Pharmacology of airway smooth muscle proliferation

European Journal of Pharmacology

Volumn 585, Issue 2-3, 2008, Pages 385-397

  Gosens, Reinoud ^a   Roscioni, Sara S ^a   Dekkers, Bart G J ^a   Pera, Tonio ^a   Schmidt, Martina ^a   Schaafsma, Dedmer ^b   Zaagsma, Johan ^a   Meurs, Herman ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Airway Remodeling; Asthma; Cytokine; Extracellular matrix; G protein coupled receptor; Growth factor

Indexed keywords

CYTOKINE; G PROTEIN COUPLED RECEPTOR; MATRIX PROTEIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE;

AIRFLOW; ASTHMA; CELL PROLIFERATION; DRUG MECHANISM; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER;

ANIMALS; CELL PROLIFERATION; CYTOKINES; EXTRACELLULAR MATRIX; HUMANS; INTEGRINS; MATRIX METALLOPROTEINASES; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; NEUROTRANSMITTER AGENTS; PROTEIN-TYROSINE KINASES; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATORY PHYSIOLOGY;

EID: 43049114930     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.01.055     Document Type: Review

References (203)

1. Absher M., Makrides W., Shapiro P., and Evans J.N. Hyperoxia inhibits proliferation of cultured rat tracheal smooth muscle cells. Am. J. Physiol. 267 (1994) L101-L105
2. Adcock I.M., Ito K., and Barnes P.J. Glucocorticoids: effects on gene transcription. Proc.Am.Thorac.Soc. 1 (2004) 247-254
3. Amishima M., Munakata M., Nasuhara Y., Sato A., Takahashi T., Homma Y., and Kawakami Y. Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am. J. Respir. Crit Care Med. 157 (1998) 1907-1912
4. Amrani Y., Panettieri Jr. R.A., Frossard N., and Bronner C. Activation of the TNF alpha-p55 receptor induces myocyte proliferation and modulates agonist-evoked calcium transients in cultured human tracheal smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 15 (1996) 55-63
5. Amrani Y., Tliba O., Choubey D., Huang C.D., Krymskaya V.P., Eszterhas A., Lazaar A.L., and Panettieri Jr. R.A. IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am. J. Physiol., Lung Cell Mol. Physiol. 284 (2003) L1063-L1071
6. An S.S., Bai T.R., Bates J.H., Black J.L., Brown R.H., Brusasco V., Chitano P., Deng L., Dowell M., Eidelman D.H., Fabry B., Fairbank N.J., Ford L.E., Fredberg J.J., Gerthoffer W.T., Gilbert S.H., Gosens R., Gunst S.J., Halayko A.J., Ingram R.H., Irvin C.G., James A.L., Janssen L.J., King G.G., Knight D.A., Lauzon A.M., Lakser O.J., Ludwig M.S., Lutchen K.R., Maksym G.N., Martin J.G., Mauad T., McParland B.E., Mijailovich S.M., Mitchell H.W., Mitchell R.W., Mitzner W., Murphy T.M., Pare P.D., Pellegrino R., Sanderson M.J., Schellenberg R.R., Seow C.Y., Silveira P.S., Smith P.G., Solway J., Stephens N.L., Sterk P.J., Stewart A.G., Tang D.D., Tepper R.S., Tran T., and Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur. Respir. J. 29 (2007) 834-860
7. Aubert J.D., Hayashi S., Hards J., Bai T.R., Pare P.D., and Hogg J.C. Platelet-derived growth factor and its receptor in lungs from patients with asthma and chronic airflow obstruction. Am. J. Physiol. 266 (1994) L655-L663
8. Barnier J.V., Papin C., Eychene A., Lecoq O., and Calothy G. The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression. J. Biol. Chem. 270 (1995) 23381-23389
9. Bauerfeld C.P., Hershenson M.B., and Page K. Cdc42, but not RhoA, regulates cyclin D1 expression in bovine tracheal myocytes. Am. J. Physiol., Lung Cell Mol. Physiol. 280 (2001) L974-L982
10. Berger P., Perng D.W., Thabrew H., Compton S.J., Cairns J.A., McEuen A.R., Marthan R., Tunon de Lara J.M., and Walls A.F. Tryptase and agonists of PAR-2 induce the proliferation of human airway smooth muscle cells. J. Appl. Physiol. 91 (2001) 1372-1379
11. Bergeron C., Boulet L.P., Page N., Laviolette M., Zimmermann N., Rothenberg M.E., and Hamid Q. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. J. Allergy Clin. Immunol. 119 (2007) 391-397
12. Billington C.K., and Penn R.B. Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Respir. Res. 4 (2003) 2
13. Billington C.K., Joseph S.K., Swan C., Scott M.G., Jobson T.M., and Hall I.P. Modulation of human airway smooth muscle proliferation by type 3 phosphodiesterase inhibition. Am. J. Physiol. 276 (1999) L412-L419
14. Billington C.K., Kong K.C., Bhattacharyya R., Wedegaertner P.B., Panettieri Jr. R.A., Chan T.O., and Penn R.B. Cooperative regulation of p70S6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry 44 (2005) 14595-14605
15. Black J.L., Burgess J.K., and Johnson P.R. Airway smooth muscle-its relationship to the extracellular matrix. Respir. Physiol. Neurobiol. 137 (2003) 339-346
16. Boer J., Duyvendak M., Schuurman F.E., Pouw F.M., Zaagsma J., and Meurs H. Role of l-arginine in the deficiency of nitric oxide and airway hyperreactivity after the allergen-induced early asthmatic reaction in guinea-pigs. Br. J. Pharmacol. 128 (1999) 1114-1120
17. Bonacci J.V., Harris T., and Stewart A.G. Impact of extracellular matrix and strain on proliferation of bovine airway smooth muscle. Clin. Exp. Pharmacol. Physiol. 30 (2003) 324-328
