Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 300, Issue 3, 2011, Pages

  Wang, Wayne C H ^a   Schillinger, Rachel M ^a   Malone, Molly M ^a   Liggett, Stephen B ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Adenylyl cyclase; Asthma; Desensitization; Gene therapy

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; ADENYLATE CYCLASE TYPE 5; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ARRESTIN; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TRACHEA MUSCLE; TRANSGENIC MOUSE;

ADENYLATE CYCLASE; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CYCLIC AMP; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; MICE; MICE, TRANSGENIC; MUSCLE RELAXATION; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; RATS; RECEPTORS, ADRENERGIC, BETA-2; TRACHEA;

EID: 79955046713     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00273.2010     Document Type: Article

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