메뉴 건너뛰기




Volumn 29, Issue 5, 2003, Pages 537-544

Prostaglandin E2 Inhibits Fibroblast to Myofibroblast Transition via E. Prostanoid Receptor 2 Signaling and Cyclic Adenosine Monophosphate Elevation

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; BUTAPROST; COLLAGEN TYPE 1; CYCLIC AMP; E PROSTANOID RECEPTOR 2; FORSKOLIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTANOID RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 0242319836     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2002-0243OC     Document Type: Article
Times cited : (269)

References (36)
  • 1
    • 0034922935 scopus 로고    scopus 로고
    • Mechanisms of pulmonary fibrosis: Conference summary
    • Strieter, R. M. 2001. Mechanisms of pulmonary fibrosis: conference summary. Chest 120 (1 Suppl):77S-85S.
    • (2001) Chest , vol.120 , Issue.1 SUPPL.
    • Strieter, R.M.1
  • 2
    • 0035895243 scopus 로고    scopus 로고
    • Idiopathic pulmonary fibrosis: Prevailing and evolving hypotheses about its pathogenesis and implications for therapy
    • Selman, M., T. E. King, and A. Pardo. 2001. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann. Intern. Med. 134:136-151.
    • (2001) Ann. Intern. Med. , vol.134 , pp. 136-151
    • Selman, M.1    King, T.E.2    Pardo, A.3
  • 5
    • 0031065164 scopus 로고    scopus 로고
    • Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta
    • Zhang, H. Y., M. Gharaee-Kermani, and S. H. Phan. 1997. Regulation of lung fibroblast alpha-smooth muscle actin expression, contractile phenotype, and apoptosis by IL-1beta. J. Immunol. 158:1392-1399.
    • (1997) J. Immunol. , vol.158 , pp. 1392-1399
    • Zhang, H.Y.1    Gharaee-Kermani, M.2    Phan, S.H.3
  • 6
    • 0030022205 scopus 로고    scopus 로고
    • Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis
    • Zhang, H. Y., M. Gharaee-Kermani, K. Zhang, S. Karmiol, and S. H. Phan. 1996. Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 148:527-537.
    • (1996) Am. J. Pathol. , vol.148 , pp. 527-537
    • Zhang, H.Y.1    Gharaee-Kermani, M.2    Zhang, K.3    Karmiol, S.4    Phan, S.H.5
  • 7
    • 0028944542 scopus 로고
    • Myofibroblast differentiation during fibrosis
    • Desmouliere, A., and G. Gabbiani. 1995. Myofibroblast differentiation during fibrosis. Exp. Nephrol. 3:134-139.
    • (1995) Exp. Nephrol. , vol.3 , pp. 134-139
    • Desmouliere, A.1    Gabbiani, G.2
  • 8
    • 0028278029 scopus 로고
    • Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: A combined immunohistochemical and in situ hybridization study
    • Zhang, K., M. D. Rekhter, D. Gordon, and S. H. Phan. 1994. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: a combined immunohistochemical and in situ hybridization study. Am. J. Pathol. 145:114-125.
    • (1994) Am. J. Pathol. , vol.145 , pp. 114-125
    • Zhang, K.1    Rekhter, M.D.2    Gordon, D.3    Phan, S.H.4
  • 9
    • 0029115157 scopus 로고
    • Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis
    • Zhang, K., K. C. Flanders, and S. H. Phan. 1995. Cellular localization of transforming growth factor-beta expression in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 147:352-361.
    • (1995) Am. J. Pathol. , vol.147 , pp. 352-361
    • Zhang, K.1    Flanders, K.C.2    Phan, S.H.3
  • 10
    • 0028135154 scopus 로고
    • Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis
    • Zhang, K., M. Gharaee-Kermani, M. L. Jones, J. S. Warren, and S. H. Phan. 1994. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J. Immunol. 153:4733-4741.
    • (1994) J. Immunol. , vol.153 , pp. 4733-4741
    • Zhang, K.1    Gharaee-Kermani, M.2    Jones, M.L.3    Warren, J.S.4    Phan, S.H.5
  • 11
    • 0029887282 scopus 로고    scopus 로고
    • Role of the myofibroblast in pulmonary fibrosis
    • Phan, S. H. 1996. Role of the myofibroblast in pulmonary fibrosis. Kidney Int. Suppl. 54:S46-S48.
