메뉴 건너뛰기




Volumn 26, Issue 1, 2013, Pages 112-120

cAMP regulation of airway smooth muscle function

Author keywords

Adrenoceptor; Airway smooth muscle; Asthma; CAMP; COPD; Epac; Protein kinase A

Indexed keywords

5 (4 ACETAMIDOPHENYL) 2(1H) PYRAZINONE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRADYKININ B2 RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM ION; CORTICOSTEROID; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; ENDOTHELIN A RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLYCERYL TRINITRATE; HISTAMINE H1 RECEPTOR; ION CHANNEL; LONG ACTING BETA AGONIST; PHOSPHODIESTERASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHOLIPASE C; PROSTAGLANDIN E2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROLIPRAM; SALBUTAMOL; SARCOPLASMIC RETICULUM ION CHANNEL; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZAPRINAST;

EID: 84873159987     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2012.05.007     Document Type: Article
Times cited : (174)

References (141)
  • 1
    • 0036912150 scopus 로고    scopus 로고
    • Effects of β-agonists on airway epithelial cells
    • Salathe M. Effects of β-agonists on airway epithelial cells. J Allergy Clin Immunol 2002, 110:S275-S281.
    • (2002) J Allergy Clin Immunol , vol.110
    • Salathe, M.1
  • 2
    • 25444440319 scopus 로고    scopus 로고
    • Signaling and regulation of G protein-coupled receptors in airway smooth muscle
    • Billington C.K., Penn R.B. Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Respir Res 2003, 4:2.
    • (2003) Respir Res , vol.4 , pp. 2
    • Billington, C.K.1    Penn, R.B.2
  • 3
    • 40949165358 scopus 로고    scopus 로고
    • A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids
    • Giembycz M.A., Kaur M., Leigh R., Newton R. A Holy Grail of asthma management: toward understanding how long-acting beta(2)-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids. Br J Pharmacol 2008, 153:1090-1104.
    • (2008) Br J Pharmacol , vol.153 , pp. 1090-1104
    • Giembycz, M.A.1    Kaur, M.2    Leigh, R.3    Newton, R.4
  • 4
    • 52949140176 scopus 로고    scopus 로고
    • PDE4 inhibitors: current status
    • Spina D. PDE4 inhibitors: current status. Br J Pharmacol 2008, 155:308-315.
    • (2008) Br J Pharmacol , vol.155 , pp. 308-315
    • Spina, D.1
  • 5
    • 79956098321 scopus 로고    scopus 로고
    • PDE4-inhibitors: a novel, targeted therapy for obstructive airways disease
    • Diamant Z., Spina D. PDE4-inhibitors: a novel, targeted therapy for obstructive airways disease. Pulm Pharmacol Ther 2011, 24:353-360.
    • (2011) Pulm Pharmacol Ther , vol.24 , pp. 353-360
    • Diamant, Z.1    Spina, D.2
  • 6
    • 84862290893 scopus 로고    scopus 로고
    • Selective PDE inhibitors as novel treatments for respiratory diseases
    • Page C., Spina D. Selective PDE inhibitors as novel treatments for respiratory diseases. Curr Opin Pharmacol 2012.
    • (2012) Curr Opin Pharmacol
    • Page, C.1    Spina, D.2
  • 7
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
    • Beavo J.A. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 1995, 75:725-748.
    • (1995) Physiol Rev , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 8
    • 0027442594 scopus 로고
    • Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle
    • Torphy T.J., Undem B.J., Cieslinski L.B., Luttmann M.A., Reeves M.L., Hay D.W. Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle. J Pharmacol Exp Ther 1993, 265:1213-1223.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 1213-1223
    • Torphy, T.J.1    Undem, B.J.2    Cieslinski, L.B.3    Luttmann, M.A.4    Reeves, M.L.5    Hay, D.W.6
  • 9
    • 0027300647 scopus 로고
    • Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization
    • Rabe K.F., Tenor H., Dent G., Schudt C., Liebig S., Magnussen H. Phosphodiesterase isozymes modulating inherent tone in human airways: identification and characterization. Am J Physiol 1993, 264:L458-L464.
    • (1993) Am J Physiol , vol.264
    • Rabe, K.F.1    Tenor, H.2    Dent, G.3    Schudt, C.4    Liebig, S.5    Magnussen, H.6
  • 10
    • 37549019345 scopus 로고    scopus 로고
    • A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells
    • Billington C.K., Le Jeune I.R., Young K.W., Hall I.P. A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2008, 38:1-7.
