A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 42, 2007, Pages 16657-16662

  Wisler, James W ^a   DeWire, Scott M ^a   Whalen, Erin J ^a   Violin, Jonathan D ^a   Drake, Matthew T ^a,b   Ahn, Seungkirl ^a   Shenoy, Sudha K ^a   Lefkowitz, Robert J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Mayo Clinic   (United States)

Author keywords

adrenergic receptor; Antagonist; ERK 1 2; Internalization; Scaffold

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ACEBUTOLOL; ADENYLATE CYCLASE; ALPRENOLOL; ATENOLOL; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; BETAXOLOL; BISOPROLOL; CARVEDILOL; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR KINASE; LABETALOL; METOPROLOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NADOLOL; OXPRENOLOL; PINDOLOL; PRACTOLOL; PROPRANOLOL; SOTALOL; TIMOLOL;

ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADRENERGIC BETA-ANTAGONISTS; ARRESTINS; CARBAZOLES; CELL LINE; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION;

EID: 36749094552     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0707936104     Document Type: Article

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