Inhibition of human airway smooth muscle cell proliferation by β2-adrenergic receptors and cAMP is PKA independent: Evidence for EPAC involvement

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 294, Issue 1, 2008, Pages

  Kassel, Karen M ^a   Wyatt, Todd A ^a   Panettieri Jr , Reynold A ^b   Toews, Myron L ^a,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Asthma; Epidermal growth factor; Exchange protein directly activated by cAMP; Lysophosphatidic acid

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR; FORSKOLIN; ISOPRENALINE; LYSOPHOSPHATIDIC ACID; PROSTAGLANDIN E2; THYMIDINE;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; SMOOTH MUSCLE FIBER;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; CELL CULTURE TECHNIQUES; CELL DIVISION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPIDERMAL GROWTH FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; ISOPROTERENOL; MUSCLE, SMOOTH; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY PHYSIOLOGY;

EID: 40749147710     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00381.2007     Document Type: Article

References (35)

1. Amishima M, Munakata M, Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y. Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. Am J Respir Crit Care Med 157: 1907-1912, 1998.
2. Aronoff DM, Canetti C, Serezani CH, Luo M, Peters-Golden M. Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J Immunol 174: 595-599, 2005.
3. Cerutis D, Nogami M, Anderson JL, Churchill JD, Romberger DJ, Rennard SI, Toews ML. Lysophosphatidic acid and EGF stimulate mitogenesis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 273: L10-L15, 1997.
4. Clarke LE, Leitzel K, Smith J, Ali SM, Lipton A. Epidermal growth factor receptor mRNA in peripheral blood of patients with pancreatic, lung, and colon carcinomas detected by RT-PCR. Int J Oncol 22: 425-430, 2003.
5. de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396: 474-477, 1998.
6. Dunnill MS, Massarella GR, Anderson JA. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 24: 176-179, 1969.
7. Ebina M, Takahashi T, Chiba T, Motomiya M. Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma. A 3-D morphometric study. Am Rev Respir Dis 148: 720-726, 1993.
8. Ediger TL, Toews ML. Synergistic stimulation of airway smooth muscle cell mitogenesis. J Pharmacol Exp Ther 294: 1076-1082, 2000.
9. Florio C, Martin JG, Styhler A, Heisler S. Antiproliferative effect of prostaglandin E2 in cultured guinea pig tracheal smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 266: L131-L137, 1994.
10. Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, Natarajan V. Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clin Exp Allergy 37: 311-322, 2007.
11. Guo M, Pascual RM, Wang S, Fontana MF, Valancius CA, Panettieri RA Jr, Tilley SL, Penn RB. Cytokines regulate beta-2-adrenergic receptor responsiveness in airway smooth muscle via multiple PKA- and EP2 receptor-dependent mechanisms. Biochemistry 44: 13771-13782, 2005.
12. James A. Airway remodeling in asthma. Curr Opin Pulm Med 11: 1-6, 2005.
13. Jiang H, Colbran JL, Francis SH, Corbin JD. Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem 267: 1015-1019, 1992.
14. Johnson PR, Armour CL, Carey D, Black JL. Heparin and PGE2 inhibit DNA synthesis in human airway smooth muscle cells in culture. Am J Physiol Lung Cell Mol Physiol 269: L514-L519, 1995.
15. Laurenza A, Sutkowski EM, Seamon KB. Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? Trends Pharmacol Sci 10: 442-447, 1989.
16. Lazaar AL, Panettieri RA Jr. Is airway remodeling clinically relevant in asthma? Am J Med 115: 652-659, 2003.
17. Lee JH, Johnson PR, Roth M, Hunt NH, Black JL. ERK activation and mitogenesis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 280: L1019-L1029, 2001.
18. Nelson HS. Is there a problem with inhaled long-acting beta-adrenergic agonists? J Allergy Clin Immunol 117: 3-16, 2006.
19. Nogami M, Whittle SM, Romberger DJ, Rennard SI, Toews ML. Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells. Mol Pharmacol 48: 766-773, 1995.
20. Noveral JP, Grunstein MM. Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol 267: L291-L299, 1994.
21. Oliver MN, Fabry B, Marinkovic A, Mijailovich SM, Butler JP, Fredberg JJ. Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason? Am J Respir Cell Mol Biol 37: 264-272, 2007.
22. Panettieri RA, Murray RK, DePalo LR, Yadvish PA, Kotlikoff MI. A human airway smooth muscle cell line that retains physiological responsiveness. Am J Physiol Cell Physiol 256: C329-C335, 1989.
23. Panettieri RA, Murray RK, DePalo LR, Yadvish PA, Kotlikoff MI. A human airway smooth muscle cell line that retains physiological responsiveness. Am J Physiol Cell Physiol 256: C329-C335, 1989.
24. Panettieri RA, Tan EM, Ciocca V, Luttmann MA, Leonard TB, Hay DW. Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction in vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. Am J Respir Cell Mol Biol 19: 453-461, 1998.
25. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, Davies DE. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J 14: 1362-1374, 2000.
26. Ramos-Barbon D, Ludwig MS, Martin JG. Airway remodeling: lessons from animal models. Clin Rev Allergy Immunol 27: 3-21, 2004.
27. Ranson M. Epidermal growth factor receptor tyrosine kinase inhibitors. Br J Cancer 90: 2250-2255, 2004.
28. Scott MG, Swan C, Jobson TM, Rees S, Hall IP. Effects of a range of beta2 adrenoceptor agonists on changes in intracellular cyclic AMP and on cyclic AMP driven gene expression in cultured human airway smooth muscle cells. Br J Pharmacol 128: 721-729, 1999.
29. Shimizu H, Daly JW, Creveling CR. A radioisotopic method for measuring the formation of adenosine 3′,5′-cyclic monophosphate in incubated slices of brain. J Neurochem 16: 1609-1619, 1969.
30. Stoloff S, Poinsett-Holmes K, Dorinsky PM. Combination therapy with inhaled long-acting beta2-agonists and inhaled corticosteroids: a paradigm shift in asthma management. Pharmacotherapy 22: 212-226, 2002.
31. Takeyama K, Dabbagh K, Lee HM, Agusti C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci USA 96: 3081-3086, 1999.
32. Toews ML, Ediger TL, Romberger DJ, Rennard SI. Lysophosphatidic acid in airway function and disease. Biochim Biophys Acta 1582: 240-250, 2002.
33. Tomlinson PR, Wilson JW, Stewart AG. Salbutamol inhibits the proliferation of human airway smooth muscle cells grown in culture: relationship to elevated cAMP levels. Biochem Pharmacol 49: 1809-1819, 1995.
34. Vancheri C, Mastruzzo C, Sortino MA, Crimi N. The lung as a privileged site for the beneficial actions of PGE2. Trends Immunol 25: 40-46, 2004.
35. Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and beta-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol 273: 137-143, 1995.