A phosphodiesterase 4 inhibitor inhibits matrix protein deposition in airways in vitro

Journal of Allergy and Clinical Immunology

Volumn 118, Issue 3, 2006, Pages 649-657

  Burgess, Janette K ^a,b   Oliver, Brian G G ^a   Poniris, Maree H ^a   Ge, Qi ^a   Boustany, Sarah ^b   Cox, Natalie ^a   Moir, Lyn M ^b   Johnson, Peter R A ^a,b   Black, Judith L ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

agonists; airway remodeling; Asthma; connective tissue growth factor; corticosteroids; fibronectin; human airway smooth muscle cells; phosphodiesterase inhibitors

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CORTICOSTEROID; FIBRONECTIN; FLUTICASONE; FORMOTEROL; INTERLEUKIN 6; MATRIX PROTEIN; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST; SALMETEROL; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; ASTHMA; BRONCHUS; BRONCHUS MUSCLE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADULT; AMINOPYRIDINES; BENZAMIDES; BRONCHI; CELLS, CULTURED; COLLAGEN TYPE I; CYCLOPROPANES; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; HUMANS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MIDDLE AGED; MYOCYTES, SMOOTH MUSCLE; RNA, MESSENGER;

EID: 33748047115     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.05.019     Document Type: Article

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