
    • (2003) Mol Cell , vol.11 , Issue.3 , pp. 577-590
    • Mihara, M.1    Erster, S.2    Zaika, A.3
  • 15
    • 77952227625 scopus 로고    scopus 로고
    • Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species
    • Suzuki S,Tanaka T,Poyurovsky MV, et al.Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.Proc Natl Acad Sci U S A. 2010;107 (16): 7461-6.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.16 , pp. 7461-7466
    • Suzuki, S.1    Tanaka, T.2    Poyurovsky, M.V.3
  • 16
    • 61449206074 scopus 로고    scopus 로고
    • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation
    • Zhao Y,Coloff JL,Ferguson EC,Jacobs SR,Cui K,Rathmell JC.Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.J Biol Chem. 2008;283 (52): 36344-53.
    • (2008) J Biol Chem , vol.283 , Issue.52 , pp. 36344-36353
    • Zhao, Y.1    Coloff, J.L.2    Ferguson, E.C.3    Jacobs, S.R.4    Cui, K.5    Rathmell, J.C.6
  • 17
    • 35448940790 scopus 로고    scopus 로고
    • A pivotal role for p53: balancing aerobic respiration and glycolysis
    • Ma W,Sung HJ,Park JY,Matoba S,Hwang PM.A pivotal role for p53: balancing aerobic respiration and glycolysis.J Bioenerg Biomembr. 2007;39 (3): 243-6.
    • (2007) J Bioenerg Biomembr , vol.39 , Issue.3 , pp. 243-246
    • Ma, W.1    Sung, H.J.2    Park, J.Y.3    Matoba, S.4    Hwang, P.M.5
  • 18
    • 0030882879 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells: the type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
    • Mathupala SP,Heese C,Pedersen PL.Glucose catabolism in cancer cells: the type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.J Biol Chem. 1997;272 (36): 22776-80.
    • (1997) J Biol Chem , vol.272 , Issue.36 , pp. 22776-22780
    • Mathupala, S.P.1    Heese, C.2    Pedersen, P.L.3
  • 19
    • 61849161672 scopus 로고    scopus 로고
    • Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity
    • Shakya A,Cooksey R,Cox JE,Wang V,McClain DA,Tantin D.Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity.Nat Cell Biol. 2009;11 (3): 320-7.
    • (2009) Nat Cell Biol , vol.11 , Issue.3 , pp. 320-327
    • Shakya, A.1    Cooksey, R.2    Cox, J.E.3    Wang, V.4    McClain, D.A.5    Tantin, D.6
  • 20
    • 0041352962 scopus 로고    scopus 로고
    • S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component
    • Zheng L,Roeder RG,Luo Y.S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component.Cell. 2003;114 (2): 255-66.
    • (2003) Cell , vol.114 , Issue.2 , pp. 255-266
    • Zheng, L.1    Roeder, R.G.2    Luo, Y.3
  • 21
    • 79953157651 scopus 로고    scopus 로고
    • AKT requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells
    • Coloff JL,Mason EF,Altman BJ, et al.AKT requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.J Biol Chem. 2011;286 (7): 5921-33.
    • (2011) J Biol Chem , vol.286 , Issue.7 , pp. 5921-5933
    • Coloff, J.L.1    Mason, E.F.2    Altman, B.J.3
  • 22
    • 0012249041 scopus 로고
    • Metabolism of neoplastic tissue: IV. A study of lipid synthesis in neoplastic tissue slices in vitro
    • Medes G,Thomas A,Weinhouse S.Metabolism of neoplastic tissue: IV. A study of lipid synthesis in neoplastic tissue slices in vitro.Cancer Res. 1953;13 (1): 27-9.
    • (1953) Cancer Res , vol.13 , Issue.1 , pp. 27-29
    • Medes, G.1    Thomas, A.2    Weinhouse, S.3
  • 23
    • 77955470822 scopus 로고    scopus 로고
    • Metabolism and proliferation share common regulatory pathways in cancer cells
    • Fritz V,Fajas L.Metabolism and proliferation share common regulatory pathways in cancer cells.Oncogene. 2010;29 (31): 4369-77.