    • (1996) Kidney Int. Suppl. , vol.54
    • Phan, S.H.1
  • 12
    • 0029149053 scopus 로고
    • Factors influencing myofibroblast differentiation during wound healing and fibrosis
    • Desmouliere, A. 1995. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol. Int. 19:471-476.
    • (1995) Cell Biol. Int. , vol.19 , pp. 471-476
    • Desmouliere, A.1
  • 13
    • 0027212686 scopus 로고
    • Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
    • Desmouliere, A., A. Geinoz, F. Gabbiani, and G. Gabbiani. 1993. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J. Cell Biol. 122:103-111.
    • (1993) J. Cell Biol. , vol.122 , pp. 103-111
    • Desmouliere, A.1    Geinoz, A.2    Gabbiani, F.3    Gabbiani, G.4
  • 14
    • 0024811224 scopus 로고
    • Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells
    • Hansson, G. K., M. Hellstrand, L. Rymo, L. Rubbia, and G. Gabbiani. 1989. Interferon gamma inhibits both proliferation and expression of differentiation-specific alpha-smooth muscle actin in arterial smooth muscle cells. J. Exp. Med. 170:1595-1608.
    • (1989) J. Exp. Med. , vol.170 , pp. 1595-1608
    • Hansson, G.K.1    Hellstrand, M.2    Rymo, L.3    Rubbia, L.4    Gabbiani, G.5
  • 15
    • 0026776365 scopus 로고
    • Alpha-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by gamma-interferon
    • Desmouliere, A., L. Rubbia-Brandt, A. Abdiu, T. Walz, A. Macieira-Coelho, and G. Gabbiani. 1992. Alpha-smooth muscle actin is expressed in a subpopulation of cultured and cloned fibroblasts and is modulated by gamma-interferon. Exp. Cell Res. 201:64-73.
    • (1992) Exp. Cell Res. , vol.201 , pp. 64-73
    • Desmouliere, A.1    Rubbia-Brandt, L.2    Abdiu, A.3    Walz, T.4    Macieira-Coelho, A.5    Gabbiani, G.6
  • 16
    • 0022548668 scopus 로고
    • Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators
    • Bitterman, P., N. Wewers, S. Rennard, S. Adelberg, and R. Cyrstal. 1986. Modulation of alveolar macrophage-driven fibroblast proliferation by alternative macrophage mediators. J. Clin. Invest. 77:700-708.
    • (1986) J. Clin. Invest. , vol.77 , pp. 700-708
    • Bitterman, P.1    Wewers, N.2    Rennard, S.3    Adelberg, S.4    Cyrstal, R.5
  • 17
    • 0021917592 scopus 로고
    • Human alveolar macrophage inhibition of lung fibroblast growth: A prostaglandin-dependent process
    • Elias, J., M. Rossman, R. Zurier, and R. Daniele. 1985. Human alveolar macrophage inhibition of lung fibroblast growth: a prostaglandin-dependent process. Am. Rev. Respir. Dis. 131:94-99.
    • (1985) Am. Rev. Respir. Dis. , vol.131 , pp. 94-99
    • Elias, J.1    Rossman, M.2    Zurier, R.3    Daniele, R.4
  • 18
    • 0020454449 scopus 로고
    • Modulation of collagen production following bleomycin-induced pulmonary fibrosis in hamsters: Presence of a factor in lung that increases fibroblast prostaglandin E2 and cAMP and suppresses fibroblast proliferation and collagen production
    • Clark, J. G., K. M. Kostal, and B. A. Marino. 1982. Modulation of collagen production following bleomycin-induced pulmonary fibrosis in hamsters: presence of a factor in lung that increases fibroblast prostaglandin E2 and cAMP and suppresses fibroblast proliferation and collagen production. J. Biol. Chem. 257:8098-8105.
