The role of endothelin-1 in the pathogenesis of idiopathic pulmonary fibrosis

BioDrugs

Volumn 24, Issue 1, 2010, Pages 49-54

  Swigris, Jeffrey J ^a   Brown, Kevin K ^a  

^a DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMBRISENTAN; BLEOMYCIN; BOSENTAN; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; PLACEBO;

CELL PROLIFERATION; CLINICAL TRIAL; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE OVEREXPRESSION; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; IMMUNOREACTIVITY; LUNG; LUNG FIBROSIS; LUNG FUNCTION TEST; LUNG LAVAGE; MOLECULAR BIOLOGY; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PNEUMONIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULMONARY HYPERTENSION; REVIEW; WOUND HEALING;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENDOTHELINS; HUMANS; LUNG; PULMONARY FIBROSIS; WOUND HEALING;

EID: 75149158933     PISSN: 11738804     EISSN: 1179190X     Source Type: Journal    
DOI: 10.2165/11319550-000000000-00000     Document Type: Review

References (53)

1. Ortega Mateo A, de Artinano AA. Highlights on endothelins: a review. Pharmacol Res 1997; 36: 339-351
2. Kedzierski RM, YanagisawaM. Endothelin system: the double-edged sword in health and disease. Annu Rev Pharmacol Toxicol 2001; 41: 851-876
3. Teder P, Noble PW. A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol 2000; 23: 7-10
4. Baynash A, Hammer R, Richardson J, et al. Severe growth retardation and juvenile lethality in ET-2 knockout mice. Fifth International Conference on Endothelins; 1997 Sep 12-15; Kyoto
5. Matsumoto H, Suzuki N, Onda H, et al. Abundance of endothelin-3 in rat intestine, pituitary gland and brain. Biochem Biophys Res Commun 1989; 164: 74-80
6. Battistini B, Dussault P. Biosynthesis, distribution and metabolism of endothelins in the pulmonary system. Pulm Pharmacol Ther 1998; 11: 79-88
7. Ehrenreich H, Anderson RW, Fox CH, et al. Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 1990; 172: 1741-1748
8. Giaid A, Michel RP, Stewart DJ, et al. Expression of endothelin-1 in lungs of patients with cryptogenic fibrosing alveolitis. Lancet 1993; 341: 1550-1554 (Pubitemid 23170459)
9. Sessa WC, Kaw S, Hecker M, et al. The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes. Biochem Biophys Res Commun 1991; 174: 613-618
10. Harrison VJ, Corder R, Anggard EE, et al. Evidence for vesicles that transport endothelin-1 in bovine aortic endothelial cells. J Cardiovasc Pharmacol 1993; 22 Suppl. 8: S57-60
11. Wagner OF, Christ G, Wojta J, et al. Polar secretion of endothelin-1 by cultured endothelial cells. J Biol Chem 1992; 267: 16066-16068
12. Arai H, Hori S, Aramori I, et al. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990; 348: 730-732
13. Sakurai T, Yanagisawa M, Takuwa Y, et al. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature 1990; 348: 732-735
14. Katwa LC, Guarda E, Weber KT. Endothelin receptors in cultured adult rat cardiac fibroblasts. Cardiovasc Res 1993; 27: 2125-2129
15. Masaki T, Miwa S, Sawamura T, et al. Subcellular mechanisms of endothelin action in vascular system. Eur J Pharmacol 1999; 375: 133-138
16. Ergul A, Glassberg MK, Wanner A, et al. Characterization of endothelin receptor subtypes on airway smooth muscle cells. Exp Lung Res 1995; 21: 453-468
17. Goldie RG, Henry PJ, Knott PG, et al. Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways. Am J Respir Crit Care Med 1995; 152: 1653-1658
18. Berti F, Rossoni G, Della Bella D, et al. Nitric oxide and prostacyclin influence coronary vasomotor tone in perfused rabbit heart and modulate endothelin-1 activity. J Cardiovasc Pharmacol 1993; 22: 321-326
19. Filep JG, Bodolay E, Sipka S, et al. Plasma endothelin correlates with antiendothelial antibodies in patients with mixed connective tissue disease. Circulation 1995; 92: 2969-2974
20. Wenzel RR, Fleisch M, Shaw S, et al. Hemodynamic and coronary effects of the endothelin antagonist bosentan in patients with coronary artery disease. Circulation 1998; 98: 2235-2240
21. Dupuis J, Stewart DJ, Cernacek P, et al. Human pulmonary circulation is an important site for both clearance and production of endothelin-1. Circulation 1996; 94: 1578-1584
22. Razzaque MS, Taguchi T. Pulmonary fibrosis: cellular and molecular events. Pathol Int 2003; 53: 133-145
23. Clark R. Wound repair; overview and general considerations: the molecular and cellular biology of wound repair. London: Plenum Press, 1996: 3-50
24. Moulin V. Growth factors in skin wound healing. Eur J Cell Biol 1995; 68: 1-7
25. Greenhalgh DG. The role of growth factors in wound healing. J Trauma 1996; 41: 159-167