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 1-7
    • Billington, C.K.1    Le Jeune, I.R.2    Young, K.W.3    Hall, I.P.4
  • 11
    • 79956124769 scopus 로고    scopus 로고
    • β2-agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D
    • Trian T., Burgess J.K., Niimi K., Moir L.M., Ge Q., Berger P., et al. β2-agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D. PLoS One 2011, 6:e20000.
    • (2011) PLoS One , vol.6
    • Trian, T.1    Burgess, J.K.2    Niimi, K.3    Moir, L.M.4    Ge, Q.5    Berger, P.6
  • 13
    • 0028791339 scopus 로고
    • Relaxant actions of isoprenaline on guinea-pig isolated tracheal smooth muscle
    • Ito Y., Takagi K., Tomita T. Relaxant actions of isoprenaline on guinea-pig isolated tracheal smooth muscle. Br J Pharmacol 1995, 116:2738-2742.
    • (1995) Br J Pharmacol , vol.116 , pp. 2738-2742
    • Ito, Y.1    Takagi, K.2    Tomita, T.3
  • 17
    • 40749099470 scopus 로고    scopus 로고
    • The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation
    • Komalavilas P., Penn R.B., Flynn C.R., Thresher J., Lopes L.B., Furnish E.J., et al. The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation. Am J Physiol Lung Cell Mol Physiol 2008, 294:L69-L78.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Komalavilas, P.1    Penn, R.B.2    Flynn, C.R.3    Thresher, J.4    Lopes, L.B.5    Furnish, E.J.6
  • 18
    • 79251586229 scopus 로고    scopus 로고
    • Anti-mitogenic effects of beta-agonists and PGE2 on airway smooth muscle are PKA dependent
    • Yan H., Deshpande D.A., Misior A.M., Miles M.C., Saxena H., Riemer E.C., et al. Anti-mitogenic effects of beta-agonists and PGE2 on airway smooth muscle are PKA dependent. FASEB J 2011, 25:389-397.
    • (2011) FASEB J , vol.25 , pp. 389-397
    • Yan, H.1    Deshpande, D.A.2    Misior, A.M.3    Miles, M.C.4    Saxena, H.5    Riemer, E.C.6
  • 20
    • 0034858918 scopus 로고    scopus 로고
    • Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase
    • Spicuzza L., Belvisi M.G., Birrell M.A., Barnes P.J., Hele D.J., Giembycz M.A. Evidence that the anti-spasmogenic effect of the β-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol 2001, 133:1201-1212.
    • (2001) Br J Pharmacol , vol.133 , pp. 1201-1212
    • Spicuzza, L.1    Belvisi, M.G.2    Birrell, M.A.3    Barnes, P.J.4    Hele, D.J.5    Giembycz, M.A.6
  • 21
    • 0026570943 scopus 로고
    • Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries
    • Jiang H., Colbran J.L., Francis S.H., Corbin J.D. Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem 1992, 267:1015-1019.
    • (1992) J Biol Chem , vol.267 , pp. 1015-1019
    • Jiang, H.1    Colbran, J.L.2    Francis, S.H.3    Corbin, J.D.4
  • 22
    • 0020479689 scopus 로고
    • Cyclic nucleotide-dependent protein kinases in airway smooth muscle
    • Torphy T.J., Freese W.B., Rinard G.A., Brunton L.L., Mayer S.E. Cyclic nucleotide-dependent protein kinases in airway smooth muscle. J Biol Chem 1982, 257:11609-11616.
    • (1982) J Biol Chem , vol.257 , pp. 11609-11616
    • Torphy, T.J.1    Freese, W.B.2    Rinard, G.A.3    Brunton, L.L.4    Mayer, S.E.5
  • 23
    • 0024406231 scopus 로고
    • Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways
    • Gruetter C.A., Childers C.E., Bosserman M.K., Lemke S.M., Ball J.G., Valentovic M.A. Comparison of relaxation induced by glyceryl trinitrate, isosorbide dinitrate, and sodium nitroprusside in bovine airways. Am Rev Respir Dis 1989, 139:1192-1197.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 1192-1197
    • Gruetter, C.A.1    Childers, C.E.2    Bosserman, M.K.3    Lemke, S.M.4    Ball, J.G.5    Valentovic, M.A.6
  • 25
    • 77949538387 scopus 로고    scopus 로고
    • Epac: defining a new mechanism for cAMP action
    • Gloerich M., Bos J.L. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol 2010, 50:355-375.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 355-375
    • Gloerich, M.1    Bos, J.L.2
  • 26
    • 75649097760 scopus 로고    scopus 로고
    • The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function
    • Grandoch M., Roscioni S.S., Schmidt M. The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function. Br J Pharmacol 2010, 159:265-284.
