Microneedles for drug and vaccine delivery

Advanced Drug Delivery Reviews

Volumn 64, Issue 14, 2012, Pages 1547-1568

  Kim, Yeu Chun ^a,b,c   Park, Jung Hwan ^d   Prausnitz, Mark R ^e  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Ewha Womans University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^d Gachon University   (South Korea)

^e Georgia Institute of Technology   (United States)

Author keywords

Intracellular delivery; Microfabricated device; Microneedle; Ocular drug delivery; Skin vaccination; Transdermal drug delivery

Indexed keywords

INTRACELLULAR DELIVERY; MICROFABRICATED DEVICES; MICRONEEDLES; OCULAR DRUG DELIVERY; TRANSDERMAL DRUG DELIVERY;

CONTROLLED DRUG DELIVERY; DRUG INFUSION; MANUFACTURE; MICROFABRICATION; PATIENT REHABILITATION; VACCINES;

NEEDLES;

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID METHYL ESTER; BIOLOGICAL PRODUCT; CALCEIN; CHOLERA TOXIN; DICLOFENAC; DIPHTHERIA TOXOID; DRUG; FLUZONE INTRADERMAL; INFLUENZA VACCINE; INSULIN; LIDOCAINE; MALEIC ANHYDRIDE; MALTOSE; NALTREXONE; NICKEL; NICOTINE DERIVATIVE; PARATHYROID HORMONE; PHENYLEPHRINE; POLY(METHYL METHACRYLATE); POLYCARBONATE; POLYGLACTIN; POLYGLYCOLIC ACID; POLYLACTIC ACID; PROTOPORPHYRIN; RECOMBINANT ERYTHROPOIETIN; STEEL; TANTALUM; TITANIUM; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACCINE;

BIOLOGICAL THERAPY; CATHETER; CERAMICS; COSMETIC INDUSTRY; DEVICE REMOVAL; DRUG ADMINISTRATION ROUTE; DRUG APPROVAL; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG INFUSION; DRUG MANUFACTURE; DRUG PENETRATION; DRUG SAFETY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; ELECTRONICS INDUSTRY; ENCAPSULATION; EXPERIMENTATION; FECES INCONTINENCE; HUMAN; IN VIVO STUDY; INFLUENZA; INFLUENZA VACCINATION; INJECTION SITE PAIN; LIGHT DAMAGE; MATERIAL STATE; MATERIALS; MICRONEEDLE; MICROTECHNOLOGY; NEEDLE; NONHUMAN; OSTEOPOROSIS; OUTCOME ASSESSMENT; PHOTODYNAMIC THERAPY; PREMEDICATION; PRIORITY JOURNAL; REVIEW; SKIN DEFECT; SKIN INFECTION; SKIN IRRITATION; SKIN PERMEABILITY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSDERMAL PATCH; VISCOSITY;

ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MICROINJECTIONS; MICROTECHNOLOGY; NEEDLES; PHARMACEUTICAL PREPARATIONS; VACCINES;

EID: 84868206060     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.04.005     Document Type: Review

References (350)

