Does airway smooth muscle express an inflammatory phenotype in asthma?

British Journal of Pharmacology

Volumn 163, Issue 1, 2011, Pages 68-80

  Damera, Gautam ^a   Panettieri Jr , Reynold A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

airway inflammation; airway obstruction; airway remodelling; COPD; cytokines; non canonical pathways

Indexed keywords

ACLIDINIUM BROMIDE; ANGIOTENSIN II; BETA 2 ADRENERGIC RECEPTOR; ENDOTHELIN; EOTAXIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; INTERLEUKIN 9; LEUKOTRIENE; MATRIX METALLOPROTEINASE; METHACHOLINE; MONTELUKAST; ONCOSTATIN M; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROSTAGLANDIN; PROSTAGLANDIN E2; PROTEIN G; RAPAMYCIN; SEROTONIN; TOLL LIKE RECEPTOR; TOLUENE DIISOCYANATE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

AIRWAY REMODELING; AIRWAY SMOOTH MUSCLE; ASTHMA; AUTOCRINE EFFECT; CELL INTERACTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LEUKOCYTE MIGRATION; MITOGENICITY; NONHUMAN; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT DISEASE; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

ANIMALS; ASTHMA; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MUSCLE, SMOOTH; PHENOTYPE; RESPIRATORY SYSTEM;

EID: 79953690833     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01165.x     Document Type: Review

References (159)

1. Allen IC, Hartney JM, Coffman TM, Penn RB, Wess J, Koller BH, (2006). Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. Am J Physiol Lung Cell Mol Physiol 290: L526-L533. (Pubitemid 43725097)
2. Ammit AJ, Hastie AT, Edsall LC, Hoffman RK, Amrani Y, Krymskaya VP, et al,. (2001). Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. FASEB J 15: 1212-1214.
3. Amrani Y, Tliba O, Choubey D, Huang CD, Krymskaya VP, Eszterhas A, et al,. (2003). IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am J Physiol Lung Cell Mol Physiol 284: L1063-L1071. (Pubitemid 36687143)
4. Ammit AJ, Moir LM, Oliver BG, Hughes JM, Alkhouri H, Ge Q, et al,. (2007). Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 292: L199-L206. (Pubitemid 46103444)
5. Bachar O, Adner M, Uddman R, Cardell LO, (2004). Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways. Eur J Immunol 34: 1196-1207. (Pubitemid 39255999)
6. Bansal G, Xie Z, Rao S, Nocka KH, Druey KM, (2008). Suppression of immunoglobulin E-mediated allergic responses by regulator of G protein signaling 13. Nat Immunol 9: 73-80. (Pubitemid 350286206)
7. Baraldo S, Faffe DS, Moore PE, Whitehead T, McKenna M, Silverman ES, et al,. (2003). Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK. Am J Physiol Lung Cell Mol Physiol 284: L1093-L1102. (Pubitemid 36687146)
8. Barnes PJ, (2008). The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest 118: 3546-3556.
9. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M, (2003). Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 167: 1360-1368. (Pubitemid 36609720)
10. Billington CK, Kong KC, Bhattacharyya R, Wedegaertner PB, Panettieri RA Jr, Chan TO, et al,. (2005). Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry 44: 14595-14605. (Pubitemid 41567467)
11. Bosse Y, Thompson C, McMahon S, Dubois CM, Stankova J, Rola-Pleszczynski M, (2008). Leukotriene D4-induced, epithelial cell-derived transforming growth factor beta1 in human bronchial smooth muscle cell proliferation. Clin Exp Allergy 38: 113-121. (Pubitemid 350233393)
12. Bosse Y, Stankova J, Rola-Pleszczynski M, (2009). Cysteinyl-leukotrienes in asthmatic airway smooth muscle cell hyperplasia. Ann Allergy Asthma Immunol 102: 16-21.
13. Boyce JA, (2008). Eicosanoids in asthma, allergic inflammation, and host defense. Curr Mol Med 8: 335-349.
14. Bradding P, Roberts JA, Britten KM, Montefort S, Djukanovic R, Mueller R, et al,. (1994). Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 10: 471-480.
15. Brightling C, Berry M, Amrani Y, (2008). Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol 121: 5-10; quiz 11-12.
16. Burgess JK, Ceresa C, Johnson SR, Kanabar V, Moir LM, Nguyen TT, et al,. (2009). Tissue and matrix influences on airway smooth muscle function. Pulm Pharmacol Ther 22: 379-387.