18. Bonacci J.V., Harris T., Wilson J.W., and Stewart A.G. Collagen-induced resistance to glucocorticoid anti-mitogenic actions: a potential explanation of smooth muscle hyperplasia in the asthmatic remodelled airway. Br. J. Pharmacol. 138 (2003) 1203-1206
19. Bonacci J.V., Schuliga M., Harris T., and Stewart A.G. Collagen impairs glucocorticoid actions in airway smooth muscle through integrin signalling. Br. J. Pharmacol. 149 (2006) 365-373
20. Bornfeldt K.E., and Krebs E.G. Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle. Cell. Signal. 11 (1999) 465-477
21. Bos I.S., Gosens R., Zuidhof A.B., Schaafsma D., Halayko A.J., Meurs H., and Zaagsma J. Inhibition of allergen-induced airway remodelling by tiotropium and budesonide: a comparison. Eur. Respir. J. 30 (2007) 653-661
22. Bosse Y., Thompson C., Stankova J., and Rola-Pleszczynski M. Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 34 (2006) 746-753
23. Bousquet J., Chanez P., Lacoste J.Y., White R., Vic P., Godard P., and Michel F.B. Asthma: a disease remodeling the airways. Allergy 47 (1992) 3-11
24. Bousquet J., Jeffery P.K., Busse W.W., Johnson M., and Vignola A.M. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am. J. Respir. Crit Care Med. 161 (2000) 1720-1745
25. Brar S.S., Kennedy T.P., Whorton A.R., Murphy T.M., Chitano P., and Hoidal J.R. Requirement for reactive oxygen species in serum-induced and platelet-derived growth factor-induced growth of airway smooth muscle. J. Biol. Chem. 274 (1999) 20017-20026
26. Brar S.S., Kennedy T.P., Sturrock A.B., Huecksteadt T.P., Quinn M.T., Murphy T.M., Chitano P., and Hoidal J.R. NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. Am. J. Physiol., Lung Cell Mol. Physiol. 282 (2002) L782-L795
27. Burgering B.M., and Coffer P.J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 (1995) 599-602
28. Burgering B.M., Pronk G.J., van Weeren P.C., Chardin P., and Bos J.L. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12 (1993) 4211-4220
29. Capra V., Habib A., Accomazzo M.R., Ravasi S., Citro S., Levy-Toledano S., Nicosia S., and Rovati G.E. Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation. Eur. J. Pharmacol. 474 (2003) 149-159
30. Cerutis D.R., Nogami M., Anderson J.L., Churchill J.D., Romberger D.J., Rennard S.I., and Toews M.L. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am. J. Physiol. 273 (1997) L10-L15
31. Chan V., Burgess J.K., Ratoff J.C., O'Connor B.J., Greenough A., Lee T.H., and Hirst S.J. Extracellular matrix regulates enhanced eotaxin expression in asthmatic airway smooth muscle cells. Am. J. Respir. Crit Care Med. 174 (2006) 379-385
32. Chen G., and Khalil N. TGF-beta1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases. Respir. Res. 7 (2006) 2
33. Chen Y.H., Zhao M.W., Yao W.Z., Pang Y.Z., and Tang C.S. The signal transduction pathway in the proliferation of airway smooth muscle cells induced by urotensin II. Chin. Med. J. 117 (2004) 37-41 (Engl.)
34. Citro S., Ravasi S., Rovati G.E., and Capra V. Thromboxane prostanoid receptor signals through Gi protein to rapidly activate extracellular signal-regulated kinase in human airways. Am. J. Respir. Cell Mol. Biol. 32 (2005) 326-333
35. Cohen P., Noveral J.P., Bhala A., Nunn S.E., Herrick D.J., and Grunstein M.M. Leukotriene D4 facilitates airway smooth muscle cell proliferation via modulation of the IGF axis. Am. J. Physiol. 269 (1995) L151-L157
36. Cohen M.D., Ciocca V., and Panettieri Jr. R.A. TGF-beta 1 modulates human airway smooth-muscle cell proliferation induced by mitogens. Am. J. Respir. Cell Mol. Biol. 16 (1997) 85-90
37. Cohen P., Rajah R., Rosenbloom J., and Herrick D.J. IGFBP-3 mediates TGF-beta1-induced cell growth in human airway smooth muscle cells. Am. J. Physiol., Lung Cell Mol. Physiol. 278 (2000) L545-L551
38. Cook S.J., and McCormick F. Inhibition by cAMP of Ras-dependent activation of Raf. Science 262 (1993) 1069-1072
39. Coppolino M.G., and Dedhar S. Bi-directional signal transduction by integrin receptors. Int. J. Biochem.Cell Biol. 32 (2000) 171-188
40. Couet J., Sargiacomo M., and Lisanti M.P. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem. 272 (1997) 30429-30438
41. Cox B.D., Natarajan M., Stettner M.R., and Gladson C.L. New concepts regarding focal adhesion kinase promotion of cell migration and proliferation. J. Cell. Biochem. 99 (2006) 35-52
42. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., and Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378 (1995) 785-789
43. Dashtaki R., Whorton A.R., Murphy T.M., Chitano P., Reed W., and Kennedy T.P. Dehydroepiandrosterone and analogs inhibit DNA binding of AP-1 and airway smooth muscle proliferation. J. Pharmacol. Exp. Ther. 285 (1998) 876-883
44. De S., Zelazny E.T., Souhrada J.F., and Souhrada M. Interleukin-1 beta stimulates the proliferation of cultured airway smooth muscle cells via platelet-derived growth factor. Am. J. Respir. Cell Mol. Biol. 9 (1993) 645-651