    • (2010) Br J Pharmacol , vol.159 , pp. 265-284
    • Grandoch, M.1    Roscioni, S.S.2    Schmidt, M.3
  • 27
    • 40749147710 scopus 로고    scopus 로고
    • Inhibition of human airway smooth muscle cell proliferation by β2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement
    • Kassel K.M., Wyatt T.A., Panettieri R.A., Toews M.L. Inhibition of human airway smooth muscle cell proliferation by β2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement. Am J Physiol Lung Cell Mol Physiol 2008, 294:L131-L138.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.294
    • Kassel, K.M.1    Wyatt, T.A.2    Panettieri, R.A.3    Toews, M.L.4
  • 28
    • 84859884891 scopus 로고    scopus 로고
    • Novel cyclic AMP signalling paradigms: therapeutic implications for airway disease
    • Billington C.K., Hall I.P. Novel cyclic AMP signalling paradigms: therapeutic implications for airway disease. Br J Pharmacol 2012, 166:401-410.
    • (2012) Br J Pharmacol , vol.166 , pp. 401-410
    • Billington, C.K.1    Hall, I.P.2
  • 29
    • 33750742437 scopus 로고    scopus 로고
    • Beyond the dogma: novel β2-adrenoceptor signalling in the airways
    • Giembycz M.A., Newton R. Beyond the dogma: novel β2-adrenoceptor signalling in the airways. Eur Respir J 2006, 27:1286-1306.
    • (2006) Eur Respir J , vol.27 , pp. 1286-1306
    • Giembycz, M.A.1    Newton, R.2
  • 30
    • 69249216479 scopus 로고    scopus 로고
    • EPAC proteins transduce diverse cellular actions of cAMP
    • Borland G., Smith B.O., Yarwood S.J. EPAC proteins transduce diverse cellular actions of cAMP. Br J Pharmacol 2009, 158:70-86.
    • (2009) Br J Pharmacol , vol.158 , pp. 70-86
    • Borland, G.1    Smith, B.O.2    Yarwood, S.J.3
  • 32
    • 79955764385 scopus 로고    scopus 로고
    • The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity
    • Zieba B.J., Artamonov M.V., Jin L., Momotani K., Ho R., Franke A.S., et al. The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity. J Biol Chem 2011, 286:16681-16692.
    • (2011) J Biol Chem , vol.286 , pp. 16681-16692
    • Zieba, B.J.1    Artamonov, M.V.2    Jin, L.3    Momotani, K.4    Ho, R.5    Franke, A.S.6
  • 33
    • 78650167244 scopus 로고    scopus 로고
    • PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells
    • Roscioni S.S., Kistemaker L.E., Menzen M.H., Elzinga C.R., Gosens R., Halayko A.J., et al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res 2009, 10:88.
    • (2009) Respir Res , vol.10 , pp. 88
    • Roscioni, S.S.1    Kistemaker, L.E.2    Menzen, M.H.3    Elzinga, C.R.4    Gosens, R.5    Halayko, A.J.6
  • 35
    • 65349184467 scopus 로고    scopus 로고
    • Endogenous γ-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation
    • Gallos G., Gleason N.R., Virag L., Zhang Y., Mizuta K., Whittington R.A., et al. Endogenous γ-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation. Anesthesiology 2009, 110:748-758.
    • (2009) Anesthesiology , vol.110 , pp. 748-758
    • Gallos, G.1    Gleason, N.R.2    Virag, L.3    Zhang, Y.4    Mizuta, K.5    Whittington, R.A.6
  • 36
    • 34248204113 scopus 로고    scopus 로고
    • Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma
    • An S.S., Bai T.R., Bates J.H., Black J.L., Brown R.H., Brusasco V., et al. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J 2007, 29:834-860.
    • (2007) Eur Respir J , vol.29 , pp. 834-860
    • An, S.S.1    Bai, T.R.2    Bates, J.H.3    Black, J.L.4    Brown, R.H.5    Brusasco, V.6
  • 37
    • 33750305836 scopus 로고    scopus 로고
    • Targeting G protein-coupled receptor signaling in asthma
    • Deshpande D.A., Penn R.B. Targeting G protein-coupled receptor signaling in asthma. Cell Signal 2006, 18:2105-2120.
    • (2006) Cell Signal , vol.18 , pp. 2105-2120
    • Deshpande, D.A.1    Penn, R.B.2
  • 39
    • 0023709222 scopus 로고
    • Differential inhibitory effects of forskolin, isoproterenol, and dibutyryl cyclic adenosine monophosphate on phosphoinositide hydrolysis in canine tracheal smooth muscle
    • Madison J.M., Brown J.K. Differential inhibitory effects of forskolin, isoproterenol, and dibutyryl cyclic adenosine monophosphate on phosphoinositide hydrolysis in canine tracheal smooth muscle. J Clin Invest 1988, 82:1462-1465.
