β2-adrenergic receptor agonists and cAMP arrest human cultured airway smooth muscle cells in the G1 phase of the cell cycle: Role of proteasome degradation of cyclin D1

Molecular Pharmacology

Volumn 56, Issue 5, 1999, Pages 1079-1086

  Stewart, Alastair G ^a   Harris, Trudi ^a   Fernandes, Darren J ^a   Schachte, Leslie C ^b   Koutsoubos, Valentina ^a   Guida, Elizabeth ^a   Ravenhall, Claire E ^a   Vadiveloo, Peter ^b   Wilson, John W ^c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 BROMO CYCLIC AMP; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CALPASTATIN; CYCLIC AMP; CYCLIN D1; DNA; ISOBUTYLMETHYLXANTHINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; RETINOBLASTOMA PROTEIN; SALBUTAMOL; THROMBIN; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALPAIN; CYSTEINE PROTEINASE; FLAVONOID; LEUPEPTIN; MAP2K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MULTIENZYME COMPLEX; PROTEASOME; PROTEIN SERINE THREONINE KINASE;

ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL CYCLE G1 PHASE; DNA SYNTHESIS INHIBITION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPERPLASIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE S PHASE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION REGULATION; METABOLISM; PHOSPHORYLATION; SMOOTH MUSCLE; TIME;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ADRENERGIC BETA-AGONISTS; ALBUTEROL; CALPAIN; CELLS, CULTURED; CYCLIN D1; CYSTEINE ENDOPEPTIDASES; DINOPROSTONE; DNA; FLAVONOIDS; G1 PHASE; GENE EXPRESSION REGULATION; HUMANS; LEUPEPTINS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIENZYME COMPLEXES; MUSCLE, SMOOTH; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ADRENERGIC, BETA-2; RETINOBLASTOMA PROTEIN; RNA, MESSENGER; S PHASE; THROMBIN; TIME FACTORS;

EID: 0032589725     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.5.1079     Document Type: Article

References (40)

