Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA)- and 5-aminolevulinic acid methyl ester (MAL)-induced PpIX production for topical photodynamic therapy without increase in pain or erythema

Pharmaceutical Research

Volumn 27, Issue 10, 2010, Pages 2213-2220

  Mikolajewska, Patrycja ^a   Donnelly, Ryan F ^b   Garland, Martin J ^b   Morrow, Desmond I J ^b   Singh, Thakur Raghu Raj ^b   Iani, Vladimir ^a   Moan, Johan ^a,c   Juzeniene, Asta ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

aminolevulinic acid (ALA); aminolevulinic acid methyl ester (MAL); erythema; microneedles (MNs); photodynamic therapy (PDT)

Indexed keywords

AMINOLEVULINIC ACID; AMINOLEVULINIC ACID METHYL ESTER; PROTOPORPHYRIN;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG PENETRATION; ERYTHEMA; FEMALE; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN EXPERIMENT; LIGHT EXPOSURE; MALE; MICRONEEDLE; NEEDLE; NORMAL HUMAN; PAIN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SKIN PENETRATION; SKIN WATER LOSS;

ADMINISTRATION, CUTANEOUS; ADULT; AMINOLEVULINIC ACID; ERYTHEMA; FEMALE; HUMANS; LIGHT; MALE; NEEDLES; PAIN; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PROTOPORPHYRINS; PUNCTURES; SILICON; SKIN; SKIN ABSORPTION;

EID: 77957370415     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0227-2     Document Type: Article

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