1. Giudice E.L., Campbell J.D. Needle-free vaccine delivery. Adv. Drug Deliv. Rev. 2006, 58:68-89.
2. Nir Y., Paz A., Sabo E., Potasman I. Fear of injections in young adults: prevalence and associations. Am. J. Trop. Med. Hyg. 2003, 68:341-344.
3. Hamilton J.G. Needle phobia-a neglected diagnosis. J. Fam. Pract. 1995, 41:169-175.
4. Drucker E., Alcabes P.G., Marx P.A. The injection century: massive unsterile injections and the emergence of human pathogens. Lancet 2001, 358:1989-1992.
5. Kermode M. Unsafe injections in low-income country health settings: need for injection safety promotion to prevent the spread of blood-borne viruses. Health Promot. Int. 2004, 19:95-103.
6. Singh R., Singh S., Lillard J.W. Past, present, and future technologies for oral delivery of therapeutic proteins. J. Pharm. Sci. 2008, 97:2497-2523.
7. Amorij J.P., Hinrichs W.L.J., Frijlink H.W., Wilschut J.C., Huckriede A. Needle-free influenza vaccination. Lancet Infect. Dis. 2010, 10:699-711.
8. Mitragotri S. Immunization without needles. Nat. Rev. Immunol. 2005, 5:905-916.
9. Bronaugh R.L., Maibach H.I. Percutaneous Absorption: Drugs-Cosmetics-Mechanisms-Methodology 2005, Marcel Dekker, New York.
10. Prausnitz M.R., Mikszta J.A., Cormier M., Andrianov A.K. Microneedle-based vaccines. Curr. Top. Microbiol. Immunol. 2009, 333:369-393.
11. Patel S.R., Edelhauser H.F., Prausnitz M.R. Targeted drug delivery to the eye enabled by microneedles. Drug Product Development for the Back of the Eye 2011, 331-360. American Association of Pharmaceutical Sciences, Arlington. U.B. Kompella, H.F. Edelhauser (Eds.).
12. Yum K., Yu M.F., Wang N., Xiang Y.K. Biofunctionalized nanoneedles for the direct and site-selective delivery of probes into living cells. Biochim. Biophys. Acta 2011, 1810:330-338.
13. Yum K., Wang N., Yu M.F. Nanoneedle: a multifunctional tool for biological studies in living cells. Nanoscale 2010, 2:363-372.
14. Arora A., Prausnitz M.R., Mitragotri S. Micro-scale devices for transdermal drug delivery. Int. J. Pharm. 2008, 364:227-236.
15. Banga A.K. Microporation applications for enhancing drug delivery. Expert Opin. Drug Deliv. 2009, 6:343-354.
16. Birchall J.C. Microneedle array technology: the time is right but is the science ready?. Expert Rev. Med. Devices 2006, 3:1-4.
17. Coulman S., Allender C., Birchall J. Microneedles and other physical methods for overcoming the stratum corneum barrier for cutaneous gene therapy. Crit. Rev. Ther. Drug Carrier Syst. 2006, 23:205-258.
18. Donnelly R.F., Singh T.R.R., Woolfson A.D. Microneedle-based drug delivery systems: microfabrication, drug delivery, and safety. Drug Deliv. 2010, 17:187-207.
19. Garland M.J., Migalska K., Mazlelaa T., Mahmood T., Raghu T., Singh R., Woolfson A.D., Donnelly R.F. Microneedle arrays as medical devices for enhanced transdermal drug delivery. Expert Rev. Med. Devices 2011, 8:459-482.
20. Gittard S.D., Ovsianikov A., Chichkov B.N., Doraiswamy A., Narayan R.J. Two-photon polymerization of microneedles for transdermal drug delivery. Expert Opin. Drug Deliv. 2010, 7:513-533.
21. Kalluri H., Banga A.K. Microneedles and transdermal drug delivery. J. Drug Deliv. Sci. Technol. 2009, 19:303-310.
22. Khanna P., Strom J.A., Malone J.I., Bhansali S. Microneedle-based automated therapy for diabetes mellitus. J. Diab. Sci. Technol. 2008, 2:1122-1129.
23. McAllister D.V., Allen M.G., Prausnitz M.R. Microfabricated microneedles for gene and drug delivery. Annu. Rev. Biomed. Eng. 2000, 2:289-313.
24. Milewski M., Brogden N.K., Stinchcomb A.L. Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. Expert Opin. Drug Deliv. 2010, 7:617-629.
25. Prausnitz M.R. Microneedles for transdermal drug delivery. Adv. Drug Deliv. Rev. 2004, 56:581-587.
26. Reed M.L., Lye W.K. Microsystems for drug and gene delivery. Proc. IEEE 2004, 92:56-75.
27. Sachdeva V., Banga A.K. Microneedles and their applications. Recent Pat. Drug Deliv. Formul. 2011, 5:95-132.
28. Shah U.U., Roberts M., Orlu Gul M., Tuleu C., Beresford M.W. Needle-free and microneedle drug delivery in children: a case for disease-modifying antirheumatic drugs (DMARDs). Int. J. Pharm. 2011, 416:1-11.
29. Singh T.R.R., Dunne N.J., Cunningham E., Donnelly R.F. Review of patents on microneedle applicators. Recent Pat. Drug Deliv. Formul. 2011, 5:11-23.
30. Singh T.R.R., Garland M.J., Cassidy C.M., Migalska K., Demir Y.K., Abdelghany S., Ryan E., Woolfson A.D., Donnelly R.F. Microporation techniques for enhanced delivery of therapeutic agents. Recent Pat. Drug Deliv. Formul. 2010, 4:1-17.
31. Sivamani R.K., Liepmann D., Malbach H.I. Microneedles and transdermal applications. Expert Opin. Drug Deliv. 2007, 4:19-25.
32. Vandervoort J., Ludwig A. Microneedles for transdermal drug delivery: a minireview. Front. Biosci. 2008, 13:1711-1715.
33. Bariya S.H., Gohel M.C., Mehta T.A., Sharma O.P. Microneedles: an emerging transdermal drug delivery system. J. Pharm. Pharmacol. 2012, 64:11-29.
34. Park H.A., Roy S., Khanna S., Sen C.K. Current technologies in single-cell microinjection and application to study signal transduction. Methods in Redox Signaling 2010, 71-77. Mary Ann Liebert, New Rochelle. D.K. Das (Ed.).
35. M.S. Gerstel, V.A. Place, Drug delivery device, U.S. Patent 3,964,482, (1976).
36. Madou M.J. Fundamentals of Microfabrication and Nanotechnology 2011, CRC Press, Boca Raton, FL.
37. Williams A. Transdermal and Topical Drug Delivery 2003, Pharmaceutical Press, London.
38. McAllister D.V., Wang P.M., Davis S.P., Park J.H., Canatella P.J., Allen M.G., Prausnitz M.R. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:13755-13760.
39. Wilke N., Mulcahy A., Ye S.R., Morrissey A. Process optimization and characterization of silicon microneedles fabricated by wet etch technology. Microelectron. J. 2005, 36:650-656.
40. Henry S., McAllister D.V., Allen M.G., Prausnitz M.R. Microfabricated microneedles: a novel approach to transdermal drug delivery. J. Pharm. Sci. 1998, 87:922-925.
41. Donnelly R.F., Majithiya R., Singh T.R.R., Morrow D.I.J., Garland M.J., Demir Y.K., Migalska K., Ryan E., Gillen D., Scott C.J., Woolfson A.D. Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm. Res. 2011, 28:41-57.
42. Jin C.Y., Han M.H., Lee S.S., Choi Y.H. Mass producible and biocompatible microneedle patch and functional verification of its usefulness for transdermal drug delivery. Biomed. Microdevices 2009, 11:1195-1203.
43. Moon S.J., Lee S.S., Lee H.S., Kwon T.H. Fabrication of microneedle array using LIGA and hot embossing process. Microsyst. Technol. 2005, 11:311-318.
44. Park J.H., Allen M.G., Prausnitz M.R. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J. Control. Release 2005, 104:51-66.
45. Li G.H., Badkar A., Nema S., Kolli C.S., Banga A.K. In vitro transdermal delivery of therapeutic antibodies using maltose microneedles. Int. J. Pharm. 2009, 368:109-115.
46. Gill H.S., Prausnitz M.R. Coated microneedles for transdermal delivery. J. Control. Release 2007, 117:227-237.
47. Martanto W., Davis S.P., Holiday N.R., Wang J., Gill H.S., Prausnitz M.R. Transdermal delivery of insulin using microneedles in vivo. Pharm. Res. 2004, 21:947-952.
48. Matriano J.A., Cormier M., Johnson J., Young W.A., Buttery M., Nyam K., Daddona P.E. Macroflux (R) microprojection array patch technology: a new and efficient approach for intracutaneous immunization. Pharm. Res. 2002, 19:63-70.
49. Omatsu T., Chujo K., Miyamoto K., Okida M., Nakamura K., Aoki N., Morita R. Metal microneedle fabrication using twisted light with spin. Opt. Express 2010, 18:17967-17973.
50. Jung P.G., Lee T.W., Oh D.J., Hwang S.J., Jung I.D., Lee S.M., Ko J.S. Nickel microneedles fabricated by sequential copper and nickel electroless plating and copper chemical wet etching. Sens. Mater. 2008, 20:45-53.
51. Bystrova S., Luttge R. Micromolding for ceramic microneedle arrays. Microelectron. Eng. 2011, 88:1681-1684.
52. Ovsianikov A., Chichkov B., Mente P., Monteiro-Riviere N.A., Doraiswamy A., Narayan R.J. Two photon polymerization of polymer-ceramic hybrid materials for transdermal drug delivery. Int. J. Appl. Ceram. Tec. 2007, 4:22-29.
53. Yan G., Warner K.S., Zhang J., Sharma S., Gale B.K. Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery. Int. J. Pharm. 2010, 391:7-12.
54. Ji J., Tay F.E.H., Miao J.M., Iliescu C. Microfabricated silicon microneedle array for transdermal drug delivery. International Mems Conference 2006 2006, 1127-1131. IOP Publishing Ltd., Bristol.
55. Qiu Y.Q., Gao Y.H., Hu K.J., Li F. Enhancement of skin permeation of docetaxel: a novel approach combining microneedle and elastic liposomes. J. Control. Release 2008, 129:144-150.
56. Wei-Ze L., Mei-Rong H., Jian-Ping Z., Yong-Qiang Z., Bao-Hua H., Ting L., Yong Z. Super-short solid silicon microneedles for transdermal drug delivery applications. Int. J. Pharm. 2010, 389:122-129.
57. Chen Y.T., Hsu C.C., Tsai C.H., Kang S.W. Fabrication of microneedles. J. Mar. Sci. Technol. 2010, 18:243-248.
58. Suner S., Fellows M.R., Vargas-Irwin C., Nakata G.K., Donoghue J.P. Reliability of signals from a chronically implanted, silicon-based electrode array in non-human primate primary motor cortex. IEEE Trans. Neural Syst. Rehabil. Eng. 2005, 13:524-541.
59. Rousche P.J., Normann R.A. Chronic intracortical microstimulation of cat auditory cortex using a 100 penetrating electrode array. J. Physiol. 1997, 499:87-88.
