Inflammatory and Contractile Agents Sensitize Specific Adenylyl Cyclase Isoforms in Human Airway Smooth Muscle

American Journal of Respiratory Cell and Molecular Biology

Volumn 21, Issue 5, 1999, Pages 597-606

  Billington, Charlotte K ^b   Hall, Ian P ^b   Mundell, Stuart J ^b   Parent, Jean Luc ^b   Panettieri Jr , Reynold A ^b   Benovic, Jeffrey L ^b   Penn, Raymond B ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; FORSKOLIN; HISTAMINE; ISOENZYME; SCAVENGER; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; VASOCONSTRICTOR AGENT;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; ENZYMOLOGY; HUMAN; METABOLISM; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; CELLS, CULTURED; CHOLINERGIC AGONISTS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; FREE RADICAL SCAVENGERS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HISTAMINE; HUMANS; ISOENZYMES; MUSCLE, SMOOTH; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; VASOCONSTRICTOR AGENTS;

EID: 0033219744     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.21.5.3759     Document Type: Article

References (51)

1. Penn, R. B., and J. I., Benovic. 1998, Regulation of G protein-coupled receptors. In Handbook of Physiology. P. M. Conn, editor. Oxford University Press, Oxford. 125-164
2. Fowler, M. B., J. A. Laser, G. L. Hopkins, W. Minobe, and M. R. Bristow. 1986. Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response. Circulation 74:1290-1302.
3. Bristow, M. R., R. Ginsburg, V. Umans, M. Fowler, W. Minobe, R. Rasmussen, P. Zera, R. Menlove, P. Shah, and S. Jamieson. 1986. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ. Res. 59:297-309.
4. Hall, I. P., K. Daykin, and S. Widdop. 1993. Beta 2-adrenoceptor desensitization in cultured human airway smooth muscle. Clin. Sci. (Colch.) 84:151-157.
5. Green, S. A., J. Turki, P. Bejarano, T. P. Hall, and S. B. Liggett. 1995. Influence of β2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 13:25-33.
6. 2AR-adenylyl cyclase pathway in human airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 19:338-348.
7. Vathenen, A. S., R. G. Higgins, A. J. Knox, J. R. Britton, and A. E. Tattersfield. 1988. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Lancet 1:554-558.
8. O'Connor, B. J., S. L. Aikman, and P. J. Barnes. 1992. Tolerance to the non-bronchodilator effects of inhaled beta 2-agonists in asthma. N. Engl. J. Med. 327:1204-1208.
9. Cockeroft, D. W., C. P. McParland, S. A. Britto, V. A. Swystum, and B. C. Rutherford. 1993. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 342:833-837.
10. Cheung, D., M. C. Timmers, A. H. Zwinderman, E. H. Bel, J. H. Dijkman, and P. J. Sterk. 1992. Long-term effects of a long-acting beta 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma. N. Engl. J. Med. 327:1198-1203.
11. Prather, P. L., A. W, Tsai, and P. Y. Law. 1994. Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells. Mol. Pharmacol. 270:177-184.
12. Zadina, J. E., L. M. Harrison, L. J. Ge, A. J. Kastin, and S. L. Chang. 1994. Differential regulation of mu and delta opiate receptors by morphine, selective agonists and antagonists and differentiating agents in SH-SY5Y human neuroblastoma cells. J. Pharmacol. Exp. Ther. 270:1086-1096.
13. Lampert, A., M. Nirenberg, and W. A. Klee. 1976. Tolerance and dependence evoked by an endogenous opioid peptide. Proc. Natl. Acad. Sci. USA 73:3165-3167.
14. Sharma, S. K., W. A. Klec, and M. Nirenberg. 1975. Dual regulation of adenylate cyclase for narcotic dependence and tolerance. Proc. Natl. Acad. Sci. USA 72:3092-3096.