26. Badylak SF. The extracellular matrix as a scaffold for tissue reconstruction. Semin Cell Dev Biol 2002; 13: 377-383
27. Shi-Wen X, Chen Y, Denton CP, et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Aktdependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004; 15: 2707-2719
28. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechanoregulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3: 349-363
29. Desmouliere A. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 1995; 19: 471-476
30. Hafstrom I, Ringertz B, Lundeberg T, et al. The effect of endothelin, neuropeptide Y, calcitonin gene-related peptide and substance P on neutrophil functions. Acta Physiol Scand 1993; 148: 341-346
31. McMillen MA, Sumpio BE. Endothelins: polyfunctional cytokines. J Am Coll Surg 1995; 180: 621-637
32. Shahar I, Fireman E, TopilskyM, et al. Effect of endothelin-1 on alpha-smooth muscle actin expression and on alveolar fibroblasts proliferation in interstitial lung diseases. Int J Immunopharmacol 1999; 21: 759-775
33. Peacock AJ, Dawes KE, Shock A, et al. Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts. Am J Respir Cell Mol Biol 1992; 7: 492-499
34. Cambrey AD, Harrison NK, Dawes KE, et al. Increased levels of endothelin-1 in bronchoalveolar lavage fluid from patients with systemic sclerosis contribute to fibroblast mitogenic activity in vitro. Am J Respir Cell Mol Biol 1994; 11: 439-445
35. Dawes KE, Cambrey AD, Campa JS, et al. Changes in collagen metabolism in response to endothelin-1: evidence for fibroblast heterogeneity. Int J Biochem Cell Biol 1996; 28: 229-238
36. Kahaleh MB. Endothelin, an endothelial-dependent vasoconstrictor in scleroderma: enhanced production and profibrotic action. Arthritis Rheum 1991; 34: 978-983
37. Schmitt-Graff A, Desmouliere A, Gabbiani G. Heterogeneity of myofibroblast phenotypic features: an example of fibroblastic cell plasticity. Virchows Arch 1994; 425: 3-24
38. Kulasekaren P, Scavone CA, Rogers DS, et al. Endothelin-1 and TGF-b1 independently induce fibroblast resistance to apoptosis via AKT activation. Am J Respir Cell Mol Biol 2009; 41: 484-493
39. Rodriguez-Pascual F, Redondo-Horcajo M, Lamas S. Functional cooperation between Smad proteins and activator protein-1 regulates transforming growth factor-beta-mediated induction of endothelin-1 expression. Circ Res 2003; 92: 1288-1295
40. Hocher B, Schwarz A, Fagan KA, et al. Pulmonary fibrosis and chronic lung inflammation inET-1 transgenic mice.AmJRespirCellMol Biol 2000; 23: 19-26
41. Park SH, Saleh D, Giaid A, et al. Increased endothelin-1 in bleomycin-induced pulmonary fibrosis and the effect of an endothelin receptor antagonist. Am J Respir Crit Care Med 1997; 156: 600-608
42. Mutsaers SE, Marshall RP, Goldsack NR, et al. Effect of endothelin receptor antagonists (BQ-485, Ro 47-0203) on collagen deposition during the development of bleomycin-induced pulmonary fibrosis in rats. Pulm Pharmacol Ther 1998; 11: 221-225
43. Selman M, King TE, Pardo A. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann Intern Med 2001; 134: 136-151
44. Selman M, Pardo A. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2003; 29: S93-7 (Pubitemid 37070317)
45. Clozel M, Salloukh H. Role of endothelin in fibrosis and anti-fibrotic potential of bosentan. Ann Med 2005; 37: 2-12
46. Vancheeswaran R, Azam A, Black C, et al. Localization of endothelin-1 and its binding sites in scleroderma skin. J Rheumatol 1994; 21: 1268-1276
47. Abraham DJ, Vancheeswaran R, Dashwood MR, et al. Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease. Am J Pathol 1997; 151: 831-841
48. Carpagnano GE, Kharitonov SA, Wells AU, et al. Increased vitronectin and endothelin-1 in the breath condensate of patients with fibrosing lung disease. Respiration 2003; 70: 154-160
49. Giaid A, Polak JM, Gaitonde V, et al. Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung. Am J Respir Cell Mol Biol 1991; 4: 50-58
50. Saleh D, Furukawa K, Tsao MS, et al. Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines. Am J Respir Cell Mol Biol 1997; 16: 187-193
51. Uguccioni M, Pulsatelli L, Grigolo B, et al. Endothelin-1 in idiopathic pulmonary fibrosis. J Clin Pathol 1995; 48: 330-334
52. Seibold JR, Black CM, Denton CP, et al. Bosentan versus placebo in interstitial lung disease secondary to systemic sclerosis: the BUILD 2 study. Proc Am Thor Soc 2006; 3: A243
53. King Jr TE, Behr J, Brown KK, et al. BUILD-1: a randomized placebocontrolled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2008; 177: 75-81