Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue SUPPL. 2, 2003, Pages 13755-13760

  McAllister, Devin V ^a   Wang, Ping M ^a   Davis, Shawn P ^a   Park, Jung Hwan ^a,b   Canatella, Paul J ^a   Allen, Mark G ^c   Prausnitz, Mark R ^a,b  

^a Georgia Institute of Technology   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Hollow needle injection; Microelectromechanical systems; Skin; Solid microneedle; Transdermal drug delivery

Indexed keywords

COPPER; GLASS; ISOPHANE INSULIN; METAL; NANOPARTICLE; POLYGLACTIN; POLYMER; SILICON; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; CADAVER; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; ELECTROPLATING INDUSTRY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MACROMOLECULE; MALE; MICROINJECTION; NEEDLE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RAT STRAIN; SKIN PERMEABILITY;

ADMINISTRATION, CUTANEOUS; ANIMALS; BIOMEDICAL ENGINEERING; BLOOD GLUCOSE; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; EQUIPMENT DESIGN; GLASS; HUMANS; INSULIN; MACROMOLECULAR SUBSTANCES; MALE; METALS; MICROINJECTIONS; MODELS, BIOLOGICAL; NANOTECHNOLOGY; POLYMERS; RATS; SILICON; SYRINGES;

ANIMALIA;

EID: 0344270926     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2331316100     Document Type: Article

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