메뉴 건너뛰기




Volumn 8, Issue 6, 2008, Pages 425-437

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; ANGIOTENSIN II; COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; HYPOXIA INDUCIBLE FACTOR 1; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; THROMBIN; THROMBOSPONDIN 1; VASCULOTROPIN;

EID: 44349157832     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2397     Document Type: Review
Times cited : (873)

References (156)
  • 1
    • 44349157352 scopus 로고    scopus 로고
    • Virchow, R. Die Krankhaften Geschwulste (August Hirschwald, Berlin, 1863). The first report that vascular structures in tumours are abnormal.
    • Virchow, R. Die Krankhaften Geschwulste (August Hirschwald, Berlin, 1863). The first report that vascular structures in tumours are abnormal.
  • 2
    • 84964178914 scopus 로고
    • Growth of malignant disease in man and the lower animals with special reference to vascular system
    • Goldman, E. Growth of malignant disease in man and the lower animals with special reference to vascular system. Proc. R. Soc. Med. 1, 1 (1907).
    • (1907) Proc. R. Soc. Med , vol.1 , pp. 1
    • Goldman, E.1
  • 4
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • The first to suggest that inhibition of tumour angiogenesis could have therapeutic benefit
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971). The first to suggest that inhibition of tumour angiogenesis could have therapeutic benefit.
    • (1971) N. Engl. J. Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 5
    • 0031730519 scopus 로고    scopus 로고
    • Oxygenation of human tumors: The Mainz experience
    • Vaupel, P., Thews, O., Kelleher, D. K. & Hoeckel, M. Oxygenation of human tumors: the Mainz experience. Strahlenther. Onkol. 174 (Suppl. 4), 6-12 (1998).
    • (1998) Strahlenther. Onkol , vol.174 , Issue.SUPPL. 4 , pp. 6-12
    • Vaupel, P.1    Thews, O.2    Kelleher, D.K.3    Hoeckel, M.4
  • 6
    • 0034979156 scopus 로고    scopus 로고
    • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents
    • Braun, R. D., Lanzen, J. L., Snyder, S. A. & Dewhirst, M. W. Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. Am. J. Physiol. Heart Circ. Physiol. 280, H2533-H2544 (2001).
    • (2001) Am. J. Physiol. Heart Circ. Physiol , vol.280
    • Braun, R.D.1    Lanzen, J.L.2    Snyder, S.A.3    Dewhirst, M.W.4
  • 7
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721-732 (2003).
    • (2003) Nature Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 8
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang, G. L. & Semenza, G. L. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc. Natl Acad. Sci. USA 90, 4304-4308 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 9
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Discovered that HIF1 is the oxygen-sensitive transcription factor that controls erythropoeitin synthesis
    • Semenza, G. L. & Wang, G. L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell. Biol. 12, 5447-5454 (1992). Discovered that HIF1 is the oxygen-sensitive transcription factor that controls erythropoeitin synthesis.
    • (1992) Mol. Cell. Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 10
    • 0035917808 scopus 로고    scopus 로고
    • 2-regulated prolyl hydroxylation
    • The first to report that prolyl hydroxylation, which requires molecular oxygen, is the fundamental mechanism for stabilizing HIF1α under hypoxic conditions
    • 2-regulated prolyl hydroxylation. Science 292, 468-472 (2001). The first to report that prolyl hydroxylation, which requires molecular oxygen, is the fundamental mechanism for stabilizing HIF1α under hypoxic conditions.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 11
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • The first to report that oxygen-dependent degradation of HIF1α occurs by recognition of the protein by the VHL complex
    • Ohh, M. et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nature Cell Biol. 2, 423-427 (2000). The first to report that oxygen-dependent degradation of HIF1α occurs by recognition of the protein by the VHL complex
    • (2000) Nature Cell Biol , vol.2 , pp. 423-427
    • Ohh, M.1
  • 12
    • 0021191603 scopus 로고
    • Is hypoxia involved in the mechanism of alcohol-induced liver injury?
    • Thurman, R. G., Ji, S., Matsumura, T. & Lemasters, J. J. Is hypoxia involved in the mechanism of alcohol-induced liver injury? Fundam. Appl. Toxicol. 4, 125-133 (1984).
    • (1984) Fundam. Appl. Toxicol , vol.4 , pp. 125-133
    • Thurman, R.G.1    Ji, S.2    Matsumura, T.3    Lemasters, J.J.4
  • 13
    • 0037390258 scopus 로고    scopus 로고
    • Retinal oxygen: Fundamental and clinical aspects
    • Wangsa-Wirawan, N. D. & Linsenmeier, R. A. Retinal oxygen: fundamental and clinical aspects. Arch Ophthalmol. 121, 547-557 (2003).
    • (2003) Arch Ophthalmol , vol.121 , pp. 547-557
    • Wangsa-Wirawan, N.D.1    Linsenmeier, R.A.2
  • 14
    • 0033962899 scopus 로고    scopus 로고
    • Early wound healing exhibits cytokine surge without evidence of hypoxia
    • Haroon, Z. A., Raleigh, J. A., Greenberg, C. S. & Dewhirst, M. W. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann. Surg. 231, 137-147 (2000).
    • (2000) Ann. Surg , vol.231 , pp. 137-147
    • Haroon, Z.A.1    Raleigh, J.A.2    Greenberg, C.S.3    Dewhirst, M.W.4
  • 16
    • 2542627386 scopus 로고    scopus 로고
    • Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors
    • Samoszuk, M. K., Walter, J. & Mechetner, E. Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors. J. Histochem. Cytochem. 52, 837-839 (2004).
    • (2004) J. Histochem. Cytochem , vol.52 , pp. 837-839
    • Samoszuk, M.K.1    Walter, J.2    Mechetner, E.3
  • 18
    • 34248359065 scopus 로고    scopus 로고
    • Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
    • Parmar, K., Mauch, P., Vergilio, J. A., Sackstein, R. & Down, J. D. Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia. Proc. Natl Acad. Sci. USA 104, 5431-5436 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 5431-5436
    • Parmar, K.1    Mauch, P.2    Vergilio, J.A.3    Sackstein, R.4    Down, J.D.5
  • 19
    • 0028785458 scopus 로고
    • Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver
    • Arteel, G. E., Thurman, R. G., Yates, J. M. & Raleigh, J. A. Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver. Br. J. Cancer 72, 889-895 (1995).
    • (1995) Br. J. Cancer , vol.72 , pp. 889-895
    • Arteel, G.E.1    Thurman, R.G.2    Yates, J.M.3    Raleigh, J.A.4
  • 20
    • 0030423710 scopus 로고    scopus 로고
    • Laughlin, K. M. et al. Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors. J. Pharmacol. Exp. Ther. 277, 1049-1057 (1996).
    • Laughlin, K. M. et al. Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors. J. Pharmacol. Exp. Ther. 277, 1049-1057 (1996).
  • 21
    • 0032857478 scopus 로고    scopus 로고
    • Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis
    • Rosmorduc, O. et al. Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am. J. Pathol. 155, 1065-1073 (1999).