45. De S., Zelazny E.T., Souhrada J.F., and Souhrada M. IL-1 beta and IL-6 induce hyperplasia and hypertrophy of cultured guinea pig airway smooth muscle cells. J. Appl. Physiol. 78 (1995) 1555-1563
46. de B.J., Pouw F.M., Zaagsma J., and Meurs H. Effects of endogenous superoxide anion and nitric oxide on cholinergic constriction of normal and hyperreactive guinea pig airways. Am. J. Respir. Crit Care Med. 158 (1998) 1784-1789
47. Dekkers B.G., Schaafsma D., Nelemans S.A., Zaagsma J., and Meurs H. Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function. Am. J. Physiol., Lung Cell Mol. Physiol. 292 (2007) L1405-L1413
48. Delamere F., Holland E., Patel S., Bennett J., Pavord I., and Knox A. Production of PGE2 by bovine cultured airway smooth muscle cells and its inhibition by cyclo-oxygenase inhibitors. Br. J. Pharmacol. 111 (1994) 983-988
49. Delvecchio C.J., Bilan P., Radford K., Stephen J., Trigatti B.L., Cox G., Parameswaran K., and Capone J.P. Liver X receptor stimulates cholesterol efflux and inhibits expression of proinflammatory mediators in human airway smooth muscle cells. Mol. Endocrinol. 21 (2007) 1324-1334
50. Deshpande D.A., and Penn R.B. Targeting G protein-coupled receptor signaling in asthma. Cell. Signal. 18 (2006) 2105-2120
51. Du J., Hui Y., Cheung Y., Bin G., Jiang H., Chen X., and Tang C. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels 19 (2004) 75-80
52. Dugan L.L., Kim J.S., Zhang Y., Bart R.D., Sun Y., Holtzman D.M., and Gutmann D.H. Differential effects of cAMP in neurons and astrocytes. Role of B-raf. J. Biol. Chem. 274 (1999) 25842-25848
53. Ebina M., Takahashi T., Chiba T., and Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am. Rev. Respir. Dis. 148 (1993) 720-726
54. Ediger T.L., and Toews M.L. Synergistic stimulation of airway smooth muscle cell mitogenesis. J. Pharmacol. Exp. Ther. 294 (2000) 1076-1082
55. Ediger T.L., Schulte N.A., Murphy T.J., and Toews M.L. Transcription factor activation and mitogenic synergism in airway smooth muscle cells. Eur. Respir. J. 21 (2003) 759-769
56. Emala C.W., Liu F., and Hirshman C.A. Gialpha but not gqalpha is linked to activation of p21(ras) in human airway smooth muscle cells. Am. J. Physiol. 276 (1999) L564-L570
57. Fernandes D., Guida E., Koutsoubos V., Harris T., Vadiveloo P., Wilson J.W., and Stewart A.G. Glucocorticoids inhibit proliferation, cyclin D1 expression, and retinoblastoma protein phosphorylation, but not activity of the extracellular-regulated kinases in human cultured airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 21 (1999) 77-88
58. Fernandes D.J., Ravenhall C.E., Harris T., Tran T., Vlahos R., and Stewart A.G. Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific. Br. J. Pharmacol. 142 (2004) 1182-1190
59. Fernandes D.J., Bonacci J.V., and Stewart A.G. Extracellular matrix, integrins, and mesenchymal cell function in the airways. Curr. Drug Targets. 7 (2006) 567-577
60. Florio C., Martin J.G., Styhler A., and Heisler S. Antiproliferative effect of prostaglandin E2 in cultured guinea pig tracheal smooth muscle cells. Am. J. Physiol. 266 (1994) L131-L137
61. Fowlkes J.L., and Winkler M.K. Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability. Cytokine Growth Factor Rev. 13 (2002) 277-287
62. Freund-Michel V., Bertrand C., and Frossard N. TrkA signalling pathways in human airway smooth muscle cell proliferation. Cell. Signal. 18 (2006) 621-627
63. Freyer A.M., Johnson S.R., and Hall I.P. Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. Am. J. Respir. Cell Mol. Biol. 25 (2001) 569-576
64. Giancotti F.G., and Ruoslahti E. Integrin signaling. Science 285 (1999) 1028-1032
65. Gosens R., Nelemans S.A., Grootte Bromhaar M.M., McKay S., Zaagsma J., and Meurs H. Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 28 (2003) 257-262
66. Gosens R., Nelemans S.A., Hiemstra M., Grootte Bromhaar M.M., Meurs H., and Zaagsma J. Insulin induces a hypercontractile airway smooth muscle phenotype. Eur. J. Pharmacol. 481 (2003) 125-131
67. Gosens R., Schaafsma D., Meurs H., Zaagsma J., and Nelemans S.A. Role of Rho-kinase in maintaining airway smooth muscle contractile phenotype. Eur. J. Pharmacol. 483 (2004) 71-78
68. Gosens R., Zaagsma J., Grootte B.M., Nelemans A., and Meurs H.Z. Acetylcholine: a novel regulator of airway smooth muscle remodelling?. Eur. J. Pharmacol. 500 (2004) 193-201
69. Gosens R., Bos I.S., Zaagsma J., and Meurs H. Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. Am. J. Respir. Crit Care Med. 171 (2005) 1096-1102
70. Gosens R., Grootte Bromhaar M.M., Maarsingh H., ten D.A., Meurs H., Zaagsma J., and Nelemans S.A. Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes. Eur. J. Pharmacol. 535 (2006) 253-262
71. Gosens R., Stelmack G.L., Dueck G., McNeill K.D., Yamasaki A., Gerthoffer W.T., Unruh H., Gounni A.S., Zaagsma J., and Halayko A.J. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am. J. Physiol., Lung Cell Mol. Physiol. 291 (2006) L523-L534
