Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 11, 2010, Pages 3280-3283

  Yerramreddy, Thirupathi Reddy ^a   Milewski, Mikolaj ^a   Penthala, Narsimha Reddy ^a   Stinchcomb, Audra L ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

Alcohol dependence and opioid addiction; Microneedle enhanced transdermal delivery; Naltrexone prodrugs

Indexed keywords

3 O [2 (2 (2 HYDROXYETHOXY 2 METHOXYETHOXY)ETHOXY)ETHYLCARBAMIC]NALTREXONE; 3 O [3 (2 (2 METHOXYETHOXY 2 HYDROXYETHOXY)PROPANOYL]NALTREXONE; NALTREXONE; NALTREXONE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; MICRONEEDLE ENHANCED TRANSDERMAL DELIVERY;

ADMINISTRATION, CUTANEOUS; ANIMALS; CARBOXYLIC ACIDS; NALTREXONE; NARCOTIC ANTAGONISTS; NEEDLES; PRODRUGS; SOLUBILITY; SWINE; SWINE, MINIATURE; VISCOSITY;

EID: 77953321546     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.049     Document Type: Article

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