-
1
-
-
0014691242
-
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
-
McCord, J. M. & Fridovich, I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244, 6049-6055 (1969). The authors describe the discovery of superoxide dismutase and provide an elegant example of the value of basic, rather than disease-oriented, investigations in making fundamentally important discoveries with widespread implications in normal biology and pathology.
-
(1969)
J. Biol. Chem.
, vol.224
, pp. 6049-6055
-
-
McCord, J.M.1
Fridovich, I.2
-
2
-
-
0035503501
-
Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics
-
Melov, S. et al. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21, 8348-8353 (2001).
-
(2001)
J. Neurosci.
, vol.21
, pp. 8348-8353
-
-
Melov, S.1
-
3
-
-
0033517275
-
Cell transformation by the superoxide-generating oxidase Mox1
-
Suh, Y.-A. et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401, 79-82 (1999). This paper describes the discovery of the first homologue of NADPH oxidase (NOX), NOX1 (originally known as MOX1), and its expression. The article, which proposed a growth-regulatory role for NOX1, has stimulated investigations into the role of NOX enzymes in cardiovascular disease and cancer.
-
(1999)
Nature
, vol.401
, pp. 79-82
-
-
Suh, Y.-A.1
-
4
-
-
0034306112
-
Novel homologs of gp 91phox
-
Lambeth, J. D., Cheng, G., Arnold, R. S. & Edens, W. E. Novel homologs of gp91phox. Trends Biochem. Sci. 25, 459-461 (2000).
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 459-461
-
-
Lambeth, J.D.1
Cheng, G.2
Arnold, R.S.3
Edens, W.E.4
-
5
-
-
0037082101
-
The neutrophil NADPH oxidase
-
Babior, B. M., Lambeth, J. D. & Nauseef, W. The neutrophil NADPH oxidase. Arch. Biochem. Biophys. 397, 342-344 (2002).
-
(2002)
Arch. Biochem. Biophys.
, vol.397
, pp. 342-344
-
-
Babior, B.M.1
Lambeth, J.D.2
Nauseef, W.3
-
6
-
-
0034608934
-
Identification of renox, an NAD(P)H oxidase in kidney
-
Geiszt, M., Kopp, J. B., Varnai, P. & Leto, T. L. Identification of renox, an NAD(P)H oxidase in kidney. Proc. Natl Acad. Sci. USA 97, 8010-8014 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 8010-8014
-
-
Geiszt, M.1
Kopp, J.B.2
Varnai, P.3
Leto, T.L.4
-
7
-
-
0035847051
-
A novel superoxide-producing NAD(P)H oxidase in kidney
-
Shiose, A. et al. A novel superoxide-producing NAD(P)H oxidase in kidney. J. Biol. Chem. 276, 1417-1423 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 1417-1423
-
-
Shiose, A.1
-
8
-
-
0032546955
-
Reversible inactivation of protein tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor
-
Lee, S.-R., Kwon, K.-S., Kim, S.-R. & Rhee, S. G. Reversible inactivation of protein tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J. Biol. Chem. 273, 15366-15372 (1998). This paper describes a mechanism by which reactive oxygen can act as a signal to regulate the function of enzymes such as protein tyrosine phosphatases, implying that reactive oxygen is involved in posttranslational modification of proteins in a manner that is analogous to regulatory protein phosphorylations.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15366-15372
-
-
Lee, S.-R.1
Kwon, K.-S.2
Kim, S.-R.3
Rhee, S.G.4
-
10
-
-
0036184190
-
Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
-
Meng, T. C., Fukada, T. & Tonks, N. K. Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol. Cell 9, 387-399 (2002).
-
(2002)
Mol. Cell
, vol.9
, pp. 387-399
-
-
Meng, T.C.1
Fukada, T.2
Tonks, N.K.3
-
11
-
-
0035813159
-
2+-activated NADPH oxidase in testis, spleen and lymph nodes
-
2+-activated NADPH oxidase in testis, spleen and lymph nodes. J. Biol. Chem. 276, 37594-37601 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 37594-37601
-
-
Banfi, B.1
-
12
-
-
0026625050
-
X-ray crystal structure of canine myeloperoxidase at 3 A resolution
-
Zeng, J. & Fenna, R. E. X-ray crystal structure of canine myeloperoxidase at 3 A resolution. J. Mol. Biol. 226, 185-207 (1992).