    • (1999) Am. J. Pathol , vol.155 , pp. 1065-1073
    • Rosmorduc, O.1
  • 22
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
    • Houck, K. A., Leung, D. W., Rowland, A. M., Winer, J. & Ferrara, N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 267, 26031-26037 (1992).
    • (1992) J. Biol. Chem , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 23
    • 0038661196 scopus 로고    scopus 로고
    • Binding inhibition of angiogenic factors by heparan sulfate proteoglycans in aqueous humor: Potential mechanism for maintenance of an avascular environment
    • Fannon, M. et al. Binding inhibition of angiogenic factors by heparan sulfate proteoglycans in aqueous humor: potential mechanism for maintenance of an avascular environment. FASEB J. 17, 902-904 (2003).
    • (2003) FASEB J , vol.17 , pp. 902-904
    • Fannon, M.1
  • 24
    • 1542269248 scopus 로고    scopus 로고
    • Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas
    • Chou, S. C., Azuma, Y., Varia, M. A. & Raleigh, J. A. Evidence that involucrin, a marker for differentiation, is oxygen regulated in human squamous cell carcinomas. Br. J. Cancer 90, 728-735 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 728-735
    • Chou, S.C.1    Azuma, Y.2    Varia, M.A.3    Raleigh, J.A.4
  • 25
    • 26944478634 scopus 로고    scopus 로고
    • Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer
    • Zhu, Y. et al. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene 24, 6555-6563 (2005).
    • (2005) Oncogene , vol.24 , pp. 6555-6563
    • Zhu, Y.1
  • 26
    • 34250167158 scopus 로고    scopus 로고
    • Requirements for T lymphocyte migration in explanted lymph nodes
    • Huang, J. H. et al. Requirements for T lymphocyte migration in explanted lymph nodes. J. Immunol. 178, 7747-7755 (2007).
    • (2007) J. Immunol , vol.178 , pp. 7747-7755
    • Huang, J.H.1
  • 27
    • 34047272690 scopus 로고    scopus 로고
    • Li, F. et al. Regulation of HIF-1α stability through S-nitrosylation. Mol. Cell 26, 63-74 (2007). This paper proved that nitrosylation of a cysteine residue in the oxygen-dependent degradation domain of HIF1α can prevent its degradation under aerobic conditions.
    • Li, F. et al. Regulation of HIF-1α stability through S-nitrosylation. Mol. Cell 26, 63-74 (2007). This paper proved that nitrosylation of a cysteine residue in the oxygen-dependent degradation domain of HIF1α can prevent its degradation under aerobic conditions.
  • 28
    • 0034682786 scopus 로고    scopus 로고
    • 2 sensing
    • The first report suggesting that reactive oxygen species may be responsible for stabilizing HIF1α under hypoxic conditions
    • 2 sensing. J. Biol. Chem. 275, 25130-25138 (2000). The first report suggesting that reactive oxygen species may be responsible for stabilizing HIF1α under hypoxic conditions.
    • (2000) J. Biol. Chem , vol.275 , pp. 25130-25138
    • Chandel, N.S.1
  • 29
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • Guzy, R. D. et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1, 401-408 (2005).
    • (2005) Cell Metab , vol.1 , pp. 401-408
    • Guzy, R.D.1
  • 30
    • 34250745912 scopus 로고    scopus 로고
    • The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
    • Bell, E. L. et al. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J. Cell Biol. 177, 1029-1036 (2007).
    • (2007) J. Cell Biol , vol.177 , pp. 1029-1036
    • Bell, E.L.1
  • 31
    • 0036912721 scopus 로고    scopus 로고
    • Nitric oxide as a unique signaling molecule in the vascular system: A historical overview
    • Ignarro, L. J. Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J. Physiol. Pharmacol. 53, 503-514 (2002).
    • (2002) J. Physiol. Pharmacol , vol.53 , pp. 503-514
    • Ignarro, L.J.1
  • 33
    • 30444439216 scopus 로고    scopus 로고
    • The discovery of nitric oxide and its role in vascular biology
    • Moncada, S. & Higgs, E. A. The discovery of nitric oxide and its role in vascular biology. Br. J. Pharmacol. 147 (Suppl. 1), S193-S201 (2006).
    • (2006) Br. J. Pharmacol , vol.147 , Issue.SUPPL. 1
    • Moncada, S.1    Higgs, E.A.2
  • 34
    • 0031307208 scopus 로고    scopus 로고
    • Nitric oxide in tumor biology and cancer therapy. Part 2: Therapeutic implications
    • Tozer, G. M. & Everett, S. A. Nitric oxide in tumor biology and cancer therapy. Part 2: Therapeutic implications. Clin. Oncol. (R. Coll. Radiol.) 9, 357-364 (1997).
    • (1997) Clin. Oncol. (R. Coll. Radiol.) , vol.9 , pp. 357-364
    • Tozer, G.M.1    Everett, S.A.2
  • 35
    • 0030665017 scopus 로고    scopus 로고
    • Nitric oxide in tumour biology and cancer therapy. Part 1: Physiological aspects
    • Tozer, G. M. & Everett, S. A. Nitric oxide in tumour biology and cancer therapy. Part 1: Physiological aspects. Clin. Oncol. (R. Coll. Radiol.) 9, 282-293 (1997).
    • (1997) Clin. Oncol. (R. Coll. Radiol.) , vol.9 , pp. 282-293
    • Tozer, G.M.1    Everett, S.A.2
  • 36
    • 2542506333 scopus 로고    scopus 로고
    • Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells
    • BelAiba, R. S. et al. Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells. Biol. Chem. 385, 249-257 (2004).
    • (2004) Biol. Chem , vol.385 , pp. 249-257
    • BelAiba, R.S.1
  • 37
    • 38749106115 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α stabilization in nonhypoxic conditions: Role of oxidation and intracellular ascorbate depletion
    • Page, E. L., Chan, D. A., Giaccia, A. J., Levine, M. & Richard, D. E. Hypoxia-inducible factor-1α stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol. Biol. Cell 19, 86-94 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 86-94
    • Page, E.L.1    Chan, D.A.2    Giaccia, A.J.3    Levine, M.4    Richard, D.E.5
  • 38
    • 0346027211 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways
    • Mateo, J., Garcia-Lecea, M., Cadenas, S., Hernandez, C. & Moncada, S. Regulation of hypoxia-inducible factor-1α by nitric oxide through mitochondria-dependent and -independent pathways. Biochem. J. 376, 537-544 (2003).
    • (2003) Biochem. J , vol.376 , pp. 537-544
    • Mateo, J.1    Garcia-Lecea, M.2    Cadenas, S.3    Hernandez, C.4    Moncada, S.5
  • 39
    • 0037472651 scopus 로고    scopus 로고
    • HIF-1 α protein as a target for S-nitrosation
    • Sumbayev, V. V., Budde, A., Zhou, J. & Brune, B. HIF-1 α protein as a target for S-nitrosation. FEBS Lett. 535, 106-112 (2003).