60. Rousche P.J., Normann R.A. Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex. J. Neurosci. Methods 1998, 82:1-15.
61. Kelly R.C., Smith M.A., Samonds J.M., Kohn A., Bonds A.B., Movshon J.A., Lee T.S. Comparison of recordings from microelectrode arrays and single electrodes in the visual cortex. J. Neurosci. 2007, 27:261-264.
62. Gower M.C. Industrial applications of laser micromachining. Opt. Express 2000, 7:56-67.
63. Davis S.P., Martanto W., Allen M.G., Prausnitz M.R. Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans. Biomed. Eng. 2005, 52:909-915.
64. Yuzhakov V.V. The AdminPen™ microneedle device for painless & convenient drug delivery. Drug Deliv. Technol. 2010, 10:32-36.
65. Fomani A.A., Mansour R.R. Fabrication and characterization of flexible neural microprobes with improved structural design. Sens. Actuators A Phys. 2011, 168:233-241.
66. Choi S.O., Kim Y.C., Park J.H., Hutcheson J., Gill H.S., Yoon Y.K., Prausnitz M.R., Allen M.G. An electrically active microneedle array for electroporation. Biomed. Microdevices 2010, 12:263-273.
67. Yoon Y.K., Park J.H., Allen M.G. Multidirectional UV lithography for complex 3-D MEMS structures. J. Microelectromech. Syst. 2006, 15:1121-1130.
68. Park J.H., Yoon Y.K., Choi S.O., Prausnitz M.R., Allen M.G. Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery. IEEE Trans. Biomed. Eng. 2007, 54:903-913.
69. Kim K., Park D.S., Lu H.M., Che W., Kim K., Lee J.B., Ahn C.H. A tapered hollow metallic microneedle array using backside exposure of SU-8. J. Micromech. Microeng. 2004, 14:597-603.
70. Sugiyama S., Khumpuang S., Kawaguchi G. PCT technique for deep X-ray lithography and applications. J. Micromech. Microeng. 2004, 14:1399-1404.
71. Han M., Hyun D.H., Park H.H., Lee S.S., Kim C.H., Kim C. A novel fabrication process for out-of-plane microneedle sheets of biocompatible polymer. J. Micromech. Microeng. 2007, 17:1184-1191.
72. Gittard S.D., Ovsianikov A., Monteiro-Riviere N.A., Lusk J., Morel P., Minghetti P., Lenardi C., Chichkov B.N., Narayan R.J. Fabrication of polymer microneedles using a two-photon polymerization and micromolding process. J. Diab. Sci. Technol. 2009, 3:304-311.
73. Lee K.-S., Kim R.H., Yang D.-Y., Park S.H. Advances in 3D nano/microfabrication using two-photon initiated polymerization. Prog. Polym. Sci. 2008, 33:631-681.
74. Aoyagi S., Izumi H., Fukuda M. Biodegradable polymer needle with various tip angles and consideration on insertion mechanism of mosquito's proboscis. Sens. Actuators A Phys. 2008, 143:20-28.
75. Matteucci M., Fanetti M., Casella M., Gramatica F., Gavioli L., Tormen M., Grenci G., De Angelis F., Di Fabrizio E. Poly vinyl alcohol re-usable masters for microneedle replication. Microelectron. Eng. 2009, 86:752-756.
76. Moon S.J., Lee S.S. A novel fabrication method of a microneedle array using inclined deep X-ray exposure. J. Micromech. Microeng. 2005, 15:903-911.
77. Gittard S.D., Narayan R.J., Jin C., Ovsianikov A., Chichkov B.N., Monteiro-Riviere N.A., Stafslien S., Chisholm B. Pulsed laser deposition of antimicrobial silver coating on Ormocer (R) microneedles. Biofabrication 2009, 1:041001.
78. Doraiswamy A., Jin C., Narayan R., Mageswaran P., Mente P., Modi R., Auyeung R., Chrisey D.B., Ovsianikov A., Chichkov B. Two photon induced polymerization of organic-inorganic hybrid biomaterials for microstructured medical devices. Acta Biomater. 2006, 2:267-275.
79. Aust M.C., Fernandes D., Kolokythas P., Kaplan H.M., Vogt P.M. Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity. Plast. Reconstr. Surg. 2008, 121:1421.
80. Doddaballapur S. Microneedling with dermaroller. J. Cutan. Aesthet. Surg. 2009, 2:110-111.
81. Fabbrocini G., Fardella N., Monfrecola A., Proietti I., Innocenzi D. Acne scarring treatment using skin needling. Clin. Exp. Dermatol. 2009, 34:874-879.
82. Majid I. Microneedling therapy in atrophic facial scars: an objective assessment. J. Cutan. Aesthet. Surg. 2009, 2:26-30.
83. So J.W., Park H.H., Lee S.S., Kim D.C., Shin S.C., Cho C.W. Effect of microneedle on the pharmacokinetics of ketoprofen from its transdermal formulations. Drug Deliv. 2009, 16:52-56.
84. Yoon J., Son T., Choi E.H., Choi B., Nelson J.S., Jung B. Enhancement of optical skin clearing efficacy using a microneedle roller. J. Biomed. Opt. 2008, 13:021103.
85. Zhou C.P., Liu Y.L., Wang H.L., Zhang P.X., Zhang J.L. Transdermal delivery of insulin using microneedle rollers in vivo. Int. J. Pharm. 2010, 392:127-133.
86. Park J.H., Choi S.O., Seo S., Choy Y.B., Prausnitz M.R. A microneedle roller for transdermal drug delivery. Eur. J. Pharm. Biopharm. 2010, 76:282-289.
87. Gill H.S., Prausnitz M.R. Coating formulations for microneedles. Pharm. Res. 2007, 24:1369-1380.
88. Ameri M., Fan S.C., Maa Y.-F. Parathyroid hormone PTH(1-34) formulation that enables uniform coating on a novel transdermal microprojection delivery system. Pharm. Res. 2010, 27:303-313.
89. Andrianov A.K., DeCollibus D.P., Gillis H.A., Kha H.H., Marin A., Prausnitz M.R., Babiuk L.A., Townsend H., Mutwiri G. Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:18936-18941.
90. Kim Y.C., Quan F.S., Compans R.W., Kang S.M., Prausnitz M.R. Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity. J. Control. Release 2010, 142:187-195.
91. Stokes R.J., Evans D.F., Errico M. Liquid Coating Processes 1997, Wiley-VCH, Weinheim, Germany.
92. Saurer E.M., Flessner R.M., Sullivan S.P., Prausnitz M.R., Lynn D.M. Layer-by-layer assembly of DNA- and protein-containing films on microneedles for drug delivery to the skin. Biomacromolecules 2010, 11:3136-3143.
93. DeMuth P.C., Su X.F., Samuel R.E., Hammond P.T., Irvine D.J. Nano-layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA. Adv. Mater. 2010, 22:4851-4856.
94. Chen X.F., Prow T.W., Crichton M.L., Jenkins D.W.K., Roberts M.S., Frazer I.H., Fernando G.J.P., Kendall M.A.F. Dry-coated microprojection array patches for targeted delivery of immunotherapeutics to the skin. J. Control. Release 2009, 139:212-220.
95. McGrath M.G., Vrdoljak A., O'Mahony C., Oliveira J.C., Moore A.C., Crean A.M. Determination of parameters for successful spray coating of silicon microneedle arrays. Int. J. Pharm. 2011, 415:140-149.
96. Cormier M., Johnson B., Ameri M., Nyam K., Libiran L., Zhang D.D., Daddona P. Transdermal delivery of desmopressin using a coated microneedle array patch system. J. Control. Release 2004, 97:503-511.
97. Kim Y.C., Quan F.S., Compans R.W., Kang S.M., Prausnitz M.R. Formulation of microneedles coated with influenza virus-like particle vaccine. AAPS PharmSciTech 2010, 11:1193-1201.
98. Han M., Kim D.K., Kang S.H., Yoon H.R., Kim B.Y., Lee S.S., Kim K.D., Lee H.G. Improvement in antigen-delivery using fabrication of a grooves-embedded microneedle array. Sens. Actuators B Chem. 2009, 137:274-280.
99. Gill H.S., Prausnitz M.R. Pocketed microneedles for drug delivery to the skin. J. Phys. Chem. Solids 2008, 69:1537-1541.
100. Jiang J., Gill H.S., Ghate D., McCarey B.E., Patel S.R., Edelhauser H.F., Prausnitz M.R. Coated microneedles for drug delivery to the eye. Invest. Ophthalmol. Vis. Sci. 2007, 48:4038-4043.
101. Zhang Y., Brown K., Siebenaler K., Determan A., Dohmeier D., Hansen K. Development of lidocaine-coated microneedle product for rapid, safe, and prolonged local analgesic action. Pharm. Res. 2012, 29:170-177.
102. Marin A., Andrianov A.K. Carboxymethylcellulose-chitosan-coated microneedles with modulated hydration properties. J. Appl. Polym. Sci. 2011, 121:395-401.
103. Andrianov A.K., Marin A., DeCollibus D.P. Microneedles with intrinsic immunoadjuvant properties: microfabrication, protein stability, and modulated release. Pharm. Res. 2011, 28:58-65.
104. Lin W.Q., Cormier M., Samiee A., Griffin A., Johnson B., Teng C.L., Hardee G.E., Daddona P.E. Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux (R)) technology. Pharm. Res. 2001, 18:1789-1793.
105. Quan F.S., Kim Y.C., Vunnava A., Yoo D.G., Song J.M., Prausnitz M.R., Compans R.W., Kang S.M. Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization. J. Virol. 2010, 84:7760-7769.
106. Weldon W.C., Martin M.P., Zarnitsyn V., Wang B.Z., Koutsonanos D., Skountzou I., Prausnitz M.R., Compans R.W. Microneedle vaccination with stabilized recombinant influenza virus hemagglutinin induces improved protective immunity. Clin. Vaccine Immunol. 2011, 18:647-654.
107. Corbett H.J., Fernando G.J.P., Chen X.F., Frazer I.H., Kendall M.A.F. Skin vaccination against cervical cancer associated human papillomavirus with a novel micro-projection array in a mouse model. PLoS One 2010, 5:e13460.
108. Prow T.W., Chen X., Prow N.A., Fernando G.J., Tan C.S., Raphael A.P., Chang D., Ruutu M.P., Jenkins D.W., Pyke A., Crichton M.L., Raphaelli K., Goh L.Y., Frazer I.H., Roberts M.S., Gardner J., Khromykh A.A., Suhrbier A., Hall R.A., Kendall M.A. Nanopatch-targeted skin vaccination against West Nile virus and Chikungunya virus in mice. Small 2010, 6:1776-1784.
109. Hiraishi Y., Nandakumar S., Choi S.O., Lee J.W., Kim Y.C., Posey J.E., Sable S.B., Prausnitz M.R. Bacillus Calmette-Guerin vaccination using a microneedle patch. Vaccine 2011, 29:2626-2636.
110. Gill H.S., Sõderholm J., Prausnitz M.R., Sällberg M. Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine. Gene Ther. 2010, 17:811-814.