17. Carroll NG, Mutavdzic S, James AL, (2002). Distribution and degranulation of airway mast cells in normal and asthmatic subjects. Eur Respir J 19: 879-885. (Pubitemid 34567902)
18. Cardell LO, Uddman R, Zhang Y, Adner M, (2008). Interleukin-1beta up-regulates tumor necrosis factor receptors in the mouse airways. Pulm Pharmacol Ther 21: 675-681. (Pubitemid 351982016)
19. Chambard JC, Paris S, L'Allemain G, Pouyssegur J, (1987). Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin. Nature 326: 800-803. (Pubitemid 17064233)
20. Chanez P, Wenzel SE, Anderson GP, Anto JM, Bel EH, Boulet LP, et al,. (2007). Severe asthma in adults: what are the important questions. J Allergy Clin Immunol 119: 1337-1348. (Pubitemid 46863369)
21. Chaudhuri N, Whyte MK, Sabroe I, (2007). Reducing the toll of inflammatory lung disease. Chest 131: 1550-1556. (Pubitemid 46762365)
22. Chhabra J, Li YZ, Alkhouri H, Blake AE, Ge Q, Armour CL, et al,. (2007). Histamine and tryptase modulate asthmatic airway smooth muscle GM-CSF and RANTES release. Eur Respir J 29: 861-870. (Pubitemid 46711889)
23. Chiou YL, Lin CY, (2009). Der p2 activates airway smooth muscle cells in a TLR2/MyD88-dependent manner to induce an inflammatory response. J Cell Physiol 220: 311-318.
24. Chung KF, (2000). Airway smooth muscle cells: contributing to and regulating airway mucosal inflammation. Eur Respir J 15: 961-968. (Pubitemid 30321858)
25. Clarke D, Damera G, Sukkar MB, Tliba O, (2009a). Transcriptional regulation of cytokine function in airway smooth muscle cells. Pulm Pharmacol Ther 22: 436-445.
26. Clarke DL, Dakshinamurti S, Larsson AK, Ward JE, Yamasaki A, (2009b). Lipid metabolites as regulators of airway smooth muscle function. Pulm Pharmacol Ther 22: 426-435.
27. Cooper PR, Lamb R, Day ND, Branigan PJ, Kajekar R, San Mateo L, et al,. (2009). TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation. Am J Physiol Lung Cell Mol Physiol 297: L530-L537.
28. Damera G, Tliba O, Panettieri RA Jr, (2009a). Airway smooth muscle as an immunomodulatory cell. Pulm Pharmacol Ther 22: 353-359.
29. Damera G, Zhao H, Wang M, Smith M, Kirby C, Jester WF, et al,. (2009b). Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 296: L674-L683.
30. Damera G, Jiang M, Zhao H, Fogle HW, Jester WF, Freire J, et al,. (2010). Aclidinium bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation. Eur J Pharmacol.
31. Dekkers BG, Schaafsma D, Nelemans SA, Zaagsma J, Meurs H, (2007). Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function. Am J Physiol Lung Cell Mol Physiol 292: L1405-L1413. (Pubitemid 47077356)
32. Dekkers BG, Maarsingh H, Meurs H, Gosens R, (2009). Airway structural components drive airway smooth muscle remodeling in asthma. Proc Am Thorac Soc 6: 683-692.
33. Drazen J, (1998). Clinical pharmacology of leukotriene receptor antagonists and 5-lipoxygenase inhibitors. Am J Respir Crit Care Med 157 (6 Pt 2): S233-S237; discussion S247-S248. (Pubitemid 28304149)
34. Drexler SK, Foxwell BM, (2010). The role of toll-like receptors in chronic inflammation. Int J Biochem Cell Biol 42: 506-518.