    • (2003) FEBS Lett , vol.535 , pp. 106-112
    • Sumbayev, V.V.1    Budde, A.2    Zhou, J.3    Brune, B.4
  • 40
    • 0035910429 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide
    • Kimura, H. et al. Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide. J. Biol. Chem. 276, 2292-2298 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 2292-2298
    • Kimura, H.1
  • 41
    • 0034638623 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway
    • Sandau, K. B., Faus, H. G. & Brune, B. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3K pathway. Biochem. Biophys. Res. Commun. 278, 263-267 (2000).
    • (2000) Biochem. Biophys. Res. Commun , vol.278 , pp. 263-267
    • Sandau, K.B.1    Faus, H.G.2    Brune, B.3
  • 42
    • 1642453685 scopus 로고    scopus 로고
    • Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling
    • Kasuno, K. et al. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J. Biol. Chem. 279, 2550-2558 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 2550-2558
    • Kasuno, K.1
  • 43
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
    • Mansfield, K. D. et al. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation. Cell Metab. 1, 393-399 (2005).
    • (2005) Cell Metab , vol.1 , pp. 393-399
    • Mansfield, K.D.1
  • 44
    • 12444278251 scopus 로고    scopus 로고
    • Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells
    • Venkataraman, S. et al. Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene 24, 77-89 (2005).
    • (2005) Oncogene , vol.24 , pp. 77-89
    • Venkataraman, S.1
  • 45
    • 28744439265 scopus 로고    scopus 로고
    • Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor
    • Wang, M. et al. Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor. Oncogene 24, 8154-8166 (2005).
    • (2005) Oncogene , vol.24 , pp. 8154-8166
    • Wang, M.1
  • 46
    • 0032511014 scopus 로고    scopus 로고
    • Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer
    • Liu, Y. et al. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5′ enhancer. J. Biol. Chem. 273, 15257-15262 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 15257-15262
    • Liu, Y.1
  • 47
    • 0033605676 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling
    • Huang, L. E., Willmore, W. G., Gu, J., Goldberg, M. A. & Bunn, H. F. Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. J. Biol. Chem. 274, 9038-9044 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 9038-9044
    • Huang, L.E.1    Willmore, W.G.2    Gu, J.3    Goldberg, M.A.4    Bunn, H.F.5
  • 48
    • 0348134741 scopus 로고    scopus 로고
    • Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1α
    • Hagen, T., Taylor, C. T., Lam, F. & Moncada, S. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1α. Science 302, 1975-1978 (2003).
    • (2003) Science , vol.302 , pp. 1975-1978
    • Hagen, T.1    Taylor, C.T.2    Lam, F.3    Moncada, S.4
  • 49
    • 33847307112 scopus 로고    scopus 로고
    • Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2
    • Berchner-Pfannschmidt, U., Yamac, H., Trinidad, B. & Fandrey, J. Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2. J. Biol. Chem. 282, 1788-1796 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 1788-1796
    • Berchner-Pfannschmidt, U.1    Yamac, H.2    Trinidad, B.3    Fandrey, J.4
  • 50
    • 33644884451 scopus 로고    scopus 로고
    • Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix
    • Jankovic, B. et al. Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix. Cytometry B Clin. Cytom. 70, 45-55 (2006).
    • (2006) Cytometry B Clin. Cytom , vol.70 , pp. 45-55
    • Jankovic, B.1
  • 51
    • 0032170012 scopus 로고    scopus 로고
    • Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker
    • Raleigh, J. A. et al. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker. Cancer Res. 58, 3765-3768 (1998).
    • (1998) Cancer Res , vol.58 , pp. 3765-3768
    • Raleigh, J.A.1
  • 52
    • 0038724686 scopus 로고    scopus 로고
    • Evaluation of hypoxia-inducible factor-1α (HIF-1α) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: In vitro and xenograft studies
    • Vordermark, D. & Brown, J. M. Evaluation of hypoxia-inducible factor-1α (HIF-1α) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies. Int. J. Radiat. Oncol. Biol. Phys. 56, 1184-1193 (2003).
    • (2003) Int. J. Radiat. Oncol. Biol. Phys , vol.56 , pp. 1184-1193
    • Vordermark, D.1    Brown, J.M.2
  • 53
    • 0036883983 scopus 로고    scopus 로고
    • HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors
    • Janssen, H. L. et al. HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors. Int. J. Radiat. Oncol. Biol. Phys. 54, 1537-1549 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys , vol.54 , pp. 1537-1549
    • Janssen, H.L.1
  • 54
    • 31544473721 scopus 로고    scopus 로고
    • Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1α in cancer: Role of free radical formation
    • Quintero, M., Brennan, P. A., Thomas, G. J. & Moncada, S. Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1α in cancer: role of free radical formation. Cancer Res. 66, 770-774 (2006).
    • (2006) Cancer Res , vol.66 , pp. 770-774
    • Quintero, M.1    Brennan, P.A.2    Thomas, G.J.3    Moncada, S.4
  • 55
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown, J. M. & Wilson, W. R. Exploiting tumour hypoxia in cancer treatment. Nature Rev. Cancer 4, 437-447 (2004).
    • (2004) Nature Rev. Cancer , vol.4 , pp. 437-447
    • Brown, J.M.1    Wilson, W.R.2
  • 56
    • 33846850493 scopus 로고    scopus 로고
    • Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers
    • Ljungkvist, A. S., Bussink, J., Kaanders, J. H. & van der Kogel, A. J. Dynamics of tumor hypoxia measured with bioreductive hypoxic cell markers. Radiat. Res. 167, 127-145 (2007).
    • (2007) Radiat. Res , vol.167 , pp. 127-145
    • Ljungkvist, A.S.1    Bussink, J.2    Kaanders, J.H.3    van der Kogel, A.J.4
  • 57
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response
    • Vaupel, P. & Harrison, L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist 9 (Suppl. 5), 4-9 (2004).
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 58
    • 0033000313 scopus 로고    scopus 로고
    • 2 gradients in window chamber tumours: Impact on tumour hypoxia
    • 2 gradients in window chamber tumours: impact on tumour hypoxia. Br. J. Cancer 79, 1717-1722 (1999).
    • (1999) Br. J. Cancer , vol.79 , pp. 1717-1722
    • Dewhirst, M.W.1
  • 60
    • 11044231181 scopus 로고    scopus 로고
    • Green's function methods for analysis of oxygen delivery to tissue by microvascular networks
    • Secomb, T. W., Hsu, R., Park, E. Y. & Dewhirst, M. W. Green's function methods for analysis of oxygen delivery to tissue by microvascular networks. Ann. Biomed. Eng. 32, 1519-1529 (2004).
    • (2004) Ann. Biomed. Eng , vol.32 , pp. 1519-1529
    • Secomb, T.W.1    Hsu, R.2    Park, E.Y.3    Dewhirst, M.W.4
  • 61
    • 0029948108 scopus 로고    scopus 로고
    • Microvascular studies on the origins of perfusion-limited hypoxia
    • The first report to demonstrate that arteriolar vasomotion can be involved in intermittent hypoxia
    • Dewhirst, M. W. et al. Microvascular studies on the origins of perfusion-limited hypoxia. Br. J. Cancer Suppl. 27, S247-251 (1996). The first report to demonstrate that arteriolar vasomotion can be involved in intermittent hypoxia.