-
(1992)
J. Mol. Biol.
, vol.226
, pp. 185-207
-
-
Zeng, J.1
Fenna, R.E.2
-
13
-
-
0035921417
-
Tyrosine crosslinking of extracellullar matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox
-
Edens, W.A. et al. Tyrosine crosslinking of extracellullar matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. J. Cell Biol. 154, 879-891 (2001). The authors use biochemistry and reverse genetics in Caenorhabditis elegans to show the function of dual oxidase (Duox) in the oxidative modification of the worm cuticle, providing evidence for a general function of Duox in the modification of the extracellular matrix or other extracellular molecules.
-
(2001)
J. Cell Biol.
, vol.154
, pp. 879-891
-
-
Edens, W.A.1
-
14
-
-
0036710445
-
The superoxide-generating NADPH oxidase: Structural aspects and activation mechanism
-
Vignais, P. V. The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell. Mol. Life Sci. 59, 1428-1459 (2002).
-
(2002)
Cell. Mol. Life Sci.
, vol.59
, pp. 1428-1459
-
-
Vignais, P.V.1
-
15
-
-
0037446850
-
Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation
-
Ago, T. et al. Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation. Proc. Natl Acad. Sci. USA 100, 4474-4479 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 4474-4479
-
-
Ago, T.1
-
16
-
-
0037722978
-
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
-
Groemping, Y., Lapouge, K., Smerdon, S. J. & Rittinger, K. Molecular basis of phosphorylation-induced activation of the NADPH oxidase. Cell 113, 343-355 (2003). This paper reports on the structure of p47phox domains and provides a structural rationale for the function of p47phox as a phosphorylation-regulated organizing protein that helps to orchestrate the assembly of the phagocyte NOX (Phox).
-
(2003)
Cell
, vol.113
, pp. 343-355
-
-
Groemping, Y.1
Lapouge, K.2
Smerdon, S.J.3
Rittinger, K.4
-
17
-
-
0034995037
-
Solution structure of the PX domain, a target of the SH 3 domain
-
Hiroaki, H., Ago, T., Ito, T., Sumimoto, H. & Kohda, D. Solution structure of the PX domain, a target of the SH3 domain. Nature Struct. Biol. 8, 526-530 (2001).
-
(2001)
Nature Struct. Biol.
, vol.8
, pp. 526-530
-
-
Hiroaki, H.1
Ago, T.2
Ito, T.3
Sumimoto, H.4
Kohda, D.5
-
18
-
-
0032479170
-
Regulation of the neutrophil respiratory burst oxidase: Identification of an activation domain in p 67phox
-
Han, C.-H., Freeman, J. L. R., Lee, T., Motalebi, S. A. & Lambeth, J. D. Regulation of the neutrophil respiratory burst oxidase: identification of an activation domain in p67phox. J. Biol. Chem. 273, 16663-16668 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 16663-16668
-
-
Han, C.-H.1
Freeman, J.L.R.2
Lee, T.3
Motalebi, S.A.4
Lambeth, J.D.5
-
20
-
-
0038789165
-
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1
-
Banfi, B., Clark, R. A., Steger, K. & Krause, K. H. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J. Biol. Chem. 278, 3510-3513 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3510-3513
-
-
Banfi, B.1
Clark, R.A.2
Steger, K.3
Krause, K.H.4
-
21
-
-
0038036799
-
Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells
-
Geiszt, M., Lekstrom, K., Witta, J. & Leto, T. L. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J. Biol. Chem. 278, 20006-20012 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20006-20012
-
-
Geiszt, M.1
Lekstrom, K.2
Witta, J.3
Leto, T.L.4
-
22
-
-
0042991381
-
Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases
-
Takeya, R. et al. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J. Biol. Chem. 278, 25234-25246 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25234-25246
-