15. Avidor-Reiss, T., M. Bayewitch, R. Levy, N. Malus-Leibovitch, I. Nevo, and Z. Vogel. 1995. Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment. J. Biol. Chem. 270:29732-29738.
16. Nestler, E. J., B. T. Hope, and K. L. Widnell. 1993. Drug addiction: a model for the molecular basis of neural plasticity. Neuron 11:995-1006.
17. Daykin, K., S. Widdop, and I. P. Hall. 1993. Control of histamine induced inositol phospholipid hydrolysis in cultured human tracheal smooth muscle cells. Eur. J. Pharmacol. 246:135-140.
18. Panettieri, R. A., K. K. Murray, L. R. DePalo, P. A. Yadvish, and M. I. Kotlikoff. 1989. A human smooth muscle cell line that retains physiological responsiveness. Am. J. Physiol. 256(Cell Physiol. 25):C329-C335.
19. Hall, I. P., and M. Kotlikoff. 1995. Use of cultured airway myocytes for study of airway smooth muscle. Am. J. Physiol. (Lung Cell. Mol. Physiol.) 268:1.1-1.11.
20. Mundell, S. J., and E. Kelly. 1998. Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells. Biochem. Pharmacol. 55:595-603.
21. Penn, R. B., J. L. Parent, A. N. Pronin, R. A. Panettieri, Jr., and J. I., Benovic. 1999. Pharmacological inhibition of protein kinases in intact cells; antagonism of beta adrenergic receptor ligand binding by 11-89 reveals limitations of usefulness. J. Pharmacol. Exp. Ther. 288:428-437.
22. Premont, R. T. 1994, Identification of adenylyl cyclases by amplification using degenerate primers. Methods Enzymol. 238:116-127.
23. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
24. Nevo, I., T. Avidor-Reiss, R. Levy, M. Bayewitch, E. Heldman, and Z. Vogel. 1998. Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors. Mol. Pharmacol. 54:419-426.
25. Nogami, M., S. M. Whittle, D. J. Romberger, S. I. Rennard, and M. Tocws. 1995. Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells. Mol. Pharmacol. 48:766-773.
26. Pyne, N. J., P. Stevens, N. Moughal, and S. Pyne. 1995. PKC dependent activation of the type II adenylate cyclase in airway smooth muscle limits the bradykinin-stimulated ERK-2 pathway. Biochem. Soc. Trans. 23:200S.
27. Pyne, N. J., N. Moughal, P. A. Stevens, D. Tolan, and S. Pyne. 1994. Protein kinase C-dependent cyclic AMP formation in airway smooth muscle: the role of type II adenylate cyclase and the blockade of extracellular-signal-regulated kinase-2 (ERK-2) activation. Biochem. J. 304:611-616.
28. Post, S. R., R. Hilal-Dandan, K. Urasawa, L. I., Brunton, and P. A. Insel. 1995. Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem. J. 311:75-80.
29. Adie, E. J., and G. Milligan. 1994. Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade. Biochem. J. 303:803-808.
30. MacEwan, D. J., G. D. Kim, and G. Milligan. 1996. Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor: evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity. Biochem. J. 318:1033-1039.
31. Milligan, G., I. Mullaney, G. D. Kim, and D. MacEwan. 1998. Regulation of the stoichiometry of protein components of the stimulatory adenylyl cyclase cascade. Adv. Pharmacol. 42:462-465.
32. Pang, L., and A. J. Knox. 1997. PGF2 release by bradykinin in human airway smooth muscle cells: involvement of cyclooxygenase-2 induction. Am. J, Physiol. (Lung Cell. Mol. Physiol.) 273:L1132-L1140.
33. Laporte, J. D., P. E. Moore, R. A. Panettieri, W. Moeller, J. Heyder, and S. A. Shore, 1998. Prostanoids mediate IL-1beta-induced beta-adrenergic hyporesponsiveness in human airway smooth muscle cells. Am. J. Physiol. (Lung Cell. Mol. Physiol.) 275:L491-L501.