35. Duplaa C, Couffinhal T, Dufourcq P, Llanas B, Moreau C, Bonnet J, (1997). The integrin very late antigen-4 is expressed in human smooth muscle cell. Involvement of alpha 4 and vascular cell adhesion molecule-1 during smooth muscle cell differentiation. Circ Res 80: 159-169. (Pubitemid 27056979)
36. Elias JA, Wu Y, Zheng T, Panettieri R, (1997). Cytokine- and virus-stimulated airway smooth muscle cells produce IL-11 and other IL-6-type cytokines. Am J Physiol 273 (3 Pt 1): L648-L655. (Pubitemid 27423933)
37. Elshaw SR, Henderson N, Knox AJ, Watson SA, Buttle DJ, Johnson SR, (2004). Matrix metalloproteinase expression and activity in human airway smooth muscle cells. Br J Pharmacol 142: 1318-1324. (Pubitemid 39178885)
38. Espinosa K, Bosse Y, Stankova J, Rola-Pleszczynski M, (2003). CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4. J Allergy Clin Immunol 111: 1032-1040. (Pubitemid 36570864)
39. Faffe DS, Flynt L, Mellema M, Moore PE, Silverman ES, Subramaniam V, et al,. (2005a). Oncostatin M causes eotaxin-1 release from airway smooth muscle: synergy with IL-4 and IL-13. J Allergy Clin Immunol 115: 514-520. (Pubitemid 40341704)
40. Faffe DS, Flynt L, Mellema M, Whitehead TR, Bourgeois K, Panettieri RA, et al,. (2005b). Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta. Am J Physiol Lung Cell Mol Physiol 288: L1040-L1048. (Pubitemid 40695429)
41. Fanat AI, Thomson JV, Radford K, Nair P, Sehmi R, (2009). Human airway smooth muscle promotes eosinophil differentiation. Clin Exp Allergy 39: 1009-1017.
42. Foda HD, George S, Rollo E, Drews M, Conner C, Cao J, et al,. (1999). Regulation of gelatinases in human airway smooth muscle cells: mechanism of progelatinase A activation. Am J Physiol 277 (1 Pt 1): L174-L182. (Pubitemid 29356765)
43. Freund V, Pons F, Joly V, Mathieu E, Martinet N, Frossard N, (2002). Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions. Eur Respir J 20: 458-463.
44. Freyer AM, Johnson SR, Hall IP, (2001). Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. Am J Respir Cell Mol Biol 25: 569-576. (Pubitemid 33087107)
45. Fukumoto T, Kubota Y, Kitanaka A, Yamaoka G, Ohara-Waki F, Imataki O, et al,. (2009). Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells. Cell Signal 21: 1775-1783.
46. Gauvreau GM, Watson RM, O'Byrne PM, (1999). Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 159: 31-36. (Pubitemid 29036499)
47. Gosens R, Rieks D, Meurs H, Ninaber DK, Rabe KF, Nanninga J, et al,. (2009). Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by human airway smooth muscle cells. Eur Respir J 34: 1436-1443.
48. Govindaraju V, Michoud MC, Al-Chalabi M, Ferraro P, Powell WS, Martin JG, (2006). Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration. Am J Physiol Cell Physiol 291: C957-C965. (Pubitemid 44771814)
49. Govindaraju V, Michoud MC, Ferraro P, Arkinson J, Safka K, Valderrama-Carvajal H, et al,. (2008). The effects of interleukin-8 on airway smooth muscle contraction in cystic fibrosis. Respir Res 9: 76.
50. Grunstein MM, Hakonarson H, Whelan R, Yu Z, Grunstein JS, Chuang S, (2001). Rhinovirus elicits proasthmatic changes in airway responsiveness independently of viral infection. J Allergy Clin Immunol 108: 997-1004. (Pubitemid 33151554)
51. Grunstein MM, Hakonarson H, Leiter J, Chen M, Whelan R, Grunstein JS, et al,. (2002). IL-13-dependent autocrine signaling mediates altered responsiveness of IgE-sensitized airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 282: L520-L528. (Pubitemid 34654657)
52. Gueders MM, Foidart JM, Noel A, Cataldo DD, (2006). Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. Eur J Pharmacol 533: 133-144. (Pubitemid 43340010)
53. Gueders MM, Hirst SJ, Quesada-Calvo F, Paulissen G, Hacha J, Gilles C, et al,. (2010). Matrix metalloproteinase-19 deficiency promotes tenascin-C accumulation and allergen-induced airway inflammation. Am J Respir Cell Mol Biol 43: 286-295.
54. Hackett TL, Holloway R, Holgate ST, Warner JA, (2008). Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study. Respir Res 9: 47.
55. Hakonarson H, Maskeri N, Carter C, Chuang S, Grunstein MM, (1999). Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle. J Clin Invest 104: 657-667.