    • (2010) Oncogene , vol.29 , Issue.31 , pp. 4369-4377
    • Fritz, V.1    Fajas, L.2
  • 24
    • 77953587752 scopus 로고    scopus 로고
    • GAMT joins the p53 network: branching into metabolism
    • Ide T,Chu K,Aaronson SA,Lee SW.GAMT joins the p53 network: branching into metabolism.Cell Cycle. 2010;9 (9): 1706-10.
    • (2010) Cell Cycle , vol.9 , Issue.9 , pp. 1706-1710
    • Ide, T.1    Chu, K.2    Aaronson, S.A.3    Lee, S.W.4
  • 25
    • 0024315871 scopus 로고
    • Fatty acid synthase, a proficient multifunctional enzyme
    • Wakil SJ.Fatty acid synthase, a proficient multifunctional enzyme.Biochemistry. 1989;28 (11): 4523-30.
    • (1989) Biochemistry , vol.28 , Issue.11 , pp. 4523-4530
    • Wakil, S.J.1
  • 26
    • 33645707835 scopus 로고    scopus 로고
    • The fatty acid synthase gene is a conserved p53 family target from worm to human
    • D'Erchia AM,Tullo A,Lefkimmiatis K,Saccone C,Sbisa E.The fatty acid synthase gene is a conserved p53 family target from worm to human.Cell Cycle. 2006;5 (7): 750-8.
    • (2006) Cell Cycle , vol.5 , Issue.7 , pp. 750-758
    • D'Erchia, A.M.1    Tullo, A.2    Lefkimmiatis, K.3    Saccone, C.4    Sbisa, E.5
  • 27
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
    • Buzzai M,Jones RG,Amaravadi RK, et al.Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth.Cancer Res. 2007;67 (14): 6745-52.
    • (2007) Cancer Res , vol.67 , Issue.14 , pp. 6745-6752
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 28
    • 33846005164 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth
    • Deberardinis RJ,Lum JJ,Thompson CB.Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth.J Biol Chem. 2006;281 (49): 37372-80.
    • (2006) J Biol Chem , vol.281 , Issue.49 , pp. 37372-37380
    • Deberardinis, R.J.1    Lum, J.J.2    Thompson, C.B.3
  • 29
    • 0023642627 scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • Carling D,Zammit VA,Hardie DG.A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis.FEBS Lett. 1987;223 (2): 217-22.
    • (1987) FEBS Lett , vol.223 , Issue.2 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 30
    • 61849135453 scopus 로고    scopus 로고
    • Tumor suppressors and cell metabolism: a recipe for cancer growth
    • Jones RG,Thompson CB.Tumor suppressors and cell metabolism: a recipe for cancer growth.Genes Dev. 2009;23 (5): 537-48.
    • (2009) Genes Dev , vol.23 , Issue.5 , pp. 537-548
    • Jones, R.G.1    Thompson, C.B.2
  • 31
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ,Lum JJ,Hatzivassiliou G,Thompson CB.The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.Cell Metab. 2008;7 (1): 11-20.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 32
    • 48449101433 scopus 로고    scopus 로고
    • p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov AV,Karin M.p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.Cell. 2008;134 (3): 451-60.
    • (2008) Cell , vol.134 , Issue.3 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 33
    • 0036863624 scopus 로고    scopus 로고
    • REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species
    • Ellisen LW,Ramsayer KD,Johannessen CM, et al.REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.Mol Cell. 2002;10 (5): 995-1005.
    • (2002) Mol Cell , vol.10 , Issue.5 , pp. 995-1005
    • Ellisen, L.W.1    Ramsayer, K.D.2    Johannessen, C.M.3
  • 34
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • Feng Z,Hu W,de Stanchina E, et al.The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.Cancer Res. 2007;67 (7): 3043-53.
    • (2007) Cancer Res , vol.67 , Issue.7 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    de Stanchina, E.3
  • 35
    • 20444363122 scopus 로고    scopus 로고
    • The coordinate regulation of the p53 and mTOR pathways in cells
    • Feng Z,Zhang H,Levine AJ,Jin S.The coordinate regulation of the p53 and mTOR pathways in cells.Proc Natl Acad Sci U S A. 2005;102 (23): 8204-9.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.23 , pp. 8204-8209
    • Feng, Z.1    Zhang, H.2    Levine, A.J.3    Jin, S.4
  • 36
    • 0034854091 scopus 로고    scopus 로고
    • Regulation of PTEN transcription by p53
    • Stambolic V,MacPherson D,Sas D, et al.Regulation of PTEN transcription by p53.Mol Cell. 2001;8 (2): 317-25.