-
Takeya, R.1
-
23
-
-
1042289744
-
NOXO1, regulation of lipid binding, localization and activation of Nox1 by the phox homology (PX) domain
-
Cheng, G. & Lambeth, J. D. NOXO1, regulation of lipid binding, localization and activation of Nox1 by the phox homology (PX) domain. J. Biol. Chem. 279, 4737-4742 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 4737-4742
-
-
Cheng, G.1
Lambeth, J.D.2
-
24
-
-
0033601327
-
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase
-
2)-generating enzyme in the thyroid gland, which subsequently was identified by molecular cloning to be DUOX.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37265-37269
-
-
Dupuy, C.1
-
25
-
-
0032577707
-
PU 1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91(phox) expression
-
Eklund, E. A., Jalava, A. & Kakar, R. PU. 1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91(phox) expression. J. Biol. Chem. 273, 13957-13965 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13957-13965
-
-
Eklund, E.A.1
Jalava, A.2
Kakar, R.3
-
26
-
-
0035844030
-
Novel gp91(phox) homologues in vascular smooth muscle cells: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways
-
Lassegue, B. et al. Novel gp91(phox) homologues in vascular smooth muscle cells: Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ. Res. 88, 888-894 (2001).
-
(2001)
Circ. Res.
, vol.88
, pp. 888-894
-
-
Lassegue, B.1
-
27
-
-
0038205912
-
NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91(phox) in the regulated production of superoxide by phagocytes
-
Geiszt, M. et al. NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91(phox) in the regulated production of superoxide by phagocytes. J. Immunol. 171, 299-306 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 299-306
-
-
Geiszt, M.1
-
28
-
-
0035584538
-
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo
-
Wingler, K. et al. Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Free Radic. Biol. Med. 31, 1456-1464 (2001).
-
(2001)
Free Radic. Biol. Med.
, vol.31
, pp. 1456-1464
-
-
Wingler, K.1
-
29
-
-
0030095103
-
The NADPH oxidase and chronic granulomatous disease
-
Segal, A. W. The NADPH oxidase and chronic granulomatous disease. Mol. Med. Today 2, 129-135 (1996).
-
(1996)
Mol. Med. Today
, vol.2
, pp. 129-135
-
-
Segal, A.W.1
-
30
-
-
0037177615
-
Immunology, Lethal weapons
-
Roos, D. & Winterbourn, C. C. Immunology, Lethal weapons. Science 296, 669-671 (2002).
-
(2002)
Science
, vol.296
, pp. 669-671
-
-
Roos, D.1
Winterbourn, C.C.2
-
31
-
-
0037149510
-
+ flux
-
+ flux. Nature 416, 291-297 (2002). This article describes the activation of ion fluxes by activation of Phox, and hypothesizes that bacterial killing involves a change in the ionic environment of the phagosome, which in turn activates microbicidal proteases. Reactive oxygen species (ROS)-mediated oxidations might therefore be less important than NOX activation of ion channels in microbial killing by Phox.
-
(2002)
Nature
, vol.416
, pp. 291-297
-
-
Reeves, E.P.1
-
32
-
-
0034977290
-
Type I Helicobacter pylori lipopolysaccharide stimulates toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells
-
Kawahara, T. et al. Type I Helicobacter pylori lipopolysaccharide stimulates toll-like receptor 4 and activates mitogen oxidase 1 in gastric pit cells. Infect. Immun. 69, 4382-4389 (2001).
-
(2001)
Infect. Immun.
, vol.69
, pp. 4382-4389
-
-
Kawahara, T.1
-
33
-
-
0031787341
-
Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system
-
Teshima, S., Rokutan, K., Nikawa, T. & Kishi, K. Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system. Gastroenterology 115, 1186-1196 (1998).