56. Hakonarson H, Kim C, Whelan R, Campbell D, Grunstein MM, (2001). Bi-directional activation between human airway smooth muscle cells and T lymphocytes: role in induction of altered airway responsiveness. J Immunol 166: 293-303. (Pubitemid 32038445)
57. Halayko AJ, Tran T, Ji SY, Yamasaki A, Gosens R, (2006). Airway smooth muscle phenotype and function: interactions with current asthma therapies. Curr Drug Targets 7: 525-540. (Pubitemid 43744820)
58. Halayko AJ, Tran T, Gosens R, (2008). Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins. Proc Am Thorac Soc 5: 80-88.
59. Hallstrand TS, Henderson WR Jr, (2010). An update on the role of leukotrienes in asthma. Curr Opin Allergy Clin Immunol 10: 60-66.
60. Hasaneen NA, Zucker S, Cao J, Chiarelli C, Panettieri RA, Foda HD, (2005). Cyclic mechanical strain-induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs. FASEB J 19: 1507-1509. (Pubitemid 41279013)
61. Hedges JC, Singer CA, Gerthoffer WT, (2000). Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes. Am J Respir Cell Mol Biol 23: 86-94. (Pubitemid 30597099)
62. Henderson WR Jr, Tang LO, Chu SJ, Tsao SM, Chiang GK, Jones F, et al,. (2002). A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am J Respir Crit Care Med 165: 108-116. (Pubitemid 34053366)
63. Henderson N, Markwick LJ, Elshaw SR, Freyer AM, Knox AJ, Johnson SR, (2007). Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration. Am J Physiol Lung Cell Mol Physiol 292: L1030-L1038. (Pubitemid 46608250)
64. Henness S, Johnson CK, Ge Q, Armour CL, Hughes JM, Ammit AJ, (2004). IL-17A augments TNF-alpha-induced IL-6 expression in airway smooth muscle by enhancing mRNA stability. J Allergy Clin Immunol 114: 958-964. (Pubitemid 39330273)
65. Hershenson MB, Brown M, Camoretti-Mercado B, Solway J, (2008). Airway smooth muscle in asthma. Annu Rev Pathol 3: 523-555. (Pubitemid 351488292)
66. Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, et al,. (2003). Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest 111: 445-452. (Pubitemid 36228001)
67. Hirota JA, Nguyen TT, Schaafsma D, Sharma P, Tran T, (2009). Airway smooth muscle in asthma: phenotype plasticity and function. Pulm Pharmacol Ther 22: 370-378.
68. Hirst SJ, (2003). Regulation of airway smooth muscle cell immunomodulatory function: role in asthma. Respir Physiol Neurobiol 137: 309-326. (Pubitemid 37153290)
69. Hirst SJ, Hallsworth MP, Peng Q, Lee TH, (2002). Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1beta and is mediated by the interleukin-4 receptor alpha-chain. Am J Respir Crit Care Med 165: 1161-1171. (Pubitemid 34415828)
70. Hollinger S, Hepler JR, (2002). Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev 54: 527-559.
71. Howarth PH, Babu KS, Arshad HS, Lau L, Buckley M, McConnell W, et al,. (2005). Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax 60: 1012-1018. (Pubitemid 41705469)
72. Hughes JM, Arthur CA, Baracho S, Carlin SM, Hawker KM, Johnson PR, et al,. (2000). Human eosinophil-airway smooth muscle cell interactions. Mediators Inflamm 9: 93-99. (Pubitemid 30482433)
73. Issa R, Xie S, Lee KY, Stanbridge RD, Bhavsar P, Sukkar MB, et al,. (2006). GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases. Am J Physiol Lung Cell Mol Physiol 291: L66-L74.
74. Issa R, Sorrentino R, Sukkar MB, Sriskandan S, Chung KF, Mitchell JA, (2008). Differential regulation of CCL-11/eotaxin-1 and CXCL-8/IL-8 by gram-positive and gram-negative bacteria in human airway smooth muscle cells. Respir Res 9: 30.
75. Ito I, Fixman ED, Asai K, Yoshida M, Gounni AS, Martin JG, et al,. (2009). Platelet-derived growth factor and transforming growth factor-beta modulate the expression of matrix metalloproteinases and migratory function of human airway smooth muscle cells. Clin Exp Allergy 39: 1370-1380.
76. Iwata S, Ito S, Iwaki M, Kondo M, Sashio T, Takeda N, et al,. (2009). Regulation of endothelin-1-induced interleukin-6 production by Ca2+ influx in human airway smooth muscle cells. Eur J Pharmacol 605: 15-22.