111. Chen X.F., Kask A.S., Crichton M.L., McNeilly C., Yukiko S., Dong L.C., Marshak J.O., Jarrahian C., Fernando G.J.P., Chen D.X., Koelle D.M., Kendall M.A.F. Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays. J. Control. Release 2010, 148:327-333.
112. Lee J.W., Park J.H., Prausnitz M.R. Dissolving microneedles for transdermal drug delivery. Biomaterials 2008, 29:2113-2124.
113. Raphael A.P., Prow T.W., Crichton M.L., Chen X.F., Fernando G.I.P., Kendall M.A.F. Targeted, needle-free vaccinations in skin using multi layered, densely-packed dissolving microprojection arrays. Small 2010, 6:1785-1793.
114. Ito Y., Hagiwara E., Saeki A., Sugioka N., Takada K. Sustained-release self-dissolving micropiles for percutaneous absorption of insulin in mice. J. Drug Target. 2007, 15:323-326.
115. Ito Y., Ohashi Y., Saeki A., Sugioka N., Takada K. Antihyperglycemic effect of insulin from self-dissolving micropiles in dogs. Chem. Pharm. Bull. 2008, 56:243-246.
116. Ito Y., Murakami A., Maeda T., Sugioka N., Takada K. Evaluation of self-dissolving needles containing low molecular weight heparin (LMWH) in rats. Int. J. Pharm. 2008, 349:124-129.
117. Fukushima K., Yamazaki T., Hasegawa R., Ito Y., Sugioka N., Takada K. Pharmacokinetic and pharmacodynamic evaluation of insulin dissolving microneedles in dogs. Diab. Technol. Ther. 2010, 12:465-474.
118. Ito Y., Maeda T., Fukushima K., Sugioka N., Takada K. Permeation enhancement of ascorbic acid by self-dissolving micropile array tip through rat skin. Chem. Pharm. Bull. 2010, 58:458-463.
119. Ito Y., Yamazaki T., Sugioka N., Takada K. Self-dissolving micropile array tips for percutaneous administration of insulin. J. Mater. Sci. Mater. Med. 2010, 21:835-841.
120. Ito Y., Hasegawa R., Fukushima K., Sugioka N., Takada K. Self-dissolving micropile array chip as percutaneous delivery system of protein drug. Biol. Pharm. Bull. 2010, 33:683-690.
121. Fukushima K., Ise A., Morita H., Hasegawa R., Ito Y., Sugioka N., Takada K. Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats. Pharm. Res. 2011, 28:7-21.
122. Ito Y., Murano H., Hamasaki N., Fukushima K., Takada K. Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles. Int. J. Pharm. 2011, 407:126-131.
123. Ito Y., Ohashi Y., Shiroyama K., Sugioka N., Takada K. Self-dissolving micropiles for the percutaneous absorption of recombinant human growth hormone in rats. Biol. Pharm. Bull. 2008, 31:1631-1633.
124. Ito Y., Hagiwara E., Saeki A., Sugioka N., Takada K. Feasibility of microneedles for percutaneous absorption of insulin. Eur. J. Pharm. Sci. 2006, 29:82-88.
125. Ito Y., Yoshimitsu J.I., Shiroyama K., Sugioka N., Takada K. Self-dissolving microneedles for the percutaneous absorption of EPO in mice. J. Drug Target. 2006, 14:255-261.
126. Sullivan S.P., Murthy N., Prausnitz M.R. Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv. Mater. 2008, 20:933-938.
127. Sullivan S.P., Koutsonanos D.G., Martin M.D., Lee J.W., Zarnitsyn V., Choi S.O., Murthy N., Compans R.W., Skountzou I., Prausnitz M.R. Dissolving polymer microneedle patches for influenza vaccination. Nat. Med. 2010, 16:915-920.
128. Chu L.Y., Choi S.O., Prausnitz M.R. Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs. J. Pharm. Sci. 2010, 99:4228-4238.
129. Chu L.Y., Prausnitz M.R. Separable arrowhead microneedles. J. Control. Release 2011, 149:242-249.
130. Wendorf J.R., Ghartey-Tagoe E.B., Williams S.C., Enioutina E., Singh P., Cleary G.W. Transdermal delivery of macromolecules using solid-state biodegradable microstructures. Pharm. Res. 2011, 28:22-30.
131. Park J.H., Allen M.G., Prausnitz M.R. Polymer microneedles for controlled-release drug delivery. Pharm. Res. 2006, 23:1008-1019.
132. You X., Chang J.-h., Ju B.-K., Pak J.J. Rapidly dissolving fibroin microneedles for transdermal drug delivery. Mat. Sci. Eng. C. 2011, 31:1632-1636.
133. Martin C.J., Allender C.J., Brain K.R., Morrissey A., Birchall J.C. Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications. J. Control. Release 2012, 158:93-101.
134. Miyano T., Tobinaga Y., Kanno T., Matsuzaki Y., Takeda H., Wakui M., Hanada K. Sugar micro needles as transdermic drug delivery system. Biomed. Microdevices 2005, 7:185-188.
135. Aoyagi S., Izumi H., Isono Y., Fukuda M., Ogawa H. Laser fabrication of high aspect ratio thin holes on biodegradable polymer and its application to a microneedle. Sens. Actuators A Phys. 2007, 139:293-302.
136. Kim M., Jung B., Park J.-H. Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials 2012, 33:668-678.
137. Lee K., Lee C.Y., Jung H. Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials 2011, 32:3134-3140.
138. Min J., Park J.-H., Yoon H., Choy Y. Ultrasonic welding method to fabricate polymer microstructure encapsulating protein with minimum damage. Macromol. Res. 2008, 16:570-573.
139. Park J.H., Choi S.O., Kamath R., Yoon Y.K., Allen M.G., Prausnitz M.R. Polymer particle-based micromolding to fabricate novel microstructures. Biomed. Microdevices 2007, 9:223-234.
140. Roxhed N., Gasser T.C., Griss P., Holzapfel G.A., Stemme G. Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J. Microelectromech. S. 2007, 16:1429-1440.
141. Gardeniers H.J.G.E., Luttge R., Berenschot E.J.W., de Boer M.J., Yeshurun S.Y., Hefetz M., van't Oever R., van den Berg A. Silicon micromachined hollow microneedles for transdermal liquid transport. J. Microelectromech. S. 2003, 12:855-862.
142. Luttge R., Berenschot E.J.W., de Boer M.J., Altpeter D.M., Vrouwe E.X., van den Berg A., Elwenspoek M. Integrated lithographic molding for microneedle-based devices. J. Microelectromech. S. 2007, 16:872-884.
143. Perennes F., Marmiroli B., Matteucci M., Tormen M., Vaccari L., Di Fabrizio E. Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol. J. Micromech. Microeng. 2006, 16:473-479.
144. Ma B., Liu S., Gan Z., Liu G., Cai X., Zhang H., Yang Z. A PZT insulin pump integrated with a silicon microneedle array for transdermal drug delivery. Microfluid. Nanofluid. 2006, 2:417-423.
145. Yu L.M., Tay F.E.H., Guo D.G., Xu L., Yap K.L. A microfabricated electrode with hollow microneedles for ECG measurement. Sens. Actuators A Phys. 2009, 151:17-22.
146. Teo M.A.L., Shearwood C., Ng K.C., Lu J., Moochhala S. In vitro and in vivo characterization of MEMS microneedles. Biomed. Microdevices 2005, 7:47-52.
147. Wilke N., Hibert C., O'Brien J., Morrissey A. Silicon microneedle electrode array with temperature monitoring for electroporation. Sens. Actuators A Phys. 2005, 123-24:319-325.
148. Mukerjee E., Collins S.D., Isseroff R.R., Smith R.L. Microneedle array for transdermal biological fluid extraction and in situ analysis. Sens. Actuators A Phys. 2004, 114:267-275.
149. Zhang P.Y., Dalton C.L., Jullien G. Design and fabrication of MEMS-based microneedle arrays for medical applications. Microsyst. Technol. 2009, 15:1073-1082.
150. Baron N., Passave J., Guichardaz B., Cabodevila G. Investigations of development process of high hollow beveled microneedles using a combination of ICP RIE and dicing saw. Microsyst. Technol. 2008, 14:1475-1480.
151. Wang P.M., Cornwell M., Hill J., Prausnitz M.R. Precise microinjection into skin using hollow microneedles. J. Invest. Dermatol. 2006, 126:1080-1087.
152. Daugimont L., Baron N., Vandermeulen G., Pavselj N., Miklavcic D., Jullien M.-C., Cabodevila G., Mir L., Préat V. Hollow microneedle arrays for intradermal drug delivery and DNA electroporation. J. Membr. Biol. 2010, 236:117-125.
153. Miller P.R., Gittard S.D., Edwards T.L., Lopez D.M., Xiao X., Wheeler D.R., Monteiro-Riviere N.A., Brozik S.M., Polsky R., Narayan R.J. Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing. Biomicrofluidics 2011, 5:013415.
154. Khumpuang S., Horade M., Fujioka K., Sugiyama S. Geometrical strengthening and tip-sharpening of a microneedle array fabricated by X-ray lithography. Microsyst. Technol. 2007, 13:209-214.
155. Moon S.J., Lee S.S., Lee H.S., Kwon T.H. Fabrication of microneedle array using LIGA and hot embossing process. Microsyst. Technol. 2005, 11:311-318.
156. Lee K., Lee H.C., Lee D.S., Jung H. Drawing lithography: three-dimensional fabrication of an ultrahigh-aspect-ratio microneedle. Adv. Mater. 2010, 22:483-486.
157. Bodhale D.W., Nisar A., Afzulpurkar N. Structural and microfluidic analysis of hollow side-open polymeric microneedles for transdermal drug delivery applications. Microfluid. Nanofluid. 2010, 8:373-392.
158. Jung P., Lee T.W., Oh D.J., Hwang S.J., Jung I., Lee S., Ko J. Nickel microneedles fabricated by sequential copper and nickel electroless plating and copper chemical wet etching. Sens. Mater. 2008, 20:45-53.
159. Rodriguez A., Molinero D., Valera E., Trifonov T., Marsal L.F., Pallares J., Alcubilla R. Fabrication of silicon oxide microneedles from macroporous silicon. Sens. Actuators B Chem. 2005, 109:135-140.
160. Zhu M.W., Li H.W., Chen X.L., Tang Y.F., Lu M.H., Chen Y.F. Silica needle template fabrication of metal hollow microneedle arrays. J. Micromech. Microeng. 2009, 19:115010.
161. Hafeli U.O., Mokhtari A., Liepmann D., Stoeber B. In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery. Biomed. Microdevices 2009, 11:943-950.
162. Martanto W., Moore J.S., Kashlan O., Kamath R., Wang P.M., O'Neal J.M., Prausnitz M.R. Microinfusion using hollow microneedles. Pharm. Res. 2006, 23:104-113.