    • (1996) Br. J. Cancer Suppl , vol.27
    • Dewhirst, M.W.1
  • 62
    • 0041633808 scopus 로고    scopus 로고
    • Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation
    • Erickson, K. et al. Effect of longitudinal oxygen gradients on effectiveness of manipulation of tumor oxygenation. Cancer Res. 63, 4705-4712 (2003).
    • (2003) Cancer Res , vol.63 , pp. 4705-4712
    • Erickson, K.1
  • 63
    • 20344391071 scopus 로고    scopus 로고
    • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development
    • Sorg, B. S., Moeller, B. J., Donovan, O., Cao, Y. & Dewhirst, M. W. Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J. Biomed. Opt. 10, 44004 (2005).
    • (2005) J. Biomed. Opt , vol.10 , pp. 44004
    • Sorg, B.S.1    Moeller, B.J.2    Donovan, O.3    Cao, Y.4    Dewhirst, M.W.5
  • 64
    • 0036716726 scopus 로고    scopus 로고
    • Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas
    • Ljungkvist, A. S. et al. Vascular architecture, hypoxia, and proliferation in first-generation xenografts of human head-and-neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 54, 215-228 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys , vol.54 , pp. 215-228
    • Ljungkvist, A.S.1
  • 65
    • 34248363120 scopus 로고    scopus 로고
    • Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR
    • Devasahayam, N. et al. Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR. Magn. Reson. Med. 57, 776-783 (2007).
    • (2007) Magn. Reson. Med , vol.57 , pp. 776-783
    • Devasahayam, N.1
  • 66
    • 0033891382 scopus 로고    scopus 로고
    • Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas
    • Wijffels, K. I. et al. Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas. Br. J. Cancer 83, 674-683 (2000).
    • (2000) Br. J. Cancer , vol.83 , pp. 674-683
    • Wijffels, K.I.1
  • 67
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • The first report that intermittent hypoxia that is radiobiologically important can be found in tumours
    • Brown, J. M. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br. J. Radiol 52, 650-656 (1979). The first report that intermittent hypoxia that is radiobiologically important can be found in tumours.
    • (1979) Br. J. Radiol , vol.52 , pp. 650-656
    • Brown, J.M.1
  • 68
    • 0017679443 scopus 로고
    • Oxygenation and reoxygenation in 'sandwich' tumours
    • Reinhold, H. S., Blachiwiecz, B. & Blok, A. Oxygenation and reoxygenation in 'sandwich' tumours. Bibl. Anat, 270-272 (1977).
    • (1977) Bibl. Anat , vol.270-272
    • Reinhold, H.S.1    Blachiwiecz, B.2    Blok, A.3
  • 70
    • 33847023140 scopus 로고    scopus 로고
    • Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting
    • Dewhirst, M. W. Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res. 67, 854-855 (2007).
    • (2007) Cancer Res , vol.67 , pp. 854-855
    • Dewhirst, M.W.1
  • 71
    • 0035700693 scopus 로고    scopus 로고
    • Clinical relevance of intermittent tumour blood flow
    • Durand, R. E. & Aquino-Parsons, C. Clinical relevance of intermittent tumour blood flow. Acta Oncol. 40, 929-936 (2001).
    • (2001) Acta Oncol , vol.40 , pp. 929-936
    • Durand, R.E.1    Aquino-Parsons, C.2
  • 72
    • 0023107539 scopus 로고
    • Intermittent blood flow in a murine tumor: Radiobiological effects
    • Chaplin, D. J., Olive, P. L. & Durand, R. E. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res. 47, 597-601 (1987).
    • (1987) Cancer Res , vol.47 , pp. 597-601
    • Chaplin, D.J.1    Olive, P.L.2    Durand, R.E.3
  • 74
    • 0025354544 scopus 로고
    • Intermittent blood flow in the KHT sarcoma - flow cytometry studies using Hoechst 33342
    • Minchinton, A. I., Durand, R. E. & Chaplin, D. J. Intermittent blood flow in the KHT sarcoma - flow cytometry studies using Hoechst 33342. Br. J. Cancer 62, 195-200 (1990).
    • (1990) Br. J. Cancer , vol.62 , pp. 195-200
    • Minchinton, A.I.1    Durand, R.E.2    Chaplin, D.J.3
  • 75
    • 0029954458 scopus 로고    scopus 로고
    • Transient perfusion and radiosensitizing effect after nicotinamide, carbogen, and perflubron emulsion administration
    • Thomas, C. D., Stern, S., Chaplin, D. J. & Guichard, M. Transient perfusion and radiosensitizing effect after nicotinamide, carbogen, and perflubron emulsion administration. Radiother. Oncol. 39, 235-241 (1996).
    • (1996) Radiother. Oncol , vol.39 , pp. 235-241
    • Thomas, C.D.1    Stern, S.2    Chaplin, D.J.3    Guichard, M.4
  • 76
    • 0025737554 scopus 로고
    • Effect of angiotensin II on intermittent tumour blood flow and acute hypoxia in the murine SCCVII carcinoma
    • Trotter, M. J., Chaplin, D. J. & Olive, P. L. Effect of angiotensin II on intermittent tumour blood flow and acute hypoxia in the murine SCCVII carcinoma. Eur. J. Cancer 27, 887-893 (1991).
    • (1991) Eur. J. Cancer , vol.27 , pp. 887-893
    • Trotter, M.J.1    Chaplin, D.J.2    Olive, P.L.3
  • 77
    • 0022469972 scopus 로고
    • Acute hypoxia in tumors: Implications for modifiers of radiation effects
    • Chaplin, D. J., Durand, R. E. & Olive, P. L. Acute hypoxia in tumors: implications for modifiers of radiation effects. Int. J. Radiat. Oncol. Biol. Phys. 12, 1279-1282 (1986).
    • (1986) Int. J. Radiat. Oncol. Biol. Phys , vol.12 , pp. 1279-1282
    • Chaplin, D.J.1    Durand, R.E.2    Olive, P.L.3
  • 78
    • 0035694958 scopus 로고    scopus 로고
    • Intermittent blood flow in solid tumours - an under-appreciated source of 'drug resistance'
    • Durand, R. E. Intermittent blood flow in solid tumours - an under-appreciated source of 'drug resistance'. Cancer Metastasis Rev. 20, 57-61 (2001).
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 57-61
    • Durand, R.E.1
  • 79
    • 0035682917 scopus 로고    scopus 로고
    • Non-constant tumour blood flow - implications for therapy
    • Durand, R. E. & Aquino-Parsons, C. Non-constant tumour blood flow - implications for therapy. Acta Oncol. 40, 862-869 (2001).
    • (2001) Acta Oncol , vol.40 , pp. 862-869
    • Durand, R.E.1    Aquino-Parsons, C.2
  • 80
    • 0030476061 scopus 로고    scopus 로고
    • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
    • The first report to show that intermittent hypoxia can be caused by instabilities in tumour microvessel red cell flux and that vascular stasis is not required for this effect
    • Kimura, H. et al. Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res. 56, 5522-5528 (1996). The first report to show that intermittent hypoxia can be caused by instabilities in tumour microvessel red cell flux and that vascular stasis is not required for this effect.
