CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 157, Issue 3 PART I, 1998, Pages 822-826

  Saetta, Marina ^a   Di Stefano, Antonino ^b   Turato, Graziella ^b   Facchini, Fabrizio M ^b   Curbino, Laura ^b   Mapp, Cristina E ^b   Maestrelli, Piero ^b   Ciaccia, Adalberto ^b   Fabbri, Leonardo M ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; FEMALE; HUMAN; INFLAMMATION; LUNG FUNCTION; MACROPHAGE; MALE; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; SMOKING; T LYMPHOCYTE; AIRWAY OBSTRUCTION; BRONCHITIS; BRONCHUS; CARCINOMA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CHRONIC DISEASE; COMPARATIVE STUDY; FORCED EXPIRATORY VOLUME; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; LUNG; LUNG RESECTION; LUNG TUMOR; LYMPHOCYTE COUNT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SMOOTH MUSCLE; VITAL CAPACITY;

AGED; AIRWAY OBSTRUCTION; BRONCHI; BRONCHITIS; CARCINOMA; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; CHRONIC DISEASE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOCYTE COUNT; LUNG; LUNG DISEASES, OBSTRUCTIVE; LUNG NEOPLASMS; LYMPHOCYTE COUNT; MACROPHAGES; MALE; MUSCLE, SMOOTH; NEUTROPHILS; PNEUMONECTOMY; SMOKING; VITAL CAPACITY;

EID: 0032014542     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.157.3.9709027     Document Type: Article

References (33)