77. Jarai G, Sukkar M, Garrett S, Duroudier N, Westwick J, Adcock I, et al,. (2004). Effects of interleukin-1beta, interleukin-13 and transforming growth factor-beta on gene expression in human airway smooth muscle using gene microarrays. Eur J Pharmacol 497: 255-265. (Pubitemid 39164891)
78. John AE, Zhu YM, Brightling CE, Pang L, Knox AJ, (2009). Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. J Immunol 183: 4682-4692.
79. Johnson PR, (2001). Role of human airway smooth muscle in altered extracellular matrix production in asthma. Clin Exp Pharmacol Physiol 28: 233-236. (Pubitemid 32193670)
80. Kaur M, Holden NS, Wilson SM, Sukkar MB, Chung KF, Barnes PJ, et al,. (2008). Effect of beta2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A. Am J Physiol Lung Cell Mol Physiol 295: L505-L514.
81. Kavanaugh WM, Williams LT, Ives HE, Coughlin SR, (1988). Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway. Mol Endocrinol 2: 599-605.
82. Kelly M, Hwang JM, Kubes P, (2007). Modulating leukocyte recruitment in inflammation. J Allergy Clin Immunol 120: 3-10. (Pubitemid 46990511)
83. Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, et al,. (2006). Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol 176: 4440-4448. (Pubitemid 44264424)
84. Kirstein F, Horsnell WG, Kuperman DA, Huang X, Erle DJ, Lopata AL, et al,. (2010). Expression of IL-4 receptor alpha on smooth muscle cells is not necessary for development of experimental allergic asthma. J Allergy Clin Immunol 126: 347-354.
85. Knobloch J, Peters H, Jungck D, Muller K, Strauch J, Koch A, (2009). TNFalpha-induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism. Thorax 64: 1044-1052.
86. Komuro I, Kurihara H, Sugiyama T, Yoshizumi M, Takaku F, Yazaki Y, (1988). Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett 238: 249-252.
87. Kong KC, Billington CK, Gandhi U, Panettieri RA Jr, Penn RB, (2006). Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11). FASEB J 20: 1558-1560.
88. Krymskaya VP, Orsini MJ, Eszterhas AJ, Brodbeck KC, Benovic JL, Panettieri RA, et al,. (2000). Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. Am J Respir Cell Mol Biol 23: 546-554.
89. Kunikata T, Yamane H, Segi E, Matsuoka T, Sugimoto Y, Tanaka S, et al,. (2005). Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol 6: 524-531. (Pubitemid 41716766)
90. Lagente V, Boichot E, (2010). Role of matrix metalloproteinases in the inflammatory process of respiratory diseases. J Mol Cell Cardiol 48: 440-444.
91. Lazaar AL, Panettieri RA Jr, (2005). Airway smooth muscle: a modulator of airway remodeling in asthma. J Allergy Clin Immunol 116: 488-495; quiz 496. (Pubitemid 41267115)
92. Lazaar AL, Albelda SM, Pilewski JM, Brennan B, Pure E, Panettieri RA Jr, (1994). T lymphocytes adhere to airway smooth muscle cells via integrins and CD44 and induce smooth muscle cell DNA synthesis. J Exp Med 180: 807-816. (Pubitemid 24256594)
93. Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Lee HK, et al,. (2006). Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor gamma in a murine model of toluene diisocyanate-induced asthma. J Immunol 177: 5248-5257. (Pubitemid 44527597)
94. Lex C, Zacharasiewicz A, Payne DN, Wilson NM, Nicholson AG, Kharitonov SA, et al,. (2006). Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study. Respir Res 7: 63.
95. Liang G, Bansal G, Xie Z, Druey KM, (2009). RGS16 inhibits breast cancer cell growth by mitigating phosphatidylinositol 3-kinase signaling. J Biol Chem 284: 21719-21727.
96. Malavia NK, Raub CB, Mahon SB, Brenner M, Panettieri RA Jr, George SC, (2009). Airway epithelium stimulates smooth muscle proliferation. Am J Respir Cell Mol Biol 41: 297-304.
97. Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, et al,. (2009). Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases. J Immunol 183: 1739-1750.
98. Matera MG, Calzetta L, Cazzola M, (2010). TNF-alpha inhibitors in asthma and COPD: we must not throw the baby out with the bath water. Pulm Pharmacol Ther 23: 121-128.