-
(1998)
Gastroenterology
, vol.115
, pp. 1186-1196
-
-
Teshima, S.1
Rokutan, K.2
Nikawa, T.3
Kishi, K.4
-
34
-
-
0028084859
-
Antibacterial activity of hydrogen peroxide and the lactoperoxidase-hydrogen peroxide-thiocyanate system against oral streptococci
-
Thomas, E. L., Milligan, T. W., Joyner, R. E. & Jefferson, M. M. Antibacterial activity of hydrogen peroxide and the lactoperoxidase-hydrogen peroxide-thiocyanate system against oral streptococci. Infect. Immun. 62, 529-535 (1994).
-
(1994)
Infect. Immun.
, vol.62
, pp. 529-535
-
-
Thomas, E.L.1
Milligan, T.W.2
Joyner, R.E.3
Jefferson, M.M.4
-
35
-
-
0042203535
-
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense
-
Geiszt, M., Witta, J., Baffi, J., Lekstrom, K. & Leto, T. L. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 17, 1502-1504 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 1502-1504
-
-
Geiszt, M.1
Witta, J.2
Baffi, J.3
Lekstrom, K.4
Leto, T.L.5
-
36
-
-
0028918334
-
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation
-
Burdon, R. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 18, 775-794 (1995).
-
(1995)
Free Radic. Biol. Med.
, vol.18
, pp. 775-794
-
-
Burdon, R.1
-
37
-
-
0035826733
-
Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
-
Arnold, R. S. et al. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc. Natl Acad. Sci. USA 98, 5550-5555 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5550-5555
-
-
Arnold, R.S.1
-
38
-
-
0037303555
-
Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cells
-
Pemer, A., Andresen, L., Pedersen, G. & Rask-Madsen, J. Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cells. Gut 52, 231-236 (2003).
-
(2003)
Gut
, vol.52
, pp. 231-236
-
-
Pemer, A.1
Andresen, L.2
Pedersen, G.3
Rask-Madsen, J.4
-
39
-
-
0141730304
-
Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes
-
Chamulitrat, W. et al. Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene 22, 6045-6053 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 6045-6053
-
-
Chamulitrat, W.1
-
40
-
-
1542434385
-
From SOD to Phox to Nox: A personal account of the evolving views of reactive oxygen species
-
Lambeth, J. D. From SOD to Phox to Nox: a personal account of the evolving views of reactive oxygen species. Rec. Advances Res. Updates 4, 31-40 (2003).
-
(2003)
Rec. Advances Res. Updates
, vol.4
, pp. 31-40
-
-
Lambeth, J.D.1
-
41
-
-
0042242883
-
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells
-
Brar, S. S. et al. NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU145 prostate cancer cells. Am. J. Physiol. Cell Physiol. 285, C353-C369 (2003).
-
(2003)
Am. J. Physiol. Cell Physiol.
, vol.285
-
-
Brar, S.S.1
-
42
-
-
0036087150
-
An NAD(P)H oxidase regulates growth and transcription in melanoma cells
-
Brar, S. S. et al. An NAD(P)H oxidase regulates growth and transcription in melanoma cells. Am. J. Physiol. Cell Physiol. 282, C1212-C1224 (2002).
-
(2002)
Am. J. Physiol. Cell Physiol.
, vol.282
-
-
Brar, S.S.1
-
43
-
-
0037154250
-
Reactive oxygen generated by Nox1 triggers the angiogenic switch
-
Arbiser, J. L. et al. Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc. Natl Acad. Sci. USA 99, 715-720 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 715-720
-
-
Arbiser, J.L.1
-
44
-
-
0037134506
-
NADPH oxidase is involved in prostaglandin F2α-induced hypertrophy of vascular smooth muscle cells: Induction of NOX1 by PGF2α
-
Katsuyama, M., Fan, C. & Yabe-Nishimura, C. NADPH oxidase is involved in prostaglandin F2α-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2α. J. Biol. Chem. 277, 13438-13442 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 13438-13442
-
-
Katsuyama, M.1
Fan, C.2
Yabe-Nishimura, C.3
-
45
-
-
0037177164
-
Superoxide production and expression of nox family proteins in human atherosclerosis
-
Sorescu, D. et al. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 105, 1429-1435 (2002).