1. Diener, C. F., and B. Burrows. 1975. Further observations on the course and prognosis of chronic obstructive lung disease. Am. Rev. Respir. Dis. 111:719-724.
2. Fletcher, C, and R. Peto. 1977. The natural history of chronic airflow obstruction. B.M.J. 1:1645-1648.
3. Hogg, J. C., P. T. Macklem, and W. M. Thurlbeck. 1968. Site and nature of airway obstruction in chronic obstructive lung disease. N. Engl. J. Med. 278:1355-1360.
4. American Thoracic Society. 1995. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 152:S77-S120.
5. Saetta, M., A. Di Stefano, P. Maestrelli, G. Turato, M. P. Ruggieri, A. Roggeri, P. Calcagni, C. E. Mapp, A. Ciaccia, and L. M. Fabbri. 1994. Airway eosinophilia in chronic bronchitis during exacerbations. Am. J. Respir. Crit. Care Med. 150:1646-1652.
6. Communité Européenne du Carbon et de l'Acier. 1971. Aide-Memoire of Spirographic Practice for Examining Ventilatory Function, 2nd ed. Industrial Health and Medicine, Luxemburg.
7. James, A. L., J. C. Hogg, L. A. Dunn, and P. D. Parè. 1988. The use of the internal perimeter to compare airway size and to calculate smooth muscle shortening. Am. Rev. Respir. Dis. 138:136-139.
8. Synek, M., R. Beasley, A. J. Frew, D. Goulding, L. Holloway, F. C. Lampe, W. R. Roche, and S. T. Holgate. 1996. Cellular infiltration of the airways in asthma of varying severity. Am. J. Respir. Crit. Care Med. 154:224-230.
9. Saetta, M., A. Di Stefano, C. Rosina, G. Thiene, and L. M. Fabbri. 1991. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am. Rev. Respir. Dis. 143:138-143.
10. Cosio, M., H. Ghezzo, J. C. Hogg, R. Corbin, M. Loveland, J. Dosman, and P. T. Macklem. 1977. The relations between structural changes in small airways and pulmonary-function tests. N. Engl. J. Med. 298: 1277-1281.
11. Cosio, M. G., K. A. Hale, and D. E. Niewoehner. 1980. Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am. Rev. Respir. Dis. 122:266-271.
12. Niewoehner, D. E., J. Kleinerman, and D. B. Rice. 1974. Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med. 291:755-758.
13. Berend, N., J. L. Wright, W. M. Thurlbeck, G. E. Mariin, and A. J. Woolcock. 1981. Small airway disease: reproducibility of measurements and correlation with lung function. Chest 79:263-268.
14. Wright, J. L., L. M. Lawson, P. D. Pare, S. Kennedy, B. Wiggs, and J. C. Hogg. 1984. The detection of small airways disease. Am. Rev. Respir. Dis. 129:989-994.
15. Hale, K. A., S. L. Ewing, B. A. Gosnell, and D. E. Niewoehner. 1984. Lung disease in long term cigarette smokers with and without chronic airflow obstruction. Am. Rev. Respir. Dis. 130:718-721.
16. Saetta, M., R. Fikelstein, and M. G. Cosio. 1994. Morphological and cellular basis for airflow limitation in smokers. Eur. Respir. J. 7:1505-1515.
17. Fournier, M., F. Lebargy, F. Le Roy Ladurie, E. Lenormand, and R. Pariente. 1989. Intraepithelial T-lymphocyte subsets in the airways of normal subjects and of patients with chronic bronchitis. Am. Rev. Respir. Dis. 140:737-742.
18. Ollerenshaw, S. L., and A. J. Woolcok. 1992. Characteristics of the inflammation in biopsies from large airways of subjects with asthma and subjects with chronic airflow limitation. Am. Rev. Respir. Dis. 145: 922-927.
19. Saetta, M., A. Di Stefano, P. Maestrelli, A. Ferraresso, R. Drigo, A. Potena, A. Ciaccia, and L. M. Fabbri. 1993. Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am. Rev. Respir. Dis. 147:301-306.
20. Di Stefano, A., G. Turato, P. Maestrelli, C. E. Mapp, M. P. Ruggieri, A. Roggeri, P. Boschetto, L. M. Fabbri, and M. Saetta. 1996. Airflow limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration of the bronchial mucosa. Am. J. Respir. Crit. Care Med. 153:629-632.
21. 1- Am. J. Respir. Crit. Care Med. 155:852-857.
22. Bosken, C. H., J. Hards, K. Gatter, and J. C. Hogg. 1992. Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunohistochemistry. Am. Rev. Respir. Dis. 145: 911-917.
23. Peto, R., F. E. Speizer, A. L. Cochrane, F. Moore, C. M. Fletcher, C. M. Thinker, H. T. T. Higgins, R. G. Gray, S. M. Richards, J. Gilliland, and B. Norman-Smith. 1983. The relevance in adults of airflow obstruction, but not of mucous hypersecretion, to mortality from chronic lung disease. Am. Rev. Respir. Dis. 128:491-500.
24. Anthonisen, N. R., E. C. Wright, and J. E. Hodgkin. 1986. Prognosis in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 133:14-20.
25. Traver, G. A., M. G. Cline, and B. Burrows. 1979. Predictors of mortality in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 119: 895-902.
26. 1 decline and chronic obstructive pulmonary disease morbidity. Am. J. Respir. Crit. Care Med. 153:1530-1535.
27. Ramsay, A., J. Ruby, and I. Ramshaw. 1993. A case for cytokines as effector molecules in the resolution of virus infection. Immunol. Today 14:155-157.
28. Isaacs, D., C. R. M. Bangham, and A. J. McMichael. 1987. Cell-mediated cytotoxic response to respiratory syncytial virus in infants with bronchiolitis. Lancet 2:769-771.
29. Cannon, M. J., P. J. M. Openshaw, and B. A. Askonas. 1988. Cytotoxic T-cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J. Exp. Med. 168:1163-1168.
30. Lacoste, J. Y., J. Bousquet, P. Chanez, T. V. Vyve, J. Simony-Lafontaine, N. Lequeu, P. Vic, I. Enander, P. Godard, and F. B. Michel. 1993. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease. J. Allergy Clin. Immunol 92:537-548.
31. Thompson, A. B., D. Daughton, R. A. Robbins, M. A. Ghafouri, M. Oehlerking, and S. I. Rennard. 1989. Intraluminal airway inflammation in chronic bronchitis: characterization and correaltion with clinical parameters. Am. Rev. Respir. Dis. 140:1527-1537.
32. Bosken, C. H., B. R. Wiggs, P. D. Pare, and J. C. Hogg. 1990. Small airway dimensions in smokers with obstruction to airflow. Am. Rev. Respir. Dis. 142:563-570.
33. Kuwano, K., C. H. Bosken, P. D. Parè, T. R. Bai, B. R. Wiggs, and J. C. Hogg. 1993. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 148:1220-1225.