163. Burton S., Ng C.-Y., Simmers R., Moeckly C., Brandwein D., Gilbert T., Johnson N., Brown K., Alston T., Prochnow G., Siebenaler K., Hansen K. Rapid intradermal delivery of liquid formulations using a hollow microstructured array. Pharm. Res. 2011, 28:31-40.
164. Ashraf M., Tayyaba S., Nisar A., Afzulpurkar N., Bodhale D., Lomas T., Poyai A., Tuantranont A. Design, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions. Cardiovasc. Eng. 2010, 10:91-108.
165. Ali W.G., Nagib G. Embedded control design for insulin pump. Adv. Mater. Res. 2011, 201:2399-2404.
166. Gupta J., Felner E.I., Prausnitz M.R. Minimally invasive insulin delivery in subjects with type 1 diabetes using hollow microneedles. Diab. Technol. Ther. 2009, 11:329-337.
167. Amirouche F., Zhou Y., Johnson T. Current micropump technologies and their biomedical applications. Microsyst. Technol. 2009, 15:647-666.
168. Matteucci M., Casella M., Bedoni M., Donetti E., Fanetti M., De Angelis F., Gramatica F., Di Fabrizio E. A compact and disposable transdermal drug delivery system. Microelectron. Eng. 2008, 85:1066-1073.
169. Wonglertnirant N., Todo H., Opanasopit P., Ngawhirunpat T., Sugibayashi K. Macromolecular delivery into skin using a hollow microneedle. Biol. Pharm. Bull. 2010, 33:1988-1993.
170. Harvey A., Kaestner S., Sutter D., Harvey N., Mikszta J., Pettis R. Microneedle-based intradermal delivery enables rapid lymphatic uptake and fistribution of protein drugs. Pharm. Res. 2011, 28:107-116.
171. Kim K., Lee J.B. High aspect ratio tapered hollow metallic microneedle arrays with microfluidic interconnector. Microsyst. Technol. 2007, 13:231-235.
172. Laurent P.E., Bonnet S., Alchas P., Regolini P., Mikszta J.A., Pettis R., Harvey N.G. Evaluation of the clinical performance of a new intradermal vaccine administration technique and associated delivery system. Vaccine 2007, 25:8833-8842.
173. Li T., Barnett A., Rogers K.L., Gianchandani Y.B. A blood sampling microsystem for pharmacokinetic applications: design, fabrication, and initial results. Lab Chip 2009, 9:3495-3503.
174. Vesper H.W., Wang P.M., Archibold E., Prausnitz M.R., Myers G.L. Assessment of trueness of a glucose monitor using interstitial fluid and whole blood as specimen matrix. Diab. Technol. Ther. 2006, 8:76-80.
175. Prausnitz M.R., Langer R. Transdermal drug delivery. Nat. Biotechnol. 2008, 26:1261-1268.
176. Choy Y.B., Prausnitz M.R. The rule of five for non-oral routes of drug delivery: ophthalmic, inhalation and transdermal. Pharm. Res. 2011, 28:943-948.
177. Banks S.L., Pinninti R.R., Gill H.S., Crooks P.A., Prausnitz M.R., Stinchcomb A.L. Flux across of microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro. Pharm. Res. 2008, 25:1677-1685.
178. Banks S.L., Pinninti R.R., Gill H.S., Paudel K.S., Crooks P.A., Brogden N.K., Prausnitz M.R., Stinchcomb A.L. Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs. J. Pharm. Sci. 2010, 99:3072-3080.
179. Wermeling D.P., Banks S.L., Huclson D.A., Gill H.S., Glupta J., Prausnitz M.R., Stinchcom A.L. Microneedles permit transdermal delivery of a skin-impermeant medication to humans. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:2058-2063.
180. Yerramreddy T.R., Milewski M., Penthala N.R., Stinchcomb A.L., Crooks P.A. Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery. Bioorg. Med. Chem. Lett. 2010, 20:3280-3283.
181. Banks S., Paudel K., Brogden N., Loftin C., Stinchcomb A.L. Diclofenac enables prolonged delivery of naltrexone through microneedle-treated skin. Pharm. Res. 2011, 28:1211-1219.
182. Milewski M., Yerramreddy T.R., Ghosh P., Crooks P.A., Stinchcomb A.L. In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin. J. Control. Release 2010, 146:37-44.
183. Milewski M., Stinchcomb A.L. Vehicle composition influence on the microneedle-enhanced transdermal flux of naltrexone hydrochloride. Pharm. Res. 2011, 28:124-134.
184. Donnelly R.F., Morrow D.I.J., McCarron P.A., Woolfson A.D., Morrissey A., Juzenas P., Juzeniene A., Iani V., McCarthy H.O., Moan J. Microneedle-mediated intradermal delivery of 5-aminolevulinic acid: potential for enhanced topical photodynamic therapy. J. Control. Release 2008, 129:154-162.
185. Mikolajewska P., Donnelly R.F., Garland M.J., Morrow D.I.J., Singh T.R.R., Iani V., Moan J., Juzeniene A. Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema. Pharm. Res. 2010, 27:2213-2220.
186. Donnelly R.F., Morrow D.I.J., McCarron P.A., David Woolfson A., Morrissey A., Juzenas P., Juzeniene A., Iani V., McCarthy H.O., Moan J. Microneedle arrays permit enhanced intradermal delivery of a preformed photosensitizer. Photochem. Photobiol. 2009, 85:195-204.
187. Clementoni M.T., B-Roscher M., Munavalli G.S. Photodynamic photorejuvenation of the face with a combination of microneedling, red light, and broadband pulsed light. Lasers Surg. Med. 2010, 42:150-159.
188. Baek C., Han M., Min J., Prausnitz M.R., Park J.-H., Park J.H. Local transdermal delivery of phenylephrine to the anal sphincter muscle using microneedles. J. Control. Release 2011, 154:138-147.
189. Badran M.M., Kuntsche J., Fahr A. Skin penetration enhancement by a microneedle device (Dermaroller (R)) in vitro: dependency on needle size and applied formulation. Eur. J. Pharm. Sci. 2009, 36:511-523.
190. Kim Y.T., Il Ahn S., Park H.J., Jung S.H., Hong H.K., Lee H.K., Lee D., Rhee J.M., Lee K.H., Khang G. Microneedle-mediated transdermal delivery of chondroitin sulfate. Tissue Eng. Regen. Med. 2009, 6:756-761.
191. Li X., Zhao R., Qin Z., Zhang J., Zhai S., Qiu Y., Gao Y., Xu B., Thomas S.H. Microneedle pretreatment improves efficacy of cutaneous topical anesthesia. Am. J. Emerg. Med. 2010, 28:130-134.
192. Gupta J., Denson D.D., Felner E.I., Prausnitz M.R. Rapid local anesthesia in humans using minimally invasive microneedles. Clin. J. Pain 2012, 28:129-135.
193. Sivamani R.K., Stoeber B., Wu G.C., Zhai H.B., Liepmann D., Maibach H. Clinical microneedle injection of methyl nicotinate: stratum corneum penetration. Skin Res. Technol. 2005, 11:152-156.
194. Sivamani R.K., Stoeber B., Liepmann D., Maibach H.I. Microneedle penetration and injection past the stratum corneum in humans. J. Dermatol. Treat. 2009, 20:156-159.
195. Roxhed N., Samel B., Nordquist L., Griss P., Stemme G. Painless drug delivery through microneedle-based transdermal patches featuring active infusion. IEEE Trans. Biomed. Eng. 2008, 55:1063-1071.
196. Nordquist L., Roxhed N., Griss P., Stemme G. Novel microneedle patches for active insulin delivery are efficient in maintaining glycaemic control: an initial comparison with subcutaneous administration. Pharm. Res. 2007, 24:1381-1388.
197. Gupta J., Felner E.I., Prausnitz M.R. Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects. Diab. Technol. Ther. 2011, 13:451-456.
198. Pettis R.J., Ginsberg B., Hirsch L., Sutter D., Keith S., McVey E., Harvey N.G., Hompesch M., Nosek L., Kapitza C., Heinemann L. Intradermal microneedle delivery of insulin lispro achieves faster insulin absorption and insulin action than subcutaneous injection. Diab. Technol. Ther. 2011, 13:435-442.
199. Pettis R.J., Hirsch L., Kapitza C., Nosek L., Hovelmann U., Kurth H.J., Sutter D.E., Harvey N.G., Heinemann L. Microneedle-based intradermal versus subcutaneous administration of regular human insulin or insulin lispro: pharmacokinetics and postprandial glycemic excursions in patients with type 1 diabetes. Diab. Technol. Ther. 2011, 13:443-450.
200. Lee J.W., Choi S.O., Felner E.I., Prausnitz M.R. Dissolving microneedle patch for transdermal delivery of human growth hormone. Small 2011, 7:531-539.
201. Tas C., Mansoor S., Kalluri H., Zarnitsyn V.G., Choi S.-O., Banga A.K., Prausnitz M.R. Delivery of salmon calcitonin using a microneedle patch. Int. J. Pharm. 2012, 423:257-263.
202. Ameri M., Daddona P.E., Maa Y.-F. Demonstrated solid-state stability of parathyroid hormone PTH(1-34) coated on a novel transdermal microprojection delivery system. Pharm. Res. 2009, 26:2454-2463.
203. Ameri M., Wang X., Maa Y.-F. Effect of irradiation on parathyroid hormone PTH(1-34) coated on a novel transdermal microprojection delivery system to produce a sterile product-adhesive compatibility. J. Pharm. Sci. 2010, 99:2123-2134.
204. Cormier M., Daddona P.E. Macroflux technology for transdermal delivery of therapeutic proteins and vaccines. Modified-Release Drug Delivery Technology 2003, Marcel Dekker, New York. M.J. Rathbone, J. Hadgraft, M.S. Roberts (Eds.).
205. Cosman F., Lane N.E., Bolognese M.A., Zanchetta J.R., Garcia-Hernandez P.A., Sees K., Matriano J.A., Gaumer K., Daddona P.E. Effect of transdermal teriparatide administration on bone mineral density in postmenopausal women. J. Clin. Endocrinol. Metab. 2010, 95:151-158.
206. Daddona P., Matriano J., Mandema J., Maa Y.-F. Parathyroid hormone (1-34)-coated microneedle patch system: clinical pharmacokinetics and pharmacodynamics for treatment of osteoporosis. Pharm. Res. 2011, 28:159-165.
207. Pearton M., Allender C., Brain K., Anstey A., Gateley C., Wilke N., Morrissey A., Birchall J. Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations. Pharm. Res. 2008, 25:407-416.
208. Gonzalez-Gonzalez E., Kim Y.-C., Speaker T.J., Hickerson R.P., Spitler R., Birchall J.C., Lara M.F., Hu R.-h., Liang Y., Kirkiles-Smith N., Prausnitz M.R., Milstone L.M., Contag C.H., Kaspar R.L. Visualization of plasmid delivery to keratinocytes in mouse and human epidermis. Sci. Rep. 2011, 1:158.
