Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles

Journal of Controlled Release

Volumn 147, Issue 3, 2010, Pages 326-332

  Quan, Fu Shi ^a   Kim, Yeu Chun ^a,b   Compans, Richard W ^a   Prausnitz s, Mark R ^b   Kang, Sang Moo ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Georgia Institute of Technology   (United States)

Author keywords

Dose sparing; Influenza; Microneedle; Skin; Virus like particle vaccine

Indexed keywords

ANTIBODY RESPONSE; BONE MARROW; DOSE SPARING; HIGH DOSE; IMMUNE RESPONSE; INFLUENZA; INFLUENZA VACCINES; INFLUENZA VIRUS; LOW DOSE; MICRONEEDLES; MOUSE MODELS; PROTECTIVE EFFICACY; VIRUS-LIKE PARTICLE VACCINE; VIRUS-LIKE PARTICLES;

ANTIBODIES; IMMUNIZATION; VACCINES; VIRUSES;

NEEDLES;

CYTOKINE; IMMUNOGLOBULIN G; INFLUENZA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELL SECRETION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; IMMUNE RESPONSE; INFLUENZA; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; SURVIVAL RATE; VIRUS LIKE AGENT;

ANIMALS; ANTIBODIES, VIRAL; BONE MARROW; CELL LINE; CYTOKINES; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; EQUIPMENT DESIGN; FEMALE; HEMAGGLUTINATION INHIBITION TESTS; HEMAGGLUTINATION, VIRAL; IMMUNOGLOBULIN G; INFLAMMATION MEDIATORS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA VACCINES; INJECTIONS, INTRADERMAL; INJECTIONS, INTRAMUSCULAR; LUNG; MICE; MICE, INBRED BALB C; MICROINJECTIONS; MINIATURIZATION; NEEDLES; NEUTRALIZATION TESTS; SKIN; TIME FACTORS; VACCINES, VIROSOME;

EID: 78049454969     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.07.125     Document Type: Article

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