Pharmacological inhibition of protein kinases in intact cells: Antagonism of beta adrenergic receptor ligand binding by H-89 reveals limitations of usefulness

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 428-437

  Penn, Raymond B ^a,c   Parent, Jean Luc ^a   Pronin, Alexey N ^a   Panettieri Jr , Reynold A ^b   Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISINDOLYLMALEIMIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DIMETHYL SULFOXIDE; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IODOPINDOLOL I 125; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; KT 5720; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N [2 (4 CHLOROCINNAMYLAMINO)ETHYL] N FORMYL 5 ISOQUINOLINESULFONAMIDE; N [2 (N FORMYL 4 CHLOROCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIGAND BINDING; MAST CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RESPIRATORY EPITHELIUM;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CELLS, CULTURED; COS CELLS; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; KIDNEY; KINETICS; LIGANDS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; SULFONAMIDES; TRACHEA;

EID: 0032986997     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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