99. McKay S, Sharma HS, (2002). Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle. Respir Res 3: 11.
100. Mehrotra AK, Henderson WR Jr, (2009). The role of leukotrienes in airway remodeling. Curr Mol Med 9: 383-391.
101. Misior AM, Deshpande DA, Loza MJ, Pascual RM, Hipp JD, Penn RB, (2009). Glucocorticoid- and protein kinase A-dependent transcriptome regulation in airway smooth muscle. Am J Respir Cell Mol Biol 41: 24-39.
102. Montuschi P, Mondino C, Koch P, Barnes PJ, Ciabattoni G, (2006). Effects of a leukotriene receptor antagonist on exhaled leukotriene E4 and prostanoids in children with asthma. J Allergy Clin Immunol 118: 347-353. (Pubitemid 44160715)
103. Moore WC, Peters SP, (2006). Severe asthma: an overview. J Allergy Clin Immunol 117: 487-494; quiz 495.
104. Morris GE, Whyte MK, Martin GF, Jose PJ, Dower SK, Sabroe I, (2005). Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. Am J Respir Crit Care Med 171: 814-822. (Pubitemid 40562711)
105. Mullan CS, Riley M, Clarke D, Tatler A, Sutcliffe A, Knox AJ, et al,. (2008). Beta-tryptase regulates IL-8 expression in airway smooth muscle cells by a PAR-2-independent mechanism. Am J Respir Cell Mol Biol 38: 600-608. (Pubitemid 351758679)
106. Nair P, Radford K, Fanat A, Janssen LJ, Peters-Golden M, Cox PG, (2008). The effects of leptin on airway smooth muscle responses. Am J Respir Cell Mol Biol 39: 475-481.
107. Nath P, Leung SY, Williams AS, Noble A, Xie S, McKenzie AN, et al,. (2007). Complete inhibition of allergic airway inflammation and remodelling in quadruple IL-4/5/9/13-mice. Clin Exp Allergy 37: 1427-1435. (Pubitemid 47460223)
108. Naureckas ET, Ndukwu IM, Halayko AJ, Maxwell C, Hershenson MB, Solway J, (1999). Bronchoalveolar lavage fluid from asthmatic subjects is mitogenic for human airway smooth muscle. Am J Respir Crit Care Med 160: 2062-2066. (Pubitemid 30004719)
109. Neubig RR, (2008). And the winner is. RGS4. Circ Res 103: 444-446.
110. Noveral JP, Rosenberg SM, Anbar RA, Pawlowski NA, Grunstein MM, (1992). Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells. Am J Physiol 263 (3 Pt 1): L317-L324.
111. Oenema TA, Kolahian S, Nanninga JE, Rieks D, Hiemstra PS, Zuyderduyn S, et al,. (2010). Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle. Respir Res 11: 130.
112. Ohta Y, Hayashi M, Kanemaru T, Abe K, Ito Y, Oike M, (2008). Dual modulation of airway smooth muscle contraction by Th2 cytokines via matrix metalloproteinase-1 production. J Immunol 180: 4191-4199.
113. Oliver BG, Johnston SL, Baraket M, Burgess JK, King NJ, Roth M, et al,. (2006). Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respir Res 7: 71.
114. Oltmanns U, Chung KF, Walters M, John M, Mitchell JA, (2005). Cigarette smoke induces IL-8, but inhibits eotaxin and RANTES release from airway smooth muscle. Respir Res 6: 74.
115. Owen VJ, Burton PB, Mullen AJ, Birks EJ, Barton P, Yacoub MH, (2001). Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure. Eur Heart J 22: 1015-1020. (Pubitemid 32737563)
116. Page K, Li J, Hershenson MB, (1999). Platelet-derived growth factor stimulation of mitogen-activated protein kinases and cyclin D1 promoter activity in cultured airway smooth-muscle cells. Role Ras Am J Respir Cell Mol Biol 20: 1294-1302. (Pubitemid 129503248)
117. Panettieri RA Jr, Hall IP, Maki CS, Murray RK, (1995). alpha-Thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation. Am J Respir Cell Mol Biol 13: 205-216.
118. Panettieri RA Jr, Goldie RG, Rigby PJ, Eszterhas AJ, Hay DW, (1996). Endothelin-1-induced potentiation of human airway smooth muscle proliferation: an ETA receptor-mediated phenomenon. Br J Pharmacol 118: 191-197.