72. Gosens R., Zaagsma J., Meurs H., and Halayko A.J. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir. Res. 7 (2006) 73
73. Gosens R., Dueck G., Gerthoffer W.T., Unruh H., Zaagsma J., Meurs H., and Halayko A.J. p42/p44 MAP kinase activation is localized to caveolae-free membrane domains in airway smooth muscle. Am. J. Physiol., Lung Cell Mol. Physiol. 292 (2007) L1163-L1172
74. Gosens R., Dueck G., Rector E., Nunes R.O., Gerthoffer W.T., Unruh H., Zaagsma J., Meurs H., and Halayko A.J. Cooperative regulation of GSK-3 by muscarinic and PDGF receptors is associated with airway myocyte proliferation. Am. J. Physiol., Lung Cell Mol. Physiol. 293 (2007) L1348-L1358
75. Graves L.M., Bornfeldt K.E., Raines E.W., Potts B.C., Macdonald S.G., Ross R., and Krebs E.G. Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 10300-10304
76. Guo M., Pascual R.M., Wang S., Fontana M.F., Valancius C.A., Panettieri Jr. R.A., Tilley S.L., and Penn R.B. Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms. Biochemistry 44 (2005) 13771-13782
77. Halayko A.J., Kartha S., Stelmack G.L., McConville J., Tam J., Camoretti-Mercado B., Forsythe S.M., Hershenson M.B., and Solway J. Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70S6K regulates contractile protein accumulation in airway myocyte differentiation. Am. J. Respir. Cell Mol. Biol. 31 (2004) 266-275
78. Hamad A.M., and Knox A.J. Mechanisms mediating the antiproliferative effects of nitric oxide in cultured human airway smooth muscle cells. FEBS Lett. 506 (2001) 91-96
79. Hamad A.M., Johnson S.R., and Knox A.J. Antiproliferative effects of NO and ANP in cultured human airway smooth muscle. Am. J. Physiol. 277 (1999) L910-L918
80. Hasaneen N.A., Zucker S., Cao J., Chiarelli C., Panettieri R.A., and Foda H.D. Cyclic mechanical strain-induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs. FASEB J. 19 (2005) 1507-1509
81. Hawker K.M., Johnson P.R., Hughes J.M., and Black J.L. Interleukin-4 inhibits mitogen-induced proliferation of human airway smooth muscle cells in culture. Am. J. Physiol. 275 (1998) L469-L477
82. Henderson Jr. W.R., Tang L.O., Chu S.J., Tsao S.M., Chiang G.K., Jones F., Jonas M., Pae C., Wang H., and Chi E.Y. A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model. Am. J. Respir. Crit Care Med. 165 (2002) 108-116
83. Hirst S.J. Airway smooth muscle as a target in asthma. Clin. Exp. Allergy 30 Suppl 1 (2000) 54-59
84. Hirst S.J., Barnes P.J., and Twort C.H. Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor. Am. J. Respir. Cell Mol. Biol. 7 (1992) 574-581
85. Hirst S.J., Barnes P.J., and Twort C.H. PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells. Am. J. Physiol. 270 (1996) L415-L428
86. Hirst S.J., Twort C.H., and Lee T.H. Differential effects of extracellular matrix proteins on human airway smooth muscle cell proliferation and phenotype. Am. J. Respir. Cell Mol. Biol. 23 (2000) 335-344
87. Hirst S.J., Martin J.G., Bonacci J.V., Chan V., Fixman E.D., Hamid Q.A., Herszberg B., Lavoie J.P., McVicker C.G., Moir L.M., Nguyen T.T., Peng Q., Ramos-Barbon D., and Stewart A.G. Proliferative aspects of airway smooth muscle. J. Allergy Clin. Immunol. 114 (2004) S2-S17
88. Holgate S.T., Peters-Golden M., Panettieri R.A., and Henderson Jr. W.R. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J. Allergy Clin. Immunol. 111 (2003) S18-S34
89. Holz G.G., Kang G., Harbeck M., Roe M.W., and Chepurny O.G. Cell physiology of cAMP sensor Epac. J. Physiol. 577 (2006) 5-15
90. Hsueh Y.P., and Lai M.Z. c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytes. J. Biol. Chem. 270 (1995) 18094-18098
91. Huang C.D., Chen H.H., Wang C.H., Chou C.L., Lin S.M., Lin H.C., and Kuo H.P. Human neutrophil-derived elastase induces airway smooth muscle cell proliferation. Life Sci. 74 (2004) 2479-2492
92. Johnson S., and Knox A. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. Am. J. Physiol. 277 (1999) L1109-L1117
93. Johnson P.R., Roth M., Tamm M., Hughes M., Ge Q., King G., Burgess J.K., and Black J.L. Airway smooth muscle cell proliferation is increased in asthma. Am. J. Respir. Crit Care Med. 164 (2001) 474-477
94. Johnson P.R., Burgess J.K., Underwood P.A., Au W., Poniris M.H., Tamm M., Ge Q., Roth M., and Black J.L. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J. Allergy Clin. Immunol. 113 (2004) 690-696
95. Kassel K.M., Wyatt T.A., Panettieri Jr. R.A., and Toews M. Inhibition of human airway smooth muscle cell proliferation by {beta}2-adrenergic receptors and cAMP is PKA-independent: evidence for EPAC involvement. Am. J. Physiol., Lung Cell Mol. Physiol. 294 (2008) L131-L138
96. Kato Y., Fujisawa T., Nishimori H., Katsumata H., Atsuta J., Iguchi K., and Kamiya H. Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils. Int. Arch. Allergy Immunol. 137 Suppl 1 (2005) 17-20