    • (1988) J Clin Invest , vol.82 , pp. 1462-1465
    • Madison, J.M.1    Brown, J.K.2
  • 40
    • 38449102281 scopus 로고    scopus 로고
    • Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus
    • Smith N., Browning C.A., Duroudier N., Stewart C., Peel S., Swan C., et al. Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus. Respir Res 2007, 8:68.
    • (2007) Respir Res , vol.8 , pp. 68
    • Smith, N.1    Browning, C.A.2    Duroudier, N.3    Stewart, C.4    Peel, S.5    Swan, C.6
  • 41
    • 83755177981 scopus 로고    scopus 로고
    • Beta2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids
    • Holden N.S., Bell M.J., Rider C.F., King E.M., Gaunt D.D., Leigh R., et al. Beta2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proc Natl Acad Sci U S A 2011, 108:19713-19718.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 19713-19718
    • Holden, N.S.1    Bell, M.J.2    Rider, C.F.3    King, E.M.4    Gaunt, D.D.5    Leigh, R.6
  • 45
    • 0742325000 scopus 로고    scopus 로고
    • Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue
    • Corteling R.L., Li S., Giddings J., Westwick J., Poll C., Hall I.P. Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. Am J Respir Cell Mol Biol 2004, 30:145-154.
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 145-154
    • Corteling, R.L.1    Li, S.2    Giddings, J.3    Westwick, J.4    Poll, C.5    Hall, I.P.6
  • 46
    • 0025865173 scopus 로고
    • Receptor-activated calcium influx in human airway smooth muscle cells
    • Murray R.K., Kotlikoff M.I. Receptor-activated calcium influx in human airway smooth muscle cells. J Physiol 1991, 435:123-144.
    • (1991) J Physiol , vol.435 , pp. 123-144
    • Murray, R.K.1    Kotlikoff, M.I.2
  • 47
    • 45249093865 scopus 로고    scopus 로고
    • ORAI and store-operated calcium influx in human airway smooth muscle cells
    • Peel S.E., Liu B., Hall I.P. ORAI and store-operated calcium influx in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2008, 38:744-749.
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 744-749
    • Peel, S.E.1    Liu, B.2    Hall, I.P.3
  • 49
    • 33749261117 scopus 로고    scopus 로고
    • A key role for STIM1 in store operated calcium channel activation in airway smooth muscle
    • Peel S.E., Liu B., Hall I.P. A key role for STIM1 in store operated calcium channel activation in airway smooth muscle. Respir Res 2006, 7:119.
    • (2006) Respir Res , vol.7 , pp. 119
    • Peel, S.E.1    Liu, B.2    Hall, I.P.3
  • 51
    • 0036086743 scopus 로고    scopus 로고
    • 2+ regulation in airway smooth muscle contraction: do the data contradict dogma?
    • 2+ regulation in airway smooth muscle contraction: do the data contradict dogma?. Am J Physiol Lung Cell Mol Physiol 2002, 282:L1161-L1178.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Janssen, L.J.1
  • 53
    • 0030790118 scopus 로고    scopus 로고
    • Structure and function of inositol 1,4,5-trisphosphate receptor
    • Yoshida Y., Imai S. Structure and function of inositol 1,4,5-trisphosphate receptor. Jpn J Pharmacol 1997, 74:125-137.
    • (1997) Jpn J Pharmacol , vol.74 , pp. 125-137
    • Yoshida, Y.1    Imai, S.2
  • 54
    • 0031009650 scopus 로고    scopus 로고
    • Effects of salbutamol on intracellular calcium oscillations in porcine airway smooth muscle
    • Prakash Y.S., van der Heijden H.F., Kannan M.S., Sieck G.C. Effects of salbutamol on intracellular calcium oscillations in porcine airway smooth muscle. J Appl Physiol 1997, 82:1836-1843.
    • (1997) J Appl Physiol , vol.82 , pp. 1836-1843
    • Prakash, Y.S.1    van der Heijden, H.F.2    Kannan, M.S.3    Sieck, G.C.4
  • 56
    • 0030196181 scopus 로고    scopus 로고
    • Ca channels in airway smooth muscle cells by endogenous protein kinase A
    • Ca channels in airway smooth muscle cells by endogenous protein kinase A. Am J Physiol 1996, 271:L100-L105.
