Role of Epac1 in mediating anti-proliferative effects of prostanoid EP 2 receptors and cAMP in human lung fibroblasts

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 6, 2008, Pages 617-630

  Haag, S ^a   Warnken, M ^a   Juergens, U R ^b   Racke K ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

cAMP; Epac; Lung fibroblast; Proliferation; Prostanoid receptor; Protein kinase A

Indexed keywords

8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; 8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE CYCLIC 3',5' ADENOSINE MONOPHOSPHATE; 8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; 8 BROMO CYCLIC AMP; ADENYLATE CYCLASE; ALPHA TUBULIN; BETA ACTIN; BUCLADESINE; BUTAPROST; BUTYRYL CYCLIC AMP; CELL PROTEIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; PROSTANOID RECEPTOR; PROTEIN EPAC1; PROTEIN EPAC2; SMALL INTERFERING RNA; THYMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ALPROSTADIL; CELL PROLIFERATION; CELLS, CULTURED; COLLAGEN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LUNG; PHOSPHORYLATION; RECEPTORS, PROSTAGLANDIN E; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIONUCLEOTIDES;

EID: 56549096019     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0334-3     Document Type: Article

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