Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 2, 2008, Pages 149-169

  Penn, Raymond B ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

Airway remodeling; Airway smooth muscle; Asthma; Desensitization; G protein coupled receptor; Protein kinase

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; ALPRENOLOL; AMYLIN; ANGIOTENSIN II; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; CALCITONIN GENE RELATED PEPTIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CARVEDILOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; ISOPRENALINE; MICROTUBULE ASSOCIATED PROTEIN 5; NADOLOL; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE VII; PHOSPHOLIPASE C; PROPRANOLOL; PROTEIN KINASE C; RETINA S ANTIGEN; RGS PROTEIN; SALBUTAMOL; SATAVAPTAN; UNINDEXED DRUG;

ASTHMA; BREATHING MUSCLE; CARBOXY TERMINAL SEQUENCE; DISEASE SEVERITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; RECEPTOR INTRINSIC ACTIVITY; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE;

AIRWAY RESISTANCE; ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHOCONSTRICTION; HUMANS; MUSCLE, SMOOTH; RECEPTORS, G-PROTEIN-COUPLED; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION;

EID: 47149117849     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0263-1     Document Type: Review

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