97. Keiper M., Stope M.B., Szatkowski D., Bohm A., Tysack K., Vom D.F., Saur O., Oude Weernink P.A., Evellin S., Jakobs K.H., and schmidt M. Epac- and Ca2+-controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J. Biol. Chem. 279 (2004) 46497-46508
98. Kelleher M.D., Abe M.K., Chao T.S., Jain M., Green J.M., Solway J., Rosner M.R., and Hershenson M.B. Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am. J. Physiol. 268 (1995) L894-L901
99. Kilfeather S.A., Tagoe S., Perez A.C., Okona-Mensa K., Matin R., and Page C.P. Inhibition of serum-induced proliferation of bovine tracheal smooth muscle cells in culture by heparin and related glycosaminoglycans. Br. J. Pharmacol. 114 (1995) 1442-1446
100. Kong K.C., Billington C.K., Gandhi U., Panettieri Jr. R.A., and Penn R.B. Cooperative mitogenic signaling by G protein-coupled receptors and growth factors is dependent on G(q/11). FASEB J. 20 (2006) 1558-1560
101. Krymskaya V.P., Hoffman R., Eszterhas A., Ciocca V., and Panettieri Jr. R.A. TGF-beta 1 modulates EGF-stimulated phosphatidylinositol 3-kinase activity in human airway smooth muscle cells. Am. J. Physiol. 273 (1997) L1220-L1227
102. Krymskaya V.P., Hoffman R., Eszterhas A., Kane S., Ciocca V., and Panettieri Jr. R.A. EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. Am. J. Physiol. 276 (1999) L246-L255
103. Krymskaya V.P., Penn R.B., Orsini M.J., Scott P.H., Plevin R.J., Walker T.R., Eszterhas A.J., Amrani Y., Chilvers E.R., and Panettieri Jr. R.A. Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am. J. Physiol. 277 (1999) L65-L78
104. Krymskaya V.P., Orsini M.J., Eszterhas A.J., Brodbeck K.C., Benovic J.L., Panettieri Jr. R.A., and Penn R.B. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 23 (2000) 546-554
105. Krymskaya V.P., Ammit A.J., Hoffman R.K., Eszterhas A.J., and Panettieri Jr. R.A. Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells. Am. J. Physiol., Lung Cell Mol. Physiol. 280 (2001) L1009-L1018
106. Krymskaya V.P., Goncharova E.A., Ammit A.J., Lim P.N., Goncharov D.A., Eszterhas A., and Panettieri Jr. R.A. Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. FASEB J. 19 (2005) 428-430
107. Lazaar A.L., Plotnick M.I., Kucich U., Crichton I., Lotfi S., Das S.K., Kane S., Rosenbloom J., Panettieri Jr. R.A., Schechter N.M., and Pure E. Mast cell chymase modifies cell-matrix interactions and inhibits mitogen-induced proliferation of human airway smooth muscle cells. J. Immunol. 169 (2002) 1014-1020
108. Lee J.H., Johnson P.R., Roth M., Hunt N.H., and Black J.L. ERK activation and mitogenesis in human airway smooth muscle cells. Am. J. Physiol., Lung Cell Mol. Physiol. 280 (2001) L1019-L1029
109. Lew D.B., and Rattazzi M.C. Mitogenic effect of lysosomal hydrolases on bovine tracheal myocytes in culture. J. Clin. Invest. 88 (1991) 1969-1975
110. Lin C.C., Shyr M.H., Chien C.S., Wang C.C., Chiu C.T., Hsiao L.D., and Yang C.M. Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells. Cell. Signal. 13 (2001) 257-267
111. Lin C.C., Shyr M.H., Chien C.S., Wang C.C., Chiu C.T., Hsiao L.D., and Yang C.M. Thrombin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells. Cell. Signal. 14 (2002) 265-275
112. Maarsingh H., Leusink J., Bos I.S., Zaagsma J., and Meurs H. Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma. Respir. Res. 7 (2006) 6
113. Maarsingh H., Leusink J., Zaagsma J., and Meurs H. Role of the l-citrulline/l-arginine cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma. Eur. J. Pharmacol. 546 (2006) 171-176
114. Maruno K., Absood A., and Said S.I. VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells. Am. J. Physiol. 268 (1995) L1047-L1051
115. Mayr B., and Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev., Mol. Cell Biol. 2 (2001) 599-609
116. McCawley L.J., and Matrisian L.M. Matrix metalloproteinases: they're not just for matrix anymore!. Curr. Opin. Cell Biol. 13 (2001) 534-540
117. McKay S., Bromhaar M.M., de Jongste J.C., Hoogsteden H.C., Saxena P.R., and Sharma H.S. Pro-inflammatory cytokines induce c-fos expression followed by IL-6 release in human airway smooth muscle cells. Mediat. Inflamm. 10 (2001) 135-142
118. Meurs H., Maarsingh H., and Zaagsma J. Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness. Trends Pharmacol. Sci. 24 (2003) 450-455
119. Michoud M.C., Napolitano G., Maghni K., Govindaraju V., Cogo A., and Martin J.G. Effects of extracellular triphosphate nucleotides and nucleosides on airway smooth muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 27 (2002) 732-738
120. Misior A.M., Yan H., Pascual R.M., Deshpande D.A., Panettieri Jr. R.A., and Penn R.B. Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors. Mol. Pharmacol. 73 (2008) 566-574
121. Miura M., Yamauchi H., Ichinose M., Ohuchi Y., Kageyama N., Tomaki M., Endoh N., and Shirato K. Impairment of neural nitric oxide-mediated relaxation after antigen exposure in guinea pig airways in vitro. Am. J. Respir. Crit Care Med. 156 (1997) 217-222
