Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 20, 2004, Pages 7618-7623

  Gao, Yuan ^a   Dickerson, J Bradley ^b   Guo, Fukun ^a   Zheng, Jie ^b   Zheng, Yi ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUND; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTERSECTIN; NSC 23766; PLATELET DERIVED GROWTH FACTOR; PROTEIN CDC42; PROTEIN INHIBITOR; RAC PROTEIN; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL TRANSFORMATION; CHEMICAL STRUCTURE; HUMAN; HUMAN CELL; LAMELLIPODIUM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINOQUINOLINES; HUMANS; MALE; PHENOTYPE; PROSTATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; RAC GTP-BINDING PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 2442664118     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0307512101     Document Type: Article

References (40)

1. Etienne-Manneville, S. & Hall, A. (2002) Nature 420, 629-635.
2. Zheng, Y. (2001) Trends Biochem. Sci. 26, 724-732.
3. Zohn, I. M., Campbell, S. L., Khosravi-Far, R., Rossman, K. L. & Der, C. J. (1998) Oncogene 17, 1415-1438.
4. Van Aelst, L. & D'Souza-Schorey, C. (1997) Genes Dev. 11, 2295-2322.
5. Schmitz, A. A., Govek, E. E., Bottner, B. & Van Aelst, L. (2000) Exp. Cell Res. 261, 1-12.
6. Symons, M. (2000) Curr. Biol. 10, R535-R537.
7. Fritz, G., Just, I. & Kaina, B. (1999) Int. J. Cancer 81, 682-687.
8. Mira, J. P., Benard, V., Groffen, J., Sanders, L. C. & Knaus, U. G. (2000) Proc. Natl. Acad. Sci. USA 97, 185-189.
9. Kamai, T., Arai, K., Tsujii, T., Honda, M. & Yoshida, K. (2001) BJU Int. 87, 227-231.
10. Schnelzer, A., Prechtel, D., Knaus, U., Dehne, K., Gerhard, M., Graeff, H., Harbeck, N., Schmitt, M. & Lengyel, E. (2000) Oncogene 19, 3013-3020.
11. Suwa, H., Ohshio, G., Imamura, T., Watanabe, G., Arii, S., Imamura, M., Narumiya, S., Hiai, H. & Fukumoto, M. (1998) Br. J. Cancer 77, 147-152.
12. Sahai, E. & Marshall, C. (2002) Nat. Rev. Cancer 2, 133-142.
13. Worthylake, D. K., Rossman, K. L. & Sondek, J. (2000) Nature 408, 682-688.
14. Rossman, K. L., Worthylake, D. K., Snyder, J. T., Siderovski, D. P., Campbell, S. L. & Sondek, J. (2002) EMBO J. 21, 1315-1326.
15. Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. D. & Sondek, J. (2002) Nat. Struct. Biol. 9, 468-475.
16. Gao, Y., Xing, J., Streuli, M., Leto, T. L. & Zheng, Y. (2001) J. Biol. Chem. 276, 47530-47541.
17. Karnoub, A. E., Worthylake, D. K., Rossman, K. L., Pruitt, W. M., Campbell, S. L., Sondek, J. & Der, C. J. (2001) Nat. Struct. Biol. 8, 1037-1041.
18. Waszkowycz, B., Perkins, T. D. J., Sykes, R. A. & Li, J. (2001) IBM Systems J. 40, 360-376.
19. Gruneberg, S., Wendt, B. & Klebe, G. (2001) Angew. Chem. Int. Ed. Engl. 40, 389-393.
20. Zhang, B., Zhang, Y., Wang, Z. & Zheng, Y. (2000) J. Biol. Chem. 275, 25299-25307.
21. Qiu, R. G., Abo, A., McCormick, F. & Symons, M. (1997) Mol. Cell. Biol. 17, 3449-3458.
22. Wang, L., Yang, L., Luo, Y. & Zheng, Y. (2003) J. Biol. Chem. 278, 44617-44625.
23. Hurst, T. (1994) J. Chem. Inf. Comput. Sci. 34, 190-196.
24. Rarey, M., Kramer, B., Lengauer, T. & Klebe, G. (1996) J. Mol. Biol. 261, 470-489.
25. Clark, R. D., Strizhev, A., Leonard, J. M., Blake, J. F. & Matthew, J. B. (2002) J. Mol. Graphics Model 20, 281-295.
26. Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. & Hall, A. (1992) Cell 70, 401-410.
27. Hawkins, P. T., Eguinoa, A., Qiu, R. G., Stokoe, D., Cooke, F. T., Walters, R., Wennstrom, S., Claesson-Welsh, L., Evans, T., Symons, M. & Stephens, L. (1995) Curr. Biol. 5, 393-403.
28. Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S. & Der, C. J. (1995) Mol. Cell. Biol. 15, 6443-6453.
29. Kaighn, M. E., Narayan, K. S., Ohnuki, Y., Lechner, J. F. & Jones, L. W. (1979) Invest. Urol. 17, 16-23.
30. Bastola, D. R., Pahwa, G. S., Lin, M. F. & Cheng, P. W. (2002) Mol. Cell Biochem. 236, 75-81.
31. Liliental, J., Moon, S. Y., Lesche, R., Mamillapalli, R., Li, D., Zheng, Y., Sun, H. & Wu, H. (2000) Curr. Biol. 10, 401-404.
32. Lyons, L. S., Krajewski, S. K., Welsh, C. & Burnstein, K. L. (2003) Proc. Am. Assoc. Cancer Res. 44, 273 (R1404).
33. Malliri, A., van der Kammen, R. A., Clark, K., van der Valk, M., Michiels, F. & Collard, J. G. (2002) Nature 417, 867-871.
34. Guo, F., Gao, Y., Wang, L. & Zheng, Y. (2003) J. Biol. Chem. 278, 14414-14419.
35. Guo, F. & Zheng, Y. (2003) Mol. Cell. Biol. 24, 1426-1428.
36. Engers, R., Zwaka, T. P., Gohr, L., Weber, A., Gerharz, C. D. & Gabbert, H. E. (2000) Int. J. Cancer 88, 369-376.
37. Olson, M. F., Pasteris, N. G., Gorski, J. L. & Hall, A. (1996) Curr. Biol. 6, 1628-1633.
38. Movilla, N., Dosil, M., Zheng, Y. & Bustelo, X. R. (2001) Oncogene 20, 8057-8065.
39. Del Pozo, M. A., Price, L. S., Alderson, N. B., Ren, X. D. & Schwartz, M. A. (2000) EMBO J. 19, 2008-2014.
40. Kato-Stankiewicz, J., Hakimi, I., Zhi, G., Zhang, J., Serebriiskii, I., Guo, L., Edamatsu, H., Koike, H., Menon, S., Eckl, R., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 14398-13303.