Effect of microneedle design on pain in human volunteers

Clinical Journal of Pain

Volumn 24, Issue 7, 2008, Pages 585-594

  Gill, Harvinder S ^a   Denson, Donald D ^c   Burris, Brett A ^b   Prausnitz, Mark R ^a,b,d  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b EMORY UNIVERSITY   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Georgia Institute of Technology   (United States)

Author keywords

Hypodermic needle; Microneedle dimensions; Microneedle length; Transdermal drug delivery

Indexed keywords

ADULT; ARTICLE; FEMALE; FOREARM; HUMAN; HUMAN EXPERIMENT; MALE; NEEDLE; NORMAL HUMAN; PAIN; PAIN ASSESSMENT; PRIORITY JOURNAL; THICKNESS; VISUAL ANALOG SCALE; ADOLESCENT; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EQUIPMENT; EQUIPMENT DESIGN; INJECTION; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ADULT; DOUBLE-BLIND METHOD; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEMALE; HUMANS; INJECTIONS; MALE; NEEDLES; PAIN; PAIN MEASUREMENT;

EID: 55249125056     PISSN: 07498047     EISSN: 15365409     Source Type: Journal    
DOI: 10.1097/AJP.0b013e31816778f9     Document Type: Article

References (28)

1. Prausnitz MR. Microneedles for transdermal drug delivery. Adv Drug Deliv Rev. 2004;56:581-587.
2. Hanas R. Reducing injection pain in children and adolescents with diabetes: a review of indwelling catheters. Pediatr Diabetes. 2004;5:102-111.
3. Hamilton JG. Needle phobia: a neglected diagnosis. J Fam Pract. 1995;41:169-175.
4. Deacon B, Abramowitz J. Fear of needles and vasovagal reactions among phlebotomy patients. J Anxiety Disord. 2006;20:946-960.
5. Nir Y, Paz A, Sabo E, et al. Fear of injections in young adults: prevalence and associations. Am J Trop Med Hyg. 2003;68:341-344.
6. Hauri A, Armstrong G, Hutin Y. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS. 2004;15:7-16.
7. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004;3:115-124.
8. McAllister DV, Wang PM, Davis SP, et al. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc Natl Acad Sci USA. 2003;100:13755-13760.
9. Chabri F, Bouris K, Jones T, et al. Microfabricated silicon microneedles for nonviral cutaneous gene delivery. Br J Dermatol. 2004;150:869-877.
10. Gill HS, Prausnitz MR. Coating formulations for microneedles. Pharm Res. 2007;24:1369-1380.
11. Martanto W, Davis SP, Holiday NR, et al. Transdermal delivery of insulin using microneedles in vivo. Pharm Res. 2004;21:947-952.
12. Mikszta JA, Alarcon JB, Brittingham JM, et al. Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. Nat Med. 2002;8:415-119.
13. Alarcon JB, Hartley AW, Harvey NG, et al. Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines. Clin Vaccine Immunol. 2007;14:375-381.
14. Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles. Anesth Analg. 2001;92:502-504.
15. Gill HS, Prausnitz MR. Coated microneedles for transdermal delivery. J Control Release. 2007;117:227-237.
16. Neter J, Kutner MH, Nachtsheim CJ, et al. Applied Linear Statistical Models. Homewood, IL: McGraw Hill/Irwin; 1996.
17. Dexter F, Chestnut DH. Analysis of statistical tests to compare visual analog scale measurements among groups. Anesthesiology. 1995;82:896-902.
18. CDC. Centers for Disease Control and Prevention. General recommendations on immunization. MMWR Recomm Rep. 2006; 55(No. RR-15).
19. Hanas R, Lytzen L, Ludvigsson J. Thinner needles do not influence injection pain, insulin leakage or bleeding in children and adolescents with type 1 diabetes. Pediatr Diabetes. 2000;1:142-149.
20. Oaklander AL, Siegel SM. Cutaneous innervation: form and function. J Am Acad Dermatol. 2005;53:1027-1037.
21. Davis SP, Landis BJ, Adams ZH, et al. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force. J Biomech. 2004;37:1155-1163.
22. Egekvist H, Bjerring P, Arendt-Nielsen L. Pain and mechanical injury of human skin following needle insertions. Eur J Pain. 1999;3:41-49.
23. Egekvist H, Bjerring P, Arendt-Nielsen L. Regional variations in pain to controlled mechanical skin traumas from automatic needle insertions and relations to ultrasonography. Skin Res Technol. 1999;5:247-254.
24. Fruhstorfer H, Schmelzeisen-Redeker G, Weiss T. Capillary blood sampling: relation between lancet diameter, lancing pain and blood volume. Eur J Pain. 1999;3:283-286.
25. Arendt-Nielsen L, Egekvist H, Bjerring P. Pain following controlled cutaneous insertion of needles with different diameters. Somatosens Mot Res. 2006;23:37-43.
26. Fruhstorfer H, Muller T, Scheer E. Capillary blood sampling: how much pain is necessary? Part 2: Relation between penetration depth and puncture pain. Pract Diabetes Int. 1995;12: 184-185.
27. Park J-H, Allen MG, Prausnitz MR. Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery. J Control Release. 2005;104:51-66.
28. Kettwich SC, Sibbitt WL Jr, Brandt JR, et al. Needle phobia and stress-reducing medical devices in pediatric and adult chemotherapy patients. J Pediatr Oncol Nurs. 2007;24:20-28.