122. Moir L.M., Burgess J.K., Johnson P.R., and Black J.L. Asthmatic and non-asthmatic airway smooth muscle cell proliferation is mediated via different integrins. Proc. Am. Thorac. Soc. (2007) A337
123. Moore P.K., Bhatia M., and Moochhala S. Hydrogen sulfide: from the smell of the past to the mediator of the future?. Trends Pharmacol. Sci. 24 (2003) 609-611
124. Musa N.L., Ramakrishnan M., Li J., Kartha S., Liu P., Pestell R.G., and Hershenson M.B. Forskolin inhibits cyclin D1 expression in cultured airway smooth-muscle cells. Am. J. Respir. Cell Mol. Biol. 20 (1999) 352-358
125. Nguyen T.T., Ward J.P., and Hirst S.J. beta1-integrins mediate enhancement of airway smooth muscle proliferation by collagen and fibronectin. Am. J. Respir. Crit Care Med. 171 (2005) 217-223
126. Noveral J.P., and Grunstein M.M. Role and mechanism of thromboxane-induced proliferation of cultured airway smooth muscle cells. Am. J. Physiol. 263 (1992) L555-L561
127. Noveral J.P., and Grunstein M.M. Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation. Am. J. Physiol. 267 (1994) L291-L299
128. Noveral J.P., and Grunstein M.M. Tachykinin regulation of airway smooth muscle cell proliferation. Am. J. Physiol. 269 (1995) L339-L343
129. Noveral J.P., Rosenberg S.M., Anbar R.A., Pawlowski N.A., and Grunstein M.M. Role of endothelin-1 in regulating proliferation of cultured rabbit airway smooth muscle cells. Am. J. Physiol. 263 (1992) L317-L324
130. Noveral J.P., Bhala A., Hintz R.L., Grunstein M.M., and Cohen P. Insulin-like growth factor axis in airway smooth muscle cells. Am. J. Physiol. 267 (1994) L761-L765
131. Okona-Mensah K.B., Shittu E., Page C., Costello J., and Kilfeather S.A. Inhibition of serum and transforming growth factor beta (TGF-beta1)-induced DNA synthesis in confluent airway smooth muscle by heparin. Br. J. Pharmacol. 125 (1998) 599-606
132. Oltmanns U., Sukkar M.B., Xie S., John M., and Chung K.F. Induction of human airway smooth muscle apoptosis by neutrophils and neutrophil elastase. Am. J. Respir. Cell Mol. Biol. 32 (2005) 334-341
133. Orsini M.J., Krymskaya V.P., Eszterhas A.J., Benovic J.L., Panettieri Jr. R.A., and Penn R.B. MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am. J. Physiol. 277 (1999) L479-L488
134. Page K., Li J., Hodge J.A., Liu P.T., Vanden Hoek T.L., Becker L.B., Pestell R.G., Rosner M.R., and Hershenson M.B. Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells. J. Biol. Chem. 274 (1999) 22065-22071
135. Pandya H.C., Snetkov V.A., Twort C.H., Ward J.P., and Hirst S.J. Oxygen regulates mitogen-stimulated proliferation of fetal human airway smooth muscle cells. Am. J. Physiol., Lung Cell Mol. Physiol. 283 (2002) L1220-L1230
136. Panettieri R.A., Yadvish P.A., Kelly A.M., Rubinstein N.A., and Kotlikoff M.I. Histamine stimulates proliferation of airway smooth muscle and induces c-fos expression. Am. J. Physiol. 259 (1990) L365-L371
137. Panettieri Jr. R.A., Hall I.P., Maki C.S., and Murray R.K. alpha-thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 13 (1995) 205-216
138. Panettieri R.A., Tan E.M., Ciocca V., Luttmann M.A., Leonard T.B., and Hay D.W. Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. Am. J. Respir. Cell Mol. Biol. 19 (1998) 453-461
139. Patel H.J., Belvisi M.G., Donnelly L.E., Yacoub M.H., Chung K.F., and Mitchell J.A. Constitutive expressions of type I NOS in human airway smooth muscle cells: evidence for an antiproliferative role. FASEB J. 13 (1999) 1810-1816
140. Patel H.J., Belvisi M.G., Bishop-Bailey D., Yacoub M.H., and Mitchell J.A. Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy. J. Immunol. 170 (2003) 2663-2669
141. Pilz R.B., and Casteel D.E. Regulation of gene expression by cyclic GMP. Circ. Res. 93 (2003) 1034-1046
142. Plevin R., Malarkey K., Aidulis D., McLees A., and Gould G.W. Cyclic AMP inhibitors inhibits PDGF-stimulated mitogen-activated protein kinase activity in rat aortic smooth muscle cells via inactivation of c-Raf-1 kinase and induction of MAP kinase phosphatase-1. Cell. Signal. 9 (1997) 323-328
143. Pyne S., and Pyne N.J. The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. Biochem. J. 315 Pt 3 (1996) 917-923
144. Rajah R., Nachajon R.V., Collins M.H., Hakonarson H., Grunstein M.M., and Cohen P. Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 20 (1999) 199-208
145. Razani B., and Lisanti M.P. Caveolins and caveolae: molecular and functional relationships. Exp. Cell Res. 271 (2001) 36-44
146. Razani B., Woodman S.E., and Lisanti M.P. Caveolae: from cell biology to animal physiology. Pharmacol. Rev. 54 (2002) 431-467
147. Ricciardolo F.L., Sterk P.J., Gaston B., and Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol. Rev. 84 (2004) 731-765
148. Ricciardolo F.L., Zaagsma J., and Meurs H. The therapeutic potential of drugs targeting the arginase pathway in asthma. Expert. Opin. Investig. Drugs 14 (2005) 1221-1231
149. Roche W.R., Beasley R., Williams J.H., and Holgate S.T. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1 (1989) 520-524