209. Gonzalez-Gonzalez E., Speaker T.J., Hickerson R.P., Spitler R., Flores M.A., Leake D., Contag C.H., Kaspar R.L. Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD). Mol. Ther. 2010, 18:1667-1674.
210. Kim Y.C., Prausnitz M. Enabling skin vaccination using new delivery technologies. Drug Deliv. Trans. Res. 2011, 1:7-12.
211. Mikszta J.A., Laurent P.E. Cutaneous delivery of prophylactic and therapeutic vaccines: historical perspective and future outlook. Expert Rev. Vaccines 2008, 7:1329-1339.
212. Ding Z., Van Riet E., Romeijn S., Kersten G.F.A., Jiskoot W., Bouwstra J.A. Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB/c mice after microneedle array pretreatment. Pharm. Res. 2009, 26:1635-1643.
213. Ding Z., Verbaan F.J., Bivas-Benita M., Bungener L., Huckriede A., van den Berg D.J., Kersten G., Bouwstra J.A. Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice. J. Control. Release 2009, 136:71-78.
214. Ding Z., Van Riet E., Romeijn S., Kersten G.F.A., Jiskoot W., Bouwstra J.A. Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB/c mice after microneedle array pretreatment. Pharm. Res. 2009, 26:1635-1643.
215. Slutter B., Bal S.M., Zhi D., Jiskoot W., Bouwstra J.A. Adjuvant effect of cationic liposomes and CpG depends on administration route. J. Control. Release 2011, 154:123-130.
216. Bal S., Ding Z., Kersten G., Jiskoot W., Bouwstra J. Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations. Pharm. Res. 2010, 27:1837-1847.
217. Bal S.M., Slütter B., Jiskoot W., Bouwstra J.A. Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation. Vaccine 2011, 29:4025-4032.
218. Kumar A., Li X.R., Sandoval M.A., Rodriguez B.L., Sloat B.R., Cui Z.R. Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin. Int. J. Nanomed. 2011, 6:1253-1264.
219. Mikszta J.A., Alarcon J.B., Brittingham J.M., Sutter D.E., Pettis R.J., Harvey N.G. Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. Nat. Med. 2002, 8:415-419.
220. Mikszta J.A., Sullivan V.J., Dean C., Waterston A.M., Alarcon J.B., Dekker J.P., Brittingham J.M., Huang J., Hwang C.R., Ferriter M., Jiang G., Mar K., Saikh K.U., Stiles B.G., Roy C.J., Ulrich R.G., Harvey N.G. Protective immunization against inhalational anthrax: a comparison of minimally invasive delivery platforms. J. Infect. Dis. 2005, 191:278-288.
221. Dean C.H., Alarcon J.B., Waterston A.M., Draper K., Early R., Guirakhoo F., Monath T.P., Mikszta J.A. Cutaneous delivery of a live, attenuated chimeric flavivirus vaccine against Japanese encephalitis (ChimeriVax)-JE) in non-human primates. Hum. Vaccin. 2005, 1:106-111.
222. Laurent P.E., Bourhy H., Fantino M., Alchas P., Mikszta J.A. Safety and efficacy of novel dermal and epidermal microneedle delivery systems for rabies vaccination in healthy adults. Vaccine 2010, 28:5850-5856.
223. Widera G., Johnson J., Kim L., Libiran L., Nyam K., Daddona P.E., Cormier M. Effect of delivery parameters on immunization to ovalbumin following intracutaneous administration by a coated microneedle array patch system. Vaccine 2006, 24:1653-1664.
224. Zhu Q.Y., Zarnitsyn V.G., Ye L., Wen Z.Y., Gao Y.L., Pan L., Skountzou I., Gill H.S., Prausnitz M.R., Yang C.L., Compans R.W. Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:7968-7973.
225. Koutsonanos D.G., Martin M.d.P., Zarnitsyn V.G., Sullivan S.P., Compans R.W., Prausnitz M.R., Skountzou I. Transdermal influenza immunization with vaccine-coated microneedle arrays. PLoS One 2009, 4:e4773.
226. Quan F.S., Kim Y.C., Yoo D.G., Compans R.W., Prausnitz M.R., Kang S.M. Stabilization of influenza vaccine enhances protection by microneedle delivery in the mouse skin. PLoS One 2009, 4:e7152.
227. Kim Y.C., Quan F.S., Yoo D.G., Compans R.W., Kang S.M., Prausnitz M.R. Improved influenza vaccination in the skin using vaccine coated-microneedles. Vaccine 2009, 27:6932-6938.
228. Kim Y.C., Quan F.S., Yoo D.G., Compans R.W., Kang S.M., Prausnitz M.R. Enhanced memory responses to seasonal H1N1 influenza vaccination of the skin with the use of vaccine-coated microneedles. J. Infect. Dis. 2010, 201:190-198.
229. Koutsonanos D.G., del Pilar Martin M., Zarnitsyn V.G., Jacob J., Prausnitz M.R., Compans R.W., Skountzou I. Serological memory and long-term protection to novel H1N1 influenza virus after skin vaccination. J. Infect. Dis. 2011, 204:582-591.
230. Kim Y.C., Quan F.S., Song J.M., Vunnava A., Yoo D.G., Park K.M., Compans R.W., Kang S.M., Prausnitz M.R. Influenza immunization with trehalose-stabilized virus-like particle vaccine using microneedles. Proc. Vaccinol. 2010, 2:17-21.
231. Quan F.S., Kim Y.C., Compans R.W., Prausnitz M.R., Kang S.M. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles. J. Control. Release 2010, 147:326-332.
232. Song J.M., Kim Y.C., Barlow P.G., Hossain M.J., Park K.M., Donis R.O., Prausnitz M.R., Compans R.W., Kang S.M. Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles. Antiviral Res. 2010, 88:244-247.
233. Song J.M., Kim Y.C., Lipatov A.S., Pearton M., Davis C.T., Yoo D.G., Park K.M., Chen L.M., Quan F.S., Birchall J.C., Donis R.O., Prausnitz M.R., Compans R.W., Kang S.M. Microneedle delivery of H5N1 influenza virus-like particles to the skin induces long-lasting B- and T-cell responses in mice. Clin. Vaccine Immunol. 2010, 17:1381-1389.
234. Ng K.W., Pearton M., Coulman S., Anstey A., Gateley C., Morrissey A., Allender C., Birchall J. Development of an ex vivo human skin model for intradermal vaccination: tissue viability and Langerhans cell behaviour. Vaccine 2009, 27:5948-5955.
235. Pearton M., Kang S.M., Song J.M., Kim Y.C., Quan F.S., Anstey A., Ivory M., Prausnitz M.R., Compans R.W., Birchall J.C. Influenza virus-like particles coated onto microneedles can elicit stimulatory effects on Langerhans cells in human skin. Vaccine 2010, 28:6104-6113.
236. Fernando G.J.P., Chen X.F., Prow T.W., Crichton M.L., Fairmaid E.J., Roberts M.S., Frazer I.H., Brown L.E., Kendall M.A.F. Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model. PLoS One 2010, 5:e10266.
237. Chen X.F., Corbett H.J., Yukiko S.R., Raphael A.P., Fairmaid E.J., Prow T.W., Brown L.E., Fernando G.J.P., Kendall M.A.F. Site-selectively coated, densely-packed microprojection array patches for targeted delivery of vaccines to skin. Adv. Funct. Mater. 2011, 21:464-473.
238. Andrianov A.K., DeCollibus D.P., Gillis H.A., Kha H.H., Marin A., Prausnitz M.R., Babiuk L.A., Townsend H., Mutwiri G. Poly[di(carboxylatophenoxy)phosphazene] is a potent adjuvant for intradermal immunization. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:18936-18941.
239. Kask A.S., Chen X., Marshak J.O., Dong L., Saracino M., Chen D., Jarrahian C., Kendall M.A., Koelle D.M. DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge. Vaccine 2010, 28:7483-7491.
240. Kommareddy S., Baudner B.C., Oh S., Kwon S.-y., Singh M., O'Hagan D.T. Dissolvable microneedle patches for the delivery of cell-culture-derived influenza vaccine antigens. J. Pharm. Sci. 2012, 101:1021-1027.
241. Hirschberg H.J.H.B., de Wijdeven G.G.P.V., Kelder A.B., van den Dobbelsteen G.P.J.M., Kerstena G.F.A. Bioneedles (TM) as vaccine carriers. Vaccine 2008, 26:2389-2397.
242. Hirschberg H., de Wijdeven G., Kraan H., Amorij J.P., Kersten G.F.A. Bioneedles as alternative delivery system for hepatitis B vaccine. J. Control. Release 2010, 147:211-217.
243. Flynn P.M., Shenep J.L., Mao L., Crawford R., Williams B.F., Williams B.G. Influence of needle gauge in Mantoux skin testing. Chest 1994, 106:1463-1465.
244. Alarcon J.B., Hartley A.W., Harvey N.G., Mikszta J.A. Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines. Clin. Vaccine Immunol. 2007, 14:375-381.
245. Mikszta J.A., Dekker J.P., Harvey N.G., Dean C.H., Brittingham J.M., Huang J., Sullivan V.J., Dyas B., Roy C.J., Ulrich R.G. Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine. Infect. Immun. 2006, 74:6806-6810.
246. Huang J., D'Souza A.J., Alarcon J.B., Mikszta J.A., Ford B.M., Ferriter M.S., Evans M., Stewart T., Amemiya K., Ulrich R.G., Sullivan V.J. Protective immunity in mice achieved with dry powder formulation and alternative delivery of plague F1-V vaccine. Clin. Vaccine Immunol. 2009, 16:719-725.
247. Morefield G.L., Tammariello R.F., Purcell B.K., Worsham P.L., Chapman J., Smith L.A., Alarcon J.B., Mikszta J.A., Ulrich R.G. An alternative approach to combination vaccines: intradermal administration of isolated components for control of anthrax, botulism, plague and staphylococcal toxic shock. J. Immune Based Ther. Vaccines 2008, 6:5.
248. Belshe R.B. Current status of live attenuated influenza virus vaccine in the US. Virus Res. 2004, 103:177-185.
249. Beran J., Ambrozaitis A., Laiskonis A., Mickuviene N., Bacart P., Calozet Y., Demanet E., Heijmans S., Van Belle P., Weber F., Salamand C. Intradermal influenza vaccination of healthy adults using a new microinjection system: a 3-year randomised controlled safety and immunogenicity trial. BMC Med. 2009, 7:13.
250. Leroux-Roels I., Vets E., Freese R., Seiberling M., Weber F., Salamand C., Leroux-Roels G. Seasonal influenza vaccine delivered by intradermal microinjection: a randomised controlled safety and immunogenicity trial in adults. Vaccine 2008, 26:6614-6619.
251. Holland D., Booy R., De Looze F., Eizenberg P., McDonald J., Karrasch J., McKeirnan M., Salem H., Mills G., Reid J., Weber F., Saville M. Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial. J. Infect. Dis. 2008, 198:650-658.