    • (1982) J. Biol. Chem. , vol.257 , pp. 8098-8105
    • Clark, J.G.1    Kostal, K.M.2    Marino, B.A.3
  • 19
    • 0024325755 scopus 로고
    • The differential effect of prostaglandin E2 on transforming growth factor-beta and insulin-induced collagen formation in lung fibroblasts
    • Fine, A., C. F. Poliks, L. P. Donahue, B. D. Smith, and R. H. Goldstein. 1989. The differential effect of prostaglandin E2 on transforming growth factor-beta and insulin-induced collagen formation in lung fibroblasts. J. Biol. Chem. 264:16988-16991.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16988-16991
    • Fine, A.1    Poliks, C.F.2    Donahue, L.P.3    Smith, B.D.4    Goldstein, R.H.5
  • 20
    • 0025985547 scopus 로고
    • Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E
    • Borok, Z., A. Gillissen, R. Buhl, R. F. Hoyt, R. C. Hubbard, T. Ozaki, S. I. Rennard, and R. G. Crystal. 1991. Augmentation of functional prostaglandin E levels on the respiratory epithelial surface by aerosol administration of prostaglandin E. Am. Rev. Respir. Dis. 144:1080-1084.
    • (1991) Am. Rev. Respir. Dis. , vol.144 , pp. 1080-1084
    • Borok, Z.1    Gillissen, A.2    Buhl, R.3    Hoyt, R.F.4    Hubbard, R.C.5    Ozaki, T.6    Rennard, S.I.7    Crystal, R.G.8
  • 21
    • 0034038206 scopus 로고    scopus 로고
    • Different expression of TNF-α receptors and prostaglandin E(2) production in normal and fibrotic lung fibroblasts: Potential implications for the evolution of the inflammatory process
    • Vancheri, C., M. A. Sortino, V. Tomaselli, C. Mastruzzo, F. Condorelli, G. Bellistri, M. P. Pistorio, P. L. Canonico, and N. Crimi. 2000. Different expression of TNF-α receptors and prostaglandin E(2) production in normal and fibrotic lung fibroblasts: potential implications for the evolution of the inflammatory process. Am. J. Respir. Cell Mol. Biol. 22:628-634.
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.22 , pp. 628-634
    • Vancheri, C.1    Sortino, M.A.2    Tomaselli, V.3    Mastruzzo, C.4    Condorelli, F.5    Bellistri, G.6    Pistorio, M.P.7    Canonico, P.L.8    Crimi, N.9
  • 22
    • 0028924146 scopus 로고
    • Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2
    • Wilborn, J., L. J. Crofford, M. D. Burdick, S. L. Kunkel, R. M. Strieter, and M. Peters-Golden. 1995. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J. Clin. Invest. 95:1861-1868.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1861-1868
    • Wilborn, J.1    Crofford, L.J.2    Burdick, M.D.3    Kunkel, S.L.4    Strieter, R.M.5    Peters-Golden, M.6
  • 25
    • 0020320880 scopus 로고
    • Modulation of collagen production by fibroblasts: Effects of chronic exposure to agonists that increase intracellular cyclic AMP
    • Saltzman, L. E., J. Moss, R. A. Berg, B. Hom, and R. G. Crystal. 1982. Modulation of collagen production by fibroblasts: effects of chronic exposure to agonists that increase intracellular cyclic AMP. Biochem. J. 204:25-30.
    • (1982) Biochem. J. , vol.204 , pp. 25-30
    • Saltzman, L.E.1    Moss, J.2    Berg, R.A.3    Hom, B.4    Crystal, R.G.5
  • 26
    • 0031709737 scopus 로고    scopus 로고
    • Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts
    • Choung, J., L. Taylor, K. Thomas, X. Zhou, H. Kagan, X. Yang, and P. Polgar. 1998. Role of EP2 receptors and cAMP in prostaglandin E2 regulated expression of type I collagen alpha1, lysyl oxidase, and cyclooxygenase-1 genes in human embryo lung fibroblasts. J. Cell. Biochem. 71:254-263.
    • (1998) J. Cell. Biochem. , vol.71 , pp. 254-263
    • Choung, J.1    Taylor, L.2    Thomas, K.3    Zhou, X.4    Kagan, H.5    Yang, X.6    Polgar, P.7
  • 27
    • 0033617216 scopus 로고    scopus 로고
    • OPC-13013, a cyclic nucleotide phosphodiesterase type III, inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells
    • Shimizu, E., Y. Kobayashi, Y. Oki, T. Kawasaki, T. Yoshimi, and H. Nakamura. 1999. OPC-13013, a cyclic nucleotide phosphodiesterase type III, inhibitor, inhibits cell proliferation and transdifferentiation of cultured rat hepatic stellate cells. Life Sci. 64:2081-2088.