    • (1996) Cancer Res , vol.56 , pp. 5522-5528
    • Kimura, H.1
  • 81
    • 33644506104 scopus 로고    scopus 로고
    • Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor
    • Lanzen, J. et al. Direct demonstration of instabilities in oxygen concentrations within the extravascular compartment of an experimental tumor. Cancer Res. 66, 2219-2223 (2006).
    • (2006) Cancer Res , vol.66 , pp. 2219-2223
    • Lanzen, J.1
  • 82
    • 0032835231 scopus 로고    scopus 로고
    • Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats
    • Braun, R. D., Lanzen, J. L. & Dewhirst, M. W. Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. Am. J. Physiol. 277, H551-568 (1999).
    • (1999) Am. J. Physiol , vol.277
    • Braun, R.D.1    Lanzen, J.L.2    Dewhirst, M.W.3
  • 83
    • 27944473896 scopus 로고    scopus 로고
    • 2 in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy
    • The first report that intermittent hypoxia can occur in clinically-relevant canine tumours
    • 2 in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy. Radiother. Oncol. 77, 220-226 (2005). The first report that intermittent hypoxia can occur in clinically-relevant canine tumours.
    • (2005) Radiother. Oncol , vol.77 , pp. 220-226
    • Brurberg, K.G.1    Skogmo, H.K.2    Graff, B.A.3    Olsen, D.R.4    Rofstad, E.K.5
  • 84
    • 4344571862 scopus 로고    scopus 로고
    • Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing
    • Cardenas-Navia, L. I. et al. Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing. Cancer Res. 64, 6010-6017 (2004).
    • (2004) Cancer Res , vol.64 , pp. 6010-6017
    • Cardenas-Navia, L.I.1
  • 85
    • 0030200651 scopus 로고    scopus 로고
    • Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry
    • Pigott, K. H., Hill, S. A., Chaplin, D. J. & Saunders, M. I. Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry. Radiother. Oncol. 40, 45-50 (1996).
    • (1996) Radiother. Oncol , vol.40 , pp. 45-50
    • Pigott, K.H.1    Hill, S.A.2    Chaplin, D.J.3    Saunders, M.I.4
  • 86
    • 0036895572 scopus 로고    scopus 로고
    • Orally administered pimonidazole to label hypoxic tumor cells
    • Bennewith, K. L., Raleigh, J. A. & Durand, R. E. Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res. 62, 6827-6830 (2002).
    • (2002) Cancer Res , vol.62 , pp. 6827-6830
    • Bennewith, K.L.1    Raleigh, J.A.2    Durand, R.E.3
  • 87
    • 48649095925 scopus 로고    scopus 로고
    • The pervasive presence of fluctuating oxygenation in tumors
    • in the press
    • Cardenas-Navia, L. I. et al. The pervasive presence of fluctuating oxygenation in tumors. Cancer Res. (in the press).
    • Cancer Res
    • Cardenas-Navia, L.I.1
  • 88
    • 44349193706 scopus 로고    scopus 로고
    • Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors
    • Sorg, B. S., Hardee, M. E., Agarwal, N., Moeller, B. J. & Dewhirst, M. W. Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors. J. Biomed. Opt. 13, 014026 (2008).
    • (2008) J. Biomed. Opt , vol.13 , pp. 014026
    • Sorg, B.S.1    Hardee, M.E.2    Agarwal, N.3    Moeller, B.J.4    Dewhirst, M.W.5
  • 89
    • 4444292601 scopus 로고    scopus 로고
    • Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: A marker of tumour acute hypoxia?
    • Baudelet, C. et al. Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia? Phys. Med. Biol. 49, 3389-3411 (2004).
    • (2004) Phys. Med. Biol , vol.49 , pp. 3389-3411
    • Baudelet, C.1
  • 90
    • 35148853125 scopus 로고    scopus 로고
    • Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI
    • Brurberg, K. G., Benjaminsen, I. C., Dorum, L. M. & Rofstad, E. K. Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI. Magn. Reson. Med. 58, 473-481 (2007).
    • (2007) Magn. Reson. Med , vol.58 , pp. 473-481
    • Brurberg, K.G.1    Benjaminsen, I.C.2    Dorum, L.M.3    Rofstad, E.K.4
  • 91
    • 32844470756 scopus 로고    scopus 로고
    • The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors
    • Baudelet, C. et al. The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors. NMR Biomed. 19, 69-76 (2006).
    • (2006) NMR Biomed , vol.19 , pp. 69-76
    • Baudelet, C.1
  • 92
    • 0029986979 scopus 로고    scopus 로고
    • Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: A novel mechanism of tumor angiogenesis
    • This paper is the first to connect the concept of vascular remodelling as a putative mechanism for intermittent hypoxia
    • Patan, S., Munn, L. L. & Jain, R. K. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc. Res. 51, 260-272 (1996). This paper is the first to connect the concept of vascular remodelling as a putative mechanism for intermittent hypoxia.
    • (1996) Microvasc. Res , vol.51 , pp. 260-272
    • Patan, S.1    Munn, L.L.2    Jain, R.K.3
  • 93
    • 0001229895 scopus 로고
    • eds Renkin, E. M, Michel, C. & Geiger, S. R, American Physiological Society, Bethesda
    • Chien, S., Usami, S. & Skalak, R. in Handbook of Physiology (eds Renkin, E. M., Michel, C. & Geiger, S. R.) 217-251 (American Physiological Society, Bethesda, 1984).
    • (1984) Handbook of Physiology , pp. 217-251
    • Chien, S.1    Usami, S.2    Skalak, R.3
  • 94
    • 0028270939 scopus 로고
    • Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms
    • Kiani, M. F., Pries, A. R., Hsu, L. L., Sarelius, I. H. & Cokelet, G. R. Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms. Am. J. Physiol. 266, H1822-H1828 (1994).
    • (1994) Am. J. Physiol , vol.266
    • Kiani, M.F.1    Pries, A.R.2    Hsu, L.L.3    Sarelius, I.H.4    Cokelet, G.R.5
  • 96
    • 0027536635 scopus 로고
    • The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment
    • Kavanagh, B. D., Coffey, B. E., Needham, D., Hochmuth, R. M. & Dewhirst, M. W. The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment. Br. J. Cancer 67, 734-741 (1993).
    • (1993) Br. J. Cancer , vol.67 , pp. 734-741
    • Kavanagh, B.D.1    Coffey, B.E.2    Needham, D.3    Hochmuth, R.M.4    Dewhirst, M.W.5
  • 97
    • 21344454671 scopus 로고    scopus 로고
    • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation
    • This paper provides evidence in a preclinical model that hypoxia is not a prerequisite for the initiation of tumour angiogenesis
    • Cao, Y. et al. Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. Cancer Res. 65, 5498-5505 (2005). This paper provides evidence in a preclinical model that hypoxia is not a prerequisite for the initiation of tumour angiogenesis.