    • (1996) Am J Physiol , vol.271
    • Wang, Z.W.1    Kotlikoff, M.I.2
  • 59
    • 0027333280 scopus 로고
    • 2+ channels by cAMP and cGMP in vascular smooth muscle cells
    • 2+ channels by cAMP and cGMP in vascular smooth muscle cells. Circ Res 1993, 73:1128-1137.
    • (1993) Circ Res , vol.73 , pp. 1128-1137
    • Ishikawa, T.1    Hume, J.R.2    Keef, K.D.3
  • 62
    • 84873174713 scopus 로고    scopus 로고
    • 2 agonist formoterol and inflammatory cytokines suppress SERCA-2 expression in human airway smooth muscle
    • 2 agonist formoterol and inflammatory cytokines suppress SERCA-2 expression in human airway smooth muscle. Am J Respir Crit Care Med 2010, A5302.
    • (2010) Am J Respir Crit Care Med
    • Ojo, O.O.1    Lee, T.H.2    Ward, J.P.T.3
  • 67
    • 7544221330 scopus 로고    scopus 로고
    • Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction
    • Schaafsma D., Gosens R., Bos I.S., Meurs H., Zaagsma J., Nelemans S.A. Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction. Br J Pharmacol 2004, 143:477-484.
    • (2004) Br J Pharmacol , vol.143 , pp. 477-484
    • Schaafsma, D.1    Gosens, R.2    Bos, I.S.3    Meurs, H.4    Zaagsma, J.5    Nelemans, S.A.6
  • 68
    • 37849018276 scopus 로고    scopus 로고
    • Regulation of heterotrimeric G protein signaling in airway smooth muscle
    • Penn R.B., Benovic J.L. Regulation of heterotrimeric G protein signaling in airway smooth muscle. Proc Am Thorac Soc 2008, 5:47-57.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 47-57
    • Penn, R.B.1    Benovic, J.L.2
  • 70
    • 0030795828 scopus 로고    scopus 로고
    • Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle
    • Eto M., Senba S., Morita F., Yazawa M. Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle. FEBS Lett 1997, 410:356-360.
    • (1997) FEBS Lett , vol.410 , pp. 356-360
    • Eto, M.1    Senba, S.2    Morita, F.3    Yazawa, M.4
  • 71
    • 57349099404 scopus 로고    scopus 로고
    • CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi
    • Morin C., Sirois M., Echave V., Rousseau E. CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. Am J Respir Cell Mol Biol 2008, 39:638-643.
    • (2008) Am J Respir Cell Mol Biol , vol.39 , pp. 638-643
    • Morin, C.1    Sirois, M.2    Echave, V.3    Rousseau, E.4
  • 72
    • 0035203702 scopus 로고    scopus 로고
    • Actin depolymerization via the beta-adrenoceptor in airway smooth muscle cells: a novel PKA-independent pathway
    • Hirshman C.A., Zhu D., Panettieri R.A., Emala C.W. Actin depolymerization via the beta-adrenoceptor in airway smooth muscle cells: a novel PKA-independent pathway. Am J Physiol Cell Physiol 2001, 281:C1468-C1476.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Hirshman, C.A.1    Zhu, D.2    Panettieri, R.A.3    Emala, C.W.4
  • 74
    • 0035976575 scopus 로고    scopus 로고
    • Prostaglandins and leukotrienes: advances in eicosanoid biology
    • Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001, 294:1871-1875.
    • (2001) Science , vol.294 , pp. 1871-1875
    • Funk, C.D.1
  • 84
    • 0029003113 scopus 로고
    • Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels
    • Tomlinson P.R., Wilson J.W., Stewart A.G. Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels. Biochem Pharmacol 1995, 49:1809-1819.
    • (1995) Biochem Pharmacol , vol.49 , pp. 1809-1819
    • Tomlinson, P.R.1    Wilson, J.W.2    Stewart, A.G.3
  • 85
    • 0034530199 scopus 로고    scopus 로고
    • Tumor necrosis factor-α-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate
    • Ammit A.J., Hoffman R.K., Amrani Y., Lazaar A.L., Hay D.W., Torphy T.J., et al. Tumor necrosis factor-α-induced secretion of RANTES and interleukin-6 from human airway smooth-muscle cells. Modulation by cyclic adenosine monophosphate. Am J Respir Cell Mol Biol 2000, 23:794-802.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 794-802
    • Ammit, A.J.1    Hoffman, R.K.2    Amrani, Y.3    Lazaar, A.L.4    Hay, D.W.5    Torphy, T.J.6
  • 86
    • 0032823306 scopus 로고    scopus 로고
    • Prostanoid receptors: structures, properties, and functions
    • Narumiya S., Sugimoto Y., Ushikubi F. Prostanoid receptors: structures, properties, and functions. Physiol Rev 1999, 79:1193-1226.