-
(2002)
Circulation
, vol.105
, pp. 1429-1435
-
-
Sorescu, D.1
-
46
-
-
0036141820
-
Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury
-
Szocs, K. et al. Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler. Thromb. Vasc. Biol. 22, 21-27 (2002).
-
(2002)
Arterioscler. Thromb. Vasc. Biol.
, vol.22
, pp. 21-27
-
-
Szocs, K.1
-
47
-
-
0345690184
-
Role of NADPH oxidases in the control of vascular gene expression
-
Brandes, R. P. Role of NADPH oxidases in the control of vascular gene expression. Antioxid. Redox Signal 5, 803-811 (2003).
-
(2003)
Antioxid. Redox Signal
, vol.5
, pp. 803-811
-
-
Brandes, R.P.1
-
48
-
-
0026021362
-
Production of large amounts of hydrogen peroxide by human tumor cells
-
Szatrowski, T. & Nathan, C. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Research 51, 794-798 (1991).
-
(1991)
Cancer Research
, vol.51
, pp. 794-798
-
-
Szatrowski, T.1
Nathan, C.2
-
49
-
-
0033637971
-
Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1
-
Teshima, S., Kutsumi, H., Kawahara, T., Kishi, K. & Rokutan, K. Regulation of growth and apoptosis of cultured guinea pig gastric mucosal cells by mitogenic oxidase 1. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G1169-G1176 (2000).
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.279
-
-
Teshima, S.1
Kutsumi, H.2
Kawahara, T.3
Kishi, K.4
Rokutan, K.5
-
50
-
-
1842423370
-
Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells
-
in the press
-
Helenski, L. L., Clempus, R. E., Quinn, M. T., Lambeth, J. D. & Griendling, K. K. Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. (in the press).
-
Arterioscler. Thromb. Vasc. Biol.
-
-
Helenski, L.L.1
Clempus, R.E.2
Quinn, M.T.3
Lambeth, J.D.4
Griendling, K.K.5
-
51
-
-
1342304048
-
2 and plays an integral role in insulin signal transduction
-
in the press
-
2 and plays an integral role in insulin signal transduction. Mol. Cell Biol. (in the press).
-
Mol. Cell Biol.
-
-
Mahadev, K.1
-
52
-
-
0346750816
-
Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression. Implication for native LDL oxidation
-
Hwang, J. et al. Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression. Implication for native LDL oxidation. Circ. Res. 93, 1225-1232 (2003).
-
(2003)
Circ. Res.
, vol.93
, pp. 1225-1232
-
-
Hwang, J.1
-
53
-
-
0037063119
-
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism
-
Moreno, J. C. et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N. Engl. J. Med. 347, 95-102 (2002).
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 95-102
-
-
Moreno, J.C.1
-
54
-
-
0032540225
-
phox on Serine 303 or 304
-
phox on Serine 303 or 304. J. Biol. Chem. 273, 9539-9543 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9539-9543
-
-
Inanami, O.1
-
55
-
-
0038303192
-
Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase
-
Hoyal, C. R. et al. Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. Proc. Natl Acad. Sci. USA 100, 5130-5135 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 5130-5135
-
-
Hoyal, C.R.1
-
56
-
-
0034946472
-
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K
-
Kanai, F. et al. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nature Cell Biol. 3, 675-678 (2001).
-
(2001)
Nature Cell Biol.
, vol.3
, pp. 675-678
-
-
Kanai, F.1
-
57
-
-
0037248553
-
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC δ in intracellular production of reactive oxygen species by the NADPH oxidase
-
Brown, G. E., Stewart, M. Q., Liu, H., Ha, V. L. & Yaffe, M. B. A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC δ in intracellular production of reactive oxygen species by the NADPH oxidase. Mol. Cell 11, 35-47 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 35-47
-
-
Brown, G.E.1
Stewart, M.Q.2
Liu, H.3
Ha, V.L.4
Yaffe, M.B.5
-
58
-
-
0037039667
-
The p 40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides
-
Zhan, Y., Virbasius, J. V., Song, X., Pomerleau, D. P. & Zhou, G. W. The p40phox and p47phox PX domains of NADPH oxidase target cell membranes via direct and indirect recruitment by phosphoinositides. J. Biol. Chem. 277, 4512-4518 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 4512-4518
-
-
Zhan, Y.1
Virbasius, J.V.2
Song, X.3
Pomerleau, D.P.4
Zhou, G.W.5
-
59
-
-
0036774850
-
The p47phox PX domain: Two heads are better than one!