252. Arnou R., Icardi G., De Decker M., Ambrozaitis A., Kazek M.P., Weber F., Van Damme P. Intradermal influenza vaccine for older adults: a randomized controlled multicenter phase III study. Vaccine 2009, 27:7304-7312.
253. Van Damme P., Oosterhuis-Kafeja F., Van der Wielen M., Almagor Y., Sharon O., Levin Y. Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults. Vaccine 2009, 27:454-459.
254. Wang P.M., Cornwell M., Prausnitz M.R. Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles. Diab. Technol. Ther. 2005, 7:131-141.
255. Zahn J.D., Trebotich D., Liepmann D. Microdialysis microneedles for continuous medical monitoring. Biomed. Microdevices 2005, 7:59-69.
256. Gattiker G.E., Kaler K., Mintchev M.P. Electronic mosquito: designing a semi-invasive microsystem for blood sampling, analysis and drug delivery applications. Microsyst. Technol. 2005, 12:44-51.
257. Smart W.H., Subramanian K. The use of silicon microfabrication technology in painless blood glucose monitoring. Diab. Technol. Ther. 2000, 2:549-559.
258. Corrie S.R., Fernando G.J.P., Crichton M.L., Brunck M.E.G., Anderson C.D., Kendall M.A.F. Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding. Lab Chip 2010, 10:2655-2658.
259. Windmiller J.R., Zhou N.D., Chuang M.C., Valdes-Ramirez G., Santhosh P., Miller P.R., Narayan R., Wang J. Microneedle array-based carbon paste amperometric sensors and biosensors. Analyst 2011, 136:1846-1851.
260. Lee J.-H., Seo Y., Lim T.-S., Bishop P.L., Papautsky I. MEMS needle-type sensor array for in situ measurements of dissolved oxygen and redox potential. Environ. Sci. Technol. 2007, 41:7857-7863.
261. Wassum K.M., Tolosa V.M., Wang J., Walker E., Monbouquette H.G., Maidment N.T. Silicon wafer-based platinum microelectrode array biosensor for near real-time measurement of glutamate in vivo. Sensors 2008, 8:5023-5036.
262. Bai Q., Wise K.D., Anderson D.J. A high-yield microassembly structure for three-dimensional microelectrode arrays. IEEE Trans. Biomed. Eng. 2000, 47:281-289.
263. Chen C.-H., Yao D.-J., Tseng S.-H., Lu S.-W., Chiao C.-C., Yeh S.-R. Micro-multi-probe electrode array to measure neural signals. Biosens. Bioelectron. 2009, 24:1911-1917.
264. Hoogerwerf A.C., Wise K.D. A three-dimensional microelectrode array for chronic neural recording. IEEE Trans. Biomed. Eng. 1994, 41:1136-1146.
265. Normann R.A., Maynard E.M., Rousche P.J., Warren D.J. A neural interface for a cortical vision prosthesis. Vision Res. 1999, 39:2577-2587.
266. Rajaraman S., Bragg J.A., Ross J.D., Allen M.G. Micromachined three-dimensional electrode arrays for transcutaneous nerve tracking. J. Micromech. Microeng. 2011, 21:085014.
267. Rajaraman S., Choi S.-O., McClain M.A., Ross J.D., LaPlaca M.C., Allen M.G. Metal-transfer-micromolded three-dimensional microelectrode arrays for in-vitro brain-slice recordings. J. Microelectromech. S. 2011, 20:396-409.
268. Rousche P.J., Pellinen D.S., Pivin D.P., Williams J.C., Vetter R.J., Kipke D.R. Flexible polyimide-based intracortical electrode arrays with bioactive capability. IEEE Trans. Biomed. Eng. 2001, 48:361-371.
269. Vetter R.J., Williams J.C., Hetke J.F., Nunamaker E.A., Kipke D.R. Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex. IEEE Trans. Biomed. Eng. 2004, 51:896-904.
270. Wise K.D., Sodagar A.M., Yao Y., Gulari M.N., Perlin G.E., Najafi K. Microelectrodes, microelectronics, and implantable neural microsystems. Proc. IEEE 2008, 96:1184-1202.
271. Griss P., Tolvanen-Laakso H.K., Merilainen P., Stemme G. Characterization of micromachined spiked biopotential electrodes. IEEE Trans. Biomed. Eng. 2002, 49:597-604.
272. Wu X.M., Todo H., Sugibayashi K. Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis. J. Control. Release 2007, 118:189-195.
273. Katikaneni S., Badkar A., Nema S., Banga A.K. Molecular charge mediated transport of a 13kD protein across microporated skin. Int. J. Pharm. 2009, 378:93-100.
274. Katikaneni S., Li G.H., Badkar A., Banga A.K. Transdermal delivery of a similar to 13kDa protein-an in vivo comparison of physical enhancement methods. J. Drug Target. 2010, 18:141-147.
275. Chen H.B., Zhu H.D., Zheng J.N., Mou D.S., Wan J.L., Zhang J.Y., Shi T.L., Zhao Y.J., Xu H.B., Yang X.L. Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin. J. Control. Release 2009, 139:63-72.
276. Wilson J.R., Kehl L.J., Beiraghi S. Enhanced topical anesthesia of 4% lidocaine with microneedle pretreatment and iontophoresis. Northwest Dent. 2008, 87:40-41.
277. Yan K., Todo H., Sugibayashi K. Transdermal drug delivery by in-skin electroporation using a microneedle array. Int. J. Pharm. 2010, 397:77-83.
278. Choi S.O., Kim Y.C., Lee J.W., Park J.H., Prausnitz M.R., Allen M.G. Intracellular protein delivery and gene transfection by electroporation using a microneedle electrode array. Small 2012, 8:1081-1091.
279. Lee K., Kim J.D., Lee C.Y., Her S., Jung H. A high-capacity, hybrid electro-microneedle for in-situ cutaneous gene transfer. Biomaterials 2011, 32:7705-7710.
280. Hooper J.W., Golden J.W., Ferro A.M., King A.D. Smallpox DNA vaccine delivered by novel skin electroporation device protects mice against intranasal poxvirus challenge. Vaccine 2007, 25:1814-1823.
281. Brave A., Gudmundsdotter L., Sandstrom E., Haller B.K., Hallengard D., Maltais A.-K., King A.D., Stout R.R., Blomberg P., Hoglund U., Hejdeman B., Biberfeld G., Wahren B. Biodistribution persistence and lack of integration of a multigene HIV vaccine delivered by needle-free intradermal injection and electroporation. Vaccine 2010, 28:8203-8209.
282. Roos A.-K., Eriksson F., Walters D.C., Pisa P., King A.D. Optimization of skin electroporation in mice to increase tolerability of DNA vaccine delivery to patients. Mol. Ther. 2009, 17:1637-1642.
283. Jiang J., Moore J.S., Edelhauser H.F., Prausnitz M.R. Intrascleral drug delivery to the eye using hollow microneedles. Pharm. Res. 2009, 26:395-403.
284. Patel S.R., Lin A.S.P., Edelhauser H.F., Prausnitz M.R. Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm. Res. 2011, 28:166-176.
285. Palakurthi N.K., Correa Z.M., Augsburger J.J., Banerjee R.K. Toxicity of a biodegradable microneedle implant loaded with methotrexate as a sustained release device in normal rabbit eye: a pilot study. J. Ocul. Pharmacol. Ther. 2011, 27:151-156.
286. Navarro J., Risco R., Toschi M., Schattman G. Gene therapy and intracytoplasmatic sperm injection (ICSI) - a review. Placenta 2008, 29:193-199.
287. Zhang Y., Yu L.C. Single-cell microinjection technology in cell biology. Bioessays 2008, 30:606-610.
288. Niemann H., Kues W.A. Transgenic farm animals: an update. Reprod. Fertil. Dev. 2007, 19:762-770.
289. Obataya I., Nakamura C., Han S., Nakamura N., Miyake J. Nanoscale operation of a living cell using an atomic force microscope with a nanoneedle. Nano Lett. 2005, 5:27-30.
290. Obataya F., Nakamura C., Han S.W., Nakamura N., Miyake J. Mechanical sensing of the penetration of various nanoneedles into a living cell using atomic force microscopy. Biosens. Bioelectron. 2005, 20:1652-1655.
291. Han S.W., Nakamura C., Obataya I., Nakamura N., Miyake J. Gene expression using an ultrathin needle enabling accurate displacement and low invasiveness. Biochem. Biophys. Res. Commun. 2005, 332:633-639.
292. Han S.W., Nakamura C., Obataya I., Nakamura N., Miyake J. A molecular delivery system by using AFM and nanoneedle. Biosens. Bioelectron. 2005, 20:2120-2125.
293. Han S.W., Nakamura C., Kotobuki N., Obataya I., Ohgushi H., Nagamune T., Miyake J. High-efficiency DNA injection into a single human mesenchymal stem cell using a nanoneedle and atomic force microscopy. Nanomed.-Nanotechnol. Biol. Med. 2008, 4:215-225.
294. Han S.W., Nakamura C., Imai Y., Nakamura N., Miyake J. Monitoring of hormonal drug effect in a single breast cancer cell using an estrogen responsive GFP reporter vector delivered by a nanoneedle. Biosens. Bioelectron. 2009, 24:1219-1222.
295. Kihara T., Yoshida N., Kitagawa T., Nakamura C., Nakamura N., Miyake J. Development of a novel method to detect intrinsic mRNA in a living cell by using a molecular beacon-immobilized nanoneedle. Biosens. Bioelectron. 2010, 26:1449-1454.
296. Han S.W., Mieda S., Nakamura C., Kihara T., Nakamura N., Miyake J. Successive detection of insulin-like growth factor-II bound to receptors on a living cell surface using an AFM. J. Mol. Recognit. 2011, 24:17-22.
297. Chen X., Kis A., Zettl A., Bertozzi C.R. A cell nanoinjector based on carbon nanotubes. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:8218-8222.
298. Yum K., Na S., Xiang Y., Wang N., Yu M.F. Mechanochemical delivery and dynamic tracking of fluorescent quantum dots in the cytoplasm and nucleus of living cells. Nano Lett. 2009, 9:2193-2198.
299. Singhal R., Orynbayeva Z., Sundaram R.V.K., Niu J.J., Bhattacharyya S., Vitol E.A., Schrlau M.G., Papazoglou E.S., Friedman G., Gogotsi Y. Multifunctional carbon-nanotube cellular endoscopes. Nat. Nanotechnol. 2011, 6:57-64.
300. Hashmi S., Ling P., Hashmi G., Reed M., Gaugler R., Trimmer W. Genetic transformation of nematodes using arrays of micromechanical piercing structures. Biotechniques 1995, 19:766-770.
301. Chun K., Hashiguchi G., Toshiyoshi H., Fujita H. Fabrication of array of hollow microcapillaries used for injection of genetic materials into animal/plant cells. Jpn. J. Appl. Phys. Part 2 Lett. 1999, 38:279-281.