    • (1999) Physiol Rev , vol.79 , pp. 1193-1226
    • Narumiya, S.1    Sugimoto, Y.2    Ushikubi, F.3
  • 87
    • 12144251393 scopus 로고    scopus 로고
    • Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor
    • Clarke D.L., Belvisi M.G., Smith S.J., Hardaker E., Yacoub M.H., Meja K.K., et al. Prostanoid receptor expression by human airway smooth muscle cells and regulation of the secretion of granulocyte colony-stimulating factor. Am J Physiol Lung Cell Mol Physiol 2005, 288:L238-L250.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Clarke, D.L.1    Belvisi, M.G.2    Smith, S.J.3    Hardaker, E.4    Yacoub, M.H.5    Meja, K.K.6
  • 88
    • 50849085454 scopus 로고    scopus 로고
    • s-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization
    • s-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization. Biochemistry 2008, 47:9279-9288.
    • (2008) Biochemistry , vol.47 , pp. 9279-9288
    • Kong, K.C.1    Gandhi, U.2    Martin, T.J.3    Anz, C.B.4    Yan, H.5    Misior, A.M.6
  • 89
    • 33745367077 scopus 로고    scopus 로고
    • EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis
    • Ndukwu I.M., White S.R., Leff A.R., Mitchell R.W. EP1 receptor blockade attenuates both spontaneous tone and PGE2-elicited contraction in guinea pig trachealis. Am J Physiol 1997, 273:L626-L633.
    • (1997) Am J Physiol , vol.273
    • Ndukwu, I.M.1    White, S.R.2    Leff, A.R.3    Mitchell, R.W.4
  • 91
    • 0032909759 scopus 로고    scopus 로고
    • Prostanoid receptors involved in the relaxation of human bronchial preparations
    • Norel X., Walch L., Labat C., Gascard J.P., Dulmet E., Brink C. Prostanoid receptors involved in the relaxation of human bronchial preparations. Br J Pharmacol 1999, 126:867-872.
    • (1999) Br J Pharmacol , vol.126 , pp. 867-872
    • Norel, X.1    Walch, L.2    Labat, C.3    Gascard, J.P.4    Dulmet, E.5    Brink, C.6
  • 95
    • 38549138534 scopus 로고    scopus 로고
    • Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors
    • Misior A.M., Yan H., Pascual R.M., Deshpande D.A., Panettieri R.A., Penn R.B. Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol Pharmacol 2008, 73:566-574.
    • (2008) Mol Pharmacol , vol.73 , pp. 566-574
    • Misior, A.M.1    Yan, H.2    Pascual, R.M.3    Deshpande, D.A.4    Panettieri, R.A.5    Penn, R.B.6
  • 96
    • 27144543173 scopus 로고    scopus 로고
    • Cytokines regulate β-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms
    • Guo M., Pascual R.M., Wang S., Fontana M.F., Valancius C.A., Panettieri R.A., et al. Cytokines regulate β-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms. Biochemistry 2005, 44:13771-13782.
    • (2005) Biochemistry , vol.44 , pp. 13771-13782
    • Guo, M.1    Pascual, R.M.2    Wang, S.3    Fontana, M.F.4    Valancius, C.A.5    Panettieri, R.A.6
  • 98
    • 0038511363 scopus 로고    scopus 로고
    • Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells
    • Carlin S.M., Roth M., Black J.L. Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2003, 284:L1020-L1026.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Carlin, S.M.1    Roth, M.2    Black, J.L.3
  • 100
    • 34248513300 scopus 로고    scopus 로고
    • Protein kinase A inhibits lysophosphatidic acid-induced migration of airway smooth muscle cells
    • Hirakawa M., Karashima Y., Watanabe M., Kimura C., Ito Y., Oike M. Protein kinase A inhibits lysophosphatidic acid-induced migration of airway smooth muscle cells. J Pharmacol Exp Ther 2007, 321:1102-1108.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1102-1108
    • Hirakawa, M.1    Karashima, Y.2    Watanabe, M.3    Kimura, C.4    Ito, Y.5    Oike, M.6
  • 102
    • 0032902083 scopus 로고    scopus 로고
    • Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition
    • Billington C.K., Joseph S.K., Swan C., Scott M.G., Jobson T.M., Hall I.P. Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition. Am J Physiol 1999, 276:L412-L419.
