Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 1, 2011, Pages 209-217

  Bogard, Amy S ^a   Xu, Congfeng ^a   Ostrom, Rennolds S ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 2; ADENYLATE CYCLASE 4; ADENYLATE CYCLASE 6; CALCIUM ION; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUSCLE; CAVEOLA; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; LIPID RAFT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ADENYLATE CYCLASE; BRONCHI; CALCIUM; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MEMBRANE MICRODOMAINS; MYOCYTES, SMOOTH MUSCLE;

EID: 79953012240     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.177923     Document Type: Article

References (44)

1. Anderson RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199-225.
2. Billington CK, Hall IP, Mundell SJ, Parent JL, Panettieri RA Jr, Benovic JL, and Penn RB (1999) Inflammatory and contractile agents sensitize specific adenylyl cyclase isoforms in human airway smooth muscle. Am J Respir Cell Mol Biol 21:597-606. (Pubitemid 129586595)
3. Billington CK and Penn RB (2003) Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Respir Res 4:2.
4. Daaka Y, Luttrell LM, Ahn S, Della Rocca GJ, Ferguson SS, Caron MG, and Lefkowitz RJ (1998) Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem 273:685-688. (Pubitemid 28049152)
5. 2+ channel Cav1.2. Science 293:98-101.
6. Dessauer CW (2009) Adenylyl cyclase - A-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol Pharmacol 76:935-941.
7. Ehlert FJ, Ostrom RS, and Sawyer GW (1997) Subtypes of the muscarinic receptor in smooth muscle. Life Sci 61:1729-1740. (Pubitemid 27440628)
8. Galbiati F, Razani B, and Lisanti MP (2001) Emerging themes in lipid rafts and caveolae. Cell 106:403-411. (Pubitemid 32786984)
9. Gille A, Lushington GH, Mou TC, Doughty MB, Johnson RA, and Seifert R (2004) Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides. J Biol Chem 279:19955-19969. (Pubitemid 38623438)
10. Göttle M, Geduhn J, König B, Gille A, Höcherl K, and Seifert R (2009) Characterization of mouse heart adenylyl cyclase. J Pharmacol Exp Ther 329:1156-1165.
11. Grandoch M, Roscioni SS, and Schmidt M (2010) The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol 159:265-284.
12. Hanoune J and Defer N (2001) Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 41:145-174. (Pubitemid 32385886)
13. Hill J, Howlett A, and Klein C (2000) Nitric oxide selectively inhibits adenylyl cyclase isoforms 5 and 6. Cell Signal 12:233-237. (Pubitemid 30214227)
14. Hirshman CA and Emala CW (1999) Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho. Am J Physiol 277:L653-L661. (Pubitemid 29459686)
15. Hooper NM (1999) Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review). Mol Membr Biol 16:145-156.
16. Hurley JH (1999) Structure, mechanism, and regulation of mammalian adenylyl cyclase. J Biol Chem 274:7599-7602.
17. Kotlikoff MI and Kamm KE (1996) Molecular mechanisms of β-adrenergic relaxation of airway smooth muscle. Annu Rev Physiol 58:115-141. (Pubitemid 26106715)
18. Kume H, Hall IP, Washabau RJ, Takagi K, and Kotlikoff MI (1994) β-Adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J Clin Invest 93:371-379.
19. Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, and Ostrom RS (2008) Adenylyl cyclase type 6 overexpression selectively enhances β-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts. Naunyn Schmiedebergs Arch Pharmacol 377:359-369. (Pubitemid 351868523)
20. 2 on contractions of airway smooth muscle. J Appl Physiol 66: 1397-1407.
21. McVey M, Hill J, Howlett A, and Klein C (1999) Adenylyl cyclase, a coincidence detector for nitric oxide. J Biol Chem 274:18887-18892.
22. Michel JJ and Scott JD (2002) AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol 42:235-257. (Pubitemid 34160527)
23. Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, and Sprang SR (2006) Broad specificity of mammalian adenylyl cyclase for interaction with 2′,3′- substituted purine- and pyrimidine nucleotide inhibitors. Mol Pharmacol 70:878-886. (Pubitemid 44268445)
24. Neubig RR (1994) Membrane organization in G-protein mechanisms. FASEB J 8:939-946.
25. Onda T, Hashimoto Y, Nagai M, Kuramochi H, Saito S, Yamazaki H, Toya Y, Sakai I, Homcy CJ, Nishikawa K, et al. (2001) Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J Biol Chem 276:47785-47793.
26. Ostrom RS (2002) New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains. Mol Pharmacol 61:473-476.
27. Ostrom RS, Bundey RA, and Insel PA (2004) Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes. J Biol Chem 279:19846-19853. (Pubitemid 38623425)
28. Ostrom RS and Ehlert FJ (1998) M2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle. J Pharmacol Exp Ther 286:234-242. (Pubitemid 28317996)
29. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, and Insel PA (2001) Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem 276:42063-42069.
30. Ostrom RS and Insel PA (2004) The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol 143:235-245. (Pubitemid 39315143)
31. Ostrom RS, Post SR, and Insel PA (2000) Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving Gs. J Pharmacol Exp Ther 294:407-412. (Pubitemid 30490809)
32. Pinto C, Papa D, Hübner M, Mou TC, Lushington GH, and Seifert R (2008) Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs. J Pharmacol Exp Ther 325:27-36. (Pubitemid 351439155)
33. Sadana R and Dessauer CW (2009) Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Neurosignals 17:5-22.
34. Scott MG, Swan C, Jobson TM, Rees S, and Hall IP (1999) Effects of a range of β2 adrenoceptor agonists on changes in intracellular cyclic AMP and on cyclic AMP driven gene expression in cultured human airway smooth muscle cells. Br J Pharmacol 128:721-729. (Pubitemid 29504765)
35. Shaul PW and Anderson RG (1998) Role of plasmalemmal caveolae in signal transduction. Am J Physiol 275:L843-L851.
36. Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-39.
37. Spicuzza L, Belvisi MG, Birrell MA, Barnes PJ, Hele DJ, and Giembycz MA (2001) Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol 133:1201-1212. (Pubitemid 32783479)
38. Steinberg SF and Brunton LL (2001) Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol 41:751-773. (Pubitemid 32385905)
39. Tamaoki J, Chiyotani A, Takeyama K, Yamauchi F, Tagaya E, and Konno K (1993) Relaxation and inhibition of contractile response to electrical field stimulation by Beraprost sodium in canine airway smooth muscle. Prostaglandins 45:363-373. (Pubitemid 23124401)
40. Torphy TJ (1994) β-Adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma. Trends Pharmacol Sci 15:370-374.
41. Torphy TJ, Freese WB, Rinard GA, Brunton LL, and Mayer SE (1982) Cyclic nucleotide-dependent protein kinases in airway smooth muscle. J Biol Chem 257:11609-11616.
42. Wei J, Wayman G, and Storm DR (1996) Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. J Biol Chem 271:24231-24235. (Pubitemid 26327410)
43. Xu D, Isaacs C, Hall IP, and Emala CW (2001) Human airway smooth muscle expresses 7 isoforms of adenylyl cyclase: a dominant role for isoform V. Am J Physiol Lung Cell Mol Physiol 281:L832-L843.
44. Yan H, Deshpande DA, Misior AM, Miles MC, Saxena H, Riemer EC, Pascual RM, Panettieri RA, and Penn RB (2011) Anti-mitogenic effects of β-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J 25:389-397.