    • (1999) Life Sci. , vol.64 , pp. 2081-2088
    • Shimizu, E.1    Kobayashi, Y.2    Oki, Y.3    Kawasaki, T.4    Yoshimi, T.5    Nakamura, H.6
  • 28
    • 0027772698 scopus 로고
    • Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis
    • Vyalov, S. L., G. Gabbiani, and Y. Kapanci. 1993. Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 143:1754-1765.
    • (1993) Am. J. Pathol. , vol.143 , pp. 1754-1765
    • Vyalov, S.L.1    Gabbiani, G.2    Kapanci, Y.3
  • 29
    • 0024730940 scopus 로고
    • Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation
    • Khalil, N., O. Bereznay, M. Sporn, and A. H. Greenberg. 1989. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 170:727-737.
    • (1989) J. Exp. Med. , vol.170 , pp. 727-737
    • Khalil, N.1    Bereznay, O.2    Sporn, M.3    Greenberg, A.H.4
  • 30
    • 0027049057 scopus 로고
    • Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts
    • Desmouliere, A., L. Rubbia-Brandt, G. Grau, and G. Gabbiani. 1992. Heparin induces alpha-smooth muscle actin expression in cultured fibroblasts and in granulation tissue myofibroblasts. Lab. Invest. 67:716-726.
    • (1992) Lab. Invest. , vol.67 , pp. 716-726
    • Desmouliere, A.1    Rubbia-Brandt, L.2    Grau, G.3    Gabbiani, G.4
  • 31
    • 0037016773 scopus 로고    scopus 로고
    • Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells
    • Masamune, A., K. Kikuta, M. Satoh, Y. Sakai, A. Satoh, and T. Shimosegawa. 2002. Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells. J. Biol. Chem. 277:141-147.
    • (2002) J. Biol. Chem. , vol.277 , pp. 141-147
    • Masamune, A.1    Kikuta, K.2    Satoh, M.3    Sakai, Y.4    Satoh, A.5    Shimosegawa, T.6
  • 32
    • 0028973641 scopus 로고
    • Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma
    • Ludwicka, A., T. Ohba, M. Trojanowska, A. Yamakage, C. Strange, E. A. Smith, E. C. Leroy, S. Sutherland, and R. M. Silver. 1995. Elevated levels of platelet derived growth factor and transforming growth factor-beta 1 in bronchoalveolar lavage fluid from patients with scleroderma. J. Rheumatol. 22:1876-1883.
    • (1995) J. Rheumatol. , vol.22 , pp. 1876-1883
    • Ludwicka, A.1    Ohba, T.2    Trojanowska, M.3    Yamakage, A.4    Strange, C.5    Smith, E.A.6    Leroy, E.C.7    Sutherland, S.8    Silver, R.M.9
  • 33
    • 0020645122 scopus 로고
    • Fibroblast prostaglandin E2 synthesis: Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products
    • Korn, J. H. 1983. Fibroblast prostaglandin E2 synthesis: persistence of an abnormal phenotype after short-term exposure to mononuclear cell products. J. Clin. Invest. 71:1240-1246.
    • (1983) J. Clin. Invest. , vol.71 , pp. 1240-1246
    • Korn, J.H.1
  • 34
    • 0018647202 scopus 로고
    • Unsaturated fatty acid effect on cyclic AMP levels in human embryo lung fibroblasts
    • Polgar, P., L. Taylor, and D. Downing. 1979. Unsaturated fatty acid effect on cyclic AMP levels in human embryo lung fibroblasts. Prostaglandins 18:43-52.
    • (1979) Prostaglandins , vol.18 , pp. 43-52
    • Polgar, P.1    Taylor, L.2    Downing, D.3
  • 35
    • 0035070056 scopus 로고    scopus 로고
    • Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice
    • Keerthisingam, C. B., R. G. Jenkins, N. K. Harrison, N. A. Hernandez-Rodriguez, H. Booth, G. J. Laurent, S. L. Hart, M. L. Foster, and R. J. McAnulty. 2001. Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice. Am. J. Pathol. 158:1411-1422.
    • (2001) Am. J. Pathol. , vol.158 , pp. 1411-1422
    • Keerthisingam, C.B.1    Jenkins, R.G.2    Harrison, N.K.3    Hernandez-Rodriguez, N.A.4    Booth, H.5    Laurent, G.J.6    Hart, S.L.7    Foster, M.L.8    McAnulty, R.J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.