    • (1999) Am J Physiol , vol.276
    • Billington, C.K.1    Joseph, S.K.2    Swan, C.3    Scott, M.G.4    Jobson, T.M.5    Hall, I.P.6
  • 103
    • 24644516323 scopus 로고    scopus 로고
    • Airway smooth muscle: a modulator of airway remodeling in asthma
    • quiz 96
    • Lazaar A.L., Panettieri R.A. Airway smooth muscle: a modulator of airway remodeling in asthma. J Allergy Clin Immunol 2005, 116:488-495. quiz 96.
    • (2005) J Allergy Clin Immunol , vol.116 , pp. 488-495
    • Lazaar, A.L.1    Panettieri, R.A.2
  • 106
    • 0038126890 scopus 로고    scopus 로고
    • Migration of airway smooth muscle cells
    • Madison J.M. Migration of airway smooth muscle cells. Am J Respir Cell Mol Biol 2003, 29:8-11.
    • (2003) Am J Respir Cell Mol Biol , vol.29 , pp. 8-11
    • Madison, J.M.1
  • 107
    • 37849006832 scopus 로고    scopus 로고
    • Migration of airway smooth muscle cells
    • Gerthoffer W.T. Migration of airway smooth muscle cells. Proc Am Thorac Soc 2008, 5:97-105.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 97-105
    • Gerthoffer, W.T.1
  • 108
    • 80052600665 scopus 로고    scopus 로고
    • Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle
    • Roscioni S.S., Prins A.G., Elzinga C.R., Menzen M.H., Dekkers B.G., Halayko A.J., et al. Protein kinase A and the exchange protein directly activated by cAMP (Epac) modulate phenotype plasticity in human airway smooth muscle. Br J Pharmacol 2011, 164:958-969.
    • (2011) Br J Pharmacol , vol.164 , pp. 958-969
    • Roscioni, S.S.1    Prins, A.G.2    Elzinga, C.R.3    Menzen, M.H.4    Dekkers, B.G.5    Halayko, A.J.6
  • 110
    • 0031730079 scopus 로고    scopus 로고
    • Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth
    • Belvisi M.G., Saunders M., Yacoub M., Mitchell J.A. Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth. Br J Pharmacol 1998, 125:1102-1108.
    • (1998) Br J Pharmacol , vol.125 , pp. 1102-1108
    • Belvisi, M.G.1    Saunders, M.2    Yacoub, M.3    Mitchell, J.A.4
  • 115
    • 67651162338 scopus 로고    scopus 로고
    • Noncontractile functions of airway smooth muscle cells in asthma
    • Tliba O., Panettieri R.A. Noncontractile functions of airway smooth muscle cells in asthma. Annu Rev Physiol 2009, 71:509-535.
    • (2009) Annu Rev Physiol , vol.71 , pp. 509-535
    • Tliba, O.1    Panettieri, R.A.2
  • 116
    • 0034746479 scopus 로고    scopus 로고
    • Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    • Lazzeri N., Belvisi M.G., Patel H.J., Yacoub M.H., Chung K.F., Mitchell J.A. Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy. Am J Respir Cell Mol Biol 2001, 24:44-48.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 44-48
    • Lazzeri, N.1    Belvisi, M.G.2    Patel, H.J.3    Yacoub, M.H.4    Chung, K.F.5    Mitchell, J.A.6
  • 117
    • 0033899452 scopus 로고    scopus 로고
    • Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells
    • Pang L., Knox A.J. Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. Am J Respir Cell Mol Biol 2000, 23:79-85.
    • (2000) Am J Respir Cell Mol Biol , vol.23 , pp. 79-85
    • Pang, L.1    Knox, A.J.2
  • 118
    • 33646736505 scopus 로고    scopus 로고
    • Airway smooth muscle phenotype and function: interactions with current asthma therapies
    • Halayko A.J., Tran T., Ji S.Y., Yamasaki A., Gosens R. Airway smooth muscle phenotype and function: interactions with current asthma therapies. Curr Drug Targets 2006, 7:525-540.
    • (2006) Curr Drug Targets , vol.7 , pp. 525-540
    • Halayko, A.J.1    Tran, T.2    Ji, S.Y.3    Yamasaki, A.4    Gosens, R.5
  • 122
    • 33846301667 scopus 로고    scopus 로고
    • Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus
    • Miano J.M., Long X., Fujiwara K. Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Am J Physiol Cell Physiol 2007, 292:C70-C81.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Miano, J.M.1    Long, X.2    Fujiwara, K.3
  • 123
    • 73849132541 scopus 로고    scopus 로고
    • PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression
    • Blaker A.L., Taylor J.M., Mack C.P. PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 2009, 29:2153-2160.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 2153-2160
    • Blaker, A.L.1    Taylor, J.M.2    Mack, C.P.3
  • 124
    • 0037409295 scopus 로고    scopus 로고
    • Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA
    • Davis A., Hogarth K., Fernandes D., Solway J., Niu J., Kolenko V., et al. Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA. Cell Signal 2003, 15:597-604.
