Prolonged heterologous β2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 294, Issue 6, 2008, Pages

  Hu, Aihua ^a   Nino, Gustavo ^a   Grunstein, Judith S ^a   Fatma, Sumbul ^a   Grunstein, Michael M ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Asthma; cAMP signaling; G proteins; Phosphodiesterase 4D5

Indexed keywords

ACETYLCHOLINE; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHODIESTERASE 4D5; PHOSPHODIESTERASE IV; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; ISOQUINOLINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NITRILE; PERTUSSIS TOXIN; ROLIPRAM; SULFONAMIDE;

AIRWAY; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHOSPASM; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE SILENCING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; METABOLISM; MUSCLE CONTRACTION; MUSCLE RELAXATION; PATHOPHYSIOLOGY; PHYSIOLOGY; TRACHEA;

ANIMALS; ASTHMA; BUTADIENES; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DINOPROSTONE; ENZYME INDUCTION; FORSKOLIN; HUMANS; ISOQUINOLINES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE CONTRACTION; MUSCLE RELAXATION; NITRILES; PERTUSSIS TOXIN; RABBITS; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED; ROLIPRAM; SIGNAL TRANSDUCTION; SULFONAMIDES; TRACHEA;

EID: 48949119361     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00021.2008     Document Type: Article

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