Distinct PKA and Epac compartmentalization in airway function and plasticity

Pharmacology and Therapeutics

Volumn 137, Issue 2, 2013, Pages 248-265

  Dekkers, Bart G J ^a   Racké, Kurt ^b   Schmidt, Martina ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

2 adrenoceptor agonists; A kinase anchoring protein (AKAP); Airway fibroblast; Airway smooth muscle; Compartmentalization; Exchange protein directly activated by cAMP (Epac); Prostaglandin E 2; Protein kinase A (PKA)

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIPORTER; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ARRESTIN 2; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; CYCLIC AMP ELEVATING SEVEN TRANSMEMBRANE RECEPTOR; CYTOKINE; EXCHANGE PROTEIN DIRECTLY BY CYCLIC AMP; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LONG ACTING BETA 2 ADRENOCEPTOR AGONIST; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHOLIPASE C; PHOSPHOLIPASE D; ROFLUMILAST; ROLIPRAM; SHORT ACTING BETA 2 ADRENOCEPTOR AGONIST; THEOPHYLLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AIRWAY; AIRWAY FIBROBLAST; AIRWAY SMOOTH MUSCLE CELL; ANTIINFLAMMATORY ACTIVITY; ASTHMA; BRONCHOSPASM; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL (TOPIC); COMPLEX FORMATION; CYTOKINE RELEASE; DESENSITIZATION; DISEASE CONTROL; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG TARGETING; EVIDENCE BASED MEDICINE; FIBROBLAST; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG ALVEOLUS; MOLECULAR DYNAMICS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ASTHMA; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FIBROBLASTS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MUSCLE RELAXATION; MUSCLE, SMOOTH; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 84872803761     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.10.006     Document Type: Review

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