Prostacyclin analogs inhibit fibroblast contraction of collagen gels through the cAMP-PKA pathway

American Journal of Respiratory Cell and Molecular Biology

Volumn 37, Issue 1, 2007, Pages 113-120

  Kamio, Koichiro ^b   Liu, Xiangde ^b   Sugiura, Hisatoshi ^b   Togo, Shinsaku ^b   Kobayashi, Tetsu ^b   Kawasaki, Shinsaku ^b   Wang, Xingqi ^b   Mao, Lijun ^b   Ann, Youngsoo ^b   Hogaboam, Cory ^b   Toews, Myron L ^b   Rennard, Stephen I ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NONE

Author keywords

Fibroblasts; Fibronectin; Prostacyclin; Tissue remodeling

Indexed keywords

BERAPROST; BUCLADESINE; CARBACYCLIN; COLLAGEN GEL; COLLAGEN TYPE 1; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP DERIVATIVE; FIBRONECTIN; ILOPROST; KT 5720; MESSENGER RNA; PROSTACYCLIN DERIVATIVE; PROSTACYCLIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

CARBAZOLES; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPOPROSTENOL; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; GELS; HUMANS; INDOLES; LUNG; PYRROLES;

EID: 34347206822     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0009OC     Document Type: Article

References (41)

1. Grinnell F. Fibroblasts, myofibroblasts and wound contraction. J Cell Biol 1994;124:401-404.
2. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, Cherniack RM, Rogers RM, Sciurba FC, Coxson HO, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 2004;350:2645-2653.
3. Crystal RG, Bitterman PB, Mossman B, Schwarz MI, Sheppard D, Almasy L, Chapman HA, Friedman SL, King TE Jr, Leinwand LA, et al. Future research directions in idiopathic pulmonary fibrosis: summary of a national heart, lung, and blood institute working group. Am J Respir Crit Care Med 2002;166:236-246.
4. Rubin LJ. Pulmonary arterial hypertension. Proc Am Thorac Soc 2006;3: 111-115.
5. Kohyama T, Liu X, Kim HJ, Kobayashi T, Ertl RF, Wen FQ, Takizawa H, Rennard SI. Prostacyclin analogs inhibit fibroblast migration. Am J Physiol Lung Cell Mol Physiol 2002;283:L428-L432.
6. Elsdale T, Bard J. Collagen substrata for studies on cell behavior. J Cell Biol 1972;54:626-637.
7. Mio T, Adachi Y, Romberger DJ, Ertl RF, Rennard SI. Regulation of fibroblast proliferation in three dimensional collagen gel matrix. In Vitro Cell Dev Biol 1996;32:427-433.
8. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidine thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-159.
9. Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 2000; 25:169-193.
10. Supino R. MTT assays. Methods Mol Biol 1995;43:137-149.
11. Stitham J, Stojanovic A, Ross LA, Blount AC Jr, Hwa J. Clusters of transmembrane residues are critical for human prostacyclin receptor activation. Biochemistry 2004;43:8974-8986.
12. Kase H, Iwahashi K, Nakanishi S, Matsuda Y, Yamada K, Takahashi M, Murakata C, Sato A, Kaneko M. K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun 1987;142:436-440.
13. Cabell L, Audesirk G. Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons. Int J Dev Neurosci 1993;11:357-368.
14. Stenmark KR, Davie NJ, Reeves JT, Frid MG. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 2005;98:715-721.
15. Miki H, Mio T, Nagai S, Hoshino Y, Nagao T, Kitaichi M, Izumi T. Fibroblast contractility: usual interstitial pneumonia and nonspecific interstitial pneumonia. Am J Respir Crit Care Med 2000;162:2259-2264.
16. Holz O, Zuhlke I, Jaksztat E, Muller KC, Welker L, Nakashima M, Diemel KD, Branscheid D, Magnussen H, Jorres RA. Lung fibroblasts from patients with emphysema show a reduced proliferation rate in culture. Eur Respir J 2004;24:575-579.
17. Bell E, Ivarsson B, Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci USA 1979;76:1274-1278.
18. Montesano R, Orci L. Transforming growth factor-b stimulates collagen-matrix contraction by fibroblasts: Implication for wound healing. Proc Natl Acad Sci USA 1988;85:4894-4897.