    • (2005) Cancer Res , vol.65 , pp. 5498-5505
    • Cao, Y.1
  • 98
    • 37049004518 scopus 로고    scopus 로고
    • 18F-fluoromisonidazole in head and neck cancer
    • 18F-fluoromisonidazole in head and neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 70, 235-242 (2008).
    • (2008) Int. J. Radiat. Oncol. Biol. Phys , vol.70 , pp. 235-242
    • Nehmeh, S.A.1
  • 99
    • 33751329032 scopus 로고    scopus 로고
    • Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    • Peng, Y. J. et al. Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J. Physiol. 577, 705-716 (2006).
    • (2006) J. Physiol , vol.577 , pp. 705-716
    • Peng, Y.J.1
  • 100
    • 14244256421 scopus 로고    scopus 로고
    • 2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia
    • 2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J. Biol. Chem. 280, 4321-4328 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 4321-4328
    • Yuan, G.1    Nanduri, J.2    Bhasker, C.R.3    Semenza, G.L.4    Prabhakar, N.R.5
  • 101
    • 34547883937 scopus 로고    scopus 로고
    • HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia
    • Semenza, G. L. & Prabhakar, N. R. HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxid. Redox Signal. 9, 1391-1396 (2007).
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 1391-1396
    • Semenza, G.L.1    Prabhakar, N.R.2
  • 102
    • 34848884803 scopus 로고    scopus 로고
    • Intermittent hypoxia changes HIF-1α phosphorylation pattern in endothelial cells: Unravelling of a new PKA-dependent regulation of HIF-1α
    • Toffoli, S., Feron, O., Raes, M. & Michiels, C. Intermittent hypoxia changes HIF-1α phosphorylation pattern in endothelial cells: unravelling of a new PKA-dependent regulation of HIF-1α. Biochim. Biophys. Acta 1773, 1558-1571 (2007).
    • (2007) Biochim. Biophys. Acta , vol.1773 , pp. 1558-1571
    • Toffoli, S.1    Feron, O.2    Raes, M.3    Michiels, C.4
  • 103
    • 33846204728 scopus 로고    scopus 로고
    • Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: Implications for anticancer therapies
    • This report shows that HIF1 upregulation is more strongly induced by repeated exposures to hypoxia-reoxygenation than by chronic hypoxia
    • Martinive, P. et al. Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies. Cancer Res. 66, 11736-11744 (2006). This report shows that HIF1 upregulation is more strongly induced by repeated exposures to hypoxia-reoxygenation than by chronic hypoxia.
    • (2006) Cancer Res , vol.66 , pp. 11736-11744
    • Martinive, P.1
  • 104
    • 0027244947 scopus 로고
    • Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies
    • Sioussat, T. M., Dvorak, H. F., Brock, T. A. & Senger, D. R. Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies. Arch. Biochem. Biophys. 301, 15-20 (1993).
    • (1993) Arch. Biochem. Biophys , vol.301 , pp. 15-20
    • Sioussat, T.M.1    Dvorak, H.F.2    Brock, T.A.3    Senger, D.R.4
  • 105
    • 0023039225 scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines
    • Senger, D. R., Perruzzi, C. A., Feder, J. & Dvorak, H. F. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res. 46, 5629-5632 (1986).
    • (1986) Cancer Res , vol.46 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3    Dvorak, H.F.4
  • 106
    • 0024384470 scopus 로고
    • Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
    • This is the first report that VEGF is a mitogen for endothelial cells
    • Ferrara, N. & Henzel, W. J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun 161, 851-858 (1989). This is the first report that VEGF is a mitogen for endothelial cells.
    • (1989) Biochem. Biophys. Res. Commun , vol.161 , pp. 851-858
    • Ferrara, N.1    Henzel, W.J.2
  • 107
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D. W., Cachianes, G., Kuang, W. J., Goeddel, D. V. & Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309 (1989).
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 108
    • 0029949160 scopus 로고    scopus 로고
    • Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
    • Yuan, F. et al. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proc. Natl Acad. Sci. USA 93, 14765-14770 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 14765-14770
    • Yuan, F.1
  • 109
    • 0033580889 scopus 로고    scopus 로고
    • Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
    • This report is the first to theorize that a hypoxic crisis, mediated by regression of coopted host microvasculature, may be required for tumour angiogenesis initiation
    • Holash, J. et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 284, 1994-1998 (1999). This report is the first to theorize that a hypoxic crisis, mediated by regression of coopted host microvasculature, may be required for tumour angiogenesis initiation.
    • (1999) Science , vol.284 , pp. 1994-1998
    • Holash, J.1
  • 110
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: Dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash, J., Wiegand, S. J. & Yancopoulos, G. D. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18, 5356-5362 (1999).
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 111
    • 0030726988 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth
    • This is the first paper demonstrating the importance of TIE2, the receptor for angiopoietins, as a pro-angiogenic endothelial cell receptor in tumours
    • Lin, P. et al. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. J. Clin. Invest. 100, 2072-2078 (1997). This is the first paper demonstrating the importance of TIE2, the receptor for angiopoietins, as a pro-angiogenic endothelial cell receptor in tumours.
    • (1997) J. Clin. Invest , vol.100 , pp. 2072-2078
    • Lin, P.1
  • 112
    • 2342440066 scopus 로고    scopus 로고
    • Functional significance of Tie2 signaling in the adult vasculature
    • Peters, K. G. et al. Functional significance of Tie2 signaling in the adult vasculature. Recent Prog. Horm. Res. 59, 51-71 (2004).
    • (2004) Recent Prog. Horm. Res , vol.59 , pp. 51-71
    • Peters, K.G.1
  • 113
    • 3543074874 scopus 로고
    • Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor)
    • Winkles, J. A. et al. Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor). Proc. Natl Acad. Sci. USA 84, 7124-7128 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 7124-7128
    • Winkles, J.A.1
  • 114
    • 0032549799 scopus 로고    scopus 로고
    • Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
    • Soker, S., Takashima, S., Miao, H. Q., Neufeld, G. & Klagsbrun, M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92, 735-745 (1998).
    • (1998) Cell , vol.92 , pp. 735-745
    • Soker, S.1    Takashima, S.2    Miao, H.Q.3    Neufeld, G.4    Klagsbrun, M.5
  • 115
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression
    • Mazure, N. M., Chen, E. Y., Yeh, P., Laderoute, K. R. & Giaccia, A. J. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 56, 3436-3440 (1996).
    • (1996) Cancer Res , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Laderoute, K.R.4    Giaccia, A.J.5
  • 117
    • 0033924882 scopus 로고    scopus 로고
    • Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor
    • Laderoute, K. R. et al. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin. Cancer Res. 6, 2941-2950 (2000).
    • (2000) Clin. Cancer Res , vol.6 , pp. 2941-2950
    • Laderoute, K.R.1
  • 118
    • 34248215798 scopus 로고    scopus 로고
    • Steinman, S., Wang, J., Bourne, P., Yang, Q. & Tang, P. Expression of cytokeratin markers, ER-α, PR, HER-2/neu, and EGFR in pure ductal carcinoma in situ (DCIS) and DCIS with co-existing invasive ductal carcinoma (IDC) of the breast. Ann. Clin. Lab. Sci. 37, 127-134 (2007).
