Formoterol and salmeterol induce a similar degree of β 2- adrenoceptor tolerance in human small airways but via different mechanisms

British Journal of Pharmacology

Volumn 163, Issue 3, 2011, Pages 521-532

  Cooper, P R ^a   Kurten, R C ^b   Zhang, J ^a   Nicholls, D J ^c   Dainty, I A ^c   Panettieri, R A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

airway smooth muscle; asthma; desensitization; LABA; receptor internalization

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BUDESONIDE; FORMOTEROL; ISOPRENALINE; SALBUTAMOL; SALMETEROL;

AIRWAY; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFICACY; DRUG EXPOSURE; DRUG TOLERANCE; EPITHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INCUBATION TIME; INTERNALIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ALBUTEROL; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; BUDESONIDE; CARBACHOL; DRUG TOLERANCE; EPITHELIAL CELLS; ETHANOLAMINES; HUMANS; LUNG; PROTEIN TRANSPORT; RECEPTORS, ADRENERGIC, BETA-2;

EID: 79955894620     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01257.x     Document Type: Article

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