302. Kolhar P., Doshi N., Mitragotri S. Polymer nanoneedle-mediated intracellular drug delivery. Small 2011, 7:2094-2100.
303. Reed M.L., Wu C., Kneller J., Watkins S., Vorp D.A., Nadeem A., Weiss L.E., Rebello K., Mescher M., Smith A.J.C., Rosenblum W., Feldman M.D. Micromechanical devices for intravascular drug delivery. J. Pharm. Sci. 1998, 87:1387-1394.
304. Choi Y., McClain M.A., LaPlaca M.C., Frazier A.B., Allen M.G. Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures. Biomed. Microdevices 2007, 9:7-13.
305. Harper J.C., Brozik S.M., Flemming J.H., McClain J.L., Polsky R., Raj D., Ten Eyck G.A., Wheeler D.R., Achyuthan K.E. Fabrication and testing of a microneedles sensor array for p-cresol detection with potential biofuel applications. ACS Appl. Mater. Interfaces 2009, 1:1591-1598.
306. Martanto W., Moore J.S., Couse T., Prausnitz M.R. Mechanism of fluid infusion during microneedle insertion and retraction. J. Control. Release 2006, 112:357-361.
307. Kendall M.A.F., Chong Y.F., Cock A. The mechanical properties of the skin epidermis in relation to targeted gene and drug delivery. Biomaterials 2007, 28:4968-4977.
308. Khanna P., Luongo K., Strom J.A., Bhansali S. Sharpening of hollow silicon microneedles to reduce skin penetration force. J. Micromech. Microeng. 2010, 20:045011.
309. Crichton M.L., Donose B.C., Chen X.F., Raphael A.P., Huang H., Kendall M.A.F. The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers. Biomaterials 2011, 32:4670-4681.
310. Groves R.B., Coulman S.A., Birchall J.C., Evans S.L. Quantifying the mechanical properties of human skin to optimise future microneedle device design. Comput. Meth. Biomech. Biomed. Eng. 2012, 15:73-82.
311. You S.K., Noh Y.W., Park H.H., Han M., Lee S.S., Shin S.C., Cho C.W. Effect of applying modes of the polymer microneedle-roller on the permeation of l-ascorbic acid in rats. J. Drug Target. 2010, 18:15-20.
312. Wang Q., Jaimes-Lizcano Y.A., Lawson L.B., John V.T., Papadopoulos K.D. Improved dermal delivery of FITC-BSA using a combination of passive and active methods. J. Pharm. Sci. 2011, 100:4804-4814.
313. Kalluri H., Kolli C.S., Banga A.K. Characterization of microchannels created by metal microneedles: formation and closure. AAPS J. 2011, 13:473-481.
314. Yang M., Zahn J.D. Microneedle insertion force reduction using vibratory actuation. Biomed. Microdevices 2004, 6:177-182.
315. Sun L., Wang H., Chen L., Liu Y. A novel ultrasonic micro-dissection, technique for biomedicine. Ultrasonics 2006, 44:e255-e260.
316. Verbaan F.J., Bal S.M., van den Berg D.J., Dijksman J.A., van Hecke M., Verpoorten H., van den Berg A., Luttge R., Bouwstra J.A. Improved piercing of microneedle arrays in dermatomed human skin by an impact insertion method. J. Control. Release 2008, 128:80-88.
317. Crichton M.L., Ansaldo A., Chen X.F., Prow T.W., Fernando G.J.P., Kendall M.A.F. The effect of strain rate on the precision of penetration of short densely-packed microprojection array patches coated with vaccine. Biomaterials 2010, 31:4562-4572.
318. Enfield J., O'Connell M.L., Lawlor K., Jonathan E., O'Mahony C., Leahy M. In-vivo dynamic characterization of microneedle skin penetration using optical coherence tomography. J. Biomed. Opt. 2010, 15:046001.
319. Coulman S.A., Birchall J.C., Alex A., Pearton M., Hofer B., O'Mahony C., Drexler W., Povazay B. In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography. Pharm. Res. 2011, 28:66-81.
320. Donnelly R.F., Garland M.J., Morrow D.I.J., Migalska K., Singh T.R.R., Majithiya R., Woolfson A.D. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. J. Control. Release 2010, 147:333-341.
321. Davis S.P., Landis B.J., Adams Z.H., Allen M.G., Prausnitz M.R. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J. Biomech. 2004, 37:1155-1163.
322. Park J.H., Prausnitz M.R. Analysis of mechanical failure of polymer microneedles by axial force. J. Korean Phys. Soc. 2010, 56:1223-1227.
323. Takano N., Tachikawa H., Miyano T., Nishiyabu K. Insertion testing of polyethylene glycol microneedle array into cultured human skin with biaxial tension. J. Solid Mech. Mat. Eng. 2009, 3:604-612.
324. Tachikawa H., Takano N., Nishiyabu K., Miki N., Ami Y. Effect of tension and curvature of skin on insertion characteristics of microneedle array. J. Solid Mech. Mat. Eng. 2010, 4:470-480.
325. Aggarwal P., Johnston C.R. Geometrical effects in mechanical characterizing of microneedle for biomedical applications. Sens. Actuators B Chem 2004, 102:226-234.
326. Kong X.Q., Zhou P., Wu C.W. Numerical simulation of microneedles' insertion into skin. Comput. Meth. Biomech. Biomed. Eng. 2011, 14:827-835.
327. Martanto W., Baisch S.M., Costner E.A., Prausnitz M.R., Smith M.K. Fluid dynamics in conically tapered microneedles. AICHE J. 2005, 51:1599-1607.
328. Gupta J., Park S.S., Bondy B., Felner E.I., Prausnitz M.R. Infusion pressure and pain during microneedle injection into skin of human subjects. Biomaterials 2011, 32:6823-6831.
329. Gupta J., Gill H.S., Andrews S.N., Prausnitz M.R. Kinetics of skin resealing after insertion of microneedles in human subjects. J. Control. Release 2011, 154:148-155.
330. Kim Y.C., Quan F.S., Compans R.W., Kang S.M., Prausnitz M.R. Stability kinetics of influenza vaccine coated onto microneedles during drying and storage. Pharm. Res. 2011, 28:135-144.
331. Chen X., Fernando G.J.P., Crichton M.L., Flaim C., Yukiko S.R., Fairmaid E.J., Corbett H.J., Primiero C.A., Ansaldo A.B., Frazer I.H., Brown L.E., Kendall M.A.F. Improving the reach of vaccines to low-resource regions, with a needle-free vaccine delivery device and long-term thermostabilization. J. Control. Release 2011, 152:349-355.
332. Choi H.-J., Yoo D.-G., Bondy B.J., Quan F.-S., Compans R.W., Kang S.-M., Prausnitz M.R. Stability of influenza vaccine coated onto microneedles. Biomaterials 2012, 33:3756-3769.
333. Birchall J.C., Clemo R., Anstey A., John D.N. Microneedles in clinical practice - an exploratory study into the opinions of healthcare professionals and the public. Pharm. Res. 2011, 28:95-106.
334. Arnou R., Frank M., Hagel T., Prébet A. Willingness to vaccinate/get vaccinated with an intradermal seasonal influenza vaccine: a survey of general practitioners and the general public in France and Germany. Adv. Ther. 2011, 28:555-565.
335. Kaushik S., Hord A.H., Denson D.D., McAllister D.V., Smitra S., Allen M.G., Prausnitz M.R. Lack of pain associated with microfabricated microneedles. Anesth. Analg. 2001, 92:502-504.
336. Gill H.S., Denson D.D., Burris B.A., Prausnitz M.R. Effect of microneedle design on pain in human volunteers. Clin. J. Pain 2008, 24:585-594.
337. Bal S.M., Caussin J., Pavel S., Bouwstra J.A. In vivo assessment of safety of microneedle arrays in human skin. Eur. J. Pharm. Sci. 2008, 35:193-202.
338. Haq M.I., Smith E., John D.N., Kalavala M., Edwards C., Anstey A., Morrissey A., Birchall J.C. Clinical administration of microneedles: skin puncture, pain and sensation. Biomed. Microdevices 2009, 11:35-47.
339. Noh Y.-W., Kim T.-H., Baek J.-S., Park H.-H., Lee S.S., Han M., Shin S.-C., Cho C.-W. In vitro characterization of the invasiveness of polymer microneedle against skin. Int. J. Pharm. 2010, 397:201-205.
340. Hutin Y., Hauri A., Chiarello L., Catlin M., Stilwell B., Ghebrehiwet T., Garner J., Members Injection B. Safety, best infection control practices for intradermal, subcutaneous, and intramuscular needle injections. Bull. WHO 2003, 81:491-500.
341. Kupper T.S., Fuhlbrigge R.C. Immune surveillance in the skin: mechanisms and clinical consequences. Nat. Rev. Immunol. 2004, 4:211-222.
342. Donnelly R.F., Singh T.R.R., Tunney M.M., Morrow D.I.J., McCarron P.A., O'Mahony C., Woolfson A.D. Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro. Pharm. Res. 2009, 26:2513-2522.
343. Zahn J.D., Talbot N.H., Liepmann D., Pisano A.P. Microfabricated polysilicon microneedles for minimally invasive biomedical devices. Biomed. Microdevices 2000, 2:295-303.
344. Lin L.W., Pisano A.P. Silicon-processed microneedles. J. Microelectromech. S. 1999, 8:78-84.
345. Brazzle J., Papautsky I., Frazier A.B. Micromachined needle arrays for drug delivery or fluid extraction - design and fabrication aspects of fluid coupled arrays of hollow metallic microneedles. IEEE Eng. Med. Biol. Mag. 1999, 18:53-58.
346. Belshe R.B., Newman F.K., Cannon J., Duane C., Treanor J., Van Hoecke C., Howe B.J., Dubin G. Serum antibody responses after intradermal vaccination against influenza. N. Engl. J. Med. 2004, 351:2286-2294.
347. Ansaldi F., Durando P., Icardi G. Intradermal influenza vaccine and new devices: a promising chance for vaccine improvement. Expert Opin. Biol. Ther. 2011, 11:415-427.
348. Gupta S.K., Bernstein K.J., Noorduin H., Van Peer A., Sathyan G., Haak R. Fentanyl delivery from an electrotransport system: delivery is a function of total current, not duration of current. J. Clin. Pharmacol. 1998, 38:951-958.
349. Ami Y., Tachikawa H., Takano N., Miki N. Formation of polymer microneedle arrays using soft lithography. Journal of Micro-Nanolithography Mems and Moems 2011, 10:011503.
350. Fernández L.J., Altuna A., Tijero M., Gabriel G., Villa R., Rodríguez M.J., Batlle M., Vilares R., Berganzo J., Blanco F. Study of functional viability of SU-8-based microneedles for neural applications. Journal of Micromechanics and Microengineering 2009, 19:025007.