19. Finesmith TH, Broadley KN. Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors. J Cell Physiol 1990;144:99-107.
20. Gillery P, Maquart FX, Borel JP. Fibronectin dependence of the contraction of collagen lattices by human skin fibroblasts. Exp Cell Res 1986; 167:29-37.
21. Clark RAF, Folkvord JM, Hart CE, Murray MJ, McPherson JM. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J Clin Invest 1989;84:1036-1040.
22. Fang Q, Liu X, Abe S, Kobyashi T, Wang XQ, Kohyama T, Hashimoto M, Wyatt TA, Rennard SI. Thrombin induces collagen gel contraction partially through PARI activation and PKC-e. Eur Respir J 2004;24: 918-924.
23. Grinnell F, Ho C, Lin Y, Skuta G. Differences in the regulation of fibroblast contraction of floating versus stressed collagen matrices. J Biol Chem 1999;274:918-923.
24. Oshita Y, Lee YR, Ogawa H, Yamazaki M, Tsuboi R. Endothelin-1 secreted from keratinocytes stimulates fibroblast-embedded collagen gel contraction in vitro. J Dermatol Sci 2006;43:57-59.
25. Takagi J, Strokovich K, Springer TA, Walz T. Structure of integrin α5β1 in complex with fibronectin. EMBO J 2003;22:4607-4615.
26. Welch MP, Odland GF, Clark RA. Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J Cell Biol 1990; 110:133-145.
27. Schiro JA, Chan BMC, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS. Integrin a2b1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell 1991;67:403-410.
28. Klein CE, Dressel D, Steinmayer T, Mauch C, Eckes B, Krieg T, Barkert RB, Weber TL. Integrin a2b1 is upregulated in fibroblasts and highly aggressive melanoma cells in three-dimensional collagen lattices and mediates the reorganization of collagen 1 fibrils. J Cell Biol 1991; 115:1427-1436.
29. Gullberg D, Tingstrom A, Thuresson A-C, Olsson L, Terracio L, Borg TK, Rubin K. β1 integrin-mediated collagen gel contraction is stimulated by PDGF. Exp Cell Res 1990;186:264-272.
30. Adachi Y, Mio T, Striz I, Romberger DJ, Spurzem JR, Rennard SI. Fibronectin production by cultured human lung fibroblasts in three-dimensional collagen gel culture. In Vitro Cell Dev Biol 1998;34:203-210.
31. Carnevali S, Nakamura Y, Mio T, Liu X, Takigawa K, Romberger DJ, Spurzem JR, Rennard SI. Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction. Am J Physiol Lung Cell Mol Physiol 1998;274:L591-L598.
32. Liu X, Kohyama T, Kobayashi T, Abe S, Kim HJ, Reed EC, Rennard SI. Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells. Osteoporos Int 2003;14:235-242.
33. Wang H, Liu X, Umino T, Kohyama T, Zhu YK, Wen FQ, Spurzem JR, Romberger DJ, Kim HJ, Rennard SI. Effect of cigarette smoke on fibroblast-mediated gel contraction is dependent on cell density. Am J Physiol Lung Cell Mol Physiol 2003;284:L205-L213.
34. Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 2003;4:733-738.
35. Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, Cheng X. Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dcpendent protein kinase on protein kinase B activation. J Biol Chem 2002;277:11497-11504.
36. Abramovitz M, Adam M, Boie Y, Carriere M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 2000;1483:285-293.
37. Kiriyama M, Ushikubi F, Kobayashi T, Hirata M, Sugimoto Y, Narumiya S. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 1997;122:217-224.
38. Nickolson RC, Town MH, Vorbruggen H. Prostacyclin-analogs. Med Res Rev 1985;5:1-53.
39. Whittle BJ, Moncada S, Whiting F, Vane JR. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 1980;19:605-627.
40. Melian EB, Goa KL. Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension. Drugs 2002;62:107-133.
41. Galie N, Manes A, Branzi A. The new clinical trials on pharmacological treatment in pulmonary arterial hypertension. Eur Respir J 2002;20: 1037-1049.