150. Roth M., Johnson P.R., Rudiger J.J., King G.G., Ge Q., Burgess J.K., Anderson G., Tamm M., and Black J.L. Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Lancet 360 (2002) 1293-1299
151. Roth M., Johnson P.R., Borger P., Bihl M.P., Rudiger J.J., King G.G., Ge Q., Hostettler K., Burgess J.K., Black J.L., and Tamm M. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N. Engl. J. Med. 351 (2004) 560-574
152. Ruocco S., Lallemand A., Tournier J.M., and Gaillard D. Expression and localization of epidermal growth factor, transforming growth factor-alpha, and localization of their common receptor in fetal human lung development. Pediatr. Res. 39 (1996) 448-455
153. Ryter S.W., Alam J., and Choi A.M. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol. Rev. 86 (2006) 583-650
154. schmidt M., Elzinga C.R.S., Bos I.S., Beemsterboer J.J., Warnders F.J., Van den Hoff M.J.B., Gerthoffer W.T., Halayko A.J., Nelemans S.A., and Meurs H. A key role for Epac in airway development and biology?. Am. J. Respir. Crit Care Med. (2007) A524
155. schmidt M., Sand C., Jakobs K.H., Michel M.C., and Weernink P.A. Epac and the cardiovascular system. Curr. Opin. Pharmacol. 7 (2007) 193-200
156. Schmierer B., and Hill C.S. TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility. Nat. Rev., Mol. Cell Biol. 8 (2007) 970-982
157. Schmitt J.M., and Stork P.J. Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1. Mol. Cell Biol. 21 (2001) 3671-3683
158. Scott P.H., Belham C.M., al-Hafidh J., Chilvers E.R., Peacock A.J., Gould G.W., and Plevin R. A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells. Biochem. J. 318 Pt 3 (1996) 965-971
159. Sengupta T.K., Schmitt E.M., and Ivashkiv L.B. Inhibition of cytokines and JAK-STAT activation by distinct signaling pathways. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 9499-9504
160. Sevetson B.R., Kong X., and Lawrence Jr. J.C. Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. U. S. A. 90 (1993) 10305-10309
161. Sewing A., Burger C., Brusselbach S., Schalk C., Lucibello F.C., and Muller R. Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J. Cell Sci. 104 Pt 2 (1993) 545-555
162. Shepherd M.C., Duffy S.M., Harris T., Cruse G., Schuliga M., Brightling C.E., Neylon C.B., Bradding P., and Stewart A.G. KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation. Am. J. Respir. Cell Mol. Biol. 37 (2007) 525-531
163. Simon A.R., Takahashi S., Severgnini M., Fanburg B.L., and Cochran B.H. Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells. Am. J. Physiol., Lung Cell Mol. Physiol. 282 (2002) L1296-L1304
164. Smith P.G., Janiga K.E., and Bruce M.C. Strain increases airway smooth muscle cell proliferation. Am. J. Respir. Cell Mol. Biol. 10 (1994) 85-90
165. Song R., Mahidhara R.S., Liu F., Ning W., Otterbein L.E., and Choi A.M. Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen-activated protein kinase pathway. Am. J. Respir. Cell Mol. Biol. 27 (2002) 603-610
166. Song Y., Qi H., and Wu C. Effect of 1,25-(OH)2D3 (a vitamin D analogue) on passively sensitized human airway smooth muscle cells. Respirology 12 (2007) 486-494
167. Stewart A.G. Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Pulm. Pharmacol. Ther. 14 (2001) 255-265
168. Stewart A.G., Fernandes D., and Tomlinson P.R. The effect of glucocorticoids on proliferation of human cultured airway smooth muscle. Br. J. Pharmacol. 116 (1995) 3219-3226
169. Stewart A.G., Tomlinson P.R., Fernandes D.J., Wilson J.W., and Harris T. Tumor necrosis factor alpha modulates mitogenic responses of human cultured airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 12 (1995) 110-119
170. Stewart A.G., Tomlinson P.R., and Wilson J.W. Beta 2-adrenoceptor agonist-mediated inhibition of human airway smooth muscle cell proliferation: importance of the duration of beta 2-adrenoceptor stimulation. Br. J. Pharmacol. 121 (1997) 361-368
171. Stewart A.G., Bonacci J.V., and Quan L. Factors controlling airway smooth muscle proliferation in asthma. Curr. Allergy Asthma Rep. 4 (2004) 109-115
172. Stork P.J., and Schmitt J.M. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol. 12 (2002) 258-266
173. Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., and Nurnberg B. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science 269 (1995) 690-693
174. Sturrock A., Huecksteadt T.P., Norman K., Sanders K., Murphy T.M., Chitano P., Wilson K., Hoidal J.R., and Kennedy T.P. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. Am. J. Physiol., Lung Cell Mol. Physiol. 292 (2007) L1543-L1555
175. Taille C., Almolki A., Benhamed M., Zedda C., Megret J., Berger P., Leseche G., Fadel E., Yamaguchi T., Marthan R., Aubier M., and Boczkowski J. Heme oxygenase inhibits human airway smooth muscle proliferation via a bilirubin-dependent modulation of ERK1/2 phosphorylation. J. Biol. Chem. 278 (2003) 27160-27168
176. Taille C., El-Benna J., Lanone S., Boczkowski J., and Motterlini R. Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. J. Biol. Chem. 280 (2005) 25350-25360