    • Steinman, S., Wang, J., Bourne, P., Yang, Q. & Tang, P. Expression of cytokeratin markers, ER-α, PR, HER-2/neu, and EGFR in pure ductal carcinoma in situ (DCIS) and DCIS with co-existing invasive ductal carcinoma (IDC) of the breast. Ann. Clin. Lab. Sci. 37, 127-134 (2007).
  • 119
    • 33750321934 scopus 로고    scopus 로고
    • Basal phenotype of ductal carcinoma in situ: Recognition and immunohistologic profile
    • Dabbs, D. J., Chivukula, M., Carter, G. & Bhargava, R. Basal phenotype of ductal carcinoma in situ: recognition and immunohistologic profile. Mod. Pathol. 19, 1506-1511 (2006).
    • (2006) Mod. Pathol , vol.19 , pp. 1506-1511
    • Dabbs, D.J.1    Chivukula, M.2    Carter, G.3    Bhargava, R.4
  • 120
    • 33947358207 scopus 로고    scopus 로고
    • Mutant p53 facilitates proangiogenic, hyperproliferative phenotype in response to chronic relative hypoxia
    • Kamat, C. D. et al. Mutant p53 facilitates proangiogenic, hyperproliferative phenotype in response to chronic relative hypoxia. Cancer Lett. 249, 209-219 (2007).
    • (2007) Cancer Lett , vol.249 , pp. 209-219
    • Kamat, C.D.1
  • 121
    • 34250624498 scopus 로고    scopus 로고
    • Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck
    • Zhou, S. et al. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc. Natl Acad. Sci. USA 104, 7540-7545 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7540-7545
    • Zhou, S.1
  • 122
    • 0033051030 scopus 로고    scopus 로고
    • Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras
    • Feldkamp, M. M., Lau, N., Rak, J., Kerbel, R. S. & Guha, A. Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras. Int. J. Cancer 81, 118-124 (1999).
    • (1999) Int. J. Cancer , vol.81 , pp. 118-124
    • Feldkamp, M.M.1    Lau, N.2    Rak, J.3    Kerbel, R.S.4    Guha, A.5
  • 123
    • 39049112846 scopus 로고    scopus 로고
    • AKT signaling in regulating angiogenesis
    • Jiang, B. H. & Liu, L. Z. AKT signaling in regulating angiogenesis. Curr. Cancer Drug Targets 8, 19-26 (2008).
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 19-26
    • Jiang, B.H.1    Liu, L.Z.2
  • 124
    • 33644763050 scopus 로고    scopus 로고
    • A model of human tumor dormancy: An angiogenic switch from the nonangiogenic phenotype
    • Naumov, G. N. et al. A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J. Natl Cancer Inst. 98, 316-325 (2006).
    • (2006) J. Natl Cancer Inst , vol.98 , pp. 316-325
    • Naumov, G.N.1
  • 125
    • 2342584137 scopus 로고    scopus 로고
    • Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia
    • The first report that vessel cooption can occur in human cancer
    • Stessels, F. et al. Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. Br. J. Cancer 90, 1429-1436 (2004). The first report that vessel cooption can occur in human cancer.
    • (2004) Br. J. Cancer , vol.90 , pp. 1429-1436
    • Stessels, F.1
  • 126
    • 0038509263 scopus 로고    scopus 로고
    • Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition
    • Colpaert, C. G. et al. Cutaneous breast cancer deposits show distinct growth patterns with different degrees of angiogenesis, hypoxia and fibrin deposition. Histopathology 42, 530-540 (2003).
    • (2003) Histopathology , vol.42 , pp. 530-540
    • Colpaert, C.G.1
  • 127
    • 0035925072 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 α during breast carcinogenesis
    • Bos, R. et al. Levels of hypoxia-inducible factor-1 α during breast carcinogenesis. J. Natl Cancer Inst. 93, 309-314 (2001).
    • (2001) J. Natl Cancer Inst , vol.93 , pp. 309-314
    • Bos, R.1
  • 128
    • 0036794753 scopus 로고    scopus 로고
    • Angioadaptation: Keeping the vascular system in shape
    • Zakrzewicz, A., Secomb, T. W. & Pries, A. R. Angioadaptation: keeping the vascular system in shape. News Physiol. Sci. 17, 197-201 (2002).
    • (2002) News Physiol. Sci , vol.17 , pp. 197-201
    • Zakrzewicz, A.1    Secomb, T.W.2    Pries, A.R.3
  • 129
    • 0033194695 scopus 로고    scopus 로고
    • Chemo-radiotherapy: Radiosensitizing nucleoside analogues (review)
    • Gregoire, V., Hittelman, W. N., Rosier, J. F. & Milas, L. Chemo-radiotherapy: radiosensitizing nucleoside analogues (review). Oncol. Rep. 6, 949-957 (1999).
    • (1999) Oncol. Rep , vol.6 , pp. 949-957
    • Gregoire, V.1    Hittelman, W.N.2    Rosier, J.F.3    Milas, L.4
  • 130
    • 0034114513 scopus 로고    scopus 로고
    • Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line
    • Bussink, J., Kaanders, J. H., Rijken, P. F., Raleigh, J. A. & van der Kogel, A. J. Changes in blood perfusion and hypoxia after irradiation of a human squamous cell carcinoma xenograft tumor line. Radiat. Res. 153, 398-404 (2000).
    • (2000) Radiat. Res , vol.153 , pp. 398-404
    • Bussink, J.1    Kaanders, J.H.2    Rijken, P.F.3    Raleigh, J.A.4    van der Kogel, A.J.5
  • 131
    • 0006929776 scopus 로고    scopus 로고
    • Milas, L., Milross, C. G. & Mason, K. A. Cytotoxic treatments and tumor oxygenation. Cancer J. Sci. Am. 2, 59-60; author reply 60-61 (1996).
    • Milas, L., Milross, C. G. & Mason, K. A. Cytotoxic treatments and tumor oxygenation. Cancer J. Sci. Am. 2, 59-60; author reply 60-61 (1996).
  • 132
    • 0029144003 scopus 로고
    • Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel
    • Milas, L. et al. Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res. 55, 3564-3568 (1995).
    • (1995) Cancer Res , vol.55 , pp. 3564-3568
    • Milas, L.1
  • 133
    • 0029031276 scopus 로고
    • Tumor reoxygenation as a mechanism of taxol-induced enhancement of tumor radioresponse
    • Milas, L., Hunter, N., Mason, K. A., Milross, C. & Peters, L. J. Tumor reoxygenation as a mechanism of taxol-induced enhancement of tumor radioresponse. Acta Oncol. 34, 409-412 (1995).
    • (1995) Acta Oncol , vol.34 , pp. 409-412
    • Milas, L.1    Hunter, N.2    Mason, K.A.3    Milross, C.4    Peters, L.J.5
  • 134
    • 0013963522 scopus 로고    scopus 로고
    • Rubin, P. & Casarett, G. Microcirculation of tumors. II. The supervascularized state of irradiated regressing tumors. Clin. Radiol. 17, 346-355 (1966). This paper was the first to suggest that radiation therapy induced a change in tumour vascular density that would favour increased oxygenation.
