PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-β1-stimulated fibroblasts

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 296, Issue 6, 2009, Pages

  Togo, Shinsaku ^a   Liu, Xiangde ^a   Wang, Xingqi ^a   Sugiura, Hisatoshi ^b   Kamio, Koichiro ^c   Kawasaki, Shin ^a   Kobayashi, Tetsu ^d   Ertl, Ronald F ^a   Ahn, Youngsoo ^a   Holz, Olaf ^e   Magnussen, Helgo ^e   Fredriksson, Karin ^f   Skold, C Magnus ^f   Rennard, Stephen I ^a,g  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e KRANKENHAUS GROSSHANSDORF   (Germany)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^g UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Chemotaxis; Collagen gel contraction; Phosphodiesterase 4; Prostaglandin E2; Transforming growth factor 1

Indexed keywords

COLLAGEN GEL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FIBRONECTIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; ROFLUMILAST; ROLIPRAM; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; LUNG FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM;

ADULT; AMINOPYRIDINES; BENZAMIDES; CELLS, CULTURED; CHEMOTAXIS; COLLAGEN; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOPROPANES; DINOPROSTONE; DRUG SYNERGISM; FIBROBLASTS; FIBRONECTINS; HUMANS; LUNG; PHOSPHODIESTERASE INHIBITORS; PULMONARY FIBROSIS; ROLIPRAM; TRANSFORMING GROWTH FACTOR BETA1;

EID: 67049095847     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00508.2007     Document Type: Article

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