Rap1 promotes multiple pancreatic islet cell functions and signals through mammalian target of rapamycin complex 1 to enhance proliferation

Journal of Biological Chemistry

Volumn 285, Issue 21, 2010, Pages 15777-15785

  Kelly, Patrick ^a,b   Bailey, Candice L ^a,c   Fueger, Patrick T ^a,d   Newgard, Christopher B ^a   Casey, Patrick J ^a   Kimple, Michelle E ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL BIOLOGY; CELL DYSFUNCTION; CELL FUNCTIONS; CELL SIGNALING; COMPLEX 1; G PROTEIN; GLUCOSE-STIMULATED INSULIN SECRETIONS; GTPASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INSULIN SECRETION; MAMMALIAN TARGET; PANCREATIC ISLET CELLS; PROTEIN KINASE; RAPAMYCIN; RAT ISLETS; REGULATORY PATHWAY; RIBOSOMAL PROTEINS; S6 KINASE; SIGNALING EVENTS; SIGNALING PATHWAYS;

ANTIBIOTICS; BIOLOGY; CELL PROLIFERATION; FETAL MONITORING; GLUCOSE; INSULIN; MAMMALS; PHOSPHORYLATION; PROTEINS; TARGETS;

SIGNALING;

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN S6; RAP PROTEIN; RAP1 PROTEIN; RAPAMYCIN; S6 KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOLOGY; DIABETES MELLITUS; DRUG TARGETING; INSULIN RELEASE; INSULINOMA; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DIABETES MELLITUS; GLUCOSE; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; PHOSPHORYLATION; RAP1 GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RIBOSOMAL PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

MAMMALIA; RATTUS;

EID: 77952343958     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.069112     Document Type: Article

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