Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle

British Journal of Pharmacology

Volumn 164, Issue 3, 2011, Pages 958-969

  Roscioni, Sara S ^a   Prins, Alwin G ^a   Elzinga, Carolina Rs ^a   Menzen, Mark H ^a   Dekkers, Bart Gj ^a   Halayko, Andrew J ^b   Meurs, Herman ^a   Maarsingh, Harm ^a   Schmidt, Martina ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

2 agonists; airway remodelling; airway smooth muscle; airway smooth muscle contraction; asthma; cAMP; contractile proteins; Epac; PDGF; phenotypic plasticity; PKA; proliferation

Indexed keywords

ACTIN; CALPONIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCHANGE PROTEIN DIRECTLY ACTIVATED CYCLIC AMP; MYOSIN; PLATELET DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BREATHING MUSCLE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; MUSCLE CONTRACTILITY; MUSCLE ISOMETRIC CONTRACTION; PHASE TRANSITION; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE;

ACTINS; AIRWAY REMODELING; CALCIUM-BINDING PROTEINS; CELL CYCLE; CELL GROWTH PROCESSES; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICROFILAMENT PROTEINS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOSINS; PHENOTYPE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; TRACHEA;

EID: 80052600665     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01354.x     Document Type: Article

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