-
Yaffe, M. B. The p47phox PX domain: two heads are better than one! Structure (Camb) 10, 1288-1290 (2002).
-
(2002)
Structure (Camb)
, vol.10
, pp. 1288-1290
-
-
Yaffe, M.B.1
-
60
-
-
0033609785
-
Tetratricopeptide repeat (TPR) motifs of p67phox participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase
-
Koga, H. et al. Tetratricopeptide repeat (TPR) motifs of p67phox participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase. J. Biol. Chem. 274, 25051-25060 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25051-25060
-
-
Koga, H.1
-
61
-
-
0033635228
-
Structure of the TPR domain of p67phox in complex with Rac. GTP
-
Lapouge, K. et al. Structure of the TPR domain of p67phox in complex with Rac. GTP. Mol. Cell 6, 899-907 (2000).
-
(2000)
Mol. Cell
, vol.6
, pp. 899-907
-
-
Lapouge, K.1
-
62
-
-
0025944684
-
rac1
-
rac1. Nature 353, 668-670 (1991).
-
(1991)
Nature
, vol.353
, pp. 668-670
-
-
Abo, A.1
-
63
-
-
0026335622
-
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2
-
Knaus, U. G., Heyworth, P. G., Evans, T., Curnutte, J. T. & Bokoch, G. M. Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254, 1512-1515 (1991).
-
(1991)
Science
, vol.254
, pp. 1512-1515
-
-
Knaus, U.G.1
Heyworth, P.G.2
Evans, T.3
Curnutte, J.T.4
Bokoch, G.M.5
-
64
-
-
0024403347
-
Singlet oxygen production by biological systems
-
Kanofsky, J. R. Singlet oxygen production by biological systems. Chem. Biol. Interact. 70, 1-28 (1989).
-
(1989)
Chem. Biol. Interact.
, vol.70
, pp. 1-28
-
-
Kanofsky, J.R.1
-
65
-
-
0037073888
-
Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation
-
Wentworth, P., Jr. et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science 298, 2195-2199 (2002).
-
(2002)
Science
, vol.298
, pp. 2195-2199
-
-
Wentworth Jr., P.1
-
66
-
-
0037073952
-
Immunology. Catalytic antibody bridges innate and adaptive immunity
-
Nathan, C. Immunology. Catalytic antibody bridges innate and adaptive immunity. Science 298, 2143-2144 (2002).
-
(2002)
Science
, vol.298
, pp. 2143-2144
-
-
Nathan, C.1
-
67
-
-
0042093741
-
Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin); an oxidative mechanism for restraining proteolytic activity during inflammation
-
Fu, X., Kassim, S. Y., Parks, W. C. & Heinecke, J. W. Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin); an oxidative mechanism for restraining proteolytic activity during inflammation. J. Biol. Chem. 278, 28403-28409 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 28403-28409
-
-
Fu, X.1
Kassim, S.Y.2
Parks, W.C.3
Heinecke, J.W.4
-
68
-
-
0035897653
-
Homologs of gp91phox: Cloning and tissue expression of Nox3, Nox4, and Nox5
-
Cheng, G., Cao, Z., Xu, X., van Meir, E. G. & Lambeth, J. D. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269, 131-140 (2001).
-
(2001)
Gene
, vol.269
, pp. 131-140
-
-
Cheng, G.1
Cao, Z.2
Xu, X.3
Van Meir, E.G.4
Lambeth, J.D.5
-
69
-
-
0034725643
-
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family
-
De Deken, X. et al. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J. Biol. Chem. 275, 23227-23233 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23227-23233
-
-
De Deken, X.1
|