119. Pang L, Knox AJ, (1998). Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products. J Immunol 161: 2509-2515. (Pubitemid 28397068)
120. Peng Q, Matsuda T, Hirst SJ, (2004). Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle. Am J Respir Crit Care Med 169: 596-603. (Pubitemid 38270895)
121. Phipps S, Lam CE, Foster PS, Matthaei KI, (2007). The contribution of toll-like receptors to the pathogenesis of asthma. Immunol Cell Biol 85: 463-470. (Pubitemid 47367514)
122. Prefontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, Olivenstein R, Halayko AJ, et al,. (2009). Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol 183: 5094-5103.
123. Pype JL, Dupont LJ, Menten P, Van Coillie E, Opdenakker G, Van Damme J, et al,. (1999). Expression of monocyte chemotactic protein (MCP)-1, MCP-2, and MCP-3 by human airway smooth-muscle cells. Modulation by corticosteroids and T-helper 2 cytokines. Am J Respir Cell Mol Biol 21: 528-536. (Pubitemid 129504275)
124. Pype JL, Xu H, Schuermans M, Dupont LJ, Wuyts W, Mak JC, et al,. (2001). Mechanisms of interleukin 1beta-induced human airway smooth muscle hyporesponsiveness to histamine. Involvement of p38 MAPK NF-kappaB. Am J Respir Crit Care Med 163: 1010-1017. (Pubitemid 32279647)
125. Rajah R, Nunn SE, Herrick DJ, Grunstein MM, Cohen P, (1996). Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells. Am J Physiol 271 (6 Pt 1): L1014-L1022.
126. Rajah R, Nachajon RV, Collins MH, Hakonarson H, Grunstein MM, Cohen P, (1999). Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle. Am J Respir Cell Mol Biol 20: 199-208. (Pubitemid 129504879)
127. Ramos-Barbõn D, Presley JF, Hamid QA, Fixman ED, Martin JG, (2005). Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma. J Clin Invest 115: 1580-1589. (Pubitemid 40814666)
128. Redhu NS, Saleh A, Shan L, Gerthoffer WT, Kung SK, Halayko AJ, et al,. (2009). Proinflammatory and Th2 cytokines regulate the high affinity IgE receptor (FcepsilonRI) and IgE-dependant activation of human airway smooth muscle cells. Plos One 4: e6153.
129. Ritter SL, Hall RA, (2009). Fine-tuning of GPCR activity by receptor-interacting proteins. Nat Rev Mol Cell Biol 10: 819-830.
130. Roche N, Chinet TC, Huchon GJ, (1997). Allergic and nonallergic interactions between house dust mite allergens and airway mucosa. Eur Respir J 10: 719-726. (Pubitemid 27112596)
131. Rolin S, Masereel B, Dogne JM, (2006). Prostanoids as pharmacological targets in COPD and asthma. Eur J Pharmacol 533: 89-100. (Pubitemid 43340007)
132. Roscioni SS, Kistemaker LE, Menzen MH, Elzinga CR, Gosens R, Halayko AJ, et al,. (2009). PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res 10: 88.
133. Russo C, Polosa R, (2005). TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis. Clin Sci (Lond) 109: 135-142. (Pubitemid 41117296)
134. Salmon M, Walsh DA, Huang TJ, Barnes PJ, Leonard TB, Hay DW, et al,. (1999). Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats. Br J Pharmacol 127: 1151-1158. (Pubitemid 29326638)
135. Scott PH, Belham CM, al-Hafidh J, Chilvers ER, Peacock AJ, Gould GW, et al,. (1996). A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor- stimulated bovine airway smooth-muscle cells. Biochem J 318: 965-971. (Pubitemid 26320966)
136. Sestini P, Armetti L, Gambaro G, Pieroni MG, Refini RM, Sala A, et al,. (1996). Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma. Am J Respir Crit Care Med 153: 572-575. (Pubitemid 26051332)
137. Sethakorn N, Yau DM, Dulin NO, (2010). Non-canonical functions of RGS proteins. Cell Signal 22: 1274-1281.
138. Shan X, Hu A, Veler H, Fatma S, Grunstein JS, Chuang S, et al,. (2006). Regulation of Toll-like receptor 4-induced proasthmatic changes in airway smooth muscle function by opposing actions of ERK1/2 and p38 MAPK signaling. Am J Physiol Lung Cell Mol Physiol 291: L324-L333. (Pubitemid 44343706)
139. Shan L, Redhu NS, Saleh A, Halayko AJ, Chakir J, Gounni AS, (2010). Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. J Immunol 184: 7134-7143.
