Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery

Nature Medicine

Volumn 8, Issue 4, 2002, Pages 415-419

  Mikszta, John A ^a   Alarcon, Jason B ^a   Brittingham, John M ^a   Sutter, Diane E ^a   Pettis, Ronald J ^a   Harvey, Noel G ^a  

^a BD Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMID DNA; SILICON; VACCINE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVICE; EPIDERMIS; FEMALE; GENE DELIVERY SYSTEM; GENE DISRUPTION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; GENETIC PROCEDURES; IMMUNE RESPONSE; IMMUNIZATION; MICROENHANCER ARRAY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SKIN IRRITATION; SKIN PROTECTION;

ANIMALS; BIOLISTICS; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; HUMANS; IMMUNIZATION; LUCIFERASES; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, SCANNING; PLASMIDS; SKIN;

ANIMALIA;

EID: 0036105150     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0402-415     Document Type: Article

References (20)

1. Cutaneous vaccination: The skin as an immunologically active tissue and the challenge of antigen delivery
2. + T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine
3. Transcutaneous immunization: A human vaccine delivery strategy using a patch
4. Topical application of viral vectors for epidermal gene transfer
5. Vaccination onto bare skin
6. Liposome-mediated gene transfer and expression via the skin
7. The feasibility of targeted selective gene therapy of the hair follicle
8. Efficient delivery of transgenes to human hair follicle progenitor cells using topical lipoplex
9. Microfabricated microneedles for gene and drug delivery
10. Computerized evaporimetry using the DermalLab TEWL probe
11. Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: Manipulation of affect by diazepam
12. Immunization via hair follicles by topical application of naked DNA to normal skin
13. Monitoring antigen-specific T cells using MHC-Ig dimers
14. Intradermal gene immunization: The possible role of DNA uptake in the induction of cellular immunity to viruses
15. Transdermal immunization with an integral membrane component, gap junction protein, by means of ultradeformable drug carriers, transferosomes
16. Protection against influenza virus challenge by topical application of influenza DNA vaccine
17. Topical gene delivery to murine skin
18. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates