Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease

International Journal of COPD

Volumn 2, Issue 4, 2007, Pages 409-428

  Thorley, Andrew J ^a   Tetley, Teresa D ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Chemokines; COPD; Cytokines; Epithelium; Oxidants; Proteases

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIOXIDANT; CATHEPSIN; CHEMOKINE; CIGARETTE SMOKE; COPPER ZINC SUPEROXIDE DISMUTASE; CORTICOSTEROID; ELAFIN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE PEROXIDASE; HISTONE DEACETYLASE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LUNG SURFACTANT; MANGANESE SUPEROXIDE DISMUTASE; MUCIN; NITRIC OXIDE; PROTEINASE; REACTIVE OXYGEN METABOLITE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR; SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

AIRWAY DYNAMICS; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BACTERIAL COLONIZATION; CELL DEATH; CELL SURVIVAL; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; DENDRITIC CELL; DNA DAMAGE; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SYNTHESIS; GENE INACTIVATION; GENETIC TRANSCRIPTION; HAEMOPHILUS INFLUENZAE; HUMAN; INFLAMMATION; LEUKOCYTE ACTIVATION; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; LUNG EMPHYSEMA; LUNG FUNCTION; LUNG STRUCTURE; MEMBRANE PERMEABILITY; MORAXELLA CATARRHALIS; MUCUS; NONHUMAN; OXIDATIVE STRESS; RESPIRATORY EPITHELIUM; REVIEW; SMOKING; STREPTOCOCCUS PNEUMONIAE;

CYTOKINES; EPITHELIAL CELLS; EPITHELIUM; GREAT BRITAIN; HUMANS; LUNG; OXIDATIVE STRESS; PEPTIDE HYDROLASES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 38049158522     PISSN: 11769106     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (196)

1. Aaron SD, Angel JB, Lunau M, et al. 2001. Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 163:349-55.
2. Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat Rev Immunol, 4:499-511.
3. Arcangeli G, Cupelli V, Giuliano G. 2001. Effects of silica on human lung fibroblast in culture. Sci Total Environ, 270:13 5-9.
4. Armstrong L, Medford ARL, Uppington KM, et al. 2004. Expression of functional Toll-like receptor-2 and -4 on alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 31:241-5.
5. Avissar N, Finkelstein JN, Horowitz S, et al. 1996. Extracellular glutathione peroxidase in human lung epithelial lining fluid and in lung cells. AJP - Lung Cellular and Molecular Physiology, 270:L173-82.
6. Baginski TK, Dabbagh K, Satjawatcharaphong C, et al. 2006. Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli. American Journal of Respiratory Cell and Molecular Biology, 35:165-74.
7. Barnes PJ. 1998. New therapies for chronic obstructive pulmonary disease. Thorax, 53:137-47.
8. Barnes PJ, Adcock IM, Ito K. 2005. Histone acetylation and deacetylation: importance in inflammatory lung diseases. European Respiratory Journal, 25:552-63.
9. Barnes PJ. 2004. Mediators of chronic obstructive pulmonary disease. Pharmacological Reviews, 56:515-48.
10. Barton BE. 1997. IL-6: Insights into novel biological activities. Clinical Immunology and Immunopathology, 85:16-20.
11. Beeh KM, Beier J, Kornmann O, et al. 2003. Sputum matrix metalloprotemase-9, tissue inhibitor of metalloprotinease-1, and their molar ratio in patients with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and healthy subjects. Respir Med, 97:634-9.
12. Berndt A, Derksen FJ, Venta PJ, et al. 2007. Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction. AJP - Lung Cellular and Molecular Physiology, 292:L936-43.
13. Bingle L, Tetley TD, Bingle CD. 2001. Cytokine-mediated induction of the human elafin gene in pulmonary epithelial cells is regulated by nuclear factor-kappa B. American Journal of Respiratory Cell and Molecular Biology, 25:84-91.
14. Bleck B, Tse DB, Jaspers I, et al. 2006. Diesel exhaust particle-exposed human bronchial epithelial cells induce dendritic cell maturation. The Journal of Immunology, 176:7431-7.
15. Borok Z, Lubman RL, Danto SI, et al. 1998. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5. Am J Respir Cell Mol Biol, 18:554-61.
16. Bowler RP, Barnes PJ, Crapo JD. 2004. The role of oxidative stress in chronic obstructive pulmonary disease. COPD, 1:255-77.
17. Bracke KR, D'Hulst Al, Maes T, et al. 2006. Cigarette smoke-induced pulmonary inflammation and emphysema are attenuated in CCR6-deficient mice. The Journal of Immunology, 177:4350-9.
18. Brown DJ, Lin B, Chwa M, et al. 2004. Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity. Mol Vis, 10:281-8.
19. Bucchioni E, Kharitonov SA, Allegra L, et al. 2003. High levels of interleukin-6 in the exhaled breath condensate of patients with COPD. Respiratory Medicine, 97:1299-302.
20. Buhling F, Waldburg N, Reisenauer A, et al. 2004. Lysosomal cysteine proteases in the lung: role in protein processing and immunoregulation. European Respiratory Journal, 23:620-8.
21. Burgel PR, Nadel JA. 2004. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax, 59:992-6.
22. Cantin AM, North SL, Hubbard RC, et al. 1987. Normal alveolar epithelial lining fluid contains high levels of glutathione. Journal of Applied Physiology, 63:152-7.
23. Cardozo C, Kurtz C, Lesser M. 1992. Degradation of rat lung collagens by cathepsin B. J Lab Clin. Med, 119:169-75.
24. Chapman HA, Riese RJ, Shi GP. 1997. Emerging roles for cysteine proteases in human biology. Annu. Rev Physiol, 59:63-88.
25. Church T, Pryor WA. 1985. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect, 64:111-26.
26. Churg A, Dai J, Tai H, et al. 2002. Tumor necrosis factor-{alphal} is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. American Journal of Respiratory and Critical Care Medicine, 166:849-54.
27. Churg A, Wang RD, Tai H, et al. 2003. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-{Alpha} release. American Journal of Respiratory and Critical Care Medicine, 167:1083-9.
28. Comhair SAA, Bhathena PR, Farver C, et al. 2001. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. The FASEB Journal, 15:70-8.
29. Cook W, Webb W 1966. Surfactant in chronic smokers. Ann Thorac Surg, 2:327-33.
30. Cosio MG, Hale KA, Niewoehner DE. 1980. Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am Rev Respir Dis, 122:265-71.
31. Danahay H, Jackson AD. 2005. Epithelial mucus-hypersecretion and respiratory disease. Curr Drug Targets Inflamm Allergy, 4:651-64.
32. de Boer WI, Sont JK, van Schadewijk A, et al. 2000. Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD. J Pathol, 190:619-26.
33. DeForge LE, Preston AM, Takeuchi E, et al. 1993. Regulation of interleukin 8 gene expression by oxidant stress. Journal of Biological Chemistry, 268:25568-76.
34. Demedts IK, Bracke KR, Van Pottelberge G, et al. 2007. Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 175:998-1005.
35. Demeo DL, Mariani TJ, Lange C, et al. 2006. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet, 78:253-64.
36. Desrochers PE, Jeffrey JJ, Weiss SJ. 1991. Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. J Clin Invest, 87:2258-65.
37. Dignetti P. 2002. Cytokine concentrations in induced sputum of mild COPD patients. Correlation to clinical response to inhaled corticosteroids. European Respiratory Journal, 20(Suppl 38):309s.
38. Dinarello CA. 1998. Interleukin-1 {beta}, interleukin-18, and the interleukin-1 {beta} converting enzyme. Annals of the New York Academy of Sciences, 856:1-11.
39. Dobashi K, Asayama K, Hayashibe H, et al. 1993. Immunohistochemical study of copper-zinc and manganese superoxide dismutases in the lungs of human fetuses and newborn infants: developmental profile and alterations in hyaline membrane disease and bronchopulmonary dysplasia. Virchows Arch A Pathol Anal Histopathol, 423:177-84.
40. Driscoll KE, Hassenbein DG, Carter JM, et al. 1995. TNF alpha and increased chemokine expression in rat lung after particle exposure. Toxicol Lett, 82-83:483-9.
41. Droemann D, Goldmann T, Branscheid D, et al. 2003. Toll-like receptor 2 is expressed by alveolar epithelial cells type II and macrophages in the human lung. Histochem. Cell Biol, 119:103-8.
42. Drost EM, Selby C, Lannan S, et al. 1992. Changes in neutrophil deformability following in vitro smoke exposure: mechanism and protection. Am J Respir Cell Mol Biol, 6:287-95.
43. Ermert M, Pantazis C, Duncker H-R, et al. 2003. In situ localization of TNF[alpha]/[beta], TACE AND TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. Cytokine, 22:89-100.
44. Farioli-Vecchioli S, Nardacci R, Falciatori I, et al. 2001. Catalase immunocytochemistry allows automatic detection of lung type II alveolar cells. Histochem. Cell Biol, 115:333-9.
45. Finley TN, Ladman AJ. 1972. Low yield of pulmonary surfactant in cigarette smokers. N Engl J Med, 286:223-7.
46. Frampton MW, Ghio AJ, Samet JM, et al. 1999. Effects of aqueous extracts of PM10 filters from the Utah Valley on human airway epithelial cells. AJP - Lung Cellular and Molecular Physiology, 277:L960-7.
47. Frears ER, Zhang Z, Blake DR, et al. 1996. Inactivation of tissue inhibitor of metalloproteinase-1 by peroxynitrite. FEBS Lett, 381:21-4.
48. Frerking I, Gunther A, Seeger W, et al. 2001. Pulmonary surfactant: functions, abnormalities and therapeutic options. Intensive Care Medicine, 27:1699-717.
49. Fujimoto K, Yasuo M, Urushibata K, et al. 2005. Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease. European Respiratory Journal, 25:640-6.
50. Fuke S, Betsuyaku T, Nasuhara Y, et al 2004. Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology, 31:405-12.
51. Gearing AJ, Beckett P, Christodoulou M, et al. 1994. Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature, 370:555-7.
52. Gensch E, Gallup M, Sucher A, et al. 2004. Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK. Journal of Biological Chemistry, 279:39085-93.
53. Girod S, Zahm JM, Plotkowski C, et al. 1992. Role of the physiochemical properties of mucus in the protection of the respiratory epithelium. European Respiratory Journal, 5:477-87.
54. Golpon H, Fadok VA, Taraseviciene-Stewart L, et al. 2004. Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth. FASEB J, 18:1716-18.
55. Golpon HA, Coldren CD, Zamora MR, et al. 2004. Emphysema lung tissue gene expression profiling. American Journal of Respiratory Cell and Molecular Biology, 31:595-600.
56. Gosman MME, Marike Boezen H, van Diemen CC, et al. 2007. A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology. Thorax, 62:242-7.
57. Hackett NR, Heguy A, Harvey BG, et al. 2003. Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. American Journal of Respiratory Cell and Molecular Biology, 29:331-43.
58. Han Z, Junxu, Zhong N. 2003. Expression of matrix metalloproteinases MMP-9 within the airways in asthma. Respir Med, 97:563-7.
59. Harju T, Kaarteenaho-Wiik R, Sirvio R, et al. 2004. Manganese superoxide dismutase is increased in the airways of smokers' lungs. European Respiratory Journal, 24:765-71.
60. Hasday JD, Bascom R, Costa JJ, et al. 1999. Bacterial endotoxin is an active component of cigarette smoke. Chest, 115:829-35.
61. Hauber HP, Tulic MK, Tsicopoulos A, et al. 2005. Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosis. Can Respir J, 12:13-18.
62. Hertz CJ, Wu Q, Porter EM, et al. 2003. Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human {beta} defensin-2. The Journal of Immunology, 171:6820-6.
63. Higashimoto Y, Yamagata Y, Itoh H. 2006. Complex effect of adenovirus early region proteins on innate immune system. Inflamm. Allergy Drug Targets, 5:229-37.
64. Hogg JC, Macklem PT, Thurlbeck WM, 1968. Site and nature of airway obstruction in chronic obstructive lung disease. N.Engl J Med, 278:1355-60.
65. Honda Y, Takahashi H, Kuroki Y, et al. 1996. Decreased contents of surfactant proteins A and D in BAL fluids of healthy smokers. Chest, 109:1006-9.
66. Hoshino Y, Mio T, Nagai S, et al. 2001. Cytotoxic effiects of cigarette smoke extract on an alveolar type II cell-derived cell line. AJP - Lung Cellular and Molecular Physiology, 281:L509-16.
67. Houtmeyers E, Gosselink R, Gayan-Ramirez G, et al. 1999. Regulation of mucociliary clearance in health and disease. European Respiratory Journal, 13:1177-88.
68. Ito K, Ito M, Elliott WM, et al. 2005. Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med, 352:1967-76.
69. Janardhan KS, McIsaac M, Fowlie J, et al. 2006. Toll like receptor-4 expression in lipopolysaccharide induced lung inflammation. Histol Histopathol, 21:687-96.
70. Jeffery PK. 1998. Structural and inflammatory changes in COPD: a comparison with asthma. Thorax, 53:129.
71. Jeyaseelan S, Chu HW, Young SK, et al. 2005. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infection and Immunity, 73:1754-63.
72. Johnson DA, Barrett AJ, Mason RW. 1986. Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region. Journal of Biological Chemistry, 261:14748-51.
73. Joshi UM, Kodavanti PR, Mehendale HM. 1988. Glutathione metabolism and utilization of external thiols by cigarette smoke-challenged, isolated rat and rabbit lungs. Toxicol.Appl Pharmacol, 96:324-35.
74. Kabha K, Schmegner J, Keisari Y, et al. 1997. SP-A enhances phagocytosis of Klebsiella by interaction with capsular polysaccharides and alveolar macrophages. AJP - Lung Cellular and Molecular Physiology, 272: L344-52.
75. Karimi K, Sarir H, Mortaz E, et al. 2006. Toll-like receptor-4 mediates cigarette smoke-induced cytokine production by human macrophages. Respir Res, 7:66.
76. Kasahara Y, Tuder RM, Cool CD, et al. 2001. Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema. American Journal of Respiratory and Critical Care Medicine, 163:737-44.
77. Keatings VM, Collins PD, Scott DM, et al. 1996. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. American Journal of Respiratory and Critical Care Medicine, 153:530-34.
78. Kim HJ, Henke CA, Savik SK, et al. 1997. Integrin mediation of alveolar epithelial cell migration on fibronectin and type I collagen. AJP - Lung Cellular and Molecular Physiology, 273:L134-41.
79. Kode A, Yang SR, Rahman I. 2006. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res, 7:132.
80. Koyama S, Sato E, Tsukadaira A, et al. 2002. Vascular endothelial growth factor mRNA and protein expression in airway epithelial cell lines in vitro. European Respiratory Journal, 20:1449-56.
81. Koyama S, Sato E, Nomura H, et al. 1998. Bradykinin stimulates type II alveolar cells to release neutrophil and monocyte chemotactic activity and inflammatory cytokines. American Journal of Pathology, 153:1885-93.
82. Kranenburg AR, de Boer WI, Alagappan VKT, et al. 2005. Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease, Thorax, 60:106-13.
83. Kuschner WG, D'Alessandro A, Wong H, et al. 1996. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. European Respiratory Journal, 9:1989-94.
84. Laan M, Bozinovski S, Anderson GP. 2004. Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells. The Journal of Immunology, 173:4164-70.
85. Lannan S, Donaldson K, Brown D, et al. 1994. Effect of cigarette smoke and its condensates on alveolar epithelial cell injury in vitro. AJP - Lung Cellular and Molecular Physiology, 266:L92-100.
86. Larsson L, Szponar B, Pehrson C. 2004. Tobacco smoking increases dramatically air concentrations of endotoxin. Indoor Air, 14:421-4.
87. Laurell CB, Eriksson S. 1963. The electrophoretic alpha-1-globulin pattern of serum in alpha-1-antitrypsin deficiency. Scand J Clin Lab Invest, 15:132-40.
88. Lavigne MC, Eppihimer MJ. 2005. Cigarette smoke condensate induces MMP-12 gene expression in airway-like epithelia. Biochem Biophys Res Commun, 330:194-203.
89. Li H, Cui D, Tong X, et al. 2002. The role of matrix metalloproteinases in extracellular matrix remodelling in chronic obstructive pulmonary disease rat models. Chinese Journal of Internal Medicine, 41:393-8.
90. Li W, Xu Y, Zhang Z. 2005. Activity of matrix metalloproteinase in airway epithelial cells of COPD patients. J Huazhong Univ Sci Technolog Med Sci, 25:151-4.
91. Li XY, Donaldson K, Rahman I, et al. 1994. An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro. Am J Respir Crit Care Med, 149:1518-25.
92. Li XY, Rahman I, Donaldson K, et al. 1996. Mechanisms of cigarette smoke induced increased airspace permeability. Thorax, 51:465-71.
93. Liu X, Conner H, Kobayashi T, et al. 2005. Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 33:121-9.
94. Liu Z, Zhou X, Shapiro SD, et al. 2000. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell, 102:647-55.
95. Low RB, Davis GS, Giancola MS. 1978. Biochemical analyses of bronchoalveolar lavage fluids of healthy human volunteer smokers and nonsmokers. Am Rev Respir Dis, 118:863-75.
96. Lozewicz S, Wells C, Gomez E, et al. 1990. Morphological integrity of the bronchial epithelium in mild asthma. Thorax, 45:12-15.
97. Maes T, Bracke KR, Vermaelen KY, et al. 2006. Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation. Int Arch Allergy Immunol, 141:354-68.
98. Maestrelli P, Saetta M, Mapp CE, et al. 2001. Remodeling in response to infection and injury. airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 164:S76-80.
99. Mancini NM, Bene MC, Gerard H, et al. 1993. Early effects of short-time cigarette smoking on the human lung: a study of bronchoalveolar lavage fluids. Lung, 171:277-91.
100. Mateos F, Brock JF, Perez-Arellano JL. 1998. Iron metabolism in the lower respiratory tract. Thorax, 53:594-600.
101. Mayer AK, Muehmer M, Mages J, et al. 2007. Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. The Journal of Immunology, 178:3134-42.
102. McElroy MC, Kasper M. 2004. The use of alveolar epithelial type I cell-selective markers to investigate lung injury and repair. European Respiratory Journal, 24:664-73.
103. McQuibban GA, Gong JH, Wong JP, et al. 2002. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood, 100: 1160-7.
104. Mercer B, Brinckerhoff C, D'Armiento J. 2006. Activation of the MMP-1 promoter by cigarette smoke in human small airway epithelial cells requires ERK MAP kinase signaling: differential response of the 1G and 2G promoter sequences. Proceedings of the American Thoracic Society, 3:477.
105. Mio T, Romberger DJ, Thompson AB, et al. 1997. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Am J Respir Crit Care Med, 155:1770-6.
106. Morrison D, Strieter RM, Donnelly SC, et al. 1998. Neutrophil chemokines in bronchoalveolar lavage fluid and leukocyte-conditioned medium from nonsmokers and smokers. European Respiratory Journal, 12:1067-72.
107. Neurohr C, Lenz AG, Ding I, et al. 2003. Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers. European Respiratory Journal, 22:82-7.
108. Nie J, Pei D. 2004. Rapid inactivation of alpha-1-proteinase inhibitor by neutrophil specific leukolysin/membrane-type matrix metalloproteinase 6. Exp Cell Res, 296:145-50.
109. Niewoehner DE, Kleinerman J, Rice DB. 1974. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med, 291:755-8.
110. Noda E, Hoshina H, Watanabe H, et al. 2003. Production of TNF-alpha by polymorphonuclear leukocytes during mechanical ventilation in the surfactant-depleted rabbit lung. Pediatr Pulmonol, 36:475-81.
111. Novinec M, Grass RN, Stark WJ, et al. 2007. Interaction between human cathepsins KL and S and elastins: mechanism of elastinolysis and inhibition by macromolecular inhibitors. Journal of Biological Chemistry, M610107200:
112. O'Donnell RA, Richter A, Ward J, et al. 2004. Expression of ErbB receptors and mucins in the airways of long term current smokers. Thorax, 59:1032-40.
113. Okada Y, Watanabe S, Nakanishi I, et al. 1988. Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases. FEBS Lett, 229:157-60.
114. Olivera DS, Boggs SE, Beenhouwer C, et al. 2007. Cellular mechanisms of mainstream cigarette smoke-induced lung epithelial tight junction permeability changes in vitro. Inhal. Toxicol, 19:13-22.
115. Patel IS, Roberts NJ, Lloyd-Owen SJ, et al. 2003. Air-way epithelial inflammatory responses and clinical parameters in COPD. European Respiratory Journal, 22:94-9.
116. Patel IS, Seemungal TAR, Wilks M, et al. 2002. Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations. Thorax, 57:759-64.
117. Pauwels RA, Buist AS, Calverley PMA, et al. 2001. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary. Am J Respir Crit Care Med, 163:1256.
118. Pesci A, Balbi B, Majori M, et al. 1998. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. European Respiratory Journal, 12:380-6.
119. Pham CT. 2006. Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol, 6:541-50.
120. Porth MC. 2005. Pathophysiology concepts of altered health states, 7th ed. New York: Lippincott Williams and Wilkins.
121. Profita M, Chiappara G, Mirabella. F, et al. 2003. Effect of cilomilast (Ariflo) on TNF-{alpha}, IL-8, and GM-CSF release by airway cells of patients with COPD. Thorax, 58:573-9.
122. Pryor WA, Stone K. 2007. Oxidants in cigarette smoke: radicals hydrogen peroxides peroxynitrate and peroxynitrite. Ann N Y Acad Sci, 686:12-28.
123. Rahman I. 2005. Oxidative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms. Cell Biochem Biophys, 43:167-88.
124. Rahman I, Li XY, Donaldson K, et al. 1995, Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. AJP - Lung Cellular and Molecular Physiology, 269:L285-92.
125. Rahman I, Marwick J, Kirkham P. 2004. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem.Pharmacol, 68:1255-67.
126. Reibman J, Hsu Y, Chen LC, et al. 2003. Airway epithelial cells release MIP-3 {alpha}/CCL20 in response to cytokines and ambient particulate matter. American Journal of Respiratory Cell and Molecular Biology, 28:648.
127. Reid PT, Marsden ME, Cunningham GA, et al. 1999. Human neutrophil elastase regulates the expression and secretion of elafin (elastase-specific inhibitor) in type II alveolar epithelial cells. FEBS Lett, 457:33-7.
128. Reilly JJ Jr, Chen P, Sailor LZ, et al. 1991. Cigarette smoking induces an elastolytic cysteine proteinase in macrophages distinct from cathepsin L. AJP - Lung Cellular and Molecular Physiology, 261:L41-8.
129. Reynolds PR, Cosio MG, Hoidal JR. 2006. Cigarette smoke-induced Egr-1 upregulates proinflammatory cytokines in pulmonary epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 35:314-19.
130. Ritter M, Mennerich D, Weith A, et al. 2005. Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory response. J Inflamm (Lond), 2:16.
131. Rogers DF. 2005. The role of airway secretions in COPD: pathophysiology, epidemiology and pharmacotherapeutic options. COPD, 2:341-53.
132. Russell REK, Thorley A, Culpitt SV, et al. 2002. Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. AJP - Lung Cellular and Molecular Physiology, 283:L867-73.
133. Rusznak C, Mills PR, Devalia JL, et al. 2000. Effect of cigarette smoke on the permeability and IL-1 beta and sICAM-1 release from cultured human bronchial epithelial cells of never-smokers, smokers, and patients with chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology, 23:530-6.
134. Sad S, Marcotte R, Mosmann TR. 1995. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity, 2:271-9.
135. Saetta M. 1998. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 157:822-6.
136. Saetta M, GhezzoH, Kim WD. 1985. Loss of alveolar attachments in smokers: a morphomaetric correlate of lung function impairment. Am Rev Respir Dis, 132:894-900.
137. Saetta M, Turato G, Baraldo S, et al. 2000. Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with symptoms of chronic bronchitis and chronic airflow limitation. Am J Respir Crit Care Med, 161:1016-21.
138. Saito T, Yamamoto T, Kazawa T, et al. 2005. Expression of toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouse. Cell Tissue Res, 321:75-88.
139. Sakakibara A. 1997. Possible involvement of phosphorylation of occludin in tight junction formation. The Journal of Cell Biology, 137:1393-401.
140. Sallenave JM. 2002. Antimicrobial activity of antiproteinases. Biochem Soc Trans, 30:111-15.
141. Schmeck B, Huber S, Moog K, et al. 2006. Pneumococci induced TLR- and Rac 1 -dependent NF-{kappa} B-recruitment to the IL-8 promoter in lung epithelial cells. AJP - Lung Cellular and Molecular Physiology, 290:L730-7.
142. Schmekel B, Bos JH, Khan AR, et al. 1992. Integrity of the alveolar-capillary barrier and alveolar surfactant system in smokers. Thorax, 47:603-8.
143. Schonbeck U, Mach F, Libby P. 1998. Generation of biologically active IL-1 {beta} by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 {beta} processing. The Journal of Immunology, 161:3340-6.
144. Schulz C, Kratzel K, Wolf K, et al. 2004. Activation of bronchial epithelial cells in smokers without airway obstruction and patients with COPD. Chest, 125:1706-13.
145. Schulze-Osthoff K, Los M, Baeuerle PA. 1995. Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes. Biochem. Pharmacol, 50:735-41.
146. Segura-Valdez L, Pardo A, Gaxiola M, et al. 2000. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest, 117:684-94.
147. Sethi S. 2000. Bacterial Infection and the Pathogenesis of COPD. Chest, 117:286S-291.
148. Sethi S, Maloney J, Grove L, et al. 2006. Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, 173:991-8.
149. Shao MXG, Nakanaga T, Nadel JA. 2004, Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-{alpha}-converting enzyme in human airway epithelial (NCI-H292) cells. AJP - Lung Cellular and Molecular Physiology, 287:L420-7.
150. Siafakas NM, Vermeire P, Pride NB, et al. 1995. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. European Respiratory Journal, 8:1398-420.
151. Slevogt H, Seybold J, Tiwari KN, et al, 2007. Moraxella catarrhalis is internalized in respiratory epithelial cells by a trigger-like mechanism and initiates a TLR2- and partly NOD1 -dependent inflammatory immune response. Cell Microbiol, 9:694-707.
152. Snider GL. 1992. Emphysema: the first two centuries - and beyond a historical overview, with suggestions for future research: Part 1. Am Rev Respir Dis, 146:1334-44.
153. Soler N, Ewig S, Torres A, et al. 1999. Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease. European Respiratory Journal, 14:1015-22.
154. Stringer KA, Freed BM, Dunn JS, et al. 2004. Particulate phase cigarette smoke increases MnSOD, NQO1, and CINC-1 in rat lungs. Free Radic Biol Med, 37:1527-33.
155. Taggart C, Cervantes-Laurean D, Kim G, et al. 2000. Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsill causes loss of anti-neutrophil elastase activity. Journal of Biological Chemistry, 275:27258-65.
156. Taggart CC, Lowe GJ, Greene CM, et al. 2001. Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor. Journal of Biological Chemistry, 276:33345-52.
157. Takahashi H, Ishidoh K, Muno D, et al. 1993. Cathepsin L activity is increased in alveolar macrophages and bronchoalveolar lavage fluid of smokers. Am Rev Respir Dis, 147:1562-8.
158. Takanashi S, Hasegawa Y, Kanehira Y, et al. 1999. Interleukin-10 level in sputum is reduced in bronchial asthma, COPD and in smokers. European Respiratory Journal, 14:309-14.
159. Takeuchi O, Kawai T, Muhlradt PF, et al. 2001. Discrimination of bacterial lipoproteins by Toll-like receptor 6. International Immunology, 13:933-40.
160. Tang K, Rossiter HB, Wagner PD, et al. 2004. Lung-targeted VEGF inactivation leads to emphysema phenotype in mice. Journal of Applied Physiology, 97:1559-66.
161. Tetley TD. 2002. Macrophages and the pathogenesis of COPD. Chest, 121:156S-159S.
162. Tetley TD. 2005. Antiprotease therapy. In Cazzola M et al eds. Therapeutic strategies in COPD. Oxford: Clinical Publishing p 233-45.
163. Tetley TD. 2006. Proteinase inhibitors/secretory leukoprotease inhibitor and elafin. In Laurent GJ, Shapiro SD, eds. Encyclopedia of respiratory medicine. London: Academic Press p 517-22.
164. Thorley AJ, Ford PA, Giembycz MA, et al. 2007. Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages. The Journal of Immunology, 178:463-73.
165. Thorley AJ, Goldstraw P, Young A, et al. 2005. Primary human alveolar type II epithelial cell CCL20 (macrophage inflammatory protein-3 {alpha})-induced dendritic cell migration. American Journal of Respiratory Cell and Molecular Biology, 32:262-7.
166. Tobias P, Curtiss LK. 2005. Thematic review series: the immune system and atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis. Journal of Lipid Research, 46:404-11.
167. Tomaki M, Sugiura H, Koarai A, et al... Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. Pulmonary Pharmacology and Therapeutics, In Press, Corrected Proof.
168. Traves SL, Culpitt SV, Russell REK, et al. 2002. Increased levels of the chemokines GRO {alpha} and MCP-1 in sputum samples from patients with COPD. Thorax, 57:590-5.
169. Trinchieri G, Sher A. 2007. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol, 7:179-90.
170. Tsai JR, Chong IW, Chen CC, et al. 2006. Mitogen-activated protein kinase pathway was significantly activated in human bronchial epithelial cells by nicotine. DNA Cell Biol, 25:312-22.
171. Tsuji T, Aoshiba K, Nagai A. 2004. Cigarette smoke induces senescence in alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 31:643-9.
172. Tsuji T, Aoshiba K, Nagai A. 2006. Alveolar cell senescence in patients with pulmonary emphysema. American Journal of Respiratory and Critical Care Medicine, 174:886-93.
173. Van den Steen PE, Proost P, Wuyts A, et al. 2000. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. Blood, 96:2673-81.
174. van der Vaart H, Postma DS, Timens W, et al. 2005. Acute effects of cigarette smoking on inflammation in healthy intermittent smokers. Respir Res, 6:22.
175. van Diemen CC, Postma DS, Vonk JM, et al. 2006. Polymorphisms in surfactant proteins are associated with FEV 1 decline and development of COPD in the general population. Eur Respir Rev, 15:204-6.
176. Van EP, Little RD, Dupuis J, et al. 2002. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature, 418:426-30.
177. Vernooy JHJ, Lindeman JHN, Jacobs JA, et al. 2004. Increased activity of matrix metalloproteinase-8 and matrix metalloproteinase-9 in induced
178. Vestbo J, Hogg JC. 2006. Convergence of the epidemiology and pathology of COPD. Thorax, 61:86-8.
179. Vlahovic G, Russell ML, Mercer RR, et al. 1999. Cellular and connective tissue changes in alveolar septal walls in emphysema. Am J Respir Crit Care Med, 160:2086-92.
180. Voelkel NF, Vandivier RW, Tuder RM. 2006. Vascular endothelial growth factor in the lung. AJP - Lung Cellular and Molecular Physiology, 290:L209-21.
181. Wang H, Liu X, Umino T, et al. 2001. Cigarette smoke inhibits human bronchial epithelial cell repair processes. American Journal of Respiratory Cell and Molecular Biology, 25:772-9.
182. Wanner A, Salathe M, O'Riordan TG. 1996. Mucociliary clearance in the airways. Am J Respir Crit Care Med, 154:1868-902.
183. Ward P. 2002. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. The Journal of Biological Chemistry, 277:35760-5.
184. Wassef A, Janardhan K, Pearce JW, et al. 2004. Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle. Histol Histopathol, 19:1201-8.
185. Wickenden JA, Clarke MCH, Rossi AG, et al. 2003. Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis. American Journal of Respiratory Cell and Molecular Biology, 29:562-70.
186. Williams MC. 2003. Alveolar type I cells: molecular phenotype and development. Annual Review of Physiology, 65:669-95.
187. Witherden IR, Vanden Bon EJ, Goldstraw P, et al. 2004. Primary human alveolar type II epithelial cell chemokine release: effects of cigarette smoke and neutrophil elastase. American Journal of Respiratory Cell and Molecular Biology, 30:500-9.
188. Wu H, Kuzmenko A, Wan S, et al. 2003. Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability. Journal of Clinical Investigation, 111:1589-602.
189. Wyllie DH, Kiss-Toth E, Visintin A, et al. 2000. Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. The Journal of Immunology, 165:7125-32.
190. Yu M, Zheng X, Witschi H, et al. 2002. The role of interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants. Toxicological Sciences, 68:488-97.
191. Yu Q, Stamenkovic I. 2000. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes and Development, 14:163-76.
192. Zalacain R, Sobradillo V, Amilibia J, et al. 1999. Predisposing factors to bacterial colonization in chronic obstructive pulmonary disease. European Respiratory Journal, 13:343-8.
193. Zhang X, Shan P, Jiang G, et al. 2006. Toll-like receptor 4 deficiency causes pulmonary emphysema. J Clin Invest, 116:3050-9.
194. Zhu G, Warren L, Aponte J, et al. 2007. The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. American Journal of Respiratory and Critical Care Medicine, 176:167-73.
195. Zhu J, Qiu Y, Majumdar S, et al. 2001. Exacerbations of bronchitis. Bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants. Am J Respir Crit Care Med, 164:109-16.
196. Ziegenhagen M, Benner U, Zissel G, et al. 1997. Sarcoidosis: TNF-alpha release from alveolar macrophages and serum level of sIL-2R are prognostic markers. American Journal of Respiratory and Critical Care Medicine, 156:1586-92.