177. Takeda N., Kondo M., Ito S., Ito Y., Shimokata K., and Kume H. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am. J. Respir. Cell Mol. Biol. 35 (2006) 722-729
178. Tliba O., Tliba S., Da H.C., Hoffman R.K., DeLong P., Panettieri Jr. R.A., and Amrani Y. Tumor necrosis factor alpha modulates airway smooth muscle function via the autocrine action of interferon beta. J. Biol. Chem. 278 (2003) 50615-50623
179. Tliba O., Cidlowski J.A., and Amrani Y. CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol. Pharmacol. 69 (2006) 588-596
180. Tliba O., Damera G., Banerjee A., Gu S., Baidouri H., Keslacy S., and Amrani Y. Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of IRF-1. Am. J. Respir. Cell Mol. Biol. 38 (2008) 463-472
181. Toker A., and Cantley L.C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387 (1997) 673-676
182. Tomlinson P.R., Wilson J.W., and Stewart A.G. Inhibition by salbutamol of the proliferation of human airway smooth muscle cells grown in culture. Br. J. Pharmacol. 111 (1994) 641-647
183. Tomlinson P.R., Wilson J.W., and Stewart A.G. Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels. Biochem. Pharmacol. 49 (1995) 1809-1819
184. Tran T., Ens-Blackie K., Rector E.S., Stelmack G.L., McNeill K.D., Tarone G., Gerthoffer W.T., Unruh H., and Halayko A.J. Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes. Am. J. Respir. Cell Mol. Biol. 37 (2007) 668-680
185. Trian T., Benard G., Begueret H., Rossignol R., Girodet P.O., Ghosh D., Ousova O., Vernejoux J.M., Marthan R., Tunon-de-Lara J.M., and Berger P. Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J. Exp. Med. 204 (2007) 3173-3181
186. Vanacker N.J., Palmans E., Kips J.C., and Pauwels R.A. Fluticasone inhibits but does not reverse allergen-induced structural airway changes. Am. J. Respir. Crit Care Med. 163 (2001) 674-679
187. van Biesen T., Hawes B.E., Luttrell D.K., Krueger K.M., Touhara K., Porfiri E., Sakaue M., Luttrell L.M., and Lefkowitz R.J. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature 376 (1995) 781-784
188. Vossler M.R., Yao H., York R.D., Pan M.G., Rim C.S., and Stork P.J. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89 (1997) 73-82
189. Walker T.R., Moore S.M., Lawson M.F., Panettieri Jr. R.A., and Chilvers E.R. Platelet-derived growth factor-BB and thrombin activate phosphoinositide 3-kinase and protein kinase B: role in mediating airway smooth muscle proliferation. Mol. Pharmacol. 54 (1998) 1007-1015
190. Wang C.G., Du T., Xu L.J., and Martin J.G. Role of leukotriene D4 in allergen-induced increases in airway smooth muscle in the rat. Am. Rev. Respir. Dis. 148 (1993) 413-417
191. Wang Z.L., Walker B.A., Weir T.D., Yarema M.C., Roberts C.R., Okazawa M., Pare P.D., and Bai T.R. Effect of chronic antigen and beta 2 agonist exposure on airway remodeling in guinea pigs. Am. J. Respir. Crit Care Med. 152 (1995) 2097-2104
192. Ward J.E., Gould H., Harris T., Bonacci J.V., and Stewart A.G. PPAR gamma ligands, 15-deoxy-delta12,14-prostaglandin J2 and rosiglitazone regulate human cultured airway smooth muscle proliferation through different mechanisms. Br. J. Pharmacol. 141 (2004) 517-525
193. Wei L.H., Wu G., Morris Jr. S.M., and Ignarro L.J. Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9260-9264
194. Welser J.V., Lange N., Singer C.A., Elorza M., Scowen P., Keef K.D., Gerthoffer W.T., and Burkin D.J. Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling. Circ. Res. 101 (2007) 672-681
195. Wilson J.W., and Li X. The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway. Clin. Exp. Allergy 27 (1997) 363-371
196. Woodruff P.G., Dolganov G.M., Ferrando R.E., Donnelly S., Hays S.R., Solberg O.D., Carter R., Wong H.H., Cadbury P.S., and Fahy J.V. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am. J. Respir. Crit Care Med. 169 (2004) 1001-1006
197. Wu G., and Morris Jr. S.M. Arginine metabolism: nitric oxide and beyond. Biochem. J. 336 Pt 1 (1998) 1-17
198. Xie S., Sukkar M.B., Issa R., Khorasani N.M., and Chung K.F. Mechanisms of induction of airway smooth muscle hyperplasia by transforming growth factor-beta. Am. J. Physiol., Lung Cell Mol. Physiol. 293 (2007) L245-L253
199. Yahiaoui L., Villeneuve A., Valderrama-Carvajal H., Burke F., and Fixman E.D. Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells. Cell. Physiol. Biochem. 17 (2006) 37-46
200. Yamamoto M., Toya Y., Jensen R.A., and Ishikawa Y. Caveolin is an inhibitor of platelet-derived growth factor receptor signaling. Exp. Cell Res. 247 (1999) 380-388
201. Young P.G., Skinner S.J., and Black P.N. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur. J. Pharmacol. 273 (1995) 137-143
202. Zhou L., and Hershenson M.B. Mitogenic signaling pathways in airway smooth muscle. Respir. Physiol. Neurobiol. 137 (2003) 295-308
203. Zwick E., Hackel P.O., Prenzel N., and Ullrich A. The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol. Sci. 20 (1999) 408-412