140. Sharma P, Tran T, Stelmack GL, McNeill K, Gosens R, Mutawe MM, et al,. (2008). Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation. Am J Physiol Lung Cell Mol Physiol 294: L57-L68. (Pubitemid 351380318)
141. Shore SA, Laporte J, Hall IP, Hardy E, Panettieri RA Jr, (1997). Effect of IL-1 beta on responses of cultured human airway smooth muscle cells to bronchodilator agonists. Am J Respir Cell Mol Biol 16: 702-712. (Pubitemid 127498946)
142. Siddiqui S, Mistry V, Doe C, Stinson S, Foster M, Brightling C, (2010). Airway wall expression of OX40/OX40L and interleukin-4 in asthma. Chest 137: 797-804.
143. Simeone-Penney MC, Severgnini M, Rozo L, Takahashi S, Cochran BH, Simon AR, (2008). PDGF-induced human airway smooth muscle cell proliferation requires STAT3 and the small GTPase Rac1. Am J Physiol Lung Cell Mol Physiol 294: L698-L704. (Pubitemid 351520102)
144. Singh RK, Gupta S, Dastidar S, Ray A, (2010). Cysteinyl leukotrienes and their receptors: molecular and functional characteristics. Pharmacology 85: 336-349.
145. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, et al,. (2007). Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 176: 121-128. (Pubitemid 47057847)
146. Sukkar MB, Xie S, Khorasani NM, Kon OM, Stanbridge R, Issa R, et al,. (2006). Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle. J Allergy Clin Immunol 118: 641-648. (Pubitemid 44301394)
147. Thomas PS, Heywood G, (2002). Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma. Thorax 57: 774-778. (Pubitemid 34984975)
148. Tliba O, Panettieri RA Jr, (2009). Noncontractile functions of airway smooth muscle cells in asthma. Annu Rev Physiol 71: 509-535.
149. Tliba O, Tliba S, Da Huang C, Hoffman RK, DeLong P, Panettieri RA, et al,. (2003). Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta. J Biol Chem 278: 50615-50623. (Pubitemid 37548909)
150. Tliba O, Amrani Y, Panettieri RA Jr, (2008). Is airway smooth muscle the 'missing link' modulating airway inflammation in asthma. Chest 133: 236-242.
151. Vichi P, Whelchel A, Knot H, Nelson M, Kolch W, Posada J, (1999). Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation. Am J Respir Cell Mol Biol 20: 99-105. (Pubitemid 129504847)
152. Wang SZ, Xu H, Wraith A, Bowden JJ, Alpers JH, Forsyth KD, (1998). Neutrophils induce damage to respiratory epithelial cells infected with respiratory syncytial virus. Eur Respir J 12: 612-618. (Pubitemid 28420140)
153. Whelan R, Kim C, Chen M, Leiter J, Grunstein MM, Hakonarson H, (2004). Role and regulation of interleukin-1 molecules in pro-asthmatic sensitised airway smooth muscle. Eur Respir J 24: 559-567. (Pubitemid 39406128)
154. Wollin L, Pieper MP, (2010). Tiotropium bromide exerts anti-inflammatory activity in a cigarette smoke mouse model of COPD. Pulm Pharmacol Ther 23: 345-354.
155. Xie S, Issa R, Sukkar MB, Oltmanns U, Bhavsar PK, Papi A, et al,. (2005). Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells. Respir Res 6: 148.
156. Yamasaki A, Saleh A, Koussih L, Muro S, Halayko AJ, Gounni AS, (2010). IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells. Plos One 5: e9178.
157. Yang W, Kaur D, Okayama Y, Ito A, Wardlaw AJ, Brightling CE, et al,. (2006). Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1. J Immunol 176: 1238-1243. (Pubitemid 43099728)
158. Zerfaoui M, Suzuki Y, Naura AS, Hans CP, Nichols C, Boulares AH, (2008). Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: differential requirement for PARP-1 expression and interaction. Cell Signal 20: 186-194. (Pubitemid 350138380)
159. Zuberi RI, Hsu DK, Kalayci O, Chen HY, Sheldon HK, Yu L, et al,. (2004). Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma. Am J Pathol 165: 2045-2053. (Pubitemid 39578382)