1. Brewster CEP, Howarth PH, Djukanovic R, Wilson J, Holgate ST and Roche WR (1990) Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol 3:507-511.
2. Cocks BG, Vairo G, Bodrug SE and Hamilton JA (1992) Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents. J Biol Chem 267:12307-12310.
3. Cook SJ and McCormick F (1993) Inhibition by cAMP of Ras-dependent activation of Raf. Science (Wash. DC) 262:1069-1072.
4. Diehl JA, Zindy F and Sherr CJ (1997) Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev 11:957-972.
5. Diehl JA, Cheng MG, Roussel MF and Sherr CJ (1998) Glycogen synthase kinase 3 beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev 12: 3499-3511.
6. Dudley DT, Pang L, Decker SJ, Bridges AJ and Saltiel AR (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Nat Acad Sci USA 92:7686-7689.
7. Dunnill MS and Massarella GR (1969) A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 24:176-179, 1969.
8. Ebina M, Takahashi T, Chiba T and Motomiya M (1993) Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 148:720-726.
9. Fernandes D, Guida E, Koutsoubos V, Harris T, Vadiveloo P, Wislon JW and Stewart AG (1999) Glucocorticoids inhibit proliferation, cyclin D1 expression and retinoblastoma protein phosphorylation, but not activity of the extracellular regulated kinases (ERK) in human cultured airway smooth muscle. Am J Resp Cell Mol Biol 21:77-88.
10. Gillzan KM and Stewart AG (1997) The role of potassium channels in the inhibitory effects of beta 2-adrenoceptor agonists on DNA synthesis in human cultured airway smooth muscle. Pulm Pharmacol Ther 10:71-79.
11. Herwig S and Strauss M (1997) The retinoblastoma protein: a master regulator of cell cycle, differentiation and apoptosis. Eur J Pharmacol 246:581-601.
12. 1-to-S-phase transition. Mol Cell Biol 19:2690-2698.
13. Hershenson MB, Chao TS, Abe MK, Gomes I, Kelleher MD and Solway JR Mr (1995) Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. J Biol Chem 270:19908-19913.
14. James AL, Pare PD and Hogg JC (1989) The mechanics of airway narrowing in asthma. Am Rev Resp Dis 139:242-246.
15. L'Allemain, G, Lavoie JN, Rivard N, Baldin V and Pouyssegur J (1991) Cyclin D1 expression is a major target of the cAMP-induced inhibition of cell cycle entry in fibroblasts. Oncogene 14:1981-1990
16. Lavoie JN, L'Allemain G, Brunet A, Muller R and Pouyssegur J (1996) Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the P38/HOGMAPK pathway. J Biol Chem 271:20608-20616.
17. Matsushime H, Roussel MF, Ashmun RA and Sherr CJ (1991) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 71:323-334.
18. Malarkey K, Chilvers ER, Lawson MF and Plevin R (1995) Stimulation by endothelin-1 of mitogen-activated protein kinases and DNA synthesis in bovine tracheal smooth muscle cells. Br J Pharm 116:2267-2273.
19. Maruno K, Absood A and Said SI (1995) VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells. Am J Physiol 268:L1047-L1051.
20. mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity. Mol Endocrinol 6:845-854.
21. Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Proud CG and Denton RM (1997) Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells-activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms. J Biol Chem 272:7713-7719.
22. Nakagawa R, Sato R, Futai M, Yokosawa H and Maeda M (1997) Gastric Gata-6 DNA-binding protein-proteolysis induced by cAMP. FEBS Lett 408:301-305.
23. Noveral JP and Grunstein MM (1994) Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation. Am J Physiol 267:L291-9.
24. Pardee AB (1974) A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 71:1286-1290.
25. Ramakrishnan M, Musa NL, Li J, Liu PT, Pestell RG and Hershenson MB (1998) Catalytic Activation of Extracellular Signal-regulated Kinases Induces Cyclin D1 Expression in Primary Tracheal Myocytes. Am J Respir Cell Mol Biol 18:736-740.
26. Resnitzky D and Reed SI (1995) Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol 15:3463-3469.
27. Rock KL, Gramm L, Rothstein L, Clark K, Stein R, Dick L, Hwang D and Goladberg AL (1994) Inhibitors of the proteasome block the degradation of most proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-771.
28. Schramm CM, Omlor GJ, Quinn LM and Noveral JP (1996) Methylprednisolone and isoproterenol inhibit airway smooth muscle proliferation by separate and additive mechanisms. Life Sci 59:9-14.
29. Scott PH, Belham CM, Al-Hafidh J, Chilvers ER, Peacock AJ, Gould GW and Plevin R (1996) A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells. Biochem J 318:965-971.
30. Sewen A, Burger C, Brusselbach S, Schalk C, Lucibello FC. and Muller R (1993) Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J Cell Sci 104:545-555.
31. Stewart AG, Grigoriadis G and Harris T (1994) Mitogenic actions of endothelin-1 and epidermal growth factor in cultured airway smooth muscle. Clin Exp Pharmacol Physiol 21:277-285.
32. Stewart AG, Tomlinson PR and Wilson J (1993) Airway wall remodelling in asthma: a novel target for the development of anti-asthma drugs. Trends Pharmacol Sci 14:275-279.
33. Stewart AG, Tomlinson PR and Wilson JW (1997) Beta 2-adrenoceptor agonist-mediated inhibition of human airway smooth muscle cell proliferation: Importance of the duration of beta 2-adrenoceptor stimulation. Br J Pharmacol 121:361-368.
34. Tomlinson PR, Wilson JW and Stewart AG (1994) Inhibition by salbutamol of the proliferation of human airway smooth muscle cells grown in culture. Br J Pharmacol 111:641-647.
35. Tomlinson PR, Wilson JW and Stewart AG (1995) Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: Relationship to elevated cAMP levels. Biochem Pharmacol 49:1809-1819.
36. Walker TR, Moore SM, Lawson MF, Panettieri RA and Chilvers ER (1998) Platelet-derived growth factor B and thrombin activate phosphoinositide 3-kinase and protein kinase B: Role in mediating airway smooth muscle proliferation. Mol Pharmacol 54:1007-1015.
37. Weber JD, Raben DM, Phillips, PJ and Baldassare, JJ (1997) Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase. Biochem J 326:, 61-68.
38. Vlahos R and Stewart AG (1999) Interleukin-1α and tumour necrosis factor-α modulate airway smooth muscle DNA synthesis by induction of cyclo-oxygenase-2: Inhibition by dexamethasone and fluticasone propionate. Br J Pharmacol 126: 1315-1324.
39. Xiong Y, Conolly T, Futcher B and Beach D (1991) Human D-type cyclin. Cell 66:691-699.
40. Young PG, Skinner SJ and Black PN (1995) Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol 273:137-143.