34. Shore, S. A., J. Laporte, I. P. Hall, E. Hardy, and R. A. Panettieri, Jr. 1947. Effect of IL-1 beta on responses of cultured human airway smooth muscle cells in bronchodilalor agonists. Am. J. Respir. Cell Mol. Biol. 16:702-712.
35. Stevens, P. A., S. Pyne, M. Grady, and N. J. Pyne. 1994. Bradykinin-dependent activation of adenylate cyclase activity and cyclic AMP accumulation in tracheal smooth muscle occurs via protein kinase C-dependent and -independent pathways. Biochem. J. 297:233-239.
36. Pyne, S., and N. J. Pyne. 1995. Bradykinin-stimulated phosphatidylcholine hydrolysis in airway smooth muscle: the role of Ca2+ and protein kinase C. Biochem. J. 311:637-642.
37. Pyne, N. J., and S. Pyne. 1998. PDGF-stimulatcd cyclic AMP formation in airway smooth muscle: assessment of the roles of MAP kinase, eytosolic phospholipase A2, and arachidonate metabolites. Cell. Signal 10:363-369.
38. Schears, G., J. Clancy, C. A. Hirshman, and C. W. Emala. 1997. Chronic carbachol pretreatment decreases adenylyl cyclase activity in airway smooth muscle. Am. J. Physiol. (Lung Cell. Mol. Physiol)273:L640-L647.
39. Widdop, S., K. Daykin, and I. P. Hall. 1993. Expression of muscarinic M2 receptors in cultured human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 9:541-546.
40. Murray, R., F. Shipp, and G. A. FitzGerald. 1990. Prostaglandin endoperoxide/thromboxane A2 receptor desensitization: cross-talk with adenylate cyclase in human platelets. J. Biol. Chem. 265:21670-21675.
41. Smil, M. J., D. Verzijl, and R. Tyengar. 1998, Identity of adenylyl cyclase isoform determines the rale of cell cycle progression in N1H 3T3 cells. Proc. Natl. Acad. Sci. USA 95:15084-15089.
42. Zimmermann, G., and R. Taussig. 1996, Protein kinase C alters the responsiveness of adenylyl cyclases to G protein alpha and beta-gamma subunits. J. Biol. Chem. 271:27161-27166.
43. Lustig, K. D., B. R. Conklin, P. Herzmark, R. Taussig, and H. R. Bourne. 1993, Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. J. Biol. Chem. 268:13900-13905.
44. Taussig, R., W. J. Tang, J, R. Hepler, and A. G. Gilman. 1904, Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J. Biol. Chem. 269:6093-6100.
45. Neubig, R. R. 1994, Membrane organization in G-protein mechanisms. FASEB J. 8;939-946.
46. Taussig, R., and G. Zimmermann. 1988. Typo-specific regulation of mammalian adenylyl eyelases by G protein pathways. Adv. Second Messenger Phosphoprotein Res. 32:81-98.
47. Premont, R. T., I. Matsuoka, M. G. Mattei, Y. Pouille, N. Defer, and J. Hanoune. 1996, Identification and characterization of a widely expressed form of adenylyl cyclase. J. Biol. Chem. 271:13900-13907.
48. Adie, E. J., and G. Milligan. 1994. Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor. Biochem. J. 300:709-715.
49. MacEwan, D. J., G. D, Kim, and G. Milligan. 1995. Analysis of the role of receptor number in defining the intrinsic activity and potency of partial agonists in neuroblastoma x glioma hybrid NG108-15 cells transfected to express differing levels of the human beta 2-adrenoceptor. Mol. Pharmacol. 48:316-325.
50. Mullancy, I., and G, Milligan. 1994. Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid. NG108-15, cells. FEBS Lett. 353:23123-23124.
51. Alousi, A. A., J. R. Jasper, P. A. Insel, and H. J, Motulsky. 1991. Stoichiometry of receptor-Gs-adenylate cyclase interactions. FASEB J. 5:23(X)-2303.