    • (2001) Mol Cell , vol.8 , Issue.2 , pp. 317-325
    • Stambolic, V.1    MacPherson, D.2    Sas, D.3
  • 37
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • Brugarolas J,Lei K,Hurley RL, et al.Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.Genes Dev. 2004;18 (23): 2893-904.
    • (2004) Genes Dev , vol.18 , Issue.23 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3
  • 38
    • 77954310492 scopus 로고    scopus 로고
    • The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein
    • Feng Z,Levine AJ.The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein.Trends Cell Biol. 2010;20 (7): 427-34.
    • (2010) Trends Cell Biol , vol.20 , Issue.7 , pp. 427-434
    • Feng, Z.1    Levine, A.J.2
  • 40
    • 2142815107 scopus 로고    scopus 로고
    • Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD
    • Budanov AV,Sablina AA,Feinstein E,Koonin EV,Chumakov PM.Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.Science. 2004;304 (5670): 596-600.
    • (2004) Science , vol.304 , Issue.5670 , pp. 596-600
    • Budanov, A.V.1    Sablina, A.A.2    Feinstein, E.3    Koonin, E.V.4    Chumakov, P.M.5
  • 41
    • 58249113824 scopus 로고    scopus 로고
    • Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function
    • Cano CE,Gommeaux J,Pietri S, et al.Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.Cancer Res. 2009;69 (1): 219-26.
    • (2009) Cancer Res , vol.69 , Issue.1 , pp. 219-226
    • Cano, C.E.1    Gommeaux, J.2    Pietri, S.3
  • 42
    • 0033597221 scopus 로고    scopus 로고
    • Transcriptional activation of the human glutathione peroxidase promoter by p53
    • Tan M,Li S,Swaroop M,Guan K,Oberley LW,Sun Y.Transcriptional activation of the human glutathione peroxidase promoter by p53.J Biol Chem. 1999;274 (17): 12061-6.
    • (1999) J Biol Chem , vol.274 , Issue.17 , pp. 12061-12066
    • Tan, M.1    Li, S.2    Swaroop, M.3    Guan, K.4    Oberley, L.W.5    Sun, Y.6
  • 43
    • 1942520427 scopus 로고    scopus 로고
    • Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses
    • Yoon KA,Nakamura Y,Arakawa H.Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses.J Hum Genet. 2004;49 (3): 134-40.
    • (2004) J Hum Genet , vol.49 , Issue.3 , pp. 134-140
    • Yoon, K.A.1    Nakamura, Y.2    Arakawa, H.3
  • 44
    • 67449128222 scopus 로고    scopus 로고
    • Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
    • Chen W,Sun Z,Wang XJ, et al.Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.Mol Cell. 2009;34 (6): 663-73.
    • (2009) Mol Cell , vol.34 , Issue.6 , pp. 663-673
    • Chen, W.1    Sun, Z.2    Wang, X.J.3
  • 45
    • 0035945676 scopus 로고    scopus 로고
    • Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis
    • Drane P,Bravard A,Bouvard V,May E.Reciprocal down-regulation of p53 and SOD2 gene expression-implication in p53 mediated apoptosis.Oncogene. 2001;20 (4): 430-9.
    • (2001) Oncogene , vol.20 , Issue.4 , pp. 430-439
    • Drane, P.1    Bravard, A.2    Bouvard, V.3    May, E.4
  • 46
    • 33846000687 scopus 로고    scopus 로고
    • p53 suppresses the Nrf2-dependent transcription of antioxidant response genes
    • Faraonio R,Vergara P,Di Marzo D, et al.p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.J Biol Chem. 2006;281 (52): 39776-84.
    • (2006) J Biol Chem , vol.281 , Issue.52 , pp. 39776-39784
    • Faraonio, R.1    Vergara, P.2    Di Marzo, D.3
  • 47
    • 11144356558 scopus 로고    scopus 로고
    • p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis
    • Hussain SP,Amstad P,He P, et al.p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.Cancer Res. 2004;64 (7): 2350-6.