    • (2003) Cell Signal , vol.15 , pp. 597-604
    • Davis, A.1    Hogarth, K.2    Fernandes, D.3    Solway, J.4    Niu, J.5    Kolenko, V.6
  • 125
    • 78650168159 scopus 로고    scopus 로고
    • CAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A
    • Roscioni S.S., Dekkers B.G., Prins A.G., Menzen M.H., Meurs H., Schmidt M., et al. cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A. Br J Pharmacol 2011, 162:193-209.
    • (2011) Br J Pharmacol , vol.162 , pp. 193-209
    • Roscioni, S.S.1    Dekkers, B.G.2    Prins, A.G.3    Menzen, M.H.4    Meurs, H.5    Schmidt, M.6
  • 128
    • 0035402376 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells
    • Laporte J.C., Moore P.E., Baraldo S., Jouvin M.H., Church T.L., Schwartzman I.N., et al. Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells. Am J Respir Crit Care Med 2001, 164:141-148.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 141-148
    • Laporte, J.C.1    Moore, P.E.2    Baraldo, S.3    Jouvin, M.H.4    Church, T.L.5    Schwartzman, I.N.6
  • 129
    • 0028345511 scopus 로고
    • TGF-beta 1 modulates beta-adrenergic receptor number and function in cultured human tracheal smooth muscle cells
    • Nogami M., Romberger D.J., Rennard S.I., Toews M.L. TGF-beta 1 modulates beta-adrenergic receptor number and function in cultured human tracheal smooth muscle cells. Am J Physiol 1994, 266:L187-L191.
    • (1994) Am J Physiol , vol.266
    • Nogami, M.1    Romberger, D.J.2    Rennard, S.I.3    Toews, M.L.4
  • 130
    • 0030005408 scopus 로고    scopus 로고
    • Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle
    • Hakonarson H., Herrick D.J., Serrano P.G., Grunstein M.M. Mechanism of cytokine-induced modulation of beta-adrenoceptor responsiveness in airway smooth muscle. J Clin Invest 1996, 97:2593-2600.
    • (1996) J Clin Invest , vol.97 , pp. 2593-2600
    • Hakonarson, H.1    Herrick, D.J.2    Serrano, P.G.3    Grunstein, M.M.4
  • 131
    • 0022257530 scopus 로고
    • Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein
    • Benovic J.L., Pike L.J., Cerione R.A., Staniszewski C., Yoshimasa T., Codina J., et al. Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein. J Biol Chem 1985, 260:7094-7101.
    • (1985) J Biol Chem , vol.260 , pp. 7094-7101
    • Benovic, J.L.1    Pike, L.J.2    Cerione, R.A.3    Staniszewski, C.4    Yoshimasa, T.5    Codina, J.6
  • 132
    • 0031000946 scopus 로고    scopus 로고
    • Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type
    • Belvisi M.G., Saunders M.A., Haddad el B., Hirst S.J., Yacoub M.H., Barnes P.J., et al. Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br J Pharmacol 1997, 120:910-916.
    • (1997) Br J Pharmacol , vol.120 , pp. 910-916
    • Belvisi, M.G.1    Saunders, M.A.2    Haddad el, B.3    Hirst, S.J.4    Yacoub, M.H.5    Barnes, P.J.6
  • 134
    • 46749158660 scopus 로고    scopus 로고
    • β-Arrestins specifically constrain β2-adrenergic receptor signaling and function in airway smooth muscle
    • Deshpande D.A., Theriot B.S., Penn R.B., Walker J.K. β-Arrestins specifically constrain β2-adrenergic receptor signaling and function in airway smooth muscle. FASEB J 2008, 22:2134-2141.
    • (2008) FASEB J , vol.22 , pp. 2134-2141
    • Deshpande, D.A.1    Theriot, B.S.2    Penn, R.B.3    Walker, J.K.4
  • 137
    • 0030612652 scopus 로고    scopus 로고
    • 2-Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists
    • 2-Adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. J Biol Chem 1997, 272:23871-23879.
    • (1997) J Biol Chem , vol.272 , pp. 23871-23879
    • January, B.1    Seibold, A.2    Whaley, B.3    Hipkin, R.W.4    Lin, D.5    Schonbrunn, A.6
  • 141
    • 0036912235 scopus 로고    scopus 로고
    • Adverse effects of β-agonists
    • Sears M.R. Adverse effects of β-agonists. J Allergy Clin Immunol 2002, 110:S322-S328.
    • (2002) J Allergy Clin Immunol , vol.110
    • Sears, M.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.