    • Rubin, P. & Casarett, G. Microcirculation of tumors. II. The supervascularized state of irradiated regressing tumors. Clin. Radiol. 17, 346-355 (1966). This paper was the first to suggest that radiation therapy induced a change in tumour vascular density that would favour increased oxygenation.
  • 135
    • 0025267979 scopus 로고
    • Heterogeneity in tumor microvascular response to radiation
    • Dewhirst, M. W. et al. Heterogeneity in tumor microvascular response to radiation. Int. J. Radiat. Oncol. Biol. Phys 18, 559-568 (1990).
    • (1990) Int. J. Radiat. Oncol. Biol. Phys , vol.18 , pp. 559-568
    • Dewhirst, M.W.1
  • 136
    • 2342611976 scopus 로고    scopus 로고
    • Moeller, B. J., Cao, Y., Li, C. Y. & Dewhirst, M. W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429-441 (2004). This paper demonstrated that tumour reoxygenation after radiotherapy paradoxically led to an increase in HIF1 activity through mechanisms involving free radical generation and stress granule disaggregation.
    • Moeller, B. J., Cao, Y., Li, C. Y. & Dewhirst, M. W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429-441 (2004). This paper demonstrated that tumour reoxygenation after radiotherapy paradoxically led to an increase in HIF1 activity through mechanisms involving free radical generation and stress granule disaggregation.
  • 137
    • 24944488889 scopus 로고    scopus 로고
    • A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness
    • Moeller, B. J. et al. A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. Int. J. Radiat. Oncol. Biol. Phys. 63, 545-552 (2005).
    • (2005) Int. J. Radiat. Oncol. Biol. Phys , vol.63 , pp. 545-552
    • Moeller, B.J.1
  • 138
    • 23644453277 scopus 로고    scopus 로고
    • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
    • Moeller, B. J. et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8, 99-110 (2005).
    • (2005) Cancer Cell , vol.8 , pp. 99-110
    • Moeller, B.J.1
  • 139
    • 20944449117 scopus 로고    scopus 로고
    • Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1
    • Williams, K. J. et al. Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiother. Oncol. 75, 89-98 (2005).
    • (2005) Radiother. Oncol , vol.75 , pp. 89-98
    • Williams, K.J.1
  • 140
    • 0033611157 scopus 로고    scopus 로고
    • RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 α to the assembly of mammalian stress granules
    • Kedersha, N. L., Gupta, M., Li, W., Miller, I. & Anderson, P. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 α to the assembly of mammalian stress granules. J. Cell Biol. 147, 1431-1442 (1999).
    • (1999) J. Cell Biol , vol.147 , pp. 1431-1442
    • Kedersha, N.L.1    Gupta, M.2    Li, W.3    Miller, I.4    Anderson, P.5
  • 141
    • 34447132029 scopus 로고    scopus 로고
    • Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1α-mediated tumor apoptotic switch
    • Magnon, C. et al. Radiation and inhibition of angiogenesis by canstatin synergize to induce HIF-1α-mediated tumor apoptotic switch. J. Clin. Invest. 117, 1844-1855 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1844-1855
    • Magnon, C.1
  • 142
    • 33751543273 scopus 로고    scopus 로고
    • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    • Tatum, J. L. et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int. J. Radiat. Biol. 82, 699-757 (2006).
    • (2006) Int. J. Radiat. Biol , vol.82 , pp. 699-757
    • Tatum, J.L.1
  • 145
    • 34447500409 scopus 로고    scopus 로고
    • 2 measurements by electron paramagnetic resonance oximetry: Current status and future potential for experimental and clinical studies
    • 2 measurements by electron paramagnetic resonance oximetry: current status and future potential for experimental and clinical studies. Antioxid. Redox Signal. 9, 1169-1182 (2007).
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 1169-1182
    • Khan, N.1    Williams, B.B.2    Hou, H.3    Li, H.4    Swartz, H.M.5
  • 146
    • 34447515693 scopus 로고    scopus 로고
    • Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomography
    • Srinivasan, S. et al. Developments in quantitative oxygen-saturation imaging of breast tissue in vivo using multispectral near-infrared tomography. Antioxid. Redox Signal. 9, 1143-1156 (2007).
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 1143-1156
    • Srinivasan, S.1
  • 148
    • 0036048395 scopus 로고    scopus 로고
    • Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5
    • Koch, C. J. Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5. Methods Enzymol. 352, 3-31 (2002).
    • (2002) Methods Enzymol , vol.352 , pp. 3-31
    • Koch, C.J.1
  • 149
    • 0028839715 scopus 로고    scopus 로고
    • Koch, C. J., Evans, S. M. & Lord, E. M. Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide]: analysis of drug adducts by fluorescent antibodies vs bound radioactivity. Br. J. Cancer 72, 869-874 (1995).
    • Koch, C. J., Evans, S. M. & Lord, E. M. Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2, 2, 3, 3, 3-pentafluoropropyl) acetamide]: analysis of drug adducts by fluorescent antibodies vs bound radioactivity. Br. J. Cancer 72, 869-874 (1995).
  • 150
    • 0037223816 scopus 로고    scopus 로고
    • Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles
    • Koch, C. J. & Evans, S. M. Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles. Adv. Exp. Med. Biol. 510, 285-292 (2003).
    • (2003) Adv. Exp. Med. Biol , vol.510 , pp. 285-292
    • Koch, C.J.1    Evans, S.M.2
  • 152
    • 34447503754 scopus 로고    scopus 로고
    • The potential role of intrinsic hypoxia markers as prognostic variables in cancer
    • Moon, E. J., Brizel, D. M., Chi, J. T. & Dewhirst, M. W. The potential role of intrinsic hypoxia markers as prognostic variables in cancer. Antioxid. Redox Signal. 9, 1237-1294 (2007).
    • (2007) Antioxid. Redox Signal , vol.9 , pp. 1237-1294
    • Moon, E.J.1    Brizel, D.M.2    Chi, J.T.3    Dewhirst, M.W.4
  • 153
    • 34547842084 scopus 로고    scopus 로고
    • Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas
    • Le, Q. T. et al. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 69, 167-175 (2007).
    • (2007) Int. J. Radiat. Oncol. Biol. Phys , vol.69 , pp. 167-175
    • Le, Q.T.1
  • 155
    • 0029035872 scopus 로고
    • Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors
    • Secomb, T. W., Hsu, R., Ong, E. T., Gross, J. F. & Dewhirst, M. W. Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 34, 313-316 (1995).
    • (1995) Acta Oncol , vol.34 , pp. 313-316
    • Secomb, T.W.1    Hsu, R.2    Ong, E.T.3    Gross, J.F.4    Dewhirst, M.W.5
  • 156
    • 34250219672 scopus 로고    scopus 로고
    • Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy
    • Dewhirst, M. W., Cao, Y., Li, C. Y. & Moeller, B. Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. Radiother. Oncol. 83, 249-255 (2007).
    • (2007) Radiother. Oncol , vol.83 , pp. 249-255
    • Dewhirst, M.W.1    Cao, Y.2    Li, C.Y.3    Moeller, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.