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2350-2356
    • Hussain, S.P.1    Amstad, P.2    He, P.3
  • 48
    • 16444382174 scopus 로고    scopus 로고
    • PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells
    • Liu Z,Lu H,Shi H, et al.PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells.Cancer Res. 2005;65 (5): 1647-54.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 1647-1654
    • Liu, Z.1    Lu, H.2    Shi, H.3
  • 50
    • 23844477888 scopus 로고    scopus 로고
    • The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway
    • Rivera A,Maxwell SA.The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway.J Biol Chem. 2005;280 (32): 29346-54.
    • (2005) J Biol Chem , vol.280 , Issue.32 , pp. 29346-29354
    • Rivera, A.1    Maxwell, S.A.2
  • 51
    • 85047695800 scopus 로고    scopus 로고
    • A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
    • Trinei M,Giorgio M,Cicalese A, et al.A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.Oncogene. 2002;21 (24): 3872-8.
    • (2002) Oncogene , vol.21 , Issue.24 , pp. 3872-3878
    • Trinei, M.1    Giorgio, M.2    Cicalese, A.3
  • 52
    • 41149105243 scopus 로고    scopus 로고
    • ROS and p53: a versatile partnership
    • Liu B,Chen Y,St Clair DK.ROS and p53: a versatile partnership.Free Radic Biol Med. 2008;44 (8): 1529-35.
    • (2008) Free Radic Biol Med , vol.44 , Issue.8 , pp. 1529-1535
    • Liu, B.1    Chen, Y.2    St Clair, D.K.3
  • 53
    • 77957850069 scopus 로고    scopus 로고
    • p53 and NF-kappaB: different strategies for responding to stress lead to a functional antagonism
    • Ak P,Levine AJ.p53 and NF-kappaB: different strategies for responding to stress lead to a functional antagonism.FASEB J. 2010;24 (10): 3643-52.
    • (2010) FASEB J , vol.24 , Issue.10 , pp. 3643-3652
    • Ak, P.1    Levine, A.J.2
  • 54
    • 43049139541 scopus 로고    scopus 로고
    • p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    • Kawauchi K,Araki K,Tobiume K,Tanaka N.p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation.Nat Cell Biol. 2008;10 (5): 611-8.
    • (2008) Nat Cell Biol , vol.10 , Issue.5 , pp. 611-618
    • Kawauchi, K.1    Araki, K.2    Tobiume, K.3    Tanaka, N.4
  • 55
    • 4644262462 scopus 로고    scopus 로고
    • O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits
    • Wells L,Kreppel LK,Comer FI,Wadzinski BE,Hart GW.O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits.J Biol Chem. 2004;279 (37): 38466-70.
    • (2004) J Biol Chem , vol.279 , Issue.37 , pp. 38466-38470
    • Wells, L.1    Kreppel, L.K.2    Comer, F.I.3    Wadzinski, B.E.4    Hart, G.W.5
  • 56
    • 0025193520 scopus 로고
    • Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins: identification of a uridine diphospho-N-acetylglucosamine:peptide beta-N-acetylglucosaminyltransferase
    • Haltiwanger RS,Holt GD,Hart GW.Enzymatic addition of O-GlcNAc to nuclear and cytoplasmic proteins: identification of a uridine diphospho-N-acetylglucosamine:peptide beta-N-acetylglucosaminyltransferase.J Biol Chem. 1990;265 (5): 2563-8.
    • (1990) J Biol Chem , vol.265 , Issue.5 , pp. 2563-2568
    • Haltiwanger, R.S.1    Holt, G.D.2    Hart, G.W.3
  • 58
    • 33749160125 scopus 로고    scopus 로고
    • Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
    • Yang WH,Kim JE,Nam HW, et al.Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability.Nat Cell Biol. 2006;8 (10): 1074-83.
    • (2006) Nat Cell Biol , vol.8 , Issue.10 , pp. 1074-1083
    • Yang, W.H.1    Kim, J.E.2    Nam, H.W.3
  • 59
    • 62549161375 scopus 로고    scopus 로고
    • Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification
    • Kawauchi K,Araki K,Tobiume K,Tanaka N.Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification.Proc Natl Acad Sci U S A. 2009;106 (9): 3431-6.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.9 , pp. 3431-3436
    • Kawauchi, K.1    Araki, K.2    Tobiume, K.3    Tanaka, N.4


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