-
1
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
Luo, J., Solimini, N. L. & Elledge, S. J. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136, 823-837 (2009).
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
2
-
-
79951821948
-
Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic
-
Yap, T. A., Sandhu, S. K., Carden, C. P.&deBono, J. S. Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic. CA Cancer J. Clin. 61, 31-49 (2011).
-
(2011)
CA Cancer J. Clin.
, vol.61
, pp. 31-49
-
-
Yap, T.A.1
Sandhu, S.K.2
Carden, C.P.3
Debono, J.S.4
-
3
-
-
40849097418
-
Discoveringmechanismsof signaling-mediated cysteine oxidation
-
Poole, L. B.&Nelson, K. J. Discoveringmechanismsof signaling-mediated cysteine oxidation. Curr. Opin. Chem. Biol. 12, 18-24 (2008).
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, pp. 18-24
-
-
Poole, L.B.1
Nelson, K.J.2
-
4
-
-
33748165596
-
Reactive oxygen species in cancer cells: Live by the sword, die by the sword
-
DOI 10.1016/j.ccr.2006.08.015, PII S1535610806002558
-
Schumacker, P. T. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10, 175-176 (2006). (Pubitemid 44311072)
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 175-176
-
-
Schumacker, P.T.1
-
5
-
-
67650071137
-
Targeting cancer cells by ROSmediated mechanisms: A radical therapeutic approach?
-
Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROSmediated mechanisms: a radical therapeutic approach? Natl Rev. 8, 579-591 (2009).
-
(2009)
Natl Rev.
, vol.8
, pp. 579-591
-
-
Trachootham, D.1
Alexandre, J.2
Huang, P.3
-
6
-
-
34547153634
-
CDIP, a novel pro-apoptotic gene, regulates TNFα-mediated apoptosis in a p53-dependent manner
-
DOI 10.1038/sj.emboj.7601779, PII 7601779
-
Brown, L. et al. CDIP, a novel pro-apoptotic gene, regulates TNFa-mediated apoptosis in a p53-dependent manner. EMBO J. 26, 3410-3422 (2007). (Pubitemid 47123544)
-
(2007)
EMBO Journal
, vol.26
, Issue.14
, pp. 3410-3422
-
-
Brown, L.1
Ongusaha, P.P.2
Kim, H.-G.3
Nuti, S.4
Mandinova, A.5
Lee, J.W.6
Khosravi-Far, R.7
Aaronson, S.A.8
Lee, S.W.9
-
7
-
-
33845211116
-
Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways
-
DOI 10.1016/j.tiv.2006.07.007, PII S0887233306001561
-
Bezerra, D. P. et al. Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways. Toxicol. In Vitro 21, 1-8 (2007). (Pubitemid 44855506)
-
(2007)
Toxicology in Vitro
, vol.21
, Issue.1
, pp. 1-8
-
-
Bezerra, D.P.1
Militao, G.C.G.2
De Castro, F.O.3
Pessoa, C.4
De Moraes, M.O.5
Silveira, E.R.6
Lima, M.A.S.7
Elmiro, F.J.M.8
Costa-Lotufo, L.V.9
-
8
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
DOI 10.1038/22780
-
Hahn, W. C. et al. Creation of human tumour cells with defined genetic elements. Nature 400, 464-468 (1999). (Pubitemid 29361801)
-
(1999)
Nature
, vol.400
, Issue.6743
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
9
-
-
0036315162
-
PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells
-
DOI 10.1128/MCB.22.15.5281-5295.2002
-
Ryo, A. et al. PIN1 is an E2F target gene essential for Neu/Ras-induced transformation ofmammary epithelial cells.Mol. Cell. Biol. 22, 5281-5295(2002). (Pubitemid 34755742)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.15
, pp. 5281-5295
-
-
Ryo, A.1
Liou, Y.-C.2
Wulf, G.3
Nakamura, M.4
Lee, S.W.5
Lu, K.P.6
-
10
-
-
0026587657
-
Induction ofmammary tumors by expression of polyomavirus middle T oncogene: A transgenic mouse model for metastatic disease
-
Guy, C. T., Cardiff, R. D.&Muller, W. J. Induction ofmammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol. Cell. Biol. 12, 954-961 (1992).
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 954-961
-
-
Guy, C.T.1
Cardiff, R.D.2
Muller, W.J.3
-
11
-
-
63849172494
-
Identifying the proteins to which small-molecule probes and drugs bind in cells
-
Ong, S. E. et al. Identifying the proteins to which small-molecule probes and drugs bind in cells. Proc. Natl Acad. Sci. USA 106, 4617-4622 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4617-4622
-
-
Ong, S.E.1
-
12
-
-
58149103872
-
Human carbonyl reductase 1 is an S-nitrosoglutathione reductase
-
Bateman, R. L., Rauh, D., Tavshanjian, B. & Shokat, K. M. Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. J. Biol. Chem. 283, 35756-35762 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 35756-35762
-
-
Bateman, R.L.1
Rauh, D.2
Tavshanjian, B.3
Shokat, K.M.4
-
13
-
-
30744437425
-
Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase π with activity changes in both enzymes
-
DOI 10.1021/bi0520737
-
Ralat, L. A., Manevich, Y., Fisher, A. B. & Colman, R. F. Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase p with activity changes in both enzymes. Biochemistry 45, 360-372 (2006). (Pubitemid 43100403)
-
(2006)
Biochemistry
, vol.45
, Issue.2
, pp. 360-372
-
-
Ralat, L.A.1
Manevich, Y.2
Fisher, A.B.3
Colman, R.F.4
-
14
-
-
64749093574
-
Association of reactive oxygen species levels and radioresistance in cancer stem cells
-
Diehn, M. et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 458, 780-783 (2009).
-
(2009)
Nature
, vol.458
, pp. 780-783
-
-
Diehn, M.1
-
15
-
-
33847349283
-
Reactive oxygen species: A breath of life or death?
-
DOI 10.1158/1078-0432.CCR-06-2082
-
Fruehauf, J. P. & Meyskens, F. L. Jr. Reactive oxygen species: a breath of life or death? Clin. Cancer Res. 13, 789-794 (2007). (Pubitemid 46340350)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.3
, pp. 789-794
-
-
Fruehauf, J.P.1
Meyskens Jr., F.L.2
-
16
-
-
0034699513
-
Superoxide dismutase as a target for the selective killing of cancer cells
-
Huang, P., Feng, L., Oldham, E. A., Keating, M. J. & Plunkett, W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature 407, 390-395 (2000).
-
(2000)
Nature
, vol.407
, pp. 390-395
-
-
Huang, P.1
Feng, L.2
Oldham, E.A.3
Keating, M.J.4
Plunkett, W.5
-
17
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
-
DOI 10.1016/j.ccr.2006.08.009, PII S1535610806002509
-
Trachootham, D. et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by b-phenylethyl isothiocyanate. Cancer Cell 10, 241-252 (2006). (Pubitemid 44311067)
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
Chiao, P.J.7
Achanta, G.8
Arlinghaus, R.B.9
Liu, J.10
Huang, P.11
-
18
-
-
41149105722
-
Mitochondria in cancer cells: What is so special about them?
-
Gogvadze, V., Orrenius, S.&Zhivotovsky, B. Mitochondria in cancer cells: what is so special about them? Trends Cell Biol. 18, 165-173 (2008).
-
(2008)
Trends Cell Biol.
, vol.18
, pp. 165-173
-
-
Gogvadze, V.1
Orrenius, S.2
Zhivotovsky, B.3
-
19
-
-
0026021362
-
Production of largeamounts of hydrogen peroxide by human tumor cells
-
Szatrowski, T. P.&Nathan, C. F. Production of largeamounts of hydrogen peroxide by human tumor cells. Cancer Res. 51, 794-798 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 794-798
-
-
Szatrowski, T.P.1
Nathan, C.F.2
-
20
-
-
73349094986
-
Curcumin and cancer cells: How many ways can curry kill tumor cells selectively?
-
Ravindran, J., Prasad, S. & Aggarwal, B. B. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? Am. Assoc. Pharm. Sci. J. 11, 495-510 (2009).
-
(2009)
Am. Assoc. Pharm. Sci. J.
, vol.11
, pp. 495-510
-
-
Ravindran, J.1
Prasad, S.2
Aggarwal, B.B.3
-
21
-
-
33646771034
-
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)
-
Yue, P., Zhou, Z., Khuri, F. R. & Sun, S. Y. Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana- 1, 9-dien-28-oate (CDDO-Me). Cancer Biol. Ther. 5, 492-497 (2006). (Pubitemid 43765283)
-
(2006)
Cancer Biology and Therapy
, vol.5
, Issue.5
, pp. 492-497
-
-
Yue, P.1
Zhou, Z.2
Khuri, F.R.3
Sun, S.-Y.4
-
22
-
-
20344405468
-
The GI-GPx gene is a target for Nrf2
-
DOI 10.1128/MCB.25.12.4914-4923.2005
-
Banning, A., Deubel, S., Kluth, D., Zhou, Z.& Brigelius-Flohe, R. The GI-GPx gene is a target for Nrf2. Mol. Cell Biol. 25, 4914-4923 (2005). (Pubitemid 40781093)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.12
, pp. 4914-4923
-
-
Banning, A.1
Deubel, S.2
Kluth, D.3
Zhou, Z.4
Brigelius-Flohe, R.5
-
23
-
-
77958565864
-
An exceptionally potent inducer of cytoprotective enzymes: Elucidation of the structural features that determine inducer potency and reactivity with KEAP1
-
Dinkova-Kostova, A. T. et al. An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with KEAP1. J. Biol. Chem. 285, 33747-33755 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 33747-33755
-
-
Dinkova-Kostova, A.T.1
-
24
-
-
0033583242
-
Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
-
Lee, A. C. et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936-7940 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7936-7940
-
-
Lee, A.C.1
-
25
-
-
79952123700
-
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
-
Schramek, D. et al. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nature Genet. 43, 212-219 (2011).
-
(2011)
Nature Genet.
, vol.43
, pp. 212-219
-
-
Schramek, D.1
-
26
-
-
0035877779
-
Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus
-
Wang, T., Arifoglu, P., Ronai, Z. & Tew, K. D. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J. Biol. Chem. 276, 20999-21003 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20999-21003
-
-
Wang, T.1
Arifoglu, P.2
Ronai, Z.3
Tew, K.D.4
-
27
-
-
70449377369
-
Empirical Bayes analysis of quantitative proteomics experiments
-
Margolin, A. A. et al. Empirical Bayes analysis of quantitative proteomics experiments. PLoS ONE 4, e7454 (2009).
-
(2009)
PLoS ONE
, vol